Article
Infectious Diseases
Stefan Monecke, Patrick Eberechi Akpaka, Margaret R. Smith, Chandrashekhar G. Unakal, Camille-Ann Thoms Rodriguez, Khalil Ashraph, Elke Mueller, Sascha D. Braun, Celia Diezel, Martin Reinicke, Ralf Ehricht
Summary: The aim of this study was to comprehensively characterise S. aureus strains from Trinidad and Tobago, and Jamaica. A total of 101 isolates were collected, mainly from patients with skin and soft tissue infections. The isolates were characterised using DNA microarray and the production of Panton-Valentine leukocidin (PVL) was examined. The study found high rates of PVL genes in methicillin-susceptible S. aureus (MSSA) isolates, with a local CC8-MSSA clone and CC152-MSSA being the main contributors. Ten MRSA isolates were identified, including the pandemic ST239-MRSA-III strain and five isolates with a composite SCCmec element not observed elsewhere.
Article
Microbiology
Utta Helbig, Constance Riemschneider, Guido Werner, Nancy Kriebel, Franziska Layer-Nicolaou
Summary: In Saxony, Germany, the detection of PVL-positive MRSA must be reported to the local health authority, which then takes appropriate measures to control the infection. Isolates from 2019 cases were analyzed, and various MRSA lineages with PVL were identified. Most cases were skin and soft-tissue infections and had a history of travel or migration. The presence of the same MRSA clone in households suggested a close epidemic link. Reporting PVL-positive MRSA allows for early detection and targeted control measures.
Article
Public, Environmental & Occupational Health
J. Hatcher, S. Godambe, H. Lyall, L. Tyszczuk, F. Stubbs, N. Cummings, K. Sheils, C. Hughes, T. Kadhani, S. Atkin, N. Elaby, B. Pichon, B. Patel, E. T. Brannigan
Summary: The novel coronavirus (SARS-CoV-2) is a newly emerged coronavirus that was first discovered in Wuhan, China and has caused a global pandemic. It causes COVID-19, an infectious disease that can result in symptoms such as fever, cough, and difficulty breathing. The COVID-19 pandemic has had a significant impact on global healthcare systems and economies, leading many countries to implement strict isolation and control measures, including travel restrictions, lockdowns, and social distancing measures.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Immunology
Nancy Evelyn Aguilar-Gomez, Jocelin Merida-Vieyra, Oscar Daniel Isunza-Alonso, Maria Gabriela Morales-Pirela, Oscar Colin-Martinez, Enrique Josue Juarez-Benitez, Silvestre Garcia de la Puente, Alejandra Aquino-Andrade
Summary: This study describes the phenotypic and genotypic characteristics of Staphylococcus aureus isolates from osteoarticular infections in paediatric patients. The majority of isolates were methicillin-sensitive S. aureus, and the pvl gene was only observed in these isolates. The study highlights the importance of a multidisciplinary team for the diagnosis and treatment of osteoarticular infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Tobias Grebe, Viktoria Rudolf, Christiane Sidonie Gouleu, Bettina Loeffler, Ayola Akim Adegnika, Adebayo Osagie Shittu, Stefanie Deinhardt-Emmer, Silke Niemann, Frieder Schaumburg
Summary: The study found that Africans have higher levels of neutralizing anti-PVL antibodies, but it remains uncertain whether these antibodies provide protection against PVL-related diseases.
Article
Agriculture, Dairy & Animal Science
Abraham Fikru Mechesso, Su-Jeong Kim, Ho-Sung Park, Ji-Hyun Choi, Hyun-Ju Song, Mi Hyun Kim, Suk-kyung Lim, Soon-Seek Yoon, Dong-Chan Moon
Summary: This study identified 199 Staphylococcus aureus isolates from quarter milk samples of 1,289 dairy cattle between 2014 and 2018, and found 30 MRSA strains. The research suggests that dairy cows could be a major source for spreading MRSA, indicating the need for enhanced hygienic measures.
JOURNAL OF DAIRY SCIENCE
(2021)
Review
Infectious Diseases
Pierre Louis Conan, Isabelle Podglajen, Fabrice Compain, Mehdi Osman, David Lebeaux, Edouard Flamarion
Summary: This is the first reported case of a renal abscess caused by Panton-Valentine leukocidin-producing Staphylococcus aureus in an immunocompetent patient. Treatment with percutaneous drainage and an antibiotic with toxin inhibiting effect was successful, leading to rapid improvement in the patient and complete resolution of the abscess within 6 months.
INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Maud Pichon, Maite Micaelo, Saida Rasoanandrasana, Anne-Marie Menn
Summary: The study investigated the genotype of Staphylococcus aureus in severe pneumonia cases, finding a predominance of MSSA in community-acquired infections with diverse radiological presentations requiring ICU hospitalization and mechanical ventilation. Mortality rate was 33%, with PVL, staphylococcal enterotoxins, and TSST-1 encoding genes commonly present. CC152-PVL positive strains were the most prevalent in severe pneumonia, with other virulence gene profiles observed in additional clonal lineages.
INFECTIOUS DISEASES
(2021)
Review
Pediatrics
Massimo Luca Castellazzi, Samantha Bosis, Irene Borzani, Claudia Tagliabue, Raffaella Pinzani, Paola Marchisio, Giada Maria di Pietro
Summary: This is a case report of a 6-month-old boy with severe invasive PVL-SA infection, presenting with high fever and poor general condition. The importance of prompt diagnosis and appropriate management in order to save lives and prevent serious complications is highlighted in this report. The patient received intravenous antibiotics and surgical drainage of abscess with progressive recovery.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Frederike Waldeck, Salome N. Seiffert, Susanne Manser, Danuta Zemp, Angela Walt, Christoph Berger, Werner C. Albrich, Matthias Schlegel, Tim Roloff, Adrian Egli, Oliver Nolte, Christian R. Kahlert
Summary: In our tertiary children's hospital, the number of newly detected methicillin-resistant Staphylococcus aureus (MRSA) infections among primary and secondary school students has almost doubled in recent years. Through an epidemiological investigation and characterization analysis, a cluster of pneumococci with common genetic features was identified, with a specific school being identified as a common risk factor for infection. No further cases were found after disinfection.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Dairy & Animal Science
Nadia Safia Chenouf, Olouwafemi Mistourah Mama, Chafik Redha Messai, Laura Ruiz-Ripa, Rosa Fernandez-Fernandez, Isabel Carvalho, Abdelghani Zitouni, Ahcene Hakem, Carmen Torres
Summary: This study investigated antimicrobial resistance and virulence factors in Staphylococcus aureus and coagulase-negative staphylococci in unpasteurized milk in Djelfa, Algeria. The results showed contamination of milk samples with these bacteria, with some strains exhibiting resistance to multiple drugs and carrying various resistance genes.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Microbiology
Hiroshi Kaneko, Miki Kanai, Takumi Saito, Yuka Yanagi, Hana Kobayashi, Rikuto Kurihara, Masami Ikeda, Osamu Nemoto, Naoko Baba, Yasushi Matsuzaki, Daisuke Sawamura, Fumiko Shimoe, Yoichi Inaba, Yoko Kobayashi, Satoru Kawasaki, Toru Ueki, Sakae Funatsu, Shigeho Shirahama, Misao Oba, Takaya Hasegawa, Hirotoshi Furukawa, Toshiko Miyata, Masaaki Isonokami, Shigeru Fujita, Hidemasa Nakaminami
Summary: The study indicated a significant increase in PVL-positive MRSA isolates in the Japanese community, with the USA300 variant psi USA300 emerging as the predominant clone across regions in Japan. This variant may have a greater propensity to cause deep-seated SSTIs compared to USA300.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Zahra Najafi olya, Shahin Najar-Peerayeh, Abbas Yadegar, Bita Bakhshi
Summary: A high prevalence of PVL-positive CA-MRSA strains was detected in Iran, with the majority of PVL-positive isolates being of H (mostly H2) variant, while 100% of PVL-positive MRSA strains harbored R variant. Additionally, CC8, CC22, and CC30 were identified as the dominant clones among PVL-encoding S. aureus strains.
BMC INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Nicolas Allou, Jerome Allyn, Nicolas Traversier, Marie Baron, Renaud Blonde, Celine Dupieux, Nathalie Coolen-Allou, Julien Jabot, Guillaume Miltgen
Summary: This article reports two cases of healthcare-associated pneumonia caused by PVL-producing Staphylococcus aureus in patients hospitalized for SARS-CoV-2 pneumonia in the Indian Ocean region. These cases further support the hypothesis that SARS-CoV-2 infection favors the occurrence of PVL-producing S. aureus pneumonia.
Article
Microbiology
Emma McGuire, Claire Neill, Simon M. Collin, Hannah Higgins, Rebecca Guy, Mark Ganner, Juliana Coelho, Bruno Pichon, Russell Hope, Colin S. Brown
Summary: PVL toxin detection was not associated with worse outcomes in patients with community-acquired S. aureus bacteremia.
JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
