Article
Chemistry, Multidisciplinary
Yen-Lan Chang, Pei-Bang Liao, Ping-Han Wu, Wei-Jen Chang, Sheng-Yang Lee, Haw-Ming Huang
Summary: The low-molecular-weight hyaluronic acid-conjugated superparamagnetic iron oxide nanoparticles synthesized in this study exhibited selective cytotoxicity toward cancer cells and had no cytotoxic effects on normal fibroblast cells. These nanoparticles have the potential to be used as both a candidate for magnetic resonance imaging applications and an injectable anticancer agent.
Article
Nanoscience & Nanotechnology
Yulian Chen, Qian Zhang, Xuan Qin, Jin Li, Yantao Zhao, Yang Xia
Summary: This study demonstrates that polyglucose sorbitol carboxymethyl ether (PSC) coated superparamagnetic iron oxide nanoparticles (SPIONs) can protect human gingival fibroblasts (hGFs) against invasion and inflammatory stimulation by Porphyromonas gingivalis (P. gingivalis).
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Chichong Lu, Xue Xu, Tingting Zhang, Zhijie Wang, Yuyun Chai
Summary: This study presents a simple and efficient method to engineer manganese-doped iron oxide nanoclusters (MnIO NCs) with excellent water-solubility, colloidal stability, biocompatibility, and superparamagnetic properties. MnIO NCs show great potential in T-1-T-2 dual-mode magnetic resonance imaging for deep tissue.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Pierre-Olivier Champagne, Nathalie T. Sanon, Lionel Carmant, Dang Khoa Nguyen, Sylvain Deschenes, Philippe Pouliot, Alain Bouthillier, Mohamad Sawan
Summary: In this study, it was found that the aggregation of SPIONs near active brain tissue was proportional to the level of neuronal activity. The findings suggest that the MRI signal change induced by SPIONs aggregation could serve as a powerful tool for detecting brain electrical activity.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Mona Kappes, Bernhard Friedrich, Felix Pfister, Christian Huber, Ralf Phillipp Friedrich, Rene Stein, Christian Braun, Julia Band, Eveline Schreiber, Christoph Alexiou, Christina Janko
Summary: Noncontact manipulation of cells in regenerative medicine using superparamagnetic iron oxide nanoparticles (SPIONs) allows for new possibilities in tissue engineering. SPIONs can be used as drug transporters, contrast agents, or to make cells maneuverable by magnetic forces. Different SPION coatings, such as PAM and citrate, show good cellular loading and magnetic controllability of cells. This research demonstrates the potential for using SPIONs in 3D cell cultures and highlights their ability to accelerate spheroid formation and micropatterning.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Electrochemistry
Ademola Hammed, Andriy Voronov, Scott Pryor
Summary: The newly developed tubular electrochemical system (TES) overcomes scalability and sustainability challenges in synthesizing superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs). TES operates efficiently with electrolyte reuse and supplementation, allowing for control of SPION properties and increased yield and productivity.
JOURNAL OF APPLIED ELECTROCHEMISTRY
(2021)
Article
Chemistry, Physical
Mehri Karimi Jabali, Ali Reza Allafchian, Seyed Amir Hossein Jalali, Hamideh Shakeripour, Rezvan Mohammadinezhad, Fahime Rahmani
Summary: The study introduces the use of ascorbic acid-modified chitosan as a pDNA nanocarrier, demonstrating promising pDNA release in intestinal fluids and potential biocompatibility with cell lines Vero and EPC. Chitosan effectively shields pDNA in gastric environments and allows for release in alkaline intestinal tissues, presenting a novel approach for gene delivery through oral administration.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Multidisciplinary Sciences
Yutong Liu, Kwasi Adu-Berchie, Joshua M. Brockman, Matthew Pezone, David K. Y. Zhang, Jingyi Zhou, Jason W. Pyrdol, Hua Wang, Kai W. Wucherpfennig, David J. Mooney
Summary: This study uses nanotechnology to improve adoptive T cell transfer (ACT) therapies by metabolically labeling T cells with unnatural sugar nanoparticles, allowing direct conjugation of antitumor cytokines onto the T cell surface. This approach effectively enhances the efficacy of ACT therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemical Research Methods
Hyun Gyu Lee, Kyoung J. Lee
Summary: Proper cell-cell adhesiveness can enhance the super-diffusive nature of individual cells and promote cell movement within a dense population. Interestingly, research shows that cell dispersal within a densely packed population differs from free crawling, and this phenomenon can be explained by a simple cellular Potts model.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Oncology
Nushin Mirzaei, Fredrik Waernberg, Pontus Zaar, Henrik Leonhardt, Roger Olofsson Bagge
Summary: This study aimed to determine the feasibility of detecting sentinel lymph nodes (SLNs) in breast cancer patients using an ultra-low dose of superparamagnetic iron oxide nanoparticles (SPIO). SPIO was injected intradermally 4 days before surgery, and SLNs were detected using a handheld magnetometer during surgery. The results showed that SLNs were successfully detected in all patients using the ultra-low dose of SPIO.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Gilbert Aaron Lee, Wan-Li Lin, Duen-Pang Kuo, Yi-Tien Li, Yu-Wei Chang, Yung-Chie Chen, Shiu-Wen Huang, Justin Bo-Kai Hsu, Cheng-Yu Chen
Summary: Lipid-coated SPIO nanoparticles conjugated with PD-L1 antibodies can specifically target PD-L1 expression in glioblastoma, including temozolomide-resistant cases, as demonstrated in this study through characterizations such as dynamic light scattering and in vivo T2* map MRI analysis. This approach shows promise for early diagnosis and predicting responses to targeted PD-L1 immunotherapy in glioblastoma patients.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Materials Science, Multidisciplinary
M. Irfan, N. Dogan, T. Sapmaz, A. Bingolbali
Summary: This paper presents the design, implementation, and experimental measurements of a custom-made MPI relaxometer to characterize SPIONs as an MPI tracer. Perimag (R) was found to be the highest resolution tracer material at all experimental conditions for MPI scanning. The relative signal strength of the Synomag tracer outperformed other nanoparticles that determine the signal-to-noise ratio (SNR) for MPI.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2021)
Article
Chemistry, Physical
Katrin Radeloff, Mario Ramos Tirado, Daniel Haddad, Kathrin Breuer, Jana Mueller, Sabine Hochmuth, Stephan Hackenberg, Agmal Scherzad, Norbert Kleinsasser, Andreas Radeloff
Summary: The present study found that labeling human adipose tissue-derived stromal cells (ASCs) with citrate-coated very small superparamagnetic iron oxide particles (VSOPs) does not affect cell proliferation, migration, and differentiation potential. However, indications of genotoxic effects were demonstrated despite the absence of cytotoxicity.
Article
Nanoscience & Nanotechnology
Jingxin Mo, Xianjue Chen, Meiying Li, Wenxu Liu, Wei Zhao, Lee Yong Lim, Richard D. Tilley, J. Justin Gooding, Qinghua Li
Summary: This study successfully prepared a novel nanoparticle drug for the treatment of glioblastoma. The nanoparticles can release reactive oxygen species through near-infrared radiation, enhancing cytotoxicity. The decorated cell membrane allows the nanoparticles to efficiently bypass the blood-brain barrier and specifically target glioblastoma cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Multidisciplinary Sciences
Daniel Dar, Nina Dar, Long Cai, Dianne K. Newman
Summary: The par-seqFISH method allows for recording gene expression and spatial context of microbial populations, revealing diverse physiological states coexisting within the same biofilm with high spatial resolution when studying Pseudomonas aeruginosa.
Article
Energy & Fuels
Arianna Zanoni, Ruggiero M. Pesce, Mattia Sponchioni, Lucilla Del Gaudio, Roberto Lorefice, Paola Albonico, Alessandra Belloni, Alberto Cesana, Massimo Morbidelli, Davide Moscatelli
Summary: In recent years, oil companies have been striving to reduce the amount of water extracted from reservoirs. This study introduces hydrophilic polymeric micro- and nanogels as a promising solution to decrease water production. The developed microgels were tested in a pilot field test and showed a 30% decrease in water production and an increase in oil production.
Article
Materials Science, Multidisciplinary
Nicolo Manfredini, Mattia Sponchioni, Davide Moscatelli
Summary: Thermo-responsive polymeric surfactants were synthesized to promote NP formation during eFRP and facilitate bulk polymer recovery by increasing temperature.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Davide Lanzoni, Filippo Bracco, Federica Cheli, Bianca Maria Colosimo, Davide Moscatelli, Antonella Baldi, Raffaella Rebucci, Carlotta Giromini
Summary: The constant growth of the population has led researchers to explore novel protein sources, with cellular agriculture and cultured meat production emerging as potential solutions. However, there are still significant challenges to overcome before efficient large-scale production can be achieved.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Chemical
Flavio Tollini, Lorenzo Brivio, Paolo Innocenti, Mattia Sponchioni, Davide Moscatelli
Summary: Plastic disposal poses a threat to the environment due to the lack of cost-effective technologies for producing high-quality polymers from scraps. This study investigates the efficiency of different catalytic systems in the methanolysis of PET and identifies potassium carbonate and dichloromethane as the most effective catalyst/cosolvent pair.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Arianna Zanoni, Cora Casiraghi, Riccardo Po, Paolo Biagini, Mattia Sponchioni, Davide Moscatelli
Summary: Redispersible polymer powders (RDPPs), which are dry powder additives used in the concrete industry, are mainly produced from fossil resources. This study focuses on developing bio-based RDPPs to reduce carbon footprint. Two types of bio-based core-shell nanoparticles were synthesized and found to be promising candidates as RDPPs. The powders were characterized and their potential as concrete additives were evaluated by examining changes in surface morphologies of concrete specimens.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Clinical Neurology
Edoardo Nicolo Aiello, Federica Solca, Silvia Torre, Laura Carelli, Alessia Monti, Roberta Ferrucci, Federico Verde, Nicola Ticozzi, Vincenzo Silani, Barbara Poletti
Summary: This study aimed to provide standardized regression-based reliable change indices for the Italian version of ECAS. The study evaluated ceiling/floor effects, practice effect, and test-retest reliability of ECAS measures. Regression analysis found that T0 scores predicted most ECAS measures, except for the Visuo-spatial subscale. The availability of RCIs for the Italian ECAS will be valuable for ALS-related clinical practice and research in the longitudinal dimension.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Engineering, Chemical
Arianna Zanoni, Flavio Tollini, Cora Casiraghi, Giuseppe Storti, Mattia Sponchioni, Davide Moscatelli
Summary: Engineered polylactic acid (PLA) nanoparticles synthesized from oligo(lactic acid) macromonomers have been studied for controlled drug delivery. This study compares the synthesis of PLA-based macromonomers via ring-opening polymerization (ROP) and direct polycondensation of lactic acid in the presence of 2-hydroxyethyl methacrylate (HEMA). It is found that polycondensation is a valuable alternative to ROP for macromonomers with an average chain length of up to 4, while ROP remains the main route for longer chains requiring strict control over the chain length distribution.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Clinical Neurology
Alessio Maranzano, Federico Verde, Eleonora Colombo, Barbara Poletti, Alberto Doretti, Ruggero Bonetti, Delia Gagliardi, Megi Meneri, Luca Maderna, Stefano Messina, Stefania Corti, Claudia Morelli, Vincenzo Silani, Nicola Ticozzi
Summary: Increasing evidence suggests that disease progression in ALS follows a preferential pattern with involvement of neighboring regions from the site of symptom onset. The study aimed to assess the influence of upper and lower motor neuron involvement on the directionality of disease spreading, and the association between specific patterns of disease progression and motor and neuropsychological features of different ALS subtypes. The results showed that ALS patients with lower motor neuron involvement had a higher frequency of horizontal spreading, while those with upper motor neuron involvement displayed a vertical spreading pattern. Non-contiguous disease spreading was associated with more severe upper motor neuron impairment and cognitive impairment. The study also found that regionally entrenching ALS forms were more common in patients with atypical bulbar phenotypes. These findings suggest that disease spreading in ALS may be influenced by the diffusion of toxic factors in the neuron microenvironment.
Review
Biochemistry & Molecular Biology
Matteo Guidetti, Stefano Giannoni-Luza, Tommaso Bocci, Kevin Pacheco-Barrios, Anna Maria Bianchi, Marta Parazzini, Silvio Ionta, Roberta Ferrucci, Natale Vincenzo Maiorana, Federico Verde, Nicola Ticozzi, Vincenzo Silani, Alberto Priori
Summary: Clinical findings suggest that transcutaneous spinal direct current stimulation (tsDCS) can modulate ascending sensitive, descending corticospinal, and segmental pathways in the spinal cord (SC). Realistic computational models based on MRI can predict the interaction between tsDCS-induced electric fields and anatomy. Understanding the electric field distribution in the spinal cord and its relation to clinical findings is important for optimizing tsDCS protocols.
Article
Clinical Neurology
Fabrizio Pasotti, Edoardo Nicolo Aiello, Alessandra Bollani, Matteo Querzola, Sara Cozzi, Francesca Manfrin, Stefania Bruno, Barbara Poletti, Nicola Ticozzi, Vincenzo Silani, Gabriella Bottini
Summary: This study aimed to validate and provide Italian norms for the Single-Matrix Digit Cancellation Test (SMDCT) and to provide clinical evidence for its use in acute stroke patients. The results showed that SMDCT produced reliable results in acute stroke patients and could differentiate between patients and healthy participants.
CEREBROVASCULAR DISEASES
(2023)
Review
Clinical Neurology
Francesca Mameli, Eleonora Zirone, Roberta Girlando, Elena Scagliotti, Giulia Rigamonti, Edoardo Nicolo Aiello, Barbara Poletti, Roberta Ferrucci, Nicola Ticozzi, Vincenzo Silani, Marco Locatelli, Sergio Barbieri, Fabiana Ruggiero
Summary: Deep brain stimulation (DBS) is an effective treatment for motor symptoms in Parkinson's disease (PD), but patients may experience psychological distress and social maladjustments after surgery. This review examines the role of patients' expectations regarding the outcomes of DBS and highlights the need for intervention to improve pre-operative patient education and post-operative psychosocial adjustment.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Fabiana Ruggiero, Eleonora Zirone, Maria Takeko Molisso, Tiziana Carandini, Giorgio Fumagalli, Anna Pietroboni, Roberta Ferrucci, Edoardo Nicolo Aiello, Barbara Poletti, Vincenzo Silani, Giacomo Comi, Elio Scarpini, Sergio Barbieri, Andrea Arighi, Francesca Mameli
Summary: This study evaluated the experience of telemedicine in patients with cognitive impairments and their caregivers. The findings showed positive feedback from both patients and caregivers regarding the usefulness and satisfaction of neurological video consultation. However, successful implementation of telemedicine requires support from staff and care partners in navigating technologies, and adapting technologies to the specific needs of patients and caregivers is crucial for accessible dementia care.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Silvia Peverelli, Alberto Brusati, Valeria Casiraghi, Marta Nice Sorce, Sabrina Invernizzi, Serena Santangelo, Claudia Morelli, Federico Verde, Vincenzo Silani, Nicola Ticozzi, Antonia Ratti
Summary: This study aimed to investigate if the normal C9orf72 hexanucleotide repeat (HR) length influences C9orf72 gene expression and acts as a disease modifier in ALS patients negative for C9orf72 mutation (ALS-C9Neg). The researchers found that the distribution of HR alleles was similar in ALS-C9Neg patients and healthy controls. Gene expression analysis revealed increased C9orf72 mRNA levels in ALS-C9Neg patients carrying two long alleles, but HR allele genotypes did not correlate with clinical parameters.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
I. Kacem, I. Sghaier, S. Peverelli, Y. Abida, H. Ben Brahim, A. Ratti, A. Nasri, N. Ticozzi, V. Silani, R. Gouider
Summary: This study aims to investigate the clinical features of familial ALS patients carrying different variants in the Optineurin (OPTN) gene. The findings reveal that these two families show distinct ALS clinical features and carry different OPTN variants. Screening of the OPTN gene is highly recommended among inbreeding populations, such as the Tunisian population.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Health Care Sciences & Services
Natale Vincenzo Maiorana, Edoardo Nicolo Aiello, Barbara Poletti, Fabrizio Carusi, Angelica De Sandi, Matteo Guidetti, Roberto Prandin, Sara Marceglia, Nicola Ticozzi, Vincenzo Silani, Alberto Priori, Roberta Ferrucci
Summary: Long-COVID refers to the long-term symptoms experienced by patients after recovering from a SARS-CoV-2 infection. This study aimed to investigate the relationship between self-reported long-COVID symptoms and reaction times (RTs) in a visual detection task (VDT) as a measure of attention impairment. The study found that cognition and physical factors were the most important predictors of RTs, with learning, visual impairment, and headache being the top predictors of performance in the VDT.
