Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters

The kappa opioid receptor antagonist JDTic attenuates alcohol seeking and withdrawal anxiety

(2012) Jesse R. Schank et al.   ADDICTION BIOLOGY

Conopeptide ρ-TIA Defines a New Allosteric Site on the Extracellular Surface of the α1B-Adrenoceptor

(2012) Lotten Ragnarsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo and in vitro characterization of naltrindole-derived ligands at the κ-opioid receptor

(2012) Joseph J Casal-Dominguez et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Structure of the human κ-opioid receptor in complex with JDTic

(2012) Huixian Wu et al.   NATURE

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

(2012) Aaron A. Thompson et al.   NATURE

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity

(2012) Thomas A Munro et al.   BMC Pharmacology & Toxicology

Repeated Exposure to the κ-Opioid Receptor Agonist Salvinorin A Modulates Extracellular Signal-Regulated Kinase and Reward Sensitivity

(2011) David N. Potter et al.   BIOLOGICAL PSYCHIATRY

Noradrenergic regulation of itch transmission in the spinal cord mediated by α-adrenoceptors

(2011) Yoshikazu Gotoh et al.   NEUROPHARMACOLOGY

Caveats and limitations of plate reader-based high-throughput kinetic measurements of intracellular calcium levels

(2011) Harm J. Heusinkveld et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Quantification of Functional Selectivity at the Human  1A-Adrenoceptor

(2010) B. A. Evans et al.   MOLECULAR PHARMACOLOGY

Investigation of gastrin-releasing peptide as a mediator for 5′-guanidinonaltrindole-induced compulsive scratching in mice

(2010) Saadet Inan et al.   PEPTIDES

Allostery at G Protein-Coupled Receptor Homo- and Heteromers: Uncharted Pharmacological Landscapes

(2010) N. J. Smith et al.   PHARMACOLOGICAL REVIEWS

Structure–activity relationship study on α1 adrenergic receptor antagonists from beer

(2009) Toshiyuki Wakimoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dynorphin, stress, and depression

(2009) Allison T. Knoll et al.   BRAIN RESEARCH

Subtypes of functional α1-adrenoceptor

(2009) James R. Docherty   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5′-guanidinonaltrindole-induced scratching models in mice: Behavioral and neuroanatomical evidence

(2009) Saadet Inan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

P-glycoprotein is not involved in the differential oral potency of naloxone and naltrexone

(2009) Mouna Kanaan et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

(2009) Adam J. Kimple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perspectives of P-Glycoprotein Modulating Agents in Oncology and Neurodegenerative Diseases: Pharmaceutical, Biological, and Diagnostic Potentials

(2009) Nicola Antonio Colabufo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nalfurafine prevents 5′-guanidinonaltrindole- and compound 48/80-induced spinal c-fos expression and attenuates 5′-guanidinonaltrindole-elicited scratching behavior in mice

(2009) S. Inan et al.   NEUROSCIENCE

Kappa-opioid ligands in the study and treatment of mood disorders

(2009) William A. Carlezon et al.   PHARMACOLOGY & THERAPEUTICS

Selectivity of Agonists for the Active State of M1 to M4 Muscarinic Receptor Subtypes

(2008) K. W. Figueroa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Validation of a fluorescence-based high-throughput assay for the measurement of neurotransmitter transporter uptake activity

(2007) Susanne Jørgensen et al.   JOURNAL OF NEUROSCIENCE METHODS