Article
Immunology
Ai-Mei Chang, Chen-Chih Chen, Ding-Liang Hou, Guan-Ming Ke, Jai-Wei Lee
Summary: The study revealed that GnRH vaccine can reduce hormone concentrations, lead to testicular atrophy and decreased sperm quality, and have an impact on animal mating and reproductive abilities.
Article
Medicine, General & Internal
Ghada H. Naguib, Gamal S. Abd El-Aziz, Rayyan A. Kayal, Abdulghani I. Mira, Maher S. Hajjaj, Hisham A. Mously, Mohamed T. Hamed
Summary: The study evaluated the reproductive toxicological potential of MgO NPs on testicular and ovarian tissues in male and female rats. High doses of MgO NPs caused significant changes in sex hormones and stress parameters compared to low doses and control groups. Histopathological alterations were observed in testicular and ovarian tissues in the high dose group.
ANNALS OF MEDICINE
(2023)
Article
Environmental Sciences
Danyang Li, Wei Sun, Xuejun Jiang, Ziying Yu, Yinyin Xia, Shuqun Cheng, Lejiao Mao, Shiyue Luo, Shixin Tang, Shangcheng Xu, Zhen Zou, Chengzhi Chen, Jingfu Qiu, Lixiao Zhou
Summary: This study aimed to investigate the toxic effects of coexposure to nanoplastics (NPs) and di-(2-ethylhexyl) phthalate (DEHP) on the male reproductive system. The results showed that DEHP at an environmentally relevant dose can induce male reproductive toxicity, and NPs may aggravate these toxic effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Shuanglin Jiang, Li Chen, Jianyun Shen, Di Zhang, Hai Wu, Rong Wang, Shangrong Zhang, Nan Jiang, Wenyong Li
Summary: This study investigates the effects of maternal exposure to oxidized black carbon on testicular development and steroid synthesis in male offspring. The results indicate that prenatal exposure to oxidized black carbon has detrimental effects on mouse spermatogenesis in adult offspring.
Article
Environmental Sciences
Ryan P. W. Kenny, Evelyn Barron Millar, Adenike Adesanya, Catherine Richmond, Fiona Beyer, Carolina Calderon, Judith Rankin, Mireille Toledano, Maria Feychting, Mark S. Pearce, Dawn Craig, Fiona Pearson
Summary: The World Health Organization is conducting a systematic review on the impact of exposure to radiofrequency electromagnetic fields on adverse reproductive outcomes to inform exposure guidelines.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Mariana Vassal, Sandra Rebelo, Maria de Lourdes Pereira
Summary: Metal oxide nanoparticles have versatile properties that make them valuable in healthcare, but recent studies suggest they may have negative effects on male fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Marcela Arteaga-Silva, Edith Arenas-Rios, Herlinda Bonilla-Jaime, Pablo Damian-Matzumura, Ofelia Limon-Morales, Joel Hernandez-Rodriguez, Darla Marquez-Aguiluz
Summary: Cadmium is a form of anthropogenic pollution in industrialized countries, posing a public health problem and affecting male reproduction as an endocrine disruptor. Its toxic effects on male reproductive functions are mediated through altering mitochondrial function and generating free radicals.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Entomology
Do Gyeung Byeun, Byoung-San Moon, Seungki Lee, Jung Kyu Choi
Summary: This study focused on isolating and freezing germ cells from superior brown mealworm. Various methods were used to observe the reproductive organs and cellular characteristics of the mealworms. The findings provide fundamental data for reproductive studies of other useful insects and fertility preservation of endangered insects.
Article
Environmental Sciences
Ricardo Ivan Montano-Gonzalez, Gabriela Gutierrez-Salmean, Maria Angelica Mojica-Villegas, Jose Melesio Cristobal-Luna, Jorge Briseno-Bugarin, German Chamorro-Cevallos
Summary: Spirulina and phycobiliproteins have been found to alleviate Cd-induced oxidative damage on the male reproductive system, improving sperm quality and protecting testes from oxidative stress.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Environmental Sciences
Yue Zhang, Junhong Xie, Yixin Ouyang, Shuang Li, Yulin Sun, Weilun Tan, Lihua Ren, Xianqing Zhou
Summary: This review summarizes the research status of PBDEs-induced male reproductive toxicity and its mechanisms at various levels. The study found that reactive oxygen species production, disruptions of estrogen receptor-alpha and antagonism of androgen receptor were defined as critical molecular initiating events, leading to a series of adverse outcomes at the molecular and cellular levels and then affecting the tissue or organ levels, ultimately impacting male reproductive functions.
ENVIRONMENTAL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Parisa Dolati, Mohammad Javad Zamiri, Amir Akhlaghi, Zahra Khodabandeh, Davood Mehrabani, Hadi Atashi, Iman Jamhiri
Summary: The study found that lead acetate negatively impacted fertility in male mice, affecting sperm quality and early embryonic development in both the males and their offspring. Interestingly, co-administration of quercetin seemed to alleviate some of the adverse effects of lead exposure on male fertility and their offspring.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhaolan Wei, Yunyi Wang, Shuwei Wang, Jing Xie, Qi Han, Mingqing Chen
Summary: Exposure to microplastics has negative effects on the reproductive systems and fertility of mice. Male mice experience reduced sperm quantity and increased sperm deformity, while female mice experience decreased ovary size and follicle number. Additionally, microplastic exposure alters hormone levels and leads to reduced pregnancy rates and fewer embryos in mice.
Article
Chemistry, Multidisciplinary
Zwe-Ling Kong, Athira Johnson, Tzu-Ling Ting, Po-Jen Cheng, Chien-Feng Mao
Summary: This study found that Echinacea purpurea ethanol extract can increase antioxidant enzymes levels, decrease lipid peroxidation, blood glucose levels, nitric oxide production, IL-6 levels, and TNF-alpha levels in obese rats, as well as improve sperm parameters and protein expressions related to reproductive health and inflammation.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Environmental
Haibo Jin, Tan Ma, Xiaoxuan Sha, Zhenyu Liu, Yuan Zhou, Xiannan Meng, Yabing Chen, Xiaodong Han, Jie Ding
Summary: This study investigated the toxic effects of polystyrene microplastics (PS-MPs) on male reproductive systems in mice. The results showed that PS-MPs accumulated in the testis, entered testicular cells, and led to decreased sperm quality and testosterone levels. Additionally, PS-MPs induced testicular inflammation and disruption of the blood-testis barrier, demonstrating the potential reproductive dysfunctions caused by microplastics.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Endocrinology & Metabolism
Shun Bai, Meihong Hu, Lina Yu, Linjun Chen, Jidong Zhou, Limin Wu, Bo Xu, Xiaohua Jiang, Xindong Zhang, Xianhong Tong, Qiuling Yue
Summary: Background: DNAJB7 is a highly conserved protein involved in various biological processes. However, its function in spermatogenesis and male fertility has been unclear. Methods: Dnajb7-deficient mice were generated using CRISPR/Cas9-mediated genome editing system to investigate the role of DNAJB7 in male reproduction. Results: DNAJB7 is specifically expressed in haploid germ cells. Dnajb7 knockout mice are fertile and show no defects in Sertoli cells, spermatogonia, meiotic and postmeiotic cells, suggesting that DNAJB7 is not essential for spermatogenesis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)