Article
Ornithology
Hongying Xu, Zeyu Yang, Dongping Liu, Ru Jia, Lixia Chen, Boshi Liang, Zhengwang Zhang, Guogang Zhang
Summary: The Chinese Egret is a globally threatened bird species living on the coast and islands of northeastern China. To protect their breeding population, it is important to study their distribution sites and migration routes. Research found that coastal mudflats in Liaoning and the west coast of North Korea are important feeding and roosting sites for fledgling Chinese Egrets in August and September. The birds also have specific routes for their autumn migration, with varying distances, timing, speed, and straightness.
Article
Ecology
Ke He, Ying Zhu, Shang-Chen Yang, Qing Ye, Sheng-Guo Fang, Qiu-Hong Wan
Summary: The study on the MHC gene structure of the Chinese alligator reveals the presence of Class I and Class II subregions, a unique CD1 subregion, multiple groups of MHC class I and class II duplicated loci, and a mechanism for polymorphism in antigen presentation.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Biodiversity Conservation
Wei Xu, Xiaoping Zhou, Wenzhen Fang, Xiaolin Chen
Summary: The newly developed primer pairs successfully amplified the TLR genes in the Chinese egret, revealing variable sites and single nucleotide polymorphisms. The versatility of this primer set was also confirmed in nine other bird species, providing a useful foundation for further studies on TLR conservation genetics in these birds.
CONSERVATION GENETICS RESOURCES
(2021)
Article
Immunology
Oyekunle J. Oladosu, Ishaku L. Haruna, Sibusiso A. Hadebe, Huitong Zhou, Jon G. H. Hickford
Summary: This study investigated the variability of the immune response-related gene BoLA-DQA1 in cattle from Nigeria and New Zealand. Ten alleles were identified using a PCR-SSCP approach, with two novel alleles reported for the first time through DNA sequencing. Overall, 12.60% of nucleotide positions analyzed were found to be variable.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2021)
Article
Immunology
Jia-lin Teng, Xia Chen, Jianhua Chen, Ting Zeng, Lin He, Meihang Li, Cai-nan Luo, Shuang Liu, Ting-ting Ding, Kuerbanjiang Yimaiti, Xingwang Li, Yonghe Ding, Xiao-bing Cheng, Juan Zhou, Jun-na Ye, Jue Ji, Yu-tong Su, Hui Shi, Yue Sun, Chengwen Gao, Qiong-yi Hu, Hui-hui Chi, Xuan Yuan, Zhuo-chao Zhou, Dong Wang, Ke Wang, Dong Feng, Changgui Li, Yuanchao Sun, Yujuan Niu, Xiaolei Xu, Lin-jie Chen, Jian Xu, Li-jun Wu, Zhaowei Zhou, Dun Pan, Haitao Niu, Cheng-de Yang, Yongyong Shi, Zhiqiang Li, Hong-lei Liu
Summary: In this study, independent amino acid polymorphisms in HLA molecules associated with Han Chinese patients with AOSD were identified by fine mapping the MHC locus. Specific positions in HLA-DQ alpha 1 and HLA-DR beta 1 were determined as major determinants for AOSD, along with associations with three main HLA class II alleles. This study reveals the role of functional variations in the class II HLA region in the pathogenesis of AOSD.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Ornithology
Zhijun Huang, Xiaoping Zhou, Wenzhen Fang, Xiaolin Chen
Summary: This study tracked the migration routes, wintering areas, habitat uses, and mortalities of adult Chinese Egrets using GPS satellite transmitters. The results showed different behavioral strategies of the egrets during autumn and spring migrations, with human disturbance in aquaculture ponds being the main cause of death. Therefore, international cooperation and protection of intertidal flats and offshore islands are crucial for the conservation of this vulnerable species.
Article
Ecology
Emily A. O'Connor, Helena Westerdahl
Summary: The study examines the relationship between genomic and expressed MHC diversity in songbirds, revealing that fewer MHC-I alleles are expressed than the number available, suggesting optimal MHC-I diversity might be achieved through modulating gene expression. Understanding this relationship is crucial for interpreting variation in MHC diversity in an evolutionary context.
Article
Genetics & Heredity
Yongqing Tang, Gang Liu, Shasha Zhao, Kai Li, Dong Zhang, Shuqiang Liu, Defu Hu
Summary: This study analyzed the polymorphism of major histocompatibility complex (MHC) genes in an endangered population of Przewalski's horse and found that it had less MHC variation compared to other mammals. The MHC DQA allele and genotype frequencies in the reintroduced populations deviated from the theoretical model.
Article
Ecology
Kara M. Million, Curtis M. Lively
Summary: This study characterized the MHC class IIb gene diversity in three sympatric species of darters using deep-sequencing techniques. The researchers found multiple copies of the MHC gene in darters, with a large number of genetic variants and unique amino acid sequences. Many variants were shared between different species pairs, indicating the presence of trans-specific polymorphism. Phylogenetic analysis showed that the variants did not group together based on species identity or on supertype, suggesting convergent evolution of MHC phenotypes. These findings suggest that selection acts differently on MHC genes at the genotype and supertype levels.
ECOLOGY AND EVOLUTION
(2022)
Article
Immunology
Luca D. Bertzbach, Clive A. Tregaskes, Rebecca J. Martin, Undine-Sophie Deumer, Lan Huynh, Ahmed M. Kheimar, Andele M. Conradie, Jakob Trimpert, Jim Kaufman, Benedikt B. Kaufer
Summary: The major histocompatibility complex (MHC) is crucial for appropriate immune responses against invading pathogens in chickens. VALO specific pathogen free (SPF) chickens possess MHC haplotypes that include B9, B9:02, B15, B19, and B21 at various frequencies. The study found that B15 homozygotes had the lowest tumor incidence while B21 homozygotes had the lowest number of organs with tumors. The data have immediate implications for the use of VALO SPF chickens and eggs in the life sciences.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuying Sun, Fang Yuan, Ling Wang, Dongfa Dai, Zhijian Zhang, Fei Liang, Nan Liu, Juan Long, Xiao Zhao, Yongzhi Xi
Summary: This study generated fine-scale maps of MHC recombination and de novo mutations in Han Chinese families, revealing recombination hotspots and Han-specific breakpoints. The MHC de novo mutation rate was found to be higher than the genome-wide de novo mutation rate, and the polymorphisms generated by mutation and recombination were located within and outside linkage disequilibrium regions of the MHC, respectively. The evolution of the MHC locus was mainly controlled by positive selection.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Genetics & Heredity
Deepali Vasoya, Thomas Tzelos, Lindert Benedictus, Anna Eleonora Karagianni, Scott Pirie, Celia Marr, Charlotta Oddsdottir, Constanze Fintl, Timothy Connelley
Summary: In this study, a MiSeq-based approach was developed and applied to analyze the expressed MHCI and MHCII repertoires in Thoroughbred, Icelandic, and Norwegian Fjord Horses. The results showed limited overlap in MHCI and MHCII haplotypes between different breeds, indicating diverse MHC repertoire among genetically divergent breeds. This study provided novel insights into the structure of the expressed equine MHC repertoire and highlighted unique features of the MHC in horses.
Article
Medicine, General & Internal
Erik Kindgren, Angelica P. Ahrens, Eric W. Triplett, Johnny Ludvigsson
Summary: This study investigated the role of genetic and environmental factors and infant gut microbiota in the development of juvenile idiopathic arthritis (JIA). The findings suggest that microbial dysregulation in infancy may trigger or accelerate JIA development, with environmental risk factors having a stronger impact on genetically predisposed children. These findings provide opportunities for intervention or early screening and offer new insights into JIA pathogenesis.
Article
Multidisciplinary Sciences
Ewa Pikus, Radoslaw Wlodarczyk, Jan Jedlikowski, Piotr Minias
Summary: The study found significant differentiation at the MHC class II gene between the old urban population and other populations. There was also moderate but significant divergence at the MHC between the new urban population and rural populations. The total number of MHC alleles and private alleles was lower in old urban populations compared to rural ones.
Article
Cell Biology
Anastasia Thoma, Kate E. Earl, Katarzyna Goljanek-Whysall, Adam P. Lightfoot
Summary: MHC I overexpression may play an important role in the development of autoimmune diseases such as myositis, possibly through the activation of the ER stress pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Genetics & Heredity
Wei Lei, Wenzhen Fang, Qingxian Lin, Xiaoping Zhou, Xiaolin Chen
Article
Biodiversity Conservation
Yufei Dai, Wenzhen Fang, Qingxian Lin, Xiaoping Zhou, Xiaolin Chen
CONSERVATION GENETICS RESOURCES
(2015)
Article
Ornithology
Yufei Dai, Qingxian Lin, Wenzhen Fang, Xiaoping Zhou, Xiaolin Chen
Article
Biodiversity Conservation
Wei Lei, Wenzhen Fang, Xiaoping Zhou, Qingxian Lin, Xiaolin Chen
CONSERVATION GENETICS
(2016)
Article
Ecology
Wei Lei, Xiaoping Zhou, Wenzhen Fang, Qingxian Lin, Xiaolin Chen
ECOLOGY AND EVOLUTION
(2016)
Article
Multidisciplinary Sciences
Zeng Wang, Xiaoping Zhou, Qingxian Lin, Wenzhen Fang, Xiaolin Chen
Article
Biotechnology & Applied Microbiology
Dan Zhou, Donghui Zhang, Guohui Ding, Linna Shi, Qing Hou, Yuting Ye, Yang Xu, Huayun Zhou, Chunrong Xiong, Shengdi Li, Jing Yu, Shanchao Hong, Xinyou Yu, Ping Zou, Chen Chen, Xuelian Chang, Weijie Wang, Yuan Lv, Yan Sun, Lei Ma, Bo Shen, Changliang Zhu
Article
Biodiversity Conservation
Yufei Dai, Xiaoping Zhou, Wenzhen Fang, Qingxian Lin, Xiaolin Chen
CONSERVATION GENETICS RESOURCES
(2013)
Article
Biodiversity Conservation
Xunhe Huang, Xiaoping Zhou, Qingxian Lin, Wenzhen Fang, Xiaolin Chen
CONSERVATION GENETICS RESOURCES
(2013)
Article
Multidisciplinary Sciences
Wei Xu, Xiaoping Zhou, Wenzhen Fang, Xiaolin Chen
Article
Biodiversity Conservation
Wei Xu, Xiaoping Zhou, Wenzhen Fang, Xiaolin Chen
Summary: The newly developed primer pairs successfully amplified the TLR genes in the Chinese egret, revealing variable sites and single nucleotide polymorphisms. The versatility of this primer set was also confirmed in nine other bird species, providing a useful foundation for further studies on TLR conservation genetics in these birds.
CONSERVATION GENETICS RESOURCES
(2021)
Article
Ornithology
Zhijun Huang, Xiaoping Zhou, Wenzhen Fang, Hailong Zhang, Xiaolin Chen
Summary: The study reveals that juvenile Chinese Egrets migrate southward via coastal, oceanic, and inland routes mainly during the night, with an average migration duration of 5.08 days and flight speed of 57.27 km/h. They winter in coastal wetlands in Southeast Asia. Additionally, it was found that juvenile Chinese Egrets are able to fly over the Pacific Ocean without a stopover.
Article
Ornithology
Zhijun Huang, Xiaoping Zhou, Wenzhen Fang, Xiaolin Chen
Summary: This study tracked the migration routes, wintering areas, habitat uses, and mortalities of adult Chinese Egrets using GPS satellite transmitters. The results showed different behavioral strategies of the egrets during autumn and spring migrations, with human disturbance in aquaculture ponds being the main cause of death. Therefore, international cooperation and protection of intertidal flats and offshore islands are crucial for the conservation of this vulnerable species.
Article
Ornithology
Xiaoping Zhou, Chengte Yao, Qingxian Lin, Wenzhen Fang, Xiaolin Chen
JOURNAL OF ORNITHOLOGY
(2016)