Article
Oncology
Yu Ding, Luyao Wu, Xi Zhuang, Jingsheng Cai, Houchao Tong, Yan Si, Hao Zhang, Xiaoting Wang, Meiping Shen
Summary: With the advancement in diagnostic technology, the importance of exploring molecular targets for improving the treatment and prognosis of papillary thyroid carcinoma (PTC) is evident. Studies have shown the involvement of FAM84A in the development of various tumors, making it a potential diagnostic and therapeutic target for PTC.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wojciech Gierlikowski, Katarzyna Broniarek, Lukasz Cheda, Zbigniew Rogulski, Marta Kotlarek-Lysakowska
Summary: In the context of papillary thyroid carcinoma, miR-181a-5p has been found to directly regulate the expression of SLC5A5, potentially reducing the efficacy of radioiodine treatment. This suggests that miR-181a-5p could serve as a promising target to enhance the efficacy of radioactive iodine therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Cindy Van Branteghem, Alice Augenlicht, Pieter Demetter, Ligia Craciun, Carine Maenhaut
Summary: Thyroid cancer is a common endocrine malignant tumor with increasing incidence. This study focused on miR-204-5p, which is downregulated in aggressive papillary thyroid carcinoma. Gain-of-function experiments showed that miR-204-5p inhibits cell invasion by regulating targets involved in epithelial-mesenchymal transition. The inhibition of cell invasion is achieved through direct binding and repression of HMGA2. In vivo experiments confirmed the relationship between miR-204-5p and HMGA2, suggesting that targeting HMGA2 holds promise for thyroid cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chen-Kai Chou, Shun-Yu Chi, Yi-Yung Hung, Yi-Chien Yang, Hung-Chun Fu, Jia-He Wang, Chueh-Chen Chen, Hong-Yo Kang
Summary: The present study aimed to determine the association of ER mRNA expression levels with clinicopathologic features in PTC. The expression of ER alpha 66, ER alpha 36, ER beta, and GPER1 was lower in PTC specimens than in adjacent normal thyroid tissues. Low GPER1 expression was associated with extrathyroidal extension. There was no obvious difference in expression of ERs between PTC specimens from male and female patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xiaoping Zhang, Dan Li, Chengyou Jia, Haidong Cai, Zhongwei Lv, Bo Wu
Summary: The study reveals that OIP5-AS1 is a METTL14-regulated lncRNA that plays a crucial role in the progression of PTC, providing new insights into the regulatory mechanisms of PTC development.
CELL DEATH & DISEASE
(2021)
Article
Medical Laboratory Technology
Qiuting Wen, Yulou Wang, Xingjiang Li, Xiangguo Jin, Guimei Wang
Summary: The study found that serum exosomal miR-29a expression levels were significantly decreased in PTC patients, serving as a non-invasive biomarker for PTC diagnosis and prognosis, and were significantly associated with disease recurrence and patient survival rates.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Oncology
Leticia Ferreira Alves, Murilo Vieira Geraldo
Summary: In this study, it was found that overexpression of miR-495-3p can inhibit the migration and invasion of PTC cells and affect the expression of genes related to PTC development, indicating the important role of miR-495-3p in the progression of PTC.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Chuangang Li, Yongyi Li, Yufeng Lu, Zhaorui Niu, Henan Zhao, Yan Peng, Molin Li
Summary: The miR-26 family, a group of broadly conserved small RNAs with identical sequences in the seed region, plays crucial roles in tumorigenesis and may serve as a new target for cancer therapy.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Cell Biology
Yulu Gu, Xin Zhang, Yong Li, Jikang Shi, Heran Cui, Yaxuan Ren, Sainan Liu, Yichun Qiao, Yi Cheng, Yawen Liu
Summary: In this study, we found that miR-204-5p is down-regulated in papillary thyroid carcinoma (PTC) tissues. The levels of miR-204-5p in the serum of PTC patients were associated with PTC risk, and the expression was lower in patients with both PTC and benign lesions compared to those with only PTC. Furthermore, miR-204-5p inhibited proliferation, migration, invasion, and cell cycle progression, and induced apoptosis in PTC cells. We identified AP1S2 as a target of miR-204-5p. Overall, miR-204-5p functions as a suppressor for PTC pathogenesis via the miR-204-5p/AP1S2 axis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Zongyu Li, Xin Huang, Aru Liu, Jinkai Xu, Jingyue Lai, Hao Guan, Jiancang Ma
Summary: In this study, circ_PSD3 was found to be upregulated in papillary thyroid carcinoma (PTC), promoting cell proliferation, metastasis, and inhibiting apoptosis by regulating the miR-637/HEMGN axis and activating the PI3K/Akt signaling pathway. The circ_PSD3/miR-637/HEMGN signaling axis may serve as a potential therapeutic target for PTC.
Article
Surgery
Marco Raffaelli, Luca Sessa, Carmela De Crea, Guido Fadda, Pietro Princi, Esther Diana Rossi, Emanuela Traini, Luca Revelli, Francesco Pennestri, Pierpaolo Gallucci, Luigi Ciccoritti, Francesco Greco, Rocco Bellantone
Summary: In patients with clinically unifocal papillary thyroid carcinoma, intraoperative assessment of nodal status with ipsilateral central neck dissection and frozen section examination can help identify those who may benefit from more extensive initial operative treatment. This strategy reduces the need for a second-step completion procedure and potentially lowers the risk of recurrence.
Article
Multidisciplinary Sciences
Lei Dai, Weidong Zhang, Yinchun Wang, Kejie Yu, Qi Le, Xianjiang Wu
Summary: This study analyzed the dysregulated profile of circular RNAs (circRNAs) in papillary thyroid cancer (PTC) tissues and found that circAGTPBP1 was upregulated and correlated with tumor characteristics. The downstream targets of circAGTPBP1 were identified as miR-34a-5p and NOTCH1. Functional experiments showed that circAGTPBP1 knockdown inhibited PTC cell migration, invasion, and metastasis, and miR-34a-5p inhibitor reversed these effects. CircAGTPBP1 knockdown also inhibited tumor growth in vivo, suggesting its potential as a therapeutic target for PTC.
Article
Cell Biology
Deguang Zhang, Li Tao, Nizheng Xu, Xiaoxiao Lu, Jianle Wang, Gaofei He, Qinghu Tang, Kangmao Huang, Shuying Shen, Junjie Chu
Summary: In this study, circRNA high-throughput sequencing was used to identify alterations in circRNA expression levels in PTC tissues. circTIAM1 was found to be upregulated in PTC and associated with apoptosis, proliferation, and migration of PTC cells. Mechanistically, circTIAM1 acted as a sponge of microRNA-646 and functioned in PTC by targeting miR-646 and heterogeneous ribonucleoprotein A1. These findings highlight the oncogenic role of circTIAM1 in PTC and suggest its potential as a therapeutic target for PTC progression.
CELL DEATH DISCOVERY
(2022)
Article
Endocrinology & Metabolism
Daqi Zhang, Mingyu Yang, Xin Zhang, Cheng Wang, Kunlin Li, Hongbo Wang, Hao Chi, Chengqiu Sui, Gianlorenzo Dionigi, Hui Sun
Summary: This study presents a rare case series of synchronous occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in the same thyroid gland. The synchronous MTC/PTC were classified into 4 subtypes and the clinical and pathological aspects as well as the results were presented.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ling Wang, Wei Wang, Yongcong Cai, Yuqiu Zhou, Jian Jiang, Yudong Ning, Chunyan Shui, Ronghao Sun, Yi Wang, Chao Li
Summary: A study has found that circ-NUP214, a circular RNA, is significantly upregulated in papillary thyroid carcinoma (PTC). By regulating the miR-15a-5p/HK2 axis, circ-NUP214 promotes PTC tumorigenesis. This finding provides a potential therapeutic target for PTC treatment.
BIOCHEMICAL GENETICS
(2022)