Plumbagin Ameliorates Diabetic Nephropathy via Interruption of Pathways that Include NOX4 Signalling

Vascular Nox4

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Nox4 Is a Protective Reactive Oxygen Species Generating Vascular NADPH Oxidase

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Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

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Role of Nox4 in murine models of kidney disease

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Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathways

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NADPH-Oxidase 4 Protects against Kidney Fibrosis during Chronic Renal Injury

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The Natural Anticancer Agent Plumbagin Induces Potent Cytotoxicity in MCF-7 Human Breast Cancer Cells by Inhibiting a PI-5 Kinase for ROS Generation

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A Key Role for NOX4 in Epithelial Cell Death During Development of Lung Fibrosis

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No Superoxide—No Stress?

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Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases

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NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis

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Transcription Factors Krüppel-Like Factor 6 and Peroxisome Proliferator-Activated Receptor-γ Mediate High Glucose-Induced Thioredoxin-Interacting Protein

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Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells

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New Insights into Hyperglycemia-induced Molecular Changes in Microvascular Cells

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Expression, Localization, and Function of the Thioredoxin System in Diabetic Nephropathy

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NAD(P)H Oxidase Mediates TGF- 1-Induced Activation of Kidney Myofibroblasts

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Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease

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Hypoxia-inducible factor-1α induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition

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Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells

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Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials

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Diabetic nephropathy: a disorder of oxygen metabolism?

(2009) Toshio Miyata et al.   Nature Reviews Nephrology

Plumbagin, a Medicinal Plant–Derived Naphthoquinone, Is a Novel Inhibitor of the Growth and Invasion of Hormone-Refractory Prostate Cancer

(2008) Moammir H. Aziz et al.   CANCER RESEARCH

Increased renal gene transcription of protein kinase C-β in human diabetic nephropathy: relationship to long-term glycaemic control

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Diabetic Nephropathy: Mechanisms of Renal Disease Progression

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High glucose induced endothelial cell growth inhibition is associated with an increase in TGFβ1 secretion and inhibition of Ras prenylation via suppression of the mevalonate pathway

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The role of Sgk-1 in the upregulation of transport proteins by PPAR-  agonists in human proximal tubule cells

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New insights into the mechanisms of fibrosis and sclerosis in diabetic nephropathy

(2008) Frank C. Brosius   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Mechanisms of Disease: the hypoxic tubular hypothesis of diabetic nephropathy

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Transforming growth factor-β/connective tissue growth factor axis in the kidney

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