Article
Immunology
Nur Firdaus Isa, Olivier Bensaude, Nadiah C. Aziz, Shona Murphy
Summary: The HSV-1 protein ICP22 interacts with cellular proteins to inhibit host cell gene expression and promote viral gene expression, affecting elongation of pol II through various checkpoints. ICP22 interacts with elongation regulators to inhibit transcription elongation of cellular genes. The viral activator VP16 competes with ICP22 to deliver elongation factors to viral genes.
Article
Oncology
Aileen Roth, Adrian Gihring, Joachim Bischof, Leiling Pan, Franz Oswald, Uwe Knippschild
Summary: Protein kinases of the Casein Kinase 1 family are essential for the regulation of various cellular processes, including microtubule dynamics. They directly modulate microtubule dynamics by phosphorylating tubulin isoforms and microtubule-associated proteins, which can affect microtubule stability and genomic stability. Therefore, targeting Casein Kinase 1 functions may be a potential therapeutic strategy for cancer treatment.
Article
Plant Sciences
Jin Hoon Jang, Hae Seong Seo, Ok Ran Lee
Summary: Among the three subfamilies of patatin-related phospholipase A (pPLA) group of genes, overexpression of pPLAIII gamma leads to reduced longitudinally cell expansion patterns. The altered phenotype is linked with transcriptional modulation of microtubule-associated genes and ethylene biosynthesis.
Article
Chemistry, Physical
Hasaeam Cho, Jimin Lee, Hanjoon Nho, Keunmin Lee, Bopil Gim, Juncheol Lee, Jaehee Lee, Kai K. Ewert, Youli Li, Stuart C. Feinstein, Cyrus R. Safinya, Kyeong Sik Jin, Myung Chul Choi
Summary: Aggregated and hyperphosphorylated Tau is a pathological hallmark of Alzheimer's disease. This study presents experimental results on the ionic strength dependence of the radius of gyration (Rg) of human Tau 4RS and 4RL isoforms for the first time. The findings provide insights into the ion-responsive nature of intrinsically disordered and polyampholytic Tau and its implications for the study of Tau-Tau and Tau-tubulin intermolecular structure in ionic environments.
EUROPEAN PHYSICAL JOURNAL E
(2023)
Article
Cell Biology
Moonsup Lee, Kunio Nagashima, Jaeho Yoon, Jian Sun, Ziqiu Wang, Christina Carpenter, Hyun-Kyung Lee, Yoo-Seok Hwang, Christopher J. Westlake, Ira O. Daar
Summary: The study demonstrates that Dyrk1a and CEP97 coordinate with Plk1 to promote Separase function, thus facilitating proper formation of multicilia in vertebrate MCCs.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Maria Paula Zappia, Yong-Jae Kwon, Anton Westacott, Isabel Liseth, Hyun Min Lee, Abul B. M. M. K. Islam, Jiyeon Kim, Maxim V. Frolov
Summary: The transcription factor E2F is responsible for controlling the expression of cell cycle genes by binding to their promoters. However, its significance in the regulation of metabolic genes is not well understood. In this study, the researchers introduced mutations in the E2F sites of five metabolic genes in fruit flies and found varying effects on E2F recruitment and gene expression, with the glycolytic gene Pgk being the most affected. Loss of E2F regulation on the Pgk gene led to decreased glycolytic flux, ATP content, and abnormal mitochondrial morphology. The study highlights the importance of E2F regulation on metabolic genes and its impact on overall development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Saleha Anwar, Taj Mohammad, Md. Khabeer Azhar, Hera Fatima, Afsar Alam, Gulam Mustafa Hasan, Asimul Islam, Punit Kaur, Md. Imtaiyaz Hassan
Summary: MARK4 is a kinase known for phosphorylating tau protein and causing Alzheimer's disease. Bacopa monnieri extracts have neuroprotective roles and have been used to treat neurological disorders. Bacopaside II shows strong binding affinity for MARK4 and inhibits its kinase activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Neurosciences
Li Miao, Sun Wan Qing, Lu Tao
Summary: This study aimed to investigate the effects of HAP1 on SCI and the underlying mechanisms. The results showed that HAP1 can promote neurological function rehabilitation and neurofibrillary regeneration, thus improving the prognosis of spinal cord injury.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Microbiology
Heather A. Feaga, Hye-Rim Hong, Cassidy R. Prince, Ananda Rankin, Allen R. Buskirk, Jonathan Dworkin
Summary: Elongation factor P (EF-P) is a universally conserved translation factor that prevents ribosome stalling at amino acids that form peptide bonds with low efficiency, particularly polyproline tracts. The lack of EF-P delays the expression of sporulation-specific genes in Bacillus subtilis, and this can be rescued by ectopic expression of Spo0A. These findings suggest that EF-P plays a role in sporulation initiation by affecting the expression of Spo0A, the master regulator of sporulation.
JOURNAL OF BACTERIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lukas Seebauer, Yanni Schneider, Alice Drobny, Sonja Ploetz, Tomas Koudelka, Andreas Tholey, Iryna Prots, Beate Winner, Friederike Zunke, Juergen Winkler, Wei Xiang
Summary: In this study, the impact of aSyn on microtubule organization was investigated in cell models and patient-derived neurons. The results suggest that aSyn aggregation interferes with microtubule organization, leading to impaired neuritic phenotypes in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Dong Jin Mun, Bon Seong Goo, Bo Kyoung Suh, Ji-Ho Hong, Youngsik Woo, Soo Jeong Kim, Seunghyun Kim, Su Been Lee, Yubin Won, Jin Yeong Yoo, Eunbyul Cho, Eun Jin Jang, Truong Thi My Nhung, Hong Minh Triet, Hongyul An, Haeryun Lee, Minh Dang Nguyen, Seung-Yeol Park, Seung Tae Baek, Sang Ki Park
Summary: In this study, the Gcap14-Ndel1 complex is identified as a fundamental regulator of cytoskeletal remodeling during neurodevelopment, including neuronal process elongation and migration. Deficiency of Gcap14 leads to impaired cortical lamination and defective neuronal migration. The interaction between Gcap14 and Ndel1 effectively corrects the downregulation of microtubule dynamics and the defects in neuronal migration caused by Gcap14 deficiency.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Microbiology
Jan Stephan Wichers-Misterek, Annika M. Binder, Paolo Mesen-Ramirez, Lilian Patrick Dorner, Soraya Safavi, Gwendolin Fuchs, Tobias L. Lenz, Anna Bachmann, Danny Wilson, Friedrich Frischknecht, Tim-Wolf Gilberger
Summary: The unique three-membrane pellicle is a key feature driving the transition between different life cycle stages of the malaria parasite. A novel subpellicular microtubule-associated protein, SPM3, was identified in the genus Plasmodium. Knockout of this protein resulted in malformed gametocytes and aberrant microtubules in Plasmodium falciparum, while in Plasmodium berghei, it caused perturbed microtubule architecture, aberrant sporozoite motility, and decreased transmission efficiency.
Article
Neurosciences
Nabin Koirala, Meaghan Perdue, Xing Su, Elena L. Grigorenko, Nicole Landi
Summary: The study found that reading and phonological processing skills are negatively correlated with the coherence and neurite density in white matter tracts. Additionally, phonological processing mediated the relationship between neurite indices and reading skills in most cases.
Article
Biochemistry & Molecular Biology
Yuhao Yang, Jie Yang, Yaozhong Liang, Guowei Zhang, Zhenbin Cai, Yunlong Zhang, Hongsheng Lin, Minghui Tan
Summary: Investigating novel mechanisms of neurite outgrowth via cytoskeleton is critical for developing therapeutic strategies against neural disorders. This study reveals the interaction between Rab3A and spastin, which affects the stability of spastin and eliminates its microtubule severing function, thereby modulating neurite outgrowth.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ibtissem Nabti, Babu J. N. Reddy, Rachid Rezgui, Wenqi Wang, Steven P. Gross, George T. Shubeita
Summary: This study demonstrates that phosphorylated MAP4 can bias organelle transport towards the microtubule minus-ends by impairing the force generation of kinesin-1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemical Research Methods
Phasit Charoenkwan, Eric Hwang, Robert W. Cutler, Hua-Chin Lee, Li-Wei Ko, Hui-Ling Huang, Shinn-Ying Ho
BMC BIOINFORMATICS
(2013)
Article
Multidisciplinary Sciences
Tzu-Chia Hsu, Kuang-Kai Liu, Huan-Cheng Chang, Eric Hwang, Jui-I Chao
SCIENTIFIC REPORTS
(2014)
Article
Multidisciplinary Sciences
Yung-An Huang, Chun-Wei Kao, Kuang-Kai Liu, Hou-Syun Huang, Ming-Han Chiang, Ching-Ren Soo, Huan-Cheng Chang, Tzai-Wen Chiu, Jui-I Chao, Eric Hwang
SCIENTIFIC REPORTS
(2014)
Article
Multidisciplinary Sciences
Wen-Shin Chen, Yi-Ju Chen, Yung-An Huang, Bing-Yuan Hsieh, Ho-Chieh Chiu, Pei-Ying Kao, Chih-Yuan Chao, Eric Hwang
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Yun-An Huang, Chris T. Ho, Yu-Hsuan Lin, Chen-Ju Lee, Szu-Mo Ho, Ming-Chia Li, Eric Hwang
MACROMOLECULAR BIOSCIENCE
(2018)
Article
Cell Biology
Yung-An Huang, Chih-Hsuan Hsu, Ho-Chieh Chiu, Pei-Yu Hsi, Chris T. Ho, Wei-Lun Lo, Eric Hwang
JOURNAL OF CELL SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Hung-Ming Chien, Ruei-Yu He, Chi-Chang Lee, Yung-An Huang, I-Ju Hung, Kai-Ting Hou, Jye-Chian Hsiao, Po-Chao Lu, Diksha Agnihotri, Eric Hwang, Joseph Jen-Tse Huang
Summary: This study utilized a photoinducible peptide platform to investigate glycine-alanine dipeptide repeats produced by the C9orf72 gene, revealing that their oligomers can cause cytotoxic effects such as disruption of nuclear membrane and cytosolic retention.
COMMUNICATIONS CHEMISTRY
(2021)
Article
Neurosciences
Ya-Jean Wang, Che-Jui Yeh, Zi-Han Gao, Eric Hwang, Hwei-Hisen Chen, Sheng-Nan Wu
Summary: FLV is a potent inhibitor of cholesterol biosynthesis and also has effects on K+ channels. This study demonstrates that FLV has significant effects on ionic currents and action potentials, as well as on the afterhyperpolarization current in electrically excitable cells.
Article
Food Science & Technology
Chun-Yu Lin, Yi-Ju Chen, Chih-Hsuan Hsu, Yu-Hsuan Lin, Peng-Tzu Chen, Ting-Han Kuo, Chris T. Ho, Hsin-Hua Chen, Sih-Jia Huang, Ho-Chieh Chiu, Chin-Chu Chen, Eric Hwang
Summary: Erinacines derived from Hericium erinaceus have been found to possess neuro-protective effects against neurodegenerative diseases. This study discovered a previously unknown effect of erinacine S on enhancing neurite outgrowth and promoting axon regeneration of peripheral nervous system neurons as well as overcoming regeneration obstacles of central nervous system neurons. The research also revealed that erinacine S can cause the accumulation of neurosteroids in neurons.
JOURNAL OF FOOD AND DRUG ANALYSIS
(2023)
Article
Nanoscience & Nanotechnology
Yi-Ju Chen, Yung-An Huang, Chris T. Ho, Jinn-Moon Yang, Jui- Chao, Ming-Chia Li, Eric Hwang
Summary: The study found that using nanodiamond surface topography can accelerate the development of primary neurons from both the central and peripheral nervous systems. It was discovered that miR6236 is the predominant molecule responsible for converting the surface topography into biological responses, and depleting it enhances neuroregeneration, thus raising therapeutic potential for promoting nervous system regeneration.
ACS APPLIED BIO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ruei-Yu He, Shu-Han Chao, Yu-Ju Tsai, Chi-Chang Lee, Chu-Yi Yu, Hua-De Gao, Yung-An Huang, Eric Hwang, Hsien-Ming Lee, Joseph Jen-Tse Huang