Article
Geriatrics & Gerontology
Regina Brunauer, Ian G. Xia, Shabistan N. Asrar, Lindsay A. Dawson, Connor P. Dolan, Ken Muneoka
Summary: The study revealed for the first time how aging affects epimorphic regeneration in mammals, showing that aging exacerbates tissue histolysis, delays wound closure, impairs blastema differentiation, and hinders skeletal regrowth. Aging does not limit stem cell availability in the blastema but reduces osteoblast-dependent bone formation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Oncology
Chew Leng Lim, Valerie C-L Lin
Summary: Estrogen has been found to promote the growth of estrogen receptor alpha-negative mammary tumors by stimulating the pro-tumoral activities of both high-density and low-density neutrophils in mammary tissue.
Article
Acoustics
Misa Ito, Qian Wang, Dan Hao, Hisashi Sawada, Bin Huang, Ling Guo, Alan Daugherty, Xiang-An Li
Summary: This study used ultrasound approaches to monitor septic thymus involution in mice induced with cecum ligation and puncture (CLP). The results showed significant decreases in thymus area and volume at days 3 and 10 compared to baseline, with positive correlations between thymus areas/volumes and thymus weights. Ultrasonography was found to provide reliable thymus measurements and is an optimal technique for monitoring thymus involution in septic mice.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Environmental Sciences
Xu Shi, Tong Xu, Wei Cui, Xue Qi, Shiwen Xu
Summary: The co-exposure of DEHP and MPs has an impact on skin wound healing and Nets formation, leading to delayed wound healing, increased oxidative stress and inflammatory factors, and inhibited Wnt/beta-catenin pathway and fibrosis-related factors. Moreover, the excessive activation of ROS/Nets can aggravate inflammatory responses and inhibit fibrosis, resulting in delayed wound healing.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Lei Tian, Shancheng Guo, Zhiye Zhao, Yuxu Chen, Chunmei Wang, Qingzhang Li, Ye Li
Summary: The study reveals that miR-30a-3p plays a crucial role in regulating autophagy in the mammary glands of mice during lactation and involution. It negatively regulates autophagy by targeting Atg12 gene in mammary epithelial cells. Further experiments confirmed that overexpression of miR-30a-3p inhibits autophagy and alters mammary structure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ting-ting Wei, Yuan-kang Feng, Jia-hui Cao, Jie-han Li, Shu-liang Yuan, Yi Ding, Yu-rong Chai
Summary: Resveratrol has been proven to delay aging in many organs, including the thymus. This study explored the dosage-dependent effect of resveratrol on thymus involution in senescence-accelerated mice induced by D-galactose. The results showed that resveratrol can delay thymus atrophy within a certain dose range, but higher concentrations may have toxicity. FoxN1 may play a role in the beneficial mechanism of resveratrol supplementation, which is significant for enhancing thymus immunity.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jiaxiang Meng, Zhicong Zhao, Zhifeng Xi, Qiang Xia
Summary: This study investigated the role of N6-methyladenosine RNA methylation in liver regeneration and found that the knockout of Mettl3 delays the cell cycle progression, thereby affecting liver regeneration. This suggests the importance of N6-methyladenosine mRNA modification in liver regeneration.
Article
Developmental Biology
Jihyun Park, Mi-Hee Kim, Dong-Hee Han, Jong-Yun Noh, Eun-Sang Ji, Sung-Ho Lee, Chang-Ju Kim, Sehyung Cho
Summary: Circadian rhythm disturbances, caused by dietary time shift, can significantly delay successful conception and disrupt of estrous cycle in mice.
Article
Oncology
Claire Sokas, Masami Kelly, Christina Sheu, Julia Song, H. Gilbert Welch, Regan Bergmark, Christina Minami, Quoc-Dien Trinh
Summary: The study interviewed breast and prostate cancer patients whose surgeries were delayed due to the pandemic, finding that most patients experienced significant distress, with key themes including lack of surprise and acceptance of the delays, as well as persistent worries about cancer and delay. Satisfaction with patient-physician communication and the availability of a delay strategy were key factors in patients' acceptance of the situation.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Rahul Kumar, Ajay K. Chaudhary, Jordan Woytash, Joseph R. Inigo, Abhiram A. Gokhale, Wiam Bshara, Kristopher Attwood, Jianmin Wang, Joseph A. Spernyak, Eva Rath, Neelu Yadav, Dirk Haller, David W. Goodrich, Dean G. Tang, Dhyan Chandra
Summary: The study identified the essential roles of mitochondrial proteins HSP60 and ClpP in the development of prostate cancer, highlighting their importance in maintaining mitochondrial function and promoting cancer cell survival. Inhibition of the interaction between HSP60 and ClpP can suppress PCa growth and progression.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Sadaf Noor, Yuliya Semenova, Alexandru Dosa, Joeri J. Pen, Alain Menzel, Salva Piscopo, Nicolas Wirth, Daniel-Ovidiu Costea
Summary: This article discusses alternative treatments for prostate disorders, with a particular focus on the role of nutrients. By providing an overview of the characteristics of the prostate organ and the most prevalent diseases, nutrition-based treatment methods are proposed, with an emphasis on their potential effectiveness in surgery. The article advocates for the recognition of this form of alternative treatment as a fully recognized therapy for prostate disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Oncology
Ronnie J. Zipkin, Andrew Schaefer, Changzhen Wang, Andrew P. Loehrer, Nirav S. Kapadia, Gabriel A. Brooks, Tracy Onega, Fahui Wang, Alistair J. O'Malley, Erika L. Moen
Summary: Delays in breast cancer surgery are more prevalent among urban patients compared to rural patients. Rural patients with medium- or high-volume surgeons have lower odds of delay, while rural patients whose surgeon operates at multiple hospitals are more likely to experience delays. Patient driving times over 1 hour are associated with delays only among urban patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Engineering, Biomedical
Guanglong Ma, Maja Severic, Matthew Barker, Sara Pereira, Amalia Ruiz, Calvin C. L. Cheung, Wafa T. Al-Jamal
Summary: Prostate cancer is the second-leading cancer in men with limited treatment options. PSA and PSMA have been exploited as therapeutic targets, and several activatable prodrugs have been developed. Dually targeted PSA/PSMA nanovesicles have been engineered for advanced prostate cancer, providing highly selective treatment options.
ACTA BIOMATERIALIA
(2021)
Article
Nutrition & Dietetics
Ji Hyeong Baek, Jae Soon Kang, Miyoung Song, Dong Kun Lee, Hyun Joon Kim
Summary: It was found that glutamine supplementation can activate glutamatergic neurotransmission and prevent chronic-stress-induced mild cognitive impairment (MCI). This study evaluated the effects of glutamine on glutamatergic activity and cognitive impairment in a triple-transgenic Alzheimer's disease mouse model (3xTg-AD). The results showed that a glutamine-supplemented diet delayed the onset of MCI in the mouse model predisposed to cognitive impairment and dementia.
Article
Oncology
Jinglong Zhang, Fan Zhang, Kenneth I. Porter, Panshak P. Dakup, Shuwen Wang, Gavin P. Robertson, Shobhan Gaddameedhi, Jiyue Zhu
Summary: Telomerase activation is crucial for melanomagenesis, but is hindered by telomere dysfunction in mice. The study found that telomere dysfunction delays melanoma development and leads to DNA damage and genomic instability.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Meeting Abstract
Endocrinology & Metabolism
Ronny A. Bell, Joseph Rigdon, Anna Bellatorre, Dana Dabelea, Ralph Dagostino, Jasmin Divers, Lawrence M. Dolan, Giuseppina Imperatore, Elizabeth T. Jensen, Angela D. Liese, Eva Lustigova, Santica M. Marcovina, Lina Merjaneh, David J. Pettitt, Catherine Pihoker, Amy S. Shah, Andrew M. South, Lynne E. Wagenknecht
Meeting Abstract
Endocrinology & Metabolism
Katherine A. Sauder, Deborah H. Glueck, Kylie K. Harrall, Ralph Dagostino, Lawrence M. Dolan, Abbi Lane-Cordova, Angela D. Liese, Eva Lustigova, Faisal Malik, Santica M. Marcovina, Elizabeth J. Mayer-Davis, Amy K. Mottl, Catherine Pihoker, Kristi Reynolds, Amy S. Shah, Elaine M. Urbina, Lynne E. Wagenknecht, Stephen R. Daniels, Dana Dabelea
Review
Clinical Neurology
Beddome C. Allen, Sahil Kapoor, Anthony Anzalone, Kirby P. Mayer, Stacey Q. Wolfe, Pam Duncan, Andrew W. Asimos, Ralph D'Agostino Jr, James Tripp Winslow, Aarti Sarwal
Summary: This study reviewed the feasibility of transcranial ultrasonography (TCU) as a diagnostic tool for evaluating intracranial pathology in critical care or austere settings. The results showed that TCU has reasonable sensitivity and specificity in detecting intracranial pathology including intracranial hemorrhage and tumors. This suggests that TCU can be clinically valuable in remote areas or where standard imaging is unavailable.
JOURNAL OF NEUROIMAGING
(2023)
Article
Health Care Sciences & Services
Annika Hoyer, Ralph Brinks, Thaddaeus Toennies, Sharon H. Saydah, Ralph B. D'Agostino Jr, Jasmin Divers, Scott Isom, Dana Dabelea, Jean M. Lawrence, Elizabeth J. Mayer-Davis, Catherine Pihoker, Lawrence Dolan, Giuseppina Imperatore
Summary: This study aimed to examine whether a partial differential equation (PDE) can be used to estimate the incidence of diabetes from prevalence. The results showed that the PDE method can accurately estimate the incidence rates of diabetes, and it has the advantage of cost savings compared to traditional methods.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Review
Oncology
Ryan T. Hughes, Rediet R. Gebeyehu, John Mason Kalada, Thomas W. Lycan, Bart A. Frizzell, Rebecca D. Kinney, Ralph B. D'Agostino, Paul M. Bunch, Pierre Triozzi, Wei Zhang, Cristina M. Furdui, Mercedes Porosnicu
Summary: Effective treatment options for advanced/recurrent head and neck squamous-cell carcinoma are limited. The combination of the immune checkpoint inhibitor pembrolizumab and quad-shot, a hypofractionated palliative radiotherapy regimen, shows promise as a potential treatment strategy. This study aims to evaluate the response rates, survival outcomes, and treatment toxicity of this combined therapy, as well as identify molecular biomarkers and immune-related impacts using correlative multiomics analysis.
Article
Clinical Neurology
Christine Henry, Sahil Kapoor, Vivek Krishnan, John Levi, Kyle Fargen, Ralph D'Agostino, Sheryl Hendrix, Dana Foster, Patrick Brown, Charles A. Tegeler, Aarti Sarwal
Summary: This study used transcranial color-coded duplex (TCCD) to examine the transverse venous sinus (TVS), establish normative values, analyze physiological variability, and explore the validity of using TCCD to diagnose transverse venous sinus stenosis (TVSS).
JOURNAL OF NEUROIMAGING
(2023)
Article
Endocrinology & Metabolism
Allison L. B. Shapiro, Anna Bellatorre, Dana Dabelea, Jeanette M. Stafford, Ralph D'Agostino, Amy S. Shah, Elaine M. Urbina, Catherine E. Barrett, Catherine Pihoker, Santica Marcovina, Angela D. Liese, Amy K. Mottl, Elizabeth T. Jensen, Greta Wilkening
Summary: This study examined the relationship between diabetes complications and cognitive dysfunction in young adults with type 1 or type 2 diabetes. The results showed that hypoglycemia and peripheral neuropathy were associated with cognitive deficits in type 1 diabetes, while high blood pressure was associated with cognitive deficits in type 2 diabetes. These findings provide insights for targeting specific factors to mitigate cognitive issues in young people with diabetes.
PEDIATRIC DIABETES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
W. Gregory Hundley, Ralph D'Agostino
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Katherine A. A. Sauder, Deborah H. H. Glueck, Kylie K. K. Harrall, Ralph D'Agostino, Lawrence M. M. Dolan, Abbi D. D. Lane, Angela D. D. Liese, Eva Lustigova, Faisal S. S. Malik, Santica Marcovina, Elizabeth Mayer-Davis, Amy Mottl, Catherine Pihoker, Kristi Reynolds, Amy S. S. Shah, Elaine M. M. Urbina, Lynne E. E. Wagenknecht, Stephen R. R. Daniels, Dana Dabelea
Summary: This study examined arterial stiffness in individuals with type 1 diabetes and explored the differences between Hispanic, non-Hispanic Black, and non-Hispanic White individuals. The results showed that cardiovascular and socioeconomic factors explain a quarter of the racial and ethnic differences in arterial stiffness, but non-Hispanic Black individuals still experienced higher arterial stiffness.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Oncology
Yin Liu, Margaret R. R. Smith, Yuezhu Wang, Ralph D'Agostino Jr, Jimmy Ruiz, Thomas Lycan, Gregory L. L. Kucera, Lance D. D. Miller, Wencheng Li, Michael D. D. Chan, Michael Farris, Jing Su, Qianqian Song, Dawen Zhao, Arvind Chandrasekaran, Fei Xing
Summary: This study reveals that tumor-infiltrating neutrophils secrete high levels of lipocalin 2 (LCN2), which enhances the stemness of tumor cells in brain metastasis. The interactions between neutrophils and brain metastatic cells provide new insights into treating brain metastasis.
Article
Oncology
Margaret R. Smith, Yuezhu Wang, Ralph D'Agostino, Yin Liu, Jimmy Ruiz, Thomas Lycan, George Oliver, Lance D. Miller, Umit Topaloglu, Jireh Pinkney, Mohammed N. Abdulhaleem, Michael D. Chan, Michael Farris, Jing Su, Kathryn F. Mileham, Fei Xing
Summary: Different therapy options are used for NSCLC based on tumor stage and genetic mutations. However, biomarkers to guide treatment selection are limited. A study collected clinical and sequencing data from 524 NSCLC patients to examine the association between mutation profiles and treatment response. Mutation composite scores (MCS) were generated for different treatments, and MCS showed superior predictive power compared to other biomarkers in immune therapy-treated patients.
NPJ PRECISION ONCOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Warren Szewczyk, Kerryn Reding, Richard Kar-Hang Cheng, Laura Johnson, Oxana Palesh, Alexi Vasbinder, Amy Ladd, Ralph Dagostino, Kathryn Weaver, Glenn J. Lesser, W. Gregory Hundley
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
Kelsey B. Eitel, Alissa J. Roberts, Ralph D'Agostino, Catherine E. Barrett, Ronny A. Bell, Anna Bellatorre, Angelica Cristello, Dana Dabelea, Lawrence M. Dolan, Elizabeth T. Jensen, Angela D. Liese, Elizabeth J. Mayer-Davis, Kristi Reynolds, Santica M. Marcovina, Catherine Pihoker
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Kerryn Reding, Nathaniel S. O'Connell, Warren Szewczyk, Richard K. Cheng, Johnny Nguyen, Amy C. Ladd, Jennifer H. Jordan, Alexander R. Lucas, Vanessa B. Sheppard, Yaorong Ge, Fadi N. Salloum, Youngdeok Kim, Edward J. Lesnefsky, Robert L. Franco, Giselle C. Melendez, Arnethea L. Sutton, Ralph Dagostino, Kathryn E. Weaver, Glenn J. Lesser, William G. Hundley
Meeting Abstract
Cardiac & Cardiovascular Systems
Margaret K. Wallace, Amy C. Ladd, David Innes, Kimberly McKnight, Kristine C. Olson, Unice Davis, Krishna Ravindra, Namita Raghavan, Carrie R. Mills, Ralph Dagostino, William G. Hundley, Phillip Duncan, Sangeeta B. Shah
