Article
Endocrinology & Metabolism
Jia Zhu, Anders U. Eliasen, Izzuddin M. Aris, Sara E. Stinson, Jens-Christian Holm, Torben Hansen, Marie-France Hivert, Klaus Bonnelykke, Rany M. Salem, Joel N. Hirschhorn, Yee-Ming Chan
Summary: Genetic risk factors for PCOS are associated with alterations in metabolic, growth, and developmental traits in childhood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Yiming Gao, Caihong Xin, Huaying Fan, Xin Sun, Hongli Wang
Summary: In this meta-analysis, it was found that the levels of chemerin, a newly identified adipokine, were significantly higher in patients with PCOS compared to healthy controls. However, there was no significant difference in the levels of apelin, another adipokine, between the two groups.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jia Zhu, Natalia Pujol-Gualdo, Laura B. L. Wittemans, Cecilia M. Lindgren, Triin Laisk, Joel N. Hirschhorn, Yee-Ming Chan
Summary: Genetic risk factors for PCOS have phenotypic consequences in men, indicating that they can act independently of ovarian function. Thus, PCOS in women may not always be a primary disorder of the ovaries.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Sarah Alsobaie, Arwa A. Alageel, Tahira Ishfaq, Imran Ali Khan, Khalid Khalaf Alharbi
Summary: This study investigated the association between the rs8192675 SNP and women with polycystic ovary syndrome (PCOS) in Saudi Arabia, finding a strong association between the SNP and PCOS women who developed type 2 diabetes mellitus (T2DM). This suggests that this genetic variant may be an important factor in the development of PCOS and T2DM. The findings of this study provide valuable insights into the relationship between PCOS and diabetes.
Article
Obstetrics & Gynecology
Katherine VanHise, Erica T. Wang, Keith Norris, Ricardo Azziz, Margareta D. Pisarska, Jessica L. Chan
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women worldwide. There are racial and ethnic differences in PCOS phenotypes and metabolic dysfunction. This review summarizes the current literature on disparities in PCOS diagnosis and outcomes in the United States. Future studies should focus on racial and ethnic-specific differences in PCOS and include a diverse population in PCOS research.
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Anju E. Joham, Nadira S. Kakoly, Helena J. Teede, Arul Earnest
Summary: This study found a significantly higher incidence of hypertension among women with PCOS compared to those without, especially among obese women. PCOS was independently associated with an increased risk of hypertension, further exacerbated by obesity. Including PCOS in hypertension risk assessments may help in early identification and management of the disorder.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Tansel Sapmaz, Kubra Sevgin, Sude Topkaraoglu, Muhammetnur Tekayev, Fatma Gumuskaya, Fatima Efendic, Mahmud Esad Pence, Selman Aktas, Gulam Hekimoglu, Oktay Irkorucu
Summary: This study examined the effects of propolis on ovarian folliculogenesis, p53 expression, and serum LH and P levels in PCOS modeled rats. Treatment with 50 mg/kg of propolis ameliorated cystic and primary follicles, while 150 mg/kg increased LH levels. Low concentrations of propolis cannot completely improve the hormone profile and p53 expression associated with PCOS.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Obstetrics & Gynecology
Alaa Ibrahim Ali, Wassan Nori
Summary: This study aimed to investigate visfatin as a predictive marker for insulin resistance (IR) and hyperandrogenemia in non-obese women with polycystic ovary syndrome (PCOS). The results showed a significant correlation between visfatin and IR as well as hyperandrogenemia, suggesting the importance of visfatin in the pathophysiology of PCOS.
REPRODUCTIVE SCIENCES
(2022)
Article
Clinical Neurology
Jieyu Liu, Ziwei Teng, Haiqing Xie, Hui Yuan, Minghui Liu, Jindong Chen, Hui Tang, Hui Xiang, Haishan Wu, Jing Huang
Summary: This study compares the prevalence of polycystic ovary syndrome (PCOS) and related reproductive disorders between drug-naive bipolar disorder (BD) patients and healthy controls, as well as between drug-naive BD patients and BD patients with long-term medication. It also investigates the clinical metabolic correlates among BD patients. The results show that drug-naive BD patients have a higher rate of PCOS, and the use of valproate is associated with increased occurrence and development of PCOS.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Anuradhaa Subramanian, Siang Ing Lee, Katherine Phillips, Konstantinos A. Toulis, Punith Kempegowda, Michael W. O'Reilly, Nicola J. Adderley, Shakila Thangaratinam, Wiebke Arlt, Krishnarajah Nirantharakumar
Summary: The study found that pregnant women with PCOS have a higher risk of preterm birth and cesarean delivery compared to those without PCOS, but there is no significant association with low birthweight, high birthweight, or stillbirth.
Article
Endocrinology & Metabolism
Emma Oberg, Liselotte Blomberg, Torbjorn Akerstedt, Angelica Linden Hirschberg
Summary: This study compared sleep variables in women with PCOS and controls, and assessed the impact of behavioral modification intervention on sleep. The results showed that women with PCOS had shorter sleep duration and worse sleep efficiency, but their total sleep time at night was within the normal range. Behavioral modification intervention reduced daytime sleep duration and improved sleep behavior.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Stefano Palomba, Carla Colombo, Andrea Busnelli, Donatella Caserta, Giovanni Vitale
Summary: This study comprehensively reviews the relationship between polycystic ovary syndrome (PCOS) and thyroid dysfunction by analyzing available evidence in nine main areas of interest. The results suggest that PCOS and thyroid disorders are closely related, and their coexistence may increase the reproductive and metabolic risk of patients. Regular screening for thyroid function and thyroid-specific autoantibodies in women with PCOS, particularly before and during pregnancy, is highly recommended.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zainab Hanif Samma, Haq Nawaz Khan, Sumaira Riffat, Mussarat Ashraf, Rehana Rehman
Summary: Polycystic Ovary Syndrome (PCOS) is a complex genetic disorder that affects reproductive, metabolic, cardiovascular, endocrine, and psychological aspects. The variants DENND1A rs9696009 and ERBB4 rs2178575 have been associated with the development of PCOS, as these genes regulate the production of various hormones.
BIOCHEMICAL GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Ana Teresa Brinca, Ana Cristina Ramalhinho, Angela Sousa, Antonio Helio Oliani, Luiza Breitenfeld, Luis A. Passarinha, Eugenia Gallardo
Summary: PCOS is one of the main causes of anovulatory infertility and its etiology and pathophysiology are still unclear. PCOS patients undergoing assisted reproductive techniques may experience poor response, low oocyte quality, and ovarian hyperstimulation syndrome. Metabolomic analysis can improve the success rate of assisted reproductive technology.
Review
Endocrinology & Metabolism
Lucas Bandeira Marchesan, Ramon Bossardi Ramos, Poli Mara Spritzer
Summary: The metabolic profiles of women with PCOS in Latin America are worse than those without PCOS in the same region, with higher anthropometric and metabolic parameters. Further studies evaluating metabolic comorbidities and distinct PCOS phenotypes in different Latin American countries are needed for primary and secondary prevention of PCOS in the region.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Weijing Wang, Weilong Li, Haiping Duan, Chunsheng Xu, Xiaocao Tian, Shuxia Li, Qihua Tan, Dongfeng Zhang
Summary: This study found that there is an association between body mass index (BMI) and serum uric acid (SUA), and the DNA methylation (DNAm) variation related to BMI may partially mediate this association. Specifically, certain methylated sites are involved in mediating the association between BMI and SUA.
Article
Endocrinology & Metabolism
Maria Hornstrup Christensen, Marianne Skovsager Andersen, Katrine Hass Rubin, Ellen Aagaard Nohr, Jori Aalders, Christina Anne Vinter, Dorte Moeller Jensen
Summary: This study investigated the association between previous gestational diabetes mellitus (GDM) and incident psychiatric morbidity, and explored the role of subsequent diabetes development in psychiatric morbidity risk. The findings indicated that GDM was associated with an increased risk of depression and anxiety disorders, and subsequent diabetes played a significant role in future psychiatric morbidity risk.
Article
Biotechnology & Applied Microbiology
Afsaneh Mohammadnejad, Mette Soerensen, Jonas Mengel-From, Marianne Nygaard, Maria Timofeeva, Liang He, Signe Bedsted Clemmensen, Ulrich Halekoh, Rikke Hedegaard Dahlrot, Qihua Tan, Jacob V. B. Hjelmborg
Summary: By performing a genome-wide association study on gene expression data from Danish twin pairs, 243 single nucleotide polymorphisms (SNPs) significantly associated with expression of the MGMT gene were identified, including 7 novel cis-eQTLs and 11 suggestive trans-eQTLs. These variations may regulate the function of the MGMT gene and the patient's sensitivity to therapeutic alkylating agents.
Article
Peripheral Vascular Disease
Hajir Al-Jorani, Richard Christian Jensen, Mikaela T. E. Jonasson, Anna Birukov, Anne Vibeke Schmedes, Henrik Thybo Christesen, Anja F. Dreyer, Tina K. Jensen, Dorte Glintborg, Boye L. Jensen, Marianne S. Andersen
Summary: This study investigated the association between maternal cortisol levels in the third trimester of pregnancy and offspring blood pressure (OBP). The results showed negative associations between maternal cortisol levels and OBP, specifically in boys. This suggests that maternal cortisol is not a risk factor for higher blood pressure in offspring up to the age of 5.
Article
Endocrinology & Metabolism
Hanne Mumm, Anja Fenger Dreyer, Dorthe Bleses, Dorte Glintborg, Tina Kold Jensen, Henriette Boye, Fabio Trecca, Marianne Skovsager Andersen
Summary: This prospective observational study aimed to evaluate the association between maternal third trimester cortisol and early longitudinal offspring language development, and to test whether there were sex differences in the association. The results showed that higher maternal cortisol levels in the third trimester were positively associated with early language development in children, with boys showing effects on productive vocabulary and girls showing effects on receptive vocabulary.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Andrology
Louise Lehmann Christensen, Henrik Enghusen Poulsen, Marianne Skovsager Andersen, Dorte Glintborg
Summary: Testosterone replacement therapy in aging men can reduce whole-body fat and increase lean body mass, but its safety regarding cardiovascular disease is still uncertain. This study aims to evaluate whole-body oxidative stress during testosterone replacement therapy and its association with changes in body composition.
Article
Neurosciences
Xin Zeng, Zhen Tan, Weijing Wang, Weilong Li, Shuxia Li, Dongfeng Zhang, Qihua Tan
Summary: Epidemiological studies have revealed a correlation between early life adversity and adulthood psychopathology. Using animal models, molecular genetic studies have shown altered expression of serotonin receptors in response to prenatal undernutrition and stress, which regulates the release of neurotransmitters involved in psychopathology. Due to ethical reasons, similar studies on humans have not been possible. However, using the Chinese Famine of 1959-1961 as a natural experiment, researchers investigated DNA methylation patterns in the genes of the serotonin receptor signaling pathway in adults born during the famine. The study found reduced DNA methylation in females for certain genes, providing epigenetic evidence supporting the neurodevelopmental origin of psychiatric disorders.
Article
Endocrinology & Metabolism
Jonas Jannick Andreasen, Bror Bastian Tobiasen, Richard Christian Jensen, Henriette Boye, Tina Kold Jensen, Niels Bilenberg, Marianne Skovsager Andersen, Dorte Glintborg
Summary: The cortisol level of pregnant women during the third trimester is associated with the traits of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in their offspring. This association is significant at three years of age but not at five years of age.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Cristina Garcia-Beltran, Rita Malpique, Marianne S. Andersen, Firdevs Bas, Judit Bassols, Feyza Darendeliler, Marta Diaz, Barbara Dieris, Flaminia Fanelli, Elke Froehlich-Reiterer, Alessandra Gambineri, Dorte Glintborg, Abel Lopez-Bermejo, Christopher Mann, Silvia Marin, Barbara Obermayer-Pietsch, Ronnaug Odegard, Pernille Ravn, Thomas Reinehr, Matteo Renzulli, Cristina Salvador, Viola Singer, Eszter Vanky, Juan Vicente Torres, Melek Yildiz, Francis de Zegher, Lourdes Ibanez
Summary: This study aims to evaluate the efficacy, tolerability, and safety of a new treatment (SPIOMET) for PCOS, which combines pioglitazone, metformin, and spironolactone in a fixed low-dose combination tablet, on top of lifestyle intervention.
Article
Endocrinology & Metabolism
Weijing Wang, Wenqin Yao, Qihua Tan, Shuxia Li, Haiping Duan, Xiaocao Tian, Chunsheng Xu, Dongfeng Zhang
Summary: In this study, DNA methylation variants potentially associated with fasting plasma glucose (FPG) levels were detected in Chinese monozygotic twins using a genome-wide DNA methylation analysis. Loci within the SLC6A18 gene were found to be particularly related to FPG. These findings provide important insights into the epigenetic regulation of FPG levels and diabetes.
DIABETOLOGY & METABOLIC SYNDROME
(2023)