LPS-Induced proNGF Synthesis and Release in the N9 and BV2 Microglial Cells: A New Pathway Underling Microglial Toxicity in Neuroinflammation

ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice

(2013) C Tiveron et al.   CELL DEATH AND DIFFERENTIATION

Functional Role of Matrix Metalloproteinase-8 in Stem/Progenitor Cell Migration and Their Recruitment Into Atherosclerotic Lesions

(2012) Qingzhong Xiao et al.   CIRCULATION RESEARCH

A Dual Mechanism Linking NGF/proNGF Imbalance and Early Inflammation to Alzheimer's Disease Neurodegeneration in the AD11 Anti-NGF Mouse Model

(2012) S. Capsoni et al.   CNS & Neurological Disorders-Drug Targets

Proprotein convertase furin enhances survival and migration of vascular smooth muscle cells via processing of pro-nerve growth factor

(2012) D. Urban et al.   JOURNAL OF BIOCHEMISTRY

Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology

(2012) Maria Teresa Ferretti et al.   Journal of Neuroinflammation

Matrix Metalloproteinase-7 Regulates Cleavage of Pro-Nerve Growth Factor and Is Neuroprotective following Kainic Acid-Induced Seizures

(2012) A. P. Le et al.   JOURNAL OF NEUROSCIENCE

Pro-domain in precursor nerve growth factor mediates cell death

(2012) Arunmozhiarasi Armugam et al.   NEUROCHEMISTRY INTERNATIONAL

Inhibition of Microglial Activation Protects Hippocampal Neurogenesis and Improves Cognitive Deficits in a Transgenic Mouse Model for Alzheimer’s Disease

(2012) Barbara Biscaro et al.   Neurodegenerative Diseases

Decreased Serum Levels of Mature Brain-Derived Neurotrophic Factor (BDNF), but Not Its Precursor proBDNF, in Patients with Major Depressive Disorder

(2012) Taisuke Yoshida et al.   PLoS One

Diabetes-induced peroxynitrite impairs the balance of pro-nerve growth factor and nerve growth factor, and causes neurovascular injury

(2010) T. K. Ali et al.   DIABETOLOGIA

ProNGF mediates death of Natural Killer cells through activation of the p75NTR–sortilin complex

(2010) Mary-Louise Rogers et al.   JOURNAL OF NEUROIMMUNOLOGY

Proinflammatory Orientation of the Interleukin 1 System and Downstream Induction of Matrix Metalloproteinase 9 in the Pathophysiology of Human Perinatal White Matter Damage

(2010) Sylvie Girard et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

ProNGF Induces PTEN via p75NTR to Suppress Trk-Mediated Survival Signaling in Brain Neurons

(2010) W. Song et al.   JOURNAL OF NEUROSCIENCE

MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS

(2010) Lubin Fang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Urokinase-Type Plasminogen Activator Induces BV-2 Microglial Cell Migration Through Activation of Matrix Metalloproteinase-9

(2010) Sun Mi Shin et al.   NEUROCHEMICAL RESEARCH

The proNGF-p75NTR-Sortilin Signalling Complex as New Target for the Therapeutic Treatment of Parkinsons Disease

(2009) L. Chen et al.   CNS & Neurological Disorders-Drug Targets

Cholinergic Involvement in Alzheimer’s Disease. A Link with NGF Maturation and Degradation

(2009) A. Claudio Cuello et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Increased Matrix Metalloproteinase 9 Activity in Mild Cognitive Impairment

(2009) Martin A. Bruno et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Effects of proNGF on Neuronal Viability, Neurite Growth and Amyloid-beta Metabolism

(2009) Yan-Jiang Wang et al.   NEUROTOXICITY RESEARCH

Up-regulation of pro-nerve growth factor, neurotrophin receptor p75, and sortilin is associated with retrovirus-induced spongiform encephalomyelopathy

(2008) George Stoica et al.   BRAIN RESEARCH

ProNGF inhibits NGF-mediated TrkA activation in PC12 cells

(2008) Bettina Sobottka et al.   JOURNAL OF NEUROCHEMISTRY