Characterization of the Molecular Mechanism of the Bone-Anabolic Activity of Carfilzomib in Multiple Myeloma
Published 2013 View Full Article
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Title
Characterization of the Molecular Mechanism of the Bone-Anabolic Activity of Carfilzomib in Multiple Myeloma
Authors
Keywords
Cell differentiation, Mesenchymal stem cells, Wnt signaling cascade, Cell staining, Bone marrow cells, Fluorescence microscopy, Multiple myeloma, Proteasome inhibitors
Journal
PLoS One
Volume 8, Issue 9, Pages e74191
Publisher
Public Library of Science (PLoS)
Online
2013-09-17
DOI
10.1371/journal.pone.0074191
References
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Note: Only part of the references are listed.- An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma
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- Bone Marrow Stromal Cells Create a Permissive Microenvironment for Myeloma Development: A New Stromal Role for Wnt Inhibitor Dkk1
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- Impact of bortezomib on bone health in myeloma: A review of current evidence
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- The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects
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- Proteasome Inhibitors and Bone Disease
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- Alkaline phosphatase variation during carfilzomib treatment is associated with best response in multiple myeloma patients
- (2011) Maurizio Zangari et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- Bortezomib induces osteoblast differentiation via Wnt-independent activation of -catenin/TCF signaling
- (2009) Y.-W. Qiang et al. BLOOD
- Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
- (2009) M. Fulciniti et al. BLOOD
- Characterization of Wnt/β-catenin signalling in osteoclasts in multiple myeloma
- (2009) Ya-Wei Qiang et al. BRITISH JOURNAL OF HAEMATOLOGY
- Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
- (2008) Y.-W. Qiang et al. BLOOD
- Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma
- (2008) Y.-W. Qiang et al. BLOOD
- The role of Dickkopf-1 in bone development, homeostasis, and disease
- (2008) J. J. Pinzone et al. BLOOD
- Proteasome Inhibitors in Cancer Therapy: Lessons from the First Decade
- (2008) R. Z. Orlowski et al. CLINICAL CANCER RESEARCH
- Modulation of Dickkopf-1 Attenuates Glucocorticoid Induction of Osteoblast Apoptosis, Adipocytic Differentiation, and Bone Mass Loss
- (2008) Feng-Sheng Wang et al. ENDOCRINOLOGY
- Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma
- (2008) Martin Kaiser et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression
- (2008) Wenyan Lu et al. FEBS LETTERS
- Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma
- (2008) Deborah J Heath et al. JOURNAL OF BONE AND MINERAL RESEARCH
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