Article
Oncology
Sara Bjursten, Ankur Pandita, Zhiyuan Zhao, Charlotta Frojd, Lars Ny, Christer Jensen, Tobias Ullerstam, Henrik Jespersen, Jan Boren, Malin Levin, Henrik Zetterberg, Anna Rudin, Max Levin
Summary: This case report highlights the rapid eradication of melanoma brain metastases and the development of near-fatal encephalomyelitis following double immune checkpoint blockade. The expression of ICOS on CD4+ and CD8+ T cells may play a potential role in mediating encephalomyelitis and other serious immune-related adverse events. Early diagnosis of encephalitis could be facilitated by monitoring brain damage markers in blood.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Urology & Nephrology
Tra-My Doan Ngoc, Gaelle Tilly, Richard Danger, Orianne Bonizec, Christophe Masset, Pierrick Guerif, Sarah Bruneau, Alexandre Glemain, Jean Harb, Marion Cadoux, Anais Vivet, Hoa Le Mai, Alexandra Garcia, David Laplaud, Roland Liblau, Magali Giral, Stephanie Blandin, Magalie Feyeux, Laurence Dubreuil, Claire Pecqueur, Matthew Cyr, Weiming Ni, Sophie Brouard, Nicolas Degauque
Summary: Our study reveals that humoral rejection of kidney transplants is associated with the accumulation of TEMRA CD8(+) T cells in blood and kidney graft biopsies. TEMRA CD8(+) T cells from kidney transplant recipients show enhanced migratory properties compared to EM CD8(+) T cells, with increased adhesion to activated endothelium and transmigration in response to CXCL12 chemokine. Furthermore, IL-15 stimulation promotes the migration of TEMRA and EM CD8(+) T cells induced by CXCL12 and enhances the generation of functional PSGL1, which interacts with P-selectin and facilitates adhesion to activated endothelium. Notably, inhibiting the migration of TEMRA CD8(+) T cells from kidney transplant recipients by targeting VLA-4 or LFA-1 suggests the potential therapeutic benefit of targeting these cells in transplant recipients.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Gastroenterology & Hepatology
Yongsheng Li, Zhiyong Shen, Zhen Chai, Yizhi Zhan, Yaowei Zhang, Zhengyu Liu, Yuechen Liu, Zhenkang Li, Mingdao Lin, Zhanqiao Zhang, Wei Liu, Shenyuan Guan, Jinchao Zhang, Junying Qian, Yi Ding, Guoxin Li, Yuan Fang, Haijun Deng
Summary: This study found that the transmembrane protein MS4A4A, selectively expressed in tumor-associated macrophages (TAMs), can suppress the efficacy of immune checkpoint inhibitors. Blockade of MS4A4A can inhibit tumor growth and improve the efficacy of immune checkpoint inhibitors. This research reveals the role of MS4A4A in tumor immune escape and proposes a new anticancer immunotherapy targeting MS4A4A.
Article
Multidisciplinary Sciences
Icia Santos-Zas, Jeremie Lemarie, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Jin-Bo Su, Alain Bize, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, Jose Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, Patrick Bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-Sebastien Silvestre, Hafid Ait-Oufella
Summary: This study reveals the detrimental role of CD8(+) T lymphocytes following acute myocardial infarction, showing that they release Granzyme B in the ischemic heart tissue leading to cardiomyocyte apoptosis, adverse ventricular remodeling, and deterioration of myocardial function. Depletion of CD8(+) T lymphocytes leads to reduced apoptosis, inhibited inflammatory response, limited myocardial injury, and improved heart function. Elevated circulating levels of GRANZYME B in AMI patients may predict increased risk of death at 1-year follow-up. Targeting pathogenic CD8(+) T lymphocytes could be a potential therapeutic strategy in the setting of acute myocardial infarction.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Kevin Ng, Jesse Boumelha, Katey S. S. Enfield, Jorge L. Almagro, Hongui M. Cha, Oriol Pich, Takahiro Karasaki, David Moore, Roberto Salgado, Monica Sivakumar, George Young, Miriam L. Molina-Arcas, Sophie de Carne Trecesson, Panayiotis Anastasiou, Annika C. Fendler, Lewis Au, Scott T. C. Shepherd, Carlos Martinez-Ruiz, Clare Puttick, James R. M. Black, Thomas B. K. Watkins, Hyemin Kim, Seohee Shim, Nikhil Faulkner, Jan A. Attig, Selvaraju Veeriah, Neil J. Magno, Sophia T. Ward, Alexander Frankell, Maise Al Bakir, Emilia Lim, Mark Hill, Gareth Wilson, Daniel Cook, Nicolai Birkbak, Axel Behrens, Nadia Yousaf, Sanjay Popat, Allan Hackshaw, TRACERx Consortium, CAPTURE Consortium, Crispin T. Hiley, Kevin Litchfield, Nicholas McGranahan, Mariam Jamal-Hanjani, James Larkin, Se-Hoon Lee, Samra Turajlic, Charles Swanton, Julian Downward, George Kassiotis
Summary: This study reveals that lung adenocarcinomas in both humans and mice elicit local germinal center responses and tumour-binding antibodies, with endogenous retrovirus (ERV) envelope glycoproteins as the dominant anti-tumour antibody target. ERV-targeting B cell responses are enhanced by immune checkpoint blockade (ICB) and targeted inhibition of KRAS(G12C). ERV-reactive antibodies have anti-tumour activity and improve survival in a mouse model, and ERV expression predicts the response to ICB in human lung adenocarcinoma. Furthermore, the study demonstrates that effective immunotherapy in the mouse model requires CXCL13-dependent tertiary lymphoid structure (TLS) formation, and therapeutic CXCL13 treatment enhances anti-tumour immunity and synergizes with ICB. These findings provide a potential mechanistic basis for the association between TLS and immunotherapy response.
Article
Oncology
Tamar Ben-Mordechai, Yaacov R. Lawrence, Zvi Symon, Ariel Shimoni-Sebag, Uri Amit
Summary: CX3CR1-expressing mononuclear cells invade the tumor microenvironment after radiation therapy in a mouse lung cancer model. CX3CR1 cell depletion attenuates tumor progression following radiation and sensitizes the tumor to S-phase-specific chemotherapy. Thus, we propose a novel strategy to improve radiation sensitivity by targeting the CX3CR1-expressing immune cells.
Article
Cell Biology
Caitlin C. Zebley, Hossam A. Abdelsamed, Hazem E. Ghoneim, Shanta Alli, Charmaine Brown, Dalia Haydar, Tian Mi, Tarsha Harris, Maureen A. McGargill, Giedre Krenciute, Ben Youngblood
Summary: The study found that IL-12 plays an important role in the priming of CD8 T cells, promoting TET2-mediated demethylation programming and influencing the expression of IFNg. This suggests that cytokines can guide the induction of epigenetically regulated traits in T cells.
Article
Geriatrics & Gerontology
Liang Tan, Yanan Xu, Gongbin Lan, Hongxia Wang, Zhanfeng Liang, Zhaoqi Zhang, Qianchuan Tian, Yangxiao Hou, Yong Zhao, Xubiao Xie
Summary: This study found that deficiency of TSC1 in T cells accelerates acute allograft rejection. TSC1 deficiency leads to increased accumulation of CD8(+) T cells in the allografts and enhances their responsiveness to alloantigens. TSC1-deficient recipients may be more resistant to mTOR inhibitor-mediated immunosuppression during organ transplantation.
Article
Medicine, General & Internal
Hoa Le Mai, Nicolas Degauque, Sabine Le Bot, Marie Rimbert, Karine Renaudin, Richard Danger, Florent Le Borgne, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: The study found that the percentage and absolute number of CD28-CD8+ T cells were significantly increased in kidney transplant patients with antibody-mediated rejection (ABMR). Moreover, CD28-CD8+ T cells from patients with ABMR showed a more rigorous response to stimulation compared to their CD28+ counterparts. These findings suggest that differentiated CD28-CD8+ T cells, with increased frequency, number, and function, may play a role in the pathobiology of ABMR.
Article
Chemistry, Multidisciplinary
Haiying Ji, Chengmi Zhang, Fengying Xu, Qianyun Mao, Ran Xia, Muqiao Chen, Wei Wang, Shunan Lv, Weiwei Li, Xueyin Shi
Summary: Inspired by the intrinsic recovery mechanism of efferocytosis, researchers have developed an inhalable nanozyme that promotes apoptotic cell removal and inhibits inflammation, thus alleviating acute lung injury. This nanozyme effectively mimics the signals of apoptotic bodies and scavenges excessive reactive oxygen species, addressing a critical factor in the pathogenesis of sepsis-related ALI.
Article
Oncology
Saad M. Khan, Rupen Desai, Andrew Coxon, Alexandra Livingstone, Gavin P. Dunn, Allegra Petti, Tanner M. Johanns
Summary: Dysfunctional CD4 T cells are associated with terminal CD8 T-cell exhaustion in glioblastoma, influencing the efficacy of PD-1 blockade. Adding a CD40 agonist to PD-1 blockade therapy improves survival rates in glioblastoma, suggesting a potential synergistic immunotherapeutic approach.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Cell Biology
Jared Klarquist, Eric W. Cross, Scott B. Thompson, Benjamin Willett, Daniel L. Aldridge, Alayna K. Caffrey-Carr, Zhenming Xu, Christopher A. Hunter, Andrew Getahun, Ross M. Kedl
Summary: The relationship between B cells and CD4 T cells is a collaborative one, with B cells promoting the activation and expansion of CD4 T cells, while CD4 T cells can influence the class switching and fate of B cells. Although interactions between B cells and CD8 T cells are not well studied, B cells have a significant impact on primary CD8 T cell responses, as demonstrated after vaccination.
Article
Biology
Yo-Ping Lai, Lu-Cheng Kuo, Been-Ren Lin, Hung-Ju Lin, Chih-Yu Lin, Yi-Ting Chen, Pei-Wen Hsiao, Huan-Tsung Chang, Patrick Chow-In Ko, Hsiao-Chin Chen, Hsiang-Yu Chang, Jean Lu, Hong-Nerng Ho, Betty A. Wu-Hsieh, John T. Kung, Shu-Ching Chen
Summary: CD28 costimulation inhibits CD73 upregulation in CD8(+) T cells, thereby preventing them from becoming suppressive. Lack of CD28 costimulation renders CD8(+) T cells immunosuppressive and less effective in eliminating solid tumors.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Clemence Demerle, Laurent Gorvel, Marielle Mello, Sonia Pastor, Clara Degos, Ana Zarubica, Fabien Angelis, Frederic Fiore, Jacques A. Nunes, Bernard Malissen, Laurent Greillier, Geoffrey Guittard, Herve Luche, Fabrice Barlesi, Daniel Olive
Summary: The study found that anti-HVEM18-10 can enhance the activity of human αβ-T cells and trigger T cell activation in the presence of PD-L1-negative cells. Anti-HVEM18-10 treatment inhibits the growth of HVEM-positive tumors in mouse models and promotes the presence of effector memory CD4+ T cells while suppressing exhausted CD8+ T cells and regulatory T cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Medicine, Research & Experimental
Caijun Wu, Qian Zhong, Rejeena Shrestha, Jingzhi Wang, Xiaoling Hu, Hong Li, Eric C. Rouchka, Jun Yan, Chuanlin Ding
Summary: Multidose gemcitabine treatment promotes breast cancer lung metastasis by increasing the accumulation of CCR2+ macrophages and monocytes in the lungs. Reactive myelopoiesis and enhanced production of mitochondrial ROS are involved in this process. Chemotherapy also upregulates coagulation factor X (FX) in lung interstitial macrophages, and targeting activated FXa can reduce the pro-metastatic effect of chemotherapy.
Article
Astronomy & Astrophysics
Cheng Liu, Sen Yang, Qiang Wu, Tao Zhu
Summary: This paper investigates the physical properties and optical appearance of a thin accretion disk around two types of black hole solutions in Einstein-/Ether theory. The effects of the mother field on the energy flux, temperature distribution, and electromagnetic spectrum of the disk are studied in detail. The results show that the mother field only has a certain effect on the central shadow area of the accretion disk.
JOURNAL OF COSMOLOGY AND ASTROPARTICLE PHYSICS
(2022)
Article
Astronomy & Astrophysics
Kimet Jusufi, Mustapha Azreg-Ainou, Mubasher Jamil, Qiang Wu
Summary: This paper focuses on the relationship between quasinormal modes (QNMs) and a rotating black hole shadow, using the example of a quantum deformed Kerr black hole. The study shows that, in the eikonal limit, the real part of QNMs is related to the Keplerian frequency for equatorial orbits. The paper also explores the typical shadow radius, computes the corresponding modes, and investigates the thermodynamical stability of the quantum deformed Kerr black hole, as well as other astrophysical applications.
Article
Cell Biology
Bastien Dolfi, Alexandre Gallerand, Maria M. Firulyova, Yingzheng Xu, Johanna Merlin, Adelie Dumont, Alexia Castiglione, Nathalie Vaillant, Sandrine Quemener, Heidi Gerke, Marion I. Stunault, Patricia R. Schrank, Seung-Hyeon Kim, Alisha Zhu, Jie Ding, Jerome Gilleron, Virginie Magnone, Pascal Barbry, David Dombrowicz, Christophe Duranton, Abdelilah Wakkach, Claudine Blin-Wakkach, Burkhard Becher, Sophie Pagnotta, Rafael J. Arguello, Pia Rantakari, Svetoslav Chakarov, Florent Ginhoux, Konstantin Zaitsev, Ki-Wook Kim, Laurent Yvan-Charvet, Rodolphe R. Guinamard, Jesse W. Williams, Stoyan Ivanov
Summary: This study reveals the diversity, origin, and function of adrenal gland macrophages using single-cell RNA sequencing and genetic models. The study identifies monocyte-derived and embryonically seeded adrenal gland macrophage populations, as well as a subset of macrophages in females with low MHC II expression. The distribution and functions of adrenal gland macrophages show sex-dimorphic patterns, with MHC IIlow macrophages located at the cortico-medullary junction. Depletion of adrenal gland macrophages leads to altered tissue homeostasis, modulated lipid metabolism, and decreased local aldosterone production during stress exposure.
Article
Astronomy & Astrophysics
Jian-Ming Yan, Qiang Wu, Cheng Liu, Tao Zhu, Anzhong Wang
Summary: Loop quantum gravity (LQG) can resolve both black hole and big bang singularities. In this study, the effects of self-dual spacetime arising from LQG on the orbital signatures of the S0-2 star orbiting Sgr A* in the central region of the Milky Way are investigated. No significant evidence of the self-dual spacetime is found.
JOURNAL OF COSMOLOGY AND ASTROPARTICLE PHYSICS
(2022)
Article
Optics
Hongjin Wu, Jiwei Qi, Hao Hu, Sihao Zhang, Xianhui Fu, Qiang Wu, Zongqiang Chen, Jing Chen, Xuanyi Yu, Qian Sun
Summary: In this work, a composite intrinsic chiral structure was designed by introducing an anisotropic environment around the extrinsic chiral structure. The designed structure consisted of an extrinsic chiral nanocrescent based on an anisotropic substrate. Simulation results showed that intrinsic chirality could be obtained and tuned by changing the angle between the optical axis of the anisotropic substrate and the mirror axis of the nanocrescent (f). The maximum circular dichroism (CD) value reached approximately 0.035. Additionally, the intrinsic chirality was attributed to a new symmetry breaking introduced by the anisotropic substrate to the extrinsic chiral structure, as suggested by the charge distributions. This study offers a new insight into chirality generation and has the potential to advance the application of chirality in imaging, sensing, etc.
JOURNAL OF NONLINEAR OPTICAL PHYSICS & MATERIALS
(2023)
Article
Chemistry, Physical
Shuo Li, Qiang Wu, Haokun Ding, Songsong Wu, Xinwei Cai, Rui Wang, Jun Xiong, Guangyang Lin, Wei Huang, Songyan Chen, Cheng Li
Summary: In this study, a p-WSe2/n-Ge vdW heterojunction phototransistor with a Schottky barrier collector on n-Ge for broadband photodetection is reported. The phototransistor exhibits high responsivities, photocurrent gain, and fast response time, making it suitable for high-performance broadband photodetection.
Article
Cell Biology
Fei Liu, Liwei Cao, Shejing Hu, Hongxiang Ye, Qiang Wu, Le Wu
Summary: Exploring the use of muscone to promote microglia transformation from M1 to M2 phenotype is a feasible strategy to suppress neuroinflammation and enhance functional recovery after ischemic stroke. This study provides evidence that muscone treatment reduces infarct volume and decreases pro-inflammatory factors while increasing anti-inflammatory agents through the activation of PPAR-gamma signaling pathway.
CELLULAR IMMUNOLOGY
(2023)
Article
Astronomy & Astrophysics
Cheng Gong, Tao Zhu, Rui Niu, Qiang Wu, Jing-Lei Cui, Xin Zhang, Wen Zhao, Anzhong Wang
Summary: The standard model extension (SME) is used to study the violations of Lorentz symmetry in gravitational interactions. This study focuses on the modified dispersion relation of gravitational waves (GWs) due to Lorentz violation, and calculates the modified waveforms generated by compact binary mergers. By analyzing 90 GW events and employing parameter estimation, no evidence of Lorentz violation in GW data is found, and 90% confidence intervals for each Lorentz violating coefficient are provided.
Article
Astronomy & Astrophysics
Jian-Ming Yan, Cheng Liu, Tao Zhu, Qiang Wu, Anzhong Wang
Summary: In this paper, the publicly available observational data of 17 stellar stars orbiting Sgr A* are used to test the quantum extension of Schwarzschild spacetime in loop quantum gravity (LQG). The effects of LQG on the pericenter advance of the stellar stars are calculated and compared with astrometric and spectroscopic data. Monte Carlo Markov Chain (MCMC) simulations are performed, and no significant evidence of the quantum-extended Schwarzschild black hole from LQG is found. The result of S2 provides the strongest bound on the LQG parameter A lambda, placing an upper bound at 95% confidence level of A lambda < 0.302.
Article
Cell Biology
Christine R. Fisher, Felix Mba Medie, Rebeccah J. Luu, Robert B. Gaibler, Thomas J. Mulhern, Caitlin R. Miller, Chelsea J. Zhang, Logan D. Rubio, Elizabeth E. Marr, Vidhya Vijayakumar, Elizabeth P. Gabriel, Landys Lopez Quezada, Chun-Hui Zhang, Karen S. Anderson, William L. Jorgensen, Jehan W. Alladina, Benjamin D. Medoff, Jeffrey T. Borenstein, Ashley L. Gard
Summary: This study reports SARS-CoV-2 infection and robust viral replication in the high-throughput, human primary cell-based organ-on-chip platform called PREDICT96-ALI. The unique infection kinetic profiles of lung tissue from three human donors were evaluated using immunofluorescence, RT-qPCR, and plaque assays. The antiviral efficacy of Remdesivir and MPro61 was also investigated in this system.
Article
Medicine, Research & Experimental
Wenbin Yang, Emily Jeong Cerier, Felix L. Nunez-Santana, Qiang Wu, Yuanqing Yan, Chitaru Kurihara, Xianpeng Liu, Anjana Yeldandi, Nigar Khurram, Diego Avella-Patino, Haiying Sun, G. R. Scott Budinger, Daniel Kreisel, Thalachallour Mohanakumar, Emilia Lecuona, Ankit Bharat
Summary: Preexisting lung-restricted autoantibodies (LRAs) are associated with a higher incidence of primary graft dysfunction (PGD) and can worsen graft dysfunction by causing damage to lung epithelial cells. LRA-mediated injury is distinct from ischemia-reperfusion injury and is mainly mediated by complement pathways and IL-1β-induced permeabilization of pulmonary vascular endothelium.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Melissa Querrey, Stephen Chiu, Emilia Lecuona, Qiang Wu, Haiying Sun, Megan Anderson, Megan Kelly, Sowmya Ravi, Alexander V. Misharin, Daniel Kreisel, Ankit Bharat, G. R. Scott Budinger
Summary: Using a mouse lung transplant model, researchers found that excessive activation of Toll-like receptors 2 and 4 (TLR2 and -4) on nonclassical monocytes leads to the release of CXCL2, which worsens primary graft dysfunction (PGD). Deleting CD11b in nonclassical monocytes increases CXCL2 production, while administering a CD11b agonist can inhibit CXCL2 production and alleviate PGD. Additionally, the molecule HMGB1 induces CXCL2 production via TLR4/MyD88 in nonclassical monocytes, and inhibiting HMGB1 can attenuate PGD. This study suggests that CD11b may be a potential therapeutic target for preventing PGD in lung transplant recipients.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Physics, Particles & Fields
Kimet Jusufi, Saurabh Kumar, Mustapha Azreg-Ainou, Mubasher Jamil, Qiang Wu, Cosimo Bambi
Summary: In this study, we investigate the possibility of a wormhole as a candidate for the central object of Sgr A(star) and test this idea by constraining their geometry using the motion of S2 star and the reconstructed shadow images. We consider three wormhole models and find that they satisfy the flare out condition. We also explore the accretion of infalling gas model and study the accretion rate, electromagnetic radiation intensity, and shadow images.
EUROPEAN PHYSICAL JOURNAL C
(2022)
Article
Astronomy & Astrophysics
Cheng Gong, Tao Zhu, Rui Niu, Qiang Wu, Jiang-Lei Cui, Xin Zhang, Wen Zhao, Anzhong Wan
Summary: This paper investigates the effects of high-order spatial derivatives on the propagation of gravitational waves due to Lorentz and parity violation. Bayesian inference is performed using modified waveforms and observational data from selected GW events to place lower bounds on the energy scales for Lorentz and parity violation. The results do not find significant evidence of Lorentz and parity violation at the fifth and sixth-order spatial derivatives terms.
Article
Astronomy & Astrophysics
Qiang Wu, Tao Zhu, Rui Niu, Wen Zhao, Anzhong Wang
Summary: This paper investigates the parity violating effects on gravitational wave propagation in Nieh-Yan modified teleparallel gravity. No significant deviation from general relativity is found, placing an upper bound on the energy scale of the Nieh-Yan term.