Article
Oncology
Kathleen Decker, Pascal Lambert, Katie Galloway, Oliver Bucher, Marshall Pitz, Benjamin Goldenberg, Harminder Singh, Mark Kristjanson, Tunji Fatoye, Eric J. Bow
Summary: A retrospective cohort study compared the characteristics of cancer patients visiting a cancer urgent care clinic (UCC) to those visiting an emergency department (ED), finding that chemotherapy and pre-diagnosis ED visits were the strongest predictors of UCC and ED visits, respectively. Future studies could help improve service delivery and patient satisfaction.
Article
Medicine, General & Internal
Bastian Bastiant, Jan Hendrik Oltrogge-Abiry, Pene lope-Sophie Peters, Katharina Schmalstieg-Bahr, Johanna Sophie Bobardt-Hartshorn, Nadine Janis Pohontsch, Svea Bracht, Ulrich Mayer-Runge, Martin Scherer
Summary: The establishment of an urgent care walk-in clinic has a positive impact on the utilization of hospital emergency departments by low-urgency patients, leading to a decrease in outpatient numbers and length of stay, as well as an improvement in treatment efficiency.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2023)
Article
Psychiatry
Frank Mueller, Akhilesh Munagala, Judith E. Arnetz, Eric D. Achtyes, Omayma Alshaarawy, Harland T. Holman
Summary: This retrospective cohort study found that Black/African American and American Indian or Alaska Native patients with depression were more likely to seek emergency department treatment compared to White/Caucasian patients, despite being established patients at primary care providers and having follow-up encounters.
GENERAL HOSPITAL PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Ornella Spagnolello, Matthew J. Reed
Summary: Despite the overall rise in HIV cases globally, early diagnosis and treatment can significantly impact transmission and quality of life. While 'Opt-out' screening has been studied in high-HIV prevalence areas, the effectiveness of 'targeted' screening in low prevalence areas remains uncertain.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Immunology
Simone da Silva Goes, Ricardo Roberto de Souza Fonseca, Maria Eduarda de Sousa Avelino, Sandra Souza Lima, Misma Suely Goncalves Araujo de Lima, Rogerio Valois Laurentino, Maria Alice Freitas Queiroz, Felipe Bonfim Freitas, Antonio Carlos Rosario Vallinoto, Ricardo Ishak, Luiz Fernando Almeida Machado
Summary: This study examines the seroprevalence of Chlamydia trachomatis infection among newly diagnosed HIV patients in Belem, Para, Brazil. The results show a high rate of exposure to C. trachomatis in this population, emphasizing the importance of screening for C. trachomatis in all HIV patients.
Article
Multidisciplinary Sciences
Jung-Ting Lee, Chih-Chia Hsieh, Chih-Hao Lin, Yu-Jen Lin, Chung-Yao Kao
Summary: This study developed a computational model using artificial intelligence to accurately predict the need for hospitalization among urgent patients in the emergency department. The model performed well in validation, especially among nontraumatic adult patients, showing promise for optimizing ED operations.
SCIENTIFIC REPORTS
(2021)
Article
Orthopedics
Meera M. Dhodapkar, Michael J. Gouzoulis, Scott J. Halperin, Maxwell Modrak, Brad J. Yoo, Jonathan N. Grauer
Summary: Foot and ankle fractures are common injuries that require urgent evaluation and care. Understanding the management of these fractures in different medical settings can help improve patient care and control costs.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2023)
Article
Emergency Medicine
Adam Haag, Sarah S. Dhake, Jessica Folk, Urmila Ravichadran, Andrea Maric, Sarah Donlan, Chad Konchak, Loretta Au, Nirav S. Shah, Ernest Wang
Summary: The study analyzed the bounceback rates of COVID-19 patients returning to the Emergency Department after initial discharge, finding that patients with mild symptoms had a 14.6% bounceback rate for illness progression. The median time for bouncebacks to the ED after initial testing was 9 days, with a majority of mildly symptomatic patients being discharged on the return visit. The statistical model used was not able to identify specific risk factors for these bouncebacks.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Health Care Sciences & Services
Bill Wang, Ateev Mehrotra, Ari B. Friedman
Summary: Despite reducing lower-acuity emergency department visits, the impact of urgent care centers was found to be small. Each 37 additional urgent care center visits were associated with a reduction of a single lower-acuity ED visit.
Article
Geriatrics & Gerontology
Marcello Covino, Sara Salini, Andrea Russo, Giuseppe De Matteis, Benedetta Simeoni, Giulio Maccauro, Gabriele Sganga, Francesco Landi, Antonio Gasbarrini, Francesco Franceschi
Summary: By evaluating the frailty status of adults aged 80 years and older upon admission to the emergency department, the risk of in-hospital death can be predicted. Frail patients have a higher risk of death and major complications, while those with mild frailty have a similar prognosis to more fit patients. Non-surgical management should be considered for severely frail and comorbid patients aged 80 years and older needing neurosurgery or abdominal surgery.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Medicine, General & Internal
Kathryn Hawk, Ryan McCormack, E. Jennifer Edelman, Edouard Coupet, Nicolle Toledo, Phoebe Gauthier, John Rotrosen, Marek Chawarski, Shara Martel, Patricia Owens, Michael V. Pantalon, Patrick O'Connor, Lauren K. Whiteside, Ethan Cowan, Lynne D. Richardson, Michael S. Lyons, Richard Rothman, Lisa Marsch, David A. Fiellin, Gail D'Onofrio
Summary: This qualitative study examined the experiences and perspectives of US patients with untreated OUD who sought treatment in emergency departments (EDs). The findings showed that these patients often felt stigmatized and minimized in the ED, highlighting the need for improvement in care and access to treatment.
Article
Oncology
Maysoon S. Abdalrahim, Shaymma S. Issa, Randa Albusoul
Summary: The purpose of this study was to explore the spiritual well-being among patients with cancer within the first 3 months of diagnosis. Qualitative approach using thematic analysis was used and in-depth interviews were conducted with sixteen participants. The results revealed four main themes: hopeful yet uncertain expectation of achieving future goals, a wake-up call for self-transcendence, religious struggle, and facing reality provoke questions about the meaning of life. The analysis showed evidence of the effect of cancer diagnosis on disturbing patients' beliefs and meaning of life.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Multidisciplinary Sciences
Rodrigo Lopes Sanz Duro, Robson dos Santos Souza Marinho, Valquiria Lima Santana, Elis Muriel Marques Monti, Humberto Onias, Elaine Monteiro Matsuda, Ricardo Sobhie Diaz, Karina Rente Isidoro, Eric Delwart, Elcio Leal, Shirley Vasconcelos Komninakis
Summary: This study describes two complete CRESS DNA genomes obtained from the feces of two newly diagnosed HIV patients in Brazil. These genomes are highly similar to a previous pecovirus sequence detected in a human fecal sample from Peru in 2016. Comparative analysis showed the existence of different clades of pecoviruses in South America, suggesting the circulation of distinct species of pecoviruses in Latin America.
Article
Health Care Sciences & Services
Lindsay Allen, Janet R. Cummings, Jason M. Hockenberry
Summary: The study found that open urgent care centers reduced the total number of emergency department visits by treating patients who would have otherwise visited the ED, especially those with the longest wait times. Urgent care centers also significantly decreased visits by uninsured and Medicaid patients to the emergency department.
HEALTH SERVICES RESEARCH
(2021)
Article
Surgery
Amber M. Moyer, Danielle Abbitt, Kevin Choy, Teresa S. Jones, Theresa L. Morin, Krzystof J. Wikiel, Carlton C. Barnett, John T. Moore, Thomas N. Robinson, Edward L. Jones
Summary: Establishing a dedicated GT clinic can reduce the utilization of the Emergency Department for complications related to gastrostomy tubes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Xinghuo Li, Anthony F. Daniyan, Andrea V. Lopez, Terence J. Purdon, Renier J. Brentjens
Summary: CAR T-cell therapy has shown significant efficacy in B-cell malignancies, but the lack of persistence and immune escape present challenges. By secreting IL-36 gamma, CAR T cells demonstrated improved expansion and persistence, resulting in enhanced tumor eradication. IL-36 gamma also activated endogenous APCs and T cells, delaying the progression of antigen-negative tumors. These findings support the translation of this design for a more effective CAR T-cell-mediated antitumor response.
Article
Oncology
Dylan J. Drakes, Sarwish Rafiq, Terence J. Purdon, Andrea V. Lopez, Smita S. Chandran, Christopher A. Klebanoff, Renier J. Brentjens
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Multidisciplinary Sciences
Nicholas F. Kuhn, Andrea V. Lopez, Xinghuo Li, Winson Cai, Anthony F. Daniyan, Renier J. Brentjens
NATURE COMMUNICATIONS
(2020)
Article
Dermatology
Andrea J. Lopez, Laura M. Jones, Landrye Reynolds, Rachel C. Diaz, Isaiah K. George, William Little, Derek Fleming, Anna D'souza, Monique Y. Rennie, Kendra P. Rumbaugh, Allie Clinton Smith
Summary: This study demonstrated the detection of porphyrin-producing bacteria within biofilms using bacterial fluorescence imaging in vivo, with red fluorescence readily detectable in wounds 48 hours after inoculation. The findings highlight the potential importance of this technology in biofilm research and early detection in clinical settings.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Oncology
Nora E. Rahmani, Nandini Ramachandra, Srabani Sahu, Nadege Gitego, Andrea Lopez, Kith Pradhan, Tushar D. Bhagat, Shanisha Gordon-Mitchell, Bianca Rivera Pena, Mohammad Kazemi, Keshav Rao, Orsi Giricz, Shahina Bano Maqbool, Raul Olea, Yongmei Zhao, Jinghang Zhang, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Juseong Lee, Tianyu Sun, Ulrich Steidl, Aditi Shastri, Daichi Inoue, Omar Abdel-Wahab, Andrea Pellagatti, Evripidis Gavathiotis, Jacqueline Boultwood, Amit Verma
Summary: The study suggests that leukemia cells with ASXL1 mutations are more sensitive to Venetoclax and Azacytidine, possibly due to the upregulation of BCL2 expression and DNA methylation changes caused by ASXL1 mutations. These results reveal the potential effectiveness of these therapeutic drugs for leukemia patients.
BLOOD CANCER JOURNAL
(2021)
Article
Engineering, Biomedical
Hsin-ya Yang, Fernando Fierro, Daniel J. Yoon, Anthony Gallegos, Stephanie L. Osborn, Alan Nguyen, Thomas R. Peavy, William Ferrier, Linda Talken, Betty W. Ma, Kristopher G. Galang, Andrea Medina Lopez, Daniel R. Fregoso, Heather Stewart, Eric A. Kurzrock, Athena M. Soulika, Jan A. Nolta, R. Rivkah Isseroff
Summary: A combination treatment involving human mesenchymal stem/stromal cells (MSCs) embedded in an extracellular matrix scaffold and preconditioned with hypoxia and the beta-adrenergic receptor antagonist timolol, combined with sustained application of timolol post implantation, has shown promising results for improving wound healing in a diabetic mouse model. This study extends those findings to a porcine wound model, further demonstrating the efficacy and safety of the combined treatment in promoting wound reepithelialization and angiogenesis while maintaining a safe concentration of timolol in the plasma.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Public, Environmental & Occupational Health
Andrea M. Lopez, Matthew Thomann, Zena Dhatt, Julieta Ferrera, Marwa Al-Nassir, Margaret Ambrose, Shane Sullivan
Summary: This study aims to elucidate a structurally oriented theoretical framework that considers legacies of racism, trauma, and social exclusion, and to interrogate the unmet obligations of the harm reduction infrastructure in providing equitable protections to Black and Latinx people who use drugs in Maryland. The research found that the unmet obligations included enforcement and punitive governance of drug use equipment, racism and social exclusion, and differential implications of harm reduction for different populations experiencing racialized criminalization.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Andrea Lopez, Denis E. Reyna, Nadege Gitego, Felix Kopp, Hua Zhou, Miguel A. Miranda-Roman, Lars Ulrik Nordstrom, Swathi-Rao Narayanagari, Ping Chi, Eduardo Vilar, Aristotelis Tsirigos, Evripidis Gavathiotis
Summary: Deregulation of the BCL-2 family interaction network is a major challenge in cancer treatment. This study presents a novel therapeutic strategy to overcome two anti-apoptotic mechanisms in cancer through the combination of a BAX activator and Navitoclax.
NATURE COMMUNICATIONS
(2022)
Article
Economics
Jaime L. Rubin, Andrea Lopez, Jason Booth, Penilla Gunther, Anupam B. Jena
Summary: This study examines the impact of modifications to standard cost-effectiveness analysis methods on measures of cost-effectiveness for rare chronic diseases, finding that modifying assumptions for discounting rates, utility measures, disease management costs, and drug pricing can significantly reduce the incremental cost-effectiveness ratio.
JOURNAL OF MEDICAL ECONOMICS
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Andrea Lopez, Raimundo Sanchez
Summary: This study examined the personality traits of trail runners in a competition in Chile using the NEO-FFI questionnaire. The results showed that successful mountain runners exhibited high Conscientiousness and low Neuroticism, but there were no significant differences in Openness to Experience compared to the normal population. There were also no significant differences in traits between ultradistance and shorter distance runners, or based on motivations and gender (except for Agreeableness). The findings have practical implications for sports practitioners in designing interventions based on athletes' personality profiles and challenging gender stereotypes in sports.
RETOS-NUEVAS TENDENCIAS EN EDUCACION FISICA DEPORTE Y RECREACION
(2023)
Correction
Public, Environmental & Occupational Health
Andrea M. Lopez, Matthew Thomann, Zena Dhatt, Julieta Ferrera, Marwa Al-Nassir, Maggie Ambrose, Shane Sullivan
AMERICAN JOURNAL OF PUBLIC HEALTH
(2022)
Meeting Abstract
Respiratory System
Andrea Samantha Hernandez Lopez, Arturo Orea Tejeda, Dulce Gonzalez Islas, Susana Galicia Amor, Esperanza Trejo Mellado, Juan Carlos Garcia Hernandez, Maria Fernanda Salgado Fernandez, Carlos Miguel Sanchez Moreno
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Substance Abuse
Andrea M. Lopez, Zena Dhatt, Mary Howe, Marwa Al-Nassir, Amy Billing, Eleanor Artigiani, Eric D. Wish
Summary: The study in the United States found that rates of methamphetamine use and methamphetamine-related deaths have been increasing, with methamphetamine increasingly present in opioid-related deaths. The research indicated that individuals testing positive for methamphetamine were on average five years younger than those testing negative, and nonfentanyl opioids were more common in methamphetamine positive specimens. This study suggests a need for further understanding of the co-use of methamphetamine and opioids in the context of larger socio-structural and community factors.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2021)
Meeting Abstract
Health Care Sciences & Services
Andrea Lopez, Jaime Rubin
MEDICAL DECISION MAKING
(2021)
Article
Oncology
Dulguun Amgalan, Thomas P. Garner, Ryan Pekson, Xiaotong F. Jia, Mounica Yanamandala, Victor Paulino, Felix G. Liang, J. Jose Corbalan, Jaehoon Lee, Yun Chen, George S. Karagiannis, Luis Rivera Sanchez, Huizhi Liang, Swathi-Rao Narayanagari, Kelly Mitchell, Andrea Lopez, Victoria Margulets, Marco Scarlata, Gaetano Santulli, Aarti Asnani, Randall T. Peterson, Rachel B. Hazan, John S. Condeelis, Maja H. Oktay, Ulrich Steidl, Lorrie A. Kirshenbaum, Evripidis Gavathiotis, Richard N. Kitsis