An Inducible, Isogenic Cancer Cell Line System for Targeting the State of Mismatch Repair Deficiency

Cytosine-based nucleoside analogs are selectively lethal to DNA mismatch repair-deficient tumour cells by enhancing levels of intracellular oxidative stress

(2013) M Hewish et al.   BRITISH JOURNAL OF CANCER

The path for metal complexes to a DNA target

(2013) Alexis C. Komor et al.   CHEMICAL COMMUNICATIONS

Cell-Selective Biological Activity of Rhodium Metalloinsertors Correlates with Subcellular Localization

(2012) Alexis C. Komor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Cytotoxicity of Rhodium Metalloinsertors in Mismatch Repair-Deficient Cells

(2011) Russell J. Ernst et al.   BIOCHEMISTRY

Parallel High-Throughput RNA Interference Screens Identify PINK1 as a Potential Therapeutic Target for the Treatment of DNA Mismatch Repair-Deficient Cancers

(2011) S. A. Martin et al.   CANCER RESEARCH

Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

(2011) Barthelemy Diouf et al.   NATURE MEDICINE

Mismatch Repair, But Not Heteroduplex Rejection, Is Temporally Coupled to DNA Replication

(2011) H. Hombauer et al.   SCIENCE

Therapeutic Targeting of the DNA Mismatch Repair Pathway

(2010) S. A. Martin et al.   CLINICAL CANCER RESEARCH

Double strand break repair components are frequent targets of microsatellite instability in endometrial cancer

(2010) Cristina Bilbao et al.   EUROPEAN JOURNAL OF CANCER

Microsatellite Instability in Colorectal Cancer

(2010) C. Richard Boland et al.   GASTROENTEROLOGY

Robust, Reversible Gene Knockdown Using a Single Lentiviral Short Hairpin RNA Vector

(2010) Cheryl Y. Brown et al.   HUMAN GENE THERAPY

Aberrant DNA methylation of some tumor suppressor genes in lung cancers from workers with chromate exposure

(2010) Abdellah H. K. Ali et al.   MOLECULAR CARCINOGENESIS

Mismatch repair deficient colorectal cancer in the era of personalized treatment

(2010) Madeleine Hewish et al.   Nature Reviews Clinical Oncology

Microsatellite instability in colorectal cancer—the stable evidence

(2010) Eduardo Vilar et al.   Nature Reviews Clinical Oncology

An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anticancer Agents

(2009) Melanie H. Kucherlapati et al.   GASTROENTEROLOGY

DNA Mismatch Binding and Antiproliferative Activity of Rhodium Metalloinsertors

(2009) Russell J. Ernst et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY