CYP2B6 Non-Coding Variation Associated with Smoking Cessation Is Also Associated with Differences in Allelic Expression, Splicing, and Nicotine Metabolism Independent of Common Amino-Acid Changes

Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6

(2012) A. Joseph Bloom et al.   HUMAN MOLECULAR GENETICS

Associations Between ABCB1, CYP2A6, CYP2B6, CYP2D6, and CYP3A5 Alleles in Relation to Efavirenz and Nevirapine Pharmacokinetics in HIV-Infected Individuals

(2012) Sandra G. Heil et al.   THERAPEUTIC DRUG MONITORING

Effect of CYP2B6*6 and CYP2C19*2 genotype on chlorpyrifos metabolism

(2012) Alice L. Crane et al.   TOXICOLOGY

Population Pharmacokinetic/Pharmacogenetic Model for Optimization of Efavirenz Therapy in Caucasian HIV-Infected Patients

(2011) Almudena Sánchez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Q172H Replacement Overcomes Effects on the Metabolism of Cyclophosphamide and Efavirenz Caused by CYP2B6 Variant with Arg262

(2011) N. Ariyoshi et al.   DRUG METABOLISM AND DISPOSITION

Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether

(2011) M. Honda et al.   DRUG METABOLISM AND DISPOSITION

CYP2B6 genotype is a strong predictor of systemic exposure to efavirenz in HIV-infected Zimbabweans

(2011) Milimo Maimbo et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Smoking Cessation Pharmacogenetics: Analysis of Varenicline and Bupropion in Placebo-Controlled Clinical Trials

(2011) David P King et al.   NEUROPSYCHOPHARMACOLOGY

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European–Americans

(2011) Joseph Bloom et al.   Pharmacogenetics and Genomics

Associations of CYP2A6 genotype with smoking behaviors in southern China

(2010) Tao Liu et al.   ADDICTION

CYP2B6 and OPRM1 gene variations predict methadone-related deaths

(2010) Hannah Bunten et al.   ADDICTION BIOLOGY

Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior

(2010) Thorgeir E Thorgeirsson et al.   NATURE GENETICS

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

(2010)   NATURE GENETICS

Alternative splicing and evolution: diversification, exon definition and function

(2010) Hadas Keren et al.   NATURE REVIEWS GENETICS

Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism

(2010) N. Al Koudsi et al.   XENOBIOTICA

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans

(2009) Jackson K. Mukonzo et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

(2008) A. D. Johnson et al.   BIOINFORMATICS

Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation

(2008) Lan Fan et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia

(2008) Odity Mukherjee et al.   HUMAN MUTATION

ADVIRC is caused by distinct mutations in BEST1 that alter pre-mRNA splicing

(2008) R Burgess et al.   JOURNAL OF MEDICAL GENETICS

Aberrant Splicing Caused by Single Nucleotide Polymorphism c.516G>T [Q172H], a Marker of CYP2B6*6, Is Responsible for Decreased Expression and Activity of CYP2B6 in Liver

(2008) M. H. Hofmann et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS