Development of a New DNA Vaccine for Alzheimer Disease Targeting a Wide Range of Aβ Species and Amyloidogenic Peptides

Recent advance in immunotherapies for Alzheimer disease, with special reference to DNA vaccination

(2014) Yoshio Okura et al.   Human vaccines & immunotherapeutics

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

Accumulation of intraneuronal Aβ correlates with ApoE4 genotype

(2010) Ditte Z. Christensen et al.   ACTA NEUROPATHOLOGICA

Beneficial effect of human anti-amyloid-β active immunization on neurite morphology and tau pathology

(2010) Alberto Serrano-Pozo et al.   BRAIN

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Fyn-Tau-Amyloid: A Toxic Triad

(2010) Christian Haass et al.   CELL

Immunomodulation for prion and prion-related diseases

(2010) Thomas Wisniewski et al.   Expert Review of Vaccines

Structural Convergence Among Diverse, Toxic β-Sheet Ion Channels

(2010) Hyunbum Jang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Immunomodulation Targeting Abnormal Protein Conformation Reduces Pathology in a Mouse Model of Alzheimer's Disease

(2010) Fernando Goñi et al.   PLoS One

Design and biological activity of β-sheet breaker peptide conjugates

(2009) Sandra Rocha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

(2009) Oliver Wirths et al.   JOURNAL OF NEURAL TRANSMISSION

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

Preventing β-amyloid fibrillization and deposition: β-sheet breakers and pathological chaperone inhibitors

(2008) Thomas Wisniewski et al.   BMC NEUROSCIENCE

Will anti-amyloid therapies work for Alzheimer's disease?

(2008) Peter H St George-Hyslop et al.   LANCET

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE