Article
Multidisciplinary Sciences
Violeta I. Gallardo-Montejano, Chaofeng Yang, Lisa Hahner, John L. McAfee, Joshua A. Johnson, William L. Holland, Rodrigo Fernandez-Valdivia, Perry E. Bickel
Summary: Exposure to cold induces significant changes in brown adipose tissue, with a marked increase in PLIN5, which plays a crucial role in maintaining mitochondrial structure and respiratory function. Enhancing PLIN5 function in BAT may lead to healthy remodeling of white adipose tissue and improvements in systemic glucose tolerance and hepatic steatosis, making it a potential therapeutic target for metabolic disorders.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Magdalena Fernandez-Acosta, Juan Romero, Guillermo Bernabo, Giovanna M. Velazquez-Campos, Nerina Gonzalez, M. Lucia Mares, Santiago Werbajh, L. Amaranta Avendano-Vazquez, Gerald N. Rechberger, Ronald P. Kuehnlein, Cristina Marino-Buslje, Rafael Cantera, Carolina Rezaval, M. Fernanda Ceriani
Summary: The gene orsai (osi) was identified as a key player in lipid metabolism in Drosophila. Lack of osi function leads to reduced lipid reserves and energy output, affecting food-seeking behavior and larval survival. This phenotype can be rescued by modulating the expression of lipase and electron transport chain proteins.
Article
Agriculture, Multidisciplinary
Xinbo Zhou, Junjie Zhang, Yutong Sun, Jian Shen, Bo Sun, Qingquan Ma
Summary: This study found that glutamine (Gln) has a positive effect on liver steatosis and promotes hepatic homeostasis by improving glucose metabolism and regulating signaling pathways. Obese mice fed with Gln had higher levels of colonic short-chain fatty acids (SCFAs) and lower levels of inflammation factor proteins, and a decrease in the abundance of Firmicutes bacteria was observed.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Maocheng Jiang, Zitong Meng, Zhiqiang Cheng, Kang Zhan, Xiaoyu Ma, Tianyu Yang, Yinghao Huang, Qi Yan, Xiaoxiao Gong, Guoqi Zhao
Summary: This study evaluated the effects of buffalo milk and cow milk on lipid metabolism in obese mice. The results showed that cow milk supplementation has beneficial effects on weight loss and lipid metabolism, while buffalo milk may have negative effects on inflammation.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Jiayi Chen, Dali Qian, Zhishen Wang, Yutong Sun, Bo Sun, Xinbo Zhou, Linlin Hu, Anshan Shan, Qingquan Ma
Summary: The study found that long-term threonine supplementation can inhibit fat accumulation and improve lipid metabolism, making it a potential agent to prevent the development of diet-induced obesity.
Article
Agriculture, Multidisciplinary
Licong Yang, Yanping Zhu, Shusheng Zhong, Guodong Zheng
Summary: The study showed that astilbin can reduce the effective dose of caffeine needed for an anti-obesity effect and suppress fat accumulation through the activation of AMPK.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Food Science & Technology
Haizhao Song, Xinchun Shen, Fang Wang, Yu Li, Xiaodong Zheng
Summary: This study demonstrated that supplementation of blackcurrant anthocyanins (BCA) could prevent HFD-induced obesity by targeting microbiota.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Food Science & Technology
Yanan Sun, Shanbin Chen, Fazheng Renl, Yixuan Li
Summary: This study demonstrates the ability of Lactobacillus paracasei N1115 (LC-N1115) to attenuate obesity by modulating gut microbiota and gene expression.
FOOD SCIENCE & NUTRITION
(2023)
Article
Nutrition & Dietetics
Ling-Wen Hsu, Yi-Wen Chien
Summary: Postmenopausal obesity is a rising problem, and supplementation of melatonin can improve obesity by reducing body fat accumulation and promoting browning of white adipose tissues.
Article
Multidisciplinary Sciences
Ying Tian, Yuping Huan, Lihong Chen, Suwen Peng, Zhiyan He, Qian Wang
Summary: Excess weight and obesity lead to abnormal fat accumulation in skeletal muscles, affecting muscle quality and glucose uptake. Combining high protein intake with energy restriction can reduce fat content, but the mechanisms behind the effects on protein and fat content are not well understood.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Jhih-Han Yeh, Yu-Tang Tung, Yu-Sheng Yeh, Yi-Wen Chien
Summary: Postmenopausal obesity is a serious issue and a high-fat diet may worsen lipid metabolism abnormalities. However, this study found that a specific ratio of experimental oil mixture can ameliorate these imbalances.
Article
Agriculture, Multidisciplinary
Benliang Wei, Zhen Peng, Muyan Xiao, Tao Huang, Shiyu Yang, Kui Liu, Min Wu, Wendi Zheng, Mingyong Xie, Tao Xiong
Summary: The study aimed to investigate the effects and mechanisms of three LAB strains in high-fat diet-induced obese mice. The findings showed that the strains, particularly LP, suppressed body weight gain, improved lipid disorders, and reduced chronic inflammation. Additionally, LP and LF modulated the gut microbiota, promoting the growth of beneficial bacteria and reducing bacteria associated with obesity. The underlying mechanism of LP was through the modulation of the hepatic AMPK signaling pathway and gut microbiota. Overall, LP has promising potential in obesity prevention and treatment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Junting Xie, Xiaoning Hou, Wanshi He, Jie Xiao, Yong Cao, Xiaojuan Liu
Summary: Although the specific action site and signal pathway of astaxanthin in weight loss remain unclear, this study used Caenorhabditis elegans to shed light on its efficacy and specific action sites. The supplementation of 60 μM astaxanthin significantly reduced fat deposition and triglyceride levels and prevented obesity caused by excessive energy accumulation. These effects were induced by sbp-1/mdt-15 and insulin/insulin-like growth factor pathways, and co-regulated the down-regulation of specific sites fat-6 and fat-7.
Article
Nutrition & Dietetics
Jiabao Yan, Cuiru Ren, Yunlong Dong, Jibran A. A. Wali, Hongjie Song, Ying Zhang, Hengrui Zhang, Guangning Kou, David Raubenheimer, Zhenwei Cui
Summary: Ketogenic diet combined with moderate aerobic exercise effectively reduces body weight and fat mass, with no significant adverse effects except for an increase in circulating triglyceride level. Aerobic exercise further improves blood parameters and hepatic condition in mice fed with ketogenic diet.
Article
Agriculture, Multidisciplinary
Yangzheng He, Yong Sun, Jing Li, Xiaoyu Peng, Wei Li, Yu Gao, Jiaqi Wang, Xinggang Ni, Lina Pan, Zeyuan Deng
Summary: Although formula-fed infants are more prone to obesity than breastfed ones, this study found that administering human milk fat substitutes (HMFS) did not affect body weight in rats, but significantly decreased body fat content. The study also revealed the potential mechanism by which HMFS affects body fat buildup and promotes lipid metabolism in the liver. These findings underscore the nutritional benefits of HMFS for infants.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
James P. Wirth, Fatmata Sesay, Joshua Mbai, Sundus Ibrahim Ali, William E. S. Donkor, Bradley A. Woodruff, Zahra Pilane, Kheyriya Mohamed Mohamud, Ahmed Muse, Hamda Omar Yussuf, Warsame Said Mohamed, Rosmarie Veraguth, Serge Rezzi, Thomas N. Williams, Abdullahi Muse Mohamoud, Farhan Mohamed Mohamud, Melanie Galvin, Fabian Rohner, Yvonne Katambo, Nicolai Petry
Summary: Limited data on anaemia and iron deficiency in Somalia were addressed by a 2019 micronutrient survey, which found high prevalence rates in children and women. Iron deficiency was identified as the main risk factor for anaemia, contributing to a substantial portion of the cases. Enhancing food assistance and micronutrient-specific programmes are recommended to tackle the anaemia and iron deficiency issues in Somalia.
MATERNAL AND CHILD NUTRITION
(2022)
Article
Nutrition & Dietetics
Mette M. Berger, Alan Shenkin, Anna Schweinlin, Karin Amrein, Marc Augsburger, Hans-Konrad Biesalski, Stephan C. Bischoff, Michael P. Casaer, Kursat Gundogan, Hanna-Liis Lepp, Angelique M. E. de Man, Giovanna Muscogiuri, Magdalena Pietka, Loris Pironi, Serge Rezzi, Cristina Cuerda
Summary: This guideline aims to provide information for daily clinical nutrition practice regarding assessment, monitoring, and prescription of micronutrients (MNs), and proposes a consensus terminology to reduce confusion.
CLINICAL NUTRITION
(2022)
Article
Critical Care Medicine
Lucile Equey, Philipp K. A. Agyeman, Rosemarie Veraguth, Serge Rezzi, Luregn J. Schlapbach, Eric Giannoni
Summary: This study investigated the levels of ascorbic acid (VitC) and thiamine (VitB1) in newborns and children with blood culture-proven sepsis, and found that low and deficient levels of these vitamins were frequently observed. Age, systemic inflammation, and vitamin supplementation were associated with vitamin levels during sepsis.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sofia Moco
Summary: The direct analysis of metabolic intermediates in biological samples has greatly advanced the understanding of metabolic processes. Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy have played a key role in these advancements. NMR, originally used for elucidating molecular structures, has now been extended to the analysis of complex mixtures in biological samples, known as NMR-based metabolomics. NMR is also powerful in other areas of small molecule biochemistry, including quantification of metabolites, determining metabolic fate, uncovering new metabolic pathways, studying metabolite-protein interactions, and understanding metabolic regulation and pharmacological effects. The development of computational tools and resources has contributed to a more detailed understanding of systems biochemistry.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Nutrition & Dietetics
Pollyanna Patriota, Serge Rezzi, Idris Guessous, Pedro Marques-Vidal
Summary: This population-based prospective cohort study found no association between vitamin D levels and changes in weight and waist circumference at 5- and 10-year follow-up.
Article
Nutrition & Dietetics
Eleonora Ciarlo, Magali Joffraud, Faisal Hayat, Maria Pilar Giner, Judith Giroud-Gerbetant, Jose Luis Sanchez-Garcia, Marie Rumpler, Sofia Moco, Marie E. Migaud, Carles Canto
Summary: This study demonstrates for the first time that dihydronicotinic acid riboside (NARH) can act as a NAD(+) precursor in mammalian cells, and how different NAD(+) precursors can interact and influence each other when co-administered.
Article
Biochemistry & Molecular Biology
Pollyanna Patriota, Serge Rezzi, Idris Guessous, Pedro Marques-Vidal
Summary: This study conducted in Switzerland assessed the association between 25-hydroxyvitamin D and long-term weight change. The findings suggest a limited correlation between genetically determined vitamin D levels and weight gain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Pollyanna Patriota, Serge Rezzi, Idris Guessous, Pedro Marques-Vidal
Summary: Several studies have shown an inverse association between serum levels of vitamin D and obesity. This study aimed to investigate the associations between vitamin D levels and various anthropometric markers and adipokines. The results revealed a negative correlation between vitamin D levels and most anthropometric markers, and a positive correlation with adiponectin levels in women. Total body fat was found to be the strongest marker associated with decreased vitamin D levels.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Barbara Walther, Dominik Guggisberg, Rene Badertscher, Lotti Egger, Reto Portmann, Sebastien Dubois, Max Haldimann, Katrin Kopf-Bolanz, Peter Rhyn, Otmar Zoller, Rosmarie Veraguth, Serge Rezzi
Summary: The decline in liquid milk consumption in Western countries has been compensated by the increased consumption of processed dairy products and the introduction of new plant-based beverages. However, these plant-based drinks are not real alternatives to milk in terms of nutrient composition and protein quality. Completely replacing milk with plant-based drinks without adjusting the overall diet can lead to deficiencies of certain important nutrients in the long term.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Tanja Sonntag, Sara Ancel, Sonia Karaz, Paulina Cichosz, Guillaume Jacot, Maria Pilar Giner, Jose Luis Sanchez-Garcia, Alice Pannerec, Sofia Moco, Vincenzo Sorrentino, Carles Canto, Jerome N. Feige
Summary: This study reveals the importance of Nicotinamide Riboside Kinases (NRKs) in skeletal muscle growth and repair. NRK deficiency affects muscle metabolism and tissue repair, leading to changes in muscle fiber type composition. Furthermore, NRK deficiency also impairs mitochondrial adaptations and extracellular matrix remodeling during muscle regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Nutrition & Dietetics
Antoine Equey, Mette M. Berger, Semira Gonseth-Nussle, Marc Augsburger, Serge Rezzi, Andrew C. C. Hodgson, Sandrine Estoppey, Giuseppe Pantaleo, Celine Pellaton, Maiwenn Perrais, Sebastien Lenglet, Valentin Rousson, Valerie D'Acremont, Murielle Bochud
Summary: Low plasma zinc levels are associated with higher anti-SARS-CoV-2 IgG and IgA seropositivity in the Swiss population, suggesting that adequate zinc status may play an important role in protecting against COVID-19 infection.
CLINICAL NUTRITION
(2023)
Article
Chemistry, Physical
Fatima-ezzahra Zerrad, Mohamed Taouzari, El Mostafa Makroum, Jamal El Aoufi, Salah D. Qanadli, Muharrem Karaaslan, Ahmed Jamal Abdullah Al-Gburi, Zahriladha Zakaria
Summary: In this paper, a wideband antenna is proposed for ultra-wideband microwave imaging applications. The antenna system provides a realized gain of 6 dBi, an efficiency of around 80% on the radiation bandwidth, and a wide impedance bandwidth (S11 < -10 dB) of 6.3 GHz. The proposed antenna demonstrates excellent directionality and less signal distortion, making it suitable for imaging applications.
Article
Chemistry, Multidisciplinary
Rafael V. M. Freire, Linda Hong, Miroslav Peterek, Stephane Canarelli, Serge Rezzi, Stefan Salentinig
Summary: Functional food emulsions enriched in health-promoting nutrients, such as buriti oil, have been studied for their effects on cardiometabolic health. This study investigates the colloid transformations of whey-stabilized buriti oil-in-water emulsions during simulated digestion. It is found that the oil phase transforms into highly ordered structures during simulated intestinal digestion under compromised bile conditions, and the digestion process can be modulated by adding vitamin E to the oil.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Claire L. K. Boulange, Helle K. Pedersen, Francois-Pierre Martin, Lea Siegwald, Albert Palleja C. Caro, Aron C. Eklund, Wei Jia, Huizhen Zhang, Bernard Berger, Norbert G. Sprenger, Ralf G. Heine, CINNAMON Study Investigator Grp
Summary: Cow's milk protein allergy (CMPA) is a common food allergy in infants and young children. A study was conducted on non-breastfed infants with CMPA to assess the effects of a whey-based extensively hydrolyzed formula (EHF) supplemented with 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) on the fecal microbiome and metabolome. The supplementation of human milk oligosaccharides (HMO) enriched bifidobacteria in the gut microbiome and delayed the shift of the microbiome composition towards an adult-like pattern. HMO supplementation partially corrected the dysbiosis commonly observed in infants with CMPA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Pollyanna Patriota, Idris Guessous, Serge Rezzi, Pedro Marques-Vidal
Summary: This prospective population-based study found that vitamin D levels were inversely associated with cardiovascular disease (CVD) events, but not with CVD or overall mortality.