Article
Nutrition & Dietetics
Thomas Sevrin, Charlene Sirvins, Agnes David, Audrey Aguesse, Alexis Gandon, Blandine Castellano, Dominique Darmaun, Clair-Yves Boquien, Marie-Cecile Alexandre-Gouabau
Summary: The study found that supplementation of arginine during gestation and lactation can enhance milk flow and mammary lipogenesis in rat dams nursing large litters.
JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Min Fu, Yuanpeng Gao, Wenxing Guo, Qi Meng, Qi Jin, Rui Yang, Ying Yang, Yaqi Zhang, Wanqi Zhang
Summary: This research investigates the compensation mechanism of iodine deficiency and excess in the mammary gland during lactation. The study found that milk iodine concentration is positively correlated with iodine intake, and the regulation of glycosylation and degradation of NIS by DPAGT1 and VCP in the mammary gland plays a role in regulating milk iodine level. However, the mammary gland has limited ability to compensate for iodine deficiency and excess.
Article
Agriculture, Dairy & Animal Science
Jinbo Wu, Shiming He, Zhonghua Yu, Daoliang Lan, Xianrong Xiong, Zhu Li
Summary: In this study, RNA-seq was used to analyze the mammary gland transcriptomes of high-yielding and low-yielding yaks during lactation. The results showed that 144 differential genes were identified, which were involved in various biological processes such as carbohydrate metabolism. This study provides new insights into the molecular mechanism of yak mammary gland tissue and potential strategies for improving milk production in yaks.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sanil Patel, Njeri Z. R. Sparman, Douglas Arneson, Alexandra Alvarsson, Luis C. Santos, Samuel J. J. Duesman, Alessia Centonze, Ephraim Hathaway, In Sook Ahn, Graciel Diamante, Ingrid Cely, Chung Hwan Cho, Noble Kumar Talari, Abha K. K. Rajbhandari, Leigh Goedeke, Peng Wang, Atul J. J. Butte, Cedric Blanpain, Karthickeyan Chella Krishnan, Aldons J. J. Lusis, Sarah A. A. Stanley, Xia Yang, Prashant Rajbhandari
Summary: The mammary gland ductal epithelial cells regulate cold-induced adipocyte UCP1 expression and control adipose thermogenesis through the secretion of mammokines. These findings suggest that sympathetic nerve-activated glandular epithelium plays a crucial role in adipocyte UCP1 expression and has implications for energy expenditure and subcutaneous fat loss.
Article
Biochemistry & Molecular Biology
Rong Xuan, Jianmin Wang, Qing Li, Yanyan Wang, Shanfeng Du, Qingling Duan, Yanfei Guo, Peipei He, Zhibin Ji, Tianle Chao
Summary: This study conducted transcriptome sequencing of goat-mammary-gland tissue at different developmental stages to reveal the expression characteristics and molecular functions of circRNAs during mammary involution. A total of 11,756 circRNAs were identified, with 2528 circRNAs expressed in all three stages. Gene ontology analysis showed functional diversity of circRNAs' source genes. Furthermore, differentially expressed circRNAs and circRNA-miRNA-mRNA ceRNA regulatory networks were identified, providing insights into the regulatory role of circRNAs in mammary cell involution and remodeling.
Article
Agriculture, Dairy & Animal Science
Wei Xia, Yili Liu, Juan J. Loor, Massimo Bionaz, Mingfeng Jiang
Summary: This study evaluated the transcriptome of mammary tissue in four yaks throughout the lactation cycle. The analysis identified over 6000 differentially expressed genes, with a large number of genes showing differential expression at the onset and end of lactation. The functions affected by transcriptomic adaptation to lactation in yak mammary tissue were similar to those observed in dairy cows, including induction of lipid metabolism, amino acid metabolism, and glycan biosynthesis, as well as suppression of the cell cycle and immune response.
Article
Cell Biology
Ivan Luzardo-Ocampo, Jose L. Dena-Beltran, Xarubet Ruiz-Herrera, Ana Luisa Ocampo-Ruiz, Gonzalo Martinez de la Escalera, Carmen Clapp, Yazmin Macotela
Summary: Obesity is a modern pandemic that negatively impacts women's reproductive health. Women with obesity experience changes in their mammary glands which affect their ability to exclusively breastfeed. The hormone prolactin, which is responsible for lactation, has reduced activity in the mammary glands of obese lactating rodents, contributing to impaired lactation. Treatment with prolactin has shown to improve milk production in women with inadequate lactation. This review focuses on the effects of diet-induced obesity on lactating mammary glands and how obesity impairs the lactogenic action of prolactin. While the impact of obesity on lactation has been studied in both humans and rodents, most of the research has been conducted on rodents.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Immunology
Dilay Cansever, Ekaterina Petrova, Sinduya Krishnarajah, Caroline Mussak, Christina A. Welsh, Wiebke Mildenberger, Kevin Mulder, Victor Kreiner, Elsa Roussel, Sebastian A. Stifter, Myrto Andreadou, Pascale Zwicky, Nicole Puertas Jurado, Hubert Rehrauer, Ge Tan, Zhaoyuan Liu, Camille Bleriot, Francesca Ronchi, Andrew J. Macpherson, Florent Ginhoux, Giancarlo Natalucci, Burkhard Becher, Melanie Greter
Summary: Macrophages play a role in immune defense, organogenesis, and tissue homeostasis. During lactation, a unique population of macrophages called liMacs emerges in the mammary gland and milk, which is similar to macrophages found in human milk.
Article
Agriculture, Dairy & Animal Science
J. Y. Dourmad, J. J. Matte
Summary: During lactation, the mammary gland in sows adapts its metabolism quickly in response to short-term changes in nutrient availability, demonstrating a rapid ability to adjust nutrient uptake and modify metabolism according to the nutrients in the bloodstream.
Article
Biotechnology & Applied Microbiology
Marie-France Palin, Anouk Caron, Chantal Farmer
Summary: This study aimed to explore the effect of sustained hyperprolactinemia during the late pregnancy on the global transcriptome in the mammary tissue of gilts and identify the molecular pathways involved in triggering premature mammary involution. The results showed that in the absence of suckling piglets, sustained hyperprolactinemia sends conflicting pro-survival and cell death signals to mammary epithelial cells, resulting in a mammary gland that can simultaneously synthesize milk proteins and initiate mammary involution.
Article
Biochemistry & Molecular Biology
Lilia Sanchez, Jessica Epps, Steven Wall, Cole McQueen, Scott J. Pearson, Kelly Scribner, Elizabeth A. Wellberg, Erin D. Giles, Monique Rijnkels, Weston W. Porter
Summary: The functionally differentiated mammary gland adapts to extreme levels of stress by activating specific protective mechanisms. The breast tumor suppressor gene SIM2s is identified as a novel regulator of mitophagy, a key component of this stress response.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Cell Biology
Nikita Thakkar, Ye Bin Shin, Hoon-Ki Sung
Summary: The mammary gland is a complex organ that can be regulated by nutritional stimuli, affecting glandular function and disease development. Obesity increases the risk of breast cancer, while fasting or calorie restriction may have a negative impact on mammary tumor progression. However, the specific effects of fasting on the mammary microenvironment are still not well understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Veterinary Sciences
Weihao Chen, Xinyu Gu, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Shanhe Wang, Wei Sun
Summary: This study used RNA-seq technology to analyze the expression of miRNAs and circRNAs in sheep mammary gland during different lactation periods and identified potential miRNAs and circRNAs related to sheep mammary gland development through bioinformatics analysis.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Genetics & Heredity
Elitsa Ivanova, Sandrine Le Guillou, Cathy Hue-Beauvais, Fabienne Le Provost
Summary: The mammary gland undergoes significant anatomical and physiological changes from embryogenesis through various stages, with epigenetic mechanisms playing a crucial role in these processes. Research has shown the importance of epigenetic marks in milk component biosynthesis and highlights the involvement of DNA methylation, histone modifications, polycomb protein activity, and non-coding RNA functions in regulating gene expression in the mammary gland.
Article
Agriculture, Dairy & Animal Science
Danielle Nicole Coleman, Mario Vailati-Riboni, Russell T. Pate, Ahmad Aboragah, Daniel Luchini, Felipe C. Cardoso, Juan J. Loor
Summary: Enhanced post-ruminal supply of methionine can affect mammary metabolism and immune response. Heat stress and rumen-protected methionine have been found to influence abundance and phosphorylation of signaling proteins in mammary gland. However, rumen-protected methionine supplementation does not attenuate the inflammatory response induced by lipopolysaccharide in vitro.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Nutrition & Dietetics
Luis E. Gonzalez-Salazar, Omar Granados-Portillo, Isabel Medina-Vera, Edgar Pichardo-Ontiveros, Ana Vigil-Martinez, Rocio Guizar-Heredia, Berenice Palacios-Gonzalez, Liliana Arteaga-Sanchez, Karla G. Hernandez-Gomez, Azalia Avila-Nava, Aurora E. Serralde-Zuniga, Adriana Flores-Lopez, Lilia G. Noriega, Nimbe Torres, Viridiana Olin-Sandoval, Natalia Vazquez-Manjarrez, Natali Dominguez-Velazquez, Juan G. Reyes-Garcia, Armando R. Tovar, Martha Guevara-Cruz
Summary: This study found that the presence of BCAT2 SNP can modify the effect of dietary intervention on plasma BCAA concentration in subjects with obesity and insulin resistance, leading to a greater reduction in BCAA levels after an energy-restricted dietary intervention.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Food Science & Technology
Diana Coutino-Hernandez, Monica Sanchez-Tapia, Francisco Leal-Vega, Miriam Bobadilla del Valle, Hector Ledezma, Ricardo Cervantes, Jose Pedraza-Chaverri, Omar Granados-Portillo, Daniel Diaz, Marilena Antunes-Ricardo, Janet Gutierrez-Uribe, Otoniel Maya, Viridiana Olin-Sandoval, Armando R. Tovar, Nimbe Torres
Summary: Studies have shown that honey consumption can have various health benefits, and may modify the intestinal microbiota to prevent inflammatory responses in the host. Melipona and Mantequilla honeys contain bioactive compounds and antioxidants that can benefit metabolic health by influencing gut microbiota. This study found that both honeys reduced weight gain and body fat, increased energy expenditure, and altered gut microbiota to prevent glucose intolerance and inflammation.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Food Science & Technology
Sarai Vasquez-Reyes, Ariana Vargas-Castillo, Lilia G. Noriega, Laura A. Velazquez-Villegas, Berenice Perez, Monica Sanchez-Tapia, Guillermo Ordaz, Renato Suarez-Monroy, Alfredo Ulloa-Aguirre, Halina Offner, Nimbe Torres, Armando R. Tovar
Summary: This study aims to determine whether genistein activates thermogenesis and mitochondrial activity in white adipose tissue (WAT) through the G-coupled receptor GPR30. The results show that GPR30 partially mediates genistein stimulation of WAT thermogenesis and the improvement of glucose tolerance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Nutrition & Dietetics
Tauqeerunnisa Syeda, Monica Sanchez-Tapia, Itzel Orta, Omar Granados-Portillo, Lizbeth Perez-Jimenez, Juan-de-Dios Rodriguez-Callejas, Samuel Toribio, Maria-del-Carmen Silva-Lucero, Ana-Leonor Rivera, Armando R. Tovar, Nimbe Torres, Claudia Perez-Cruz
Summary: Ingestion of bioactive foods can improve gut microbiota dysbiosis, reduce fatty liver, and cognitive damage in obese rats, and also has anti-inflammatory and neuroprotective effects.
Article
Pediatrics
Ana Laura de la Garza, Bianca Romero-Delgado, Alejandra Mayela Martinez-Tamez, Marcela Cardenas-Tueme, Bianka Dianey Camacho-Zamora, Daniel Matta-Yee-Chig, Monica Sanchez-Tapia, Nimbe Torres, Alberto Camacho-Morales
Summary: This study found that maternal high-sweeteners intake during gestation and lactation can alter gut microbiota diversity in adult male offspring rats and lead to cognitive dysfunction.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cell Biology
Daniel Cuervo-Zanatta, Tauqeerunnisa Syeda, Vicente Sanchez-Valle, Mariangel Irene-Fierro, Pablo Torres-Aguilar, Monica Adriana Torres-Ramos, Mineko Shibayama-Salas, Angelica Silva-Olivares, Lilia G. Noriega, Nimbe Torres, Armando R. Tovar, Ivan Ruminot, L. Felipe Barros, Jaime Garcia-Mena, Claudia Perez-Cruz
Summary: Fiber intake is associated with a lower risk for Alzheimer's disease in older adults. The neuroprotective effects of fiber intake may depend on the modulation of gut microbiota dysbiosis and specific actions of short-chain fatty acids in brain cells.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Nutrition & Dietetics
Luis E. Gonzalez-Salazar, Aurora E. Serralde-Zuniga, Adriana Flores-Lopez, Juan P. Diaz-Sanchez, Isabel Medina-Vera, Edgar Pichardo-Ontiveros, Rocio Guizar-Heredia, Karla G. Hernandez-Gomez, Ana Vigil-Martinez, Liliana Arteaga-Sanchez, Azalia Avila-Nava, Natalia Vazquez-Manjarrez, Nimbe Torres, Armando R. Tovar, Martha Guevara-Cruz
Summary: The present study aimed to determine the prevalence of adiposity-based chronic disease (ABCD) and its association with anthropometric indices in the Mexican population. The results showed that the prevalence of ABCD was 87.4%, increasing with age. This suggests that obesity-related complications are common in this population.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Medicine, Research & Experimental
Rocio Guizar-Heredia, Lilia G. Noriega, Ana Leonor Rivera, Osbaldo Resendis-Antonio, Martha Guevara-Cruz, Nimbe Torres, Armando R. Tovar
Summary: A prolonged and elevated postprandial glucose response (PPGR) is a key factor in the development of metabolic syndrome and type 2 diabetes, and can be prevented through dietary interventions. However, dietary recommendations alone have not always been successful in preventing alterations in PPGR, as it is also influenced by genetics, body composition, gut microbiota, and other factors. Recent advancements in continuous glucose monitoring and machine learning have made it possible to predict the effects of different dietary foods on PPGRs, allowing for personalized dietary recommendations. Additional components such as nutrigenomics, nutrigenetics, and metabolomics can further enhance the predictive algorithms. This review summarizes the evidence and future prospects of personalized nutrition in preventing PPGR and improving metabolic diseases.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Sofia Moran-Ramos, Daniel Cerqueda-Garcia, Blanca Lopez-Contreras, Elena Larrieta-Carrasco, Hugo Villamil-Ramirez, Selene Molina-Cruz, Nimbe Torres, Monica Sanchez-Tapia, Rogelio Hernandez-Pando, Carlos Aguilar-Salinas, Teresa Villarreal-Molina, Samuel Canizales-Quinteros
Summary: This study aimed to characterize the gut microbiome composition of patients with obesity and biopsy-proven NAFLD. The study found that Parabacteroides distasonis and Alistipes putredenis were enriched in fatty liver patients but not in NASH patients. Furthermore, individuals with a Prevotella copri dominant bacterial community were more likely to develop NASH, possibly due to higher intestinal permeability and lower capacity for butyrate production.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Maria E. Meneses, Daniel Martinez-Carrera, Laura Gonzalez-Ibanez, Nimbe Torres, Monica Sanchez-Tapia, Claudia C. Marquez-Mota, Gilmar Rendon, Vladimir Mitzi, Alfredo Morales, Isaac Tello-Salgado, Armando R. Tovar
Summary: Well-characterized and standardized extracts of a Mexican genotype of Ganoderma lucidum cultivated on oak sawdust (Gl-1) or oak sawdust plus acetylsalicylic acid (Gl-2, ASA) were administered to rats for 14 days to assess toxicity. The extracts showed no significant adverse effects on the rats, including on the liver, kidney, biochemical parameters, inflammatory responses, and gut microbiota.
Article
Nutrition & Dietetics
Monica Sanchez-Tapia, Alberto Mimenza-Alvarado, Lizbeth Granados-Dominguez, Adriana Flores-Lopez, Adriana Lopez-Barradas, Victor Ortiz, Claudia Perez-Cruz, Hilda Sanchez-Vidal, Julieta Hernandez-Acosta, Jose Alberto Avila-Funes, Martha Guevara-Cruz, Armando R. Tovar, Nimbe Torres
Summary: Currently, the number of individuals with mild cognitive impairment (MCI) and dementia (D) is increasing. This study investigated the role of tau protein, beta-amyloid, LPS, and curli protein in elderly individuals with MCI or D, as well as the contribution of gut microbiota. The results showed that as individuals aged, tau protein, beta-amyloid, and LPS increased significantly in serum during MCI and D. This was associated with an increase in the abundance of E. coli that synthesize the amyloid protein curli, leading to the aggregation of amyloid proteins. Rats also exhibited an increase in curli protein abundance in the brain with aging. Thus, an alteration in the gut microbiota-brain axis, characterized by an increase in curli protein and LPS, contributes to cognitive impairment and dementia through the increase in tau and beta-amyloid protein.
Article
Plant Sciences
Azalia Avila-Nava, Joshua Ayork Acevedo-Carabantes, Itzayana Alamilla-Martinez, Sandra Tobon-Cornejo, Ivan Torre-Villalvazo, Armando R. Tovar, Nimbe Torres, Lilia G. Noriega
Summary: The aim of this study was to evaluate the effects of Chaya leaf extracts on mitochondrial bioenergetics and fatty acid oxidation in muscle cells and liver cells. The results showed that Chaya leaf extracts have antioxidant activity and can increase mitochondrial function and fatty acid oxidation in liver cells, indicating their potential in treating metabolic diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Laura Gonzalez-Ibanez, Maria E. Meneses, Monica Sanchez-Tapia, Daniel Perez-Luna, Nimbe Torres, Ivan Torre-Villalvazo, Myrna Bonilla, Beatriz Petlacalco, Ivan Castillo, Adriana Lopez-Barradas, Antonio Macias, Armando R. Tovar, Daniel Martinez-Carrera
Summary: Obesity is a global public health problem, and functional foods, such as edible and medicinal mushrooms, can be used as a strategy to treat obesity. In a study with Wistar rats, the consumption of these mushrooms showed significant effects in reducing weight gain, fat mass, serum lipid parameters, and preventing adipocyte hypertrophy and collagen deposition. Mushroom consumption also reduced endoplasmic reticulum stress and inflammation while increasing adiponectin expression in subcutaneous adipose tissue, surpassing the effects of the commercial drug atorvastatin. Thus, bioactive compounds from edible, functional, and medicinal mushrooms represent promising natural therapies for obesity treatments.
Article
Biochemistry & Molecular Biology
Rebeca Fuentes-Romero, Laura A. A. Velazquez-Villegas, Sarai Vasquez-Reyes, Berenice Perez-Jimenez, Zuleima N. Dominguez N. Velazquez, Monica Sanchez-Tapia, Ariana Vargas-Castillo, Sandra Tobon-Cornejo, Adriana M. M. Lopez-Barradas, Valentin Mendoza, Nimbe Torres, Fernando Lopez-Casillas, Armando R. R. Tovar
Summary: Genistein, an isoflavone found in soybeans, has been shown to activate the thermogenic program in subcutaneous white adipose tissue (scWAT) in mice, leading to increased UCP1 expression. This effect is mediated through the interaction of genistein with estrogen and cAMP response elements on the UCP1 promoter. These findings provide mechanistic insights into genistein's role in thermogenesis and suggest its potential therapeutic applications for metabolic disorders.
Meeting Abstract
Endocrinology & Metabolism
N. Torres
ANNALS OF NUTRITION AND METABOLISM
(2023)
