Article
Physiology
Marta Reina-Couto, Carolina Silva-Pereira, Patricia Pereira-Terra, Janete Quelhas-Santos, Joao Bessa, Paula Serrao, Joana Afonso, Sandra Martins, Claudia Camila Dias, Manuela Morato, Joao T. Guimaraes, Roberto Roncon-Albuquerque, Jose-Artur Paiva, Antonio Albino-Teixeira, Teresa Sousa
Summary: Inflammation-driven endothelitis plays a significant role in acute heart failure and cardiogenic shock. This study evaluated the levels of endocan in patients with these conditions and correlated them with markers of inflammation, endothelial activation, cardiovascular dysfunction, and prognosis. The findings suggest that endocan may be a biomarker for endothelitis and a potential therapeutic target.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pathology
Ane Rivas-Macho, Maria V. Romeo, Elisabeth Rackles, Garbine Olabarria, Juan Manuel Falcon-Perez, Jesus Berganza-Granda, Aitziber L. Cortajarena, Felipe Goni-de-Cerio
Summary: This article discusses the expression of Hsp90 in samples from individuals affected by different diseases and its biological consequences, including the potential use of Hsp90 as a biomarker for diagnosing human diseases.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Article
Critical Care Medicine
Hamid Merdji, Anais Curtiaud, Antoine Aheto, Antoine Studer, Veli-Pekka Harjola, Alexandra Monnier, Kevin Duarte, Nicolas Girerd, Marion Kibler, Hafid Ait-Oufella, Julie Helms, Alexandre Mebazaa, Bruno Levy, Antoine Kimmoun, Ferhat Meziani
Summary: This study assessed the correlation between capillary refill time and 90-day mortality or the need for VA-ECMO support in patients with cardiogenic shock. The findings suggest that a prolonged capillary refill time >3 seconds is associated with an early prediction of adverse outcomes in these patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Medicine, Research & Experimental
Lu Qian, Qian Zhao, Ping Yu, Jinhui Lu, Yuefan Guo, Xin Gong, Yuanyuan Ding, Shanshan Yu, Lieying Fan, Huimin Fan, Yuzhen Zhang, Zhongmin Liu, Hongzhuan Sheng, Zuoren Yu
Summary: Heart failure is a leading cause of death worldwide, and its incidence is increasing due to the aging population. In this study, circulating miRNAs were analyzed to identify diagnostic biomarkers for heart failure. Two miRNAs, miR-30a-5p and miR-654-5p, were found to be significantly changed in the plasma of heart failure patients. A two-circulating miRNA model was developed for diagnosis and prognosis of heart failure, which showed promising potential in an independent validation cohort.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Fahimeh Ghasemi, Effat Alemzadeh, Leila Allahqoli, Esmat Alemzadeh, Afrooz Mazidimoradi, Hamid Salehiniya, Ibrahim Alkatout
Summary: Endometriosis is a chronic disease characterized by the presence of endometrial tissue outside the uterus, causing pelvic pain and infertility. The gold standard for diagnosis is laparoscopy, but a non-invasive and more accurate test is urgently needed. miRNAs have been suggested as potential biomarkers, but there is no consensus.
Article
Environmental Sciences
B. Rangaswamy, W. -s. Kim, I. -S. Kwak
Summary: Heat shock proteins are natural biomarkers that play a vital role in genetic variability and adaptive survival in organisms under environmental stress. This study assessed the effect of stressors on Heat shock protein 70 in two fish species, Hemibarbus labeo and Lepomis macrochirus. The results showed that the expression of Heat shock protein 70 in fish was influenced by physicochemical factors in the lake ecosystem, indicating a stress-relieving effect.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Medicinal
Indumathi Krishnan-Sivadoss, Ivan A. Mijares-Rojas, Ramiro A. Villarreal-Leal, Guillermo Torre-Amione, Anne A. Knowlton, C. Enrique Guerrero-Beltran
Summary: Inflammation is the main culprit in the development of cardiovascular diseases, and HSP60 is a protein that can both protect against cellular injury and trigger damaging responses. Studies have discussed the functions of HSP60, its effects on cells and immune system regulation, and its implications in the development and progression of CVD.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Cell Biology
Shanshan Sha, Yating Wang, Menglu Liu, Gang Liu, Ning Fan, Zhi Li, Weijie Dong
Summary: Pancreatic cancer is one of the top 10 causes of cancer-related death, with the majority of patients being diagnosed at the middle or advanced stage. This study identified an increase in bisecting GlcNAc structures of glycoproteins in the serum of pancreatic cancer patients. By using a lectin that specifically recognizes bisecting GlcNAc N-glycans, ceruloplasmin (Cp) was identified as a potential glycoprotein marker that can distinguish pancreatic cancer patients from acute pancreatitis patients and normal individuals.
Article
Cardiac & Cardiovascular Systems
Jing Xu, Yuejin Yang
Summary: The study identified 90 upregulated DEGs and 9 downregulated DEGs in three datasets, which were mainly enriched in GO terms related to cytokine secretion, pattern recognition receptors signaling pathway, and immune cells activation. Additionally, a cluster of eight genes including ITGAM, CLEC4D, SLC2A3, BST1, MCEMP1, PLAUR, GPR97, and MMP25 was found to be significant.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Alexandrine Bertaud, Ahmad Joshkon, Xavier Heim, Richard Bachelier, Nathalie Bardin, Aurelie S. Leroyer, Marcel Blot-Chabaud
Summary: Cardiac fibrosis is a condition characterized by irreversible necrosis of the heart muscle, caused by various acute or chronic diseases, genetic alterations, or aging. Currently, there is no curative treatment available to prevent or attenuate cardiac fibrosis, which leads to progressive cardiac dysfunction and life-threatening outcomes. This review summarizes different targets and new strategies proposed to fight cardiac fibrosis, as well as discussing future directions, such as the use of exosomes or nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Qiang Sun, Jun Zhao, Li Liu, Xiaoliang Wang, Xinshun Gu
Summary: In this study, circadian rhythms-related hub genes were identified as potential biomarkers for heart failure. The analysis of gene expression data revealed that ARNTL, CRY2, BHLHE41 and NPAS2 could serve as potential biomarkers of circadian rhythm in heart failure, providing new insights for diagnosis and treatment.
Review
Medicine, General & Internal
Luca Fazzini, Ludovica Caggiari, Martino Deidda, Carlotta Onnis, Luca Saba, Giuseppe Mercuro, Christian Cadeddu Dessalvi
Summary: Antiblastic drugs-induced cardiomyopathy is a significant cause of morbidity and mortality in chemotherapy patients. In recent years, researchers have focused on studying metabolic profiles in animals and humans to predict drug-induced cardiotoxicity and cardiovascular damage. In clinical practice, patients at risk of developing cardiotoxicity receive close monitoring and tailored therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Jia Wang, Fang Zhou, Chang-E Xiong, Gui-Ping Wang, Lin-Wanyue Chen, Yu -Tong Zhang, Shi-Ge Qi, Zhi-Hui Wang, Can Mei, Yu-Jia Xu, Jian-Bo Zhan, Jing Cheng
Summary: This study suggests that serum SIRT1 may be a promising early diagnostic biomarker for Alzheimer's Disease.
Article
Cardiac & Cardiovascular Systems
Hugo Saner, Narayan Schuetz, Philipp Buluschek, Guillaume Du Pasquier, Giuseppe Ribaudo, Prabitha Urwyler, Tobias Nef
Summary: Home monitoring systems are commonly used to monitor seniors for emergency situations, while ambient sensor systems can monitor digital biomarkers to detect clinically relevant health problems early. These sensor systems have the potential to detect early signs of HF decompensation, allowing for preventative measures to be taken to avoid further deterioration and hospitalization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Elias Rawish, Thomas Stiermaier, Francesco Santoro, Natale D. Brunetti, Ingo Eitel
Summary: Takotsubo syndrome (TTS) is an acute cardiac condition that mimics acute myocardial infarction, characterized by temporary left ventricular dysfunction. Coronary angiography with left ventriculography is the gold standard diagnostic tool for excluding or confirming TTS. TTS is often associated with severe emotional or physical stress, and further research is needed to understand the underlying pathophysiological mechanisms.
JOURNAL OF CLINICAL MEDICINE
(2021)