Article
Cell Biology
Chuxiao Liu, Yu Han, Xingyu Zhao, Bo Li, Liwen Xu, Dongsong Li, Guangyu Li
Summary: POLR2A is upregulated during osteoclastogenesis and plays a crucial role in bone resorption. Inhibition of POLR2A decreases osteoclastogenesis and blocks bone resorption, while its overexpression has the opposite effects. Additionally, POLR2A loss-of-function suppresses estrogen deficiency-induced bone resorption by regulating CREB1 assembly.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zuoxing Wu, Xuedong Li, Xiaohui Chen, Xuemei He, Yu Chen, Long Zhang, Zan Li, Mengyu Yang, Guixin Yuan, Baohong Shi, Ning Chen, Na Li, Haotian Feng, Mengyu Zhou, Gang Rui, Feng Xu, Ren Xu
Summary: This study investigates the role and mechanism of CDZ173 in osteoclast-related bone metabolism. It demonstrates that CDZ173 has a protective effect on LPS-induced osteolysis by inhibiting osteoclast activation. CDZ173 inhibits bone resorption and osteoclast fusion, while having no effect on osteoblast development. It also weakens the PI3K-AKT/MAPK-NFATc1 signal axis in osteoclasts. These findings highlight the potential pharmacological role of CDZ173 in preventing osteoclast-mediated inflammatory osteolysis and its potential clinical application.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Physical
L. Zhang, X. Hu, Y. Wu, Y. Gao, C. Lin, C. Dong, G. Li, F. Xu, S. Zhang, K. Zhang
Summary: Transition metal phosphates, specifically delta phase VOPO4 (delta-VPO) nanosheets with intrinsic V4+ defect, demonstrated superior performance as cathode materials for sodium-ion batteries (SIBs) in terms of specific capacity and cycling stability. The high V4+ defect concentration of VPO resulted in enhanced conductivity and reduced redox polarization, while delta-VPO enabled high cycling stability due to limited lateral size expansion. This work offers a potentially alternative cathode material with controllable phases and defects toward high-performance SIBs.
MATERIALS TODAY ENERGY
(2021)
Article
Orthopedics
Marco Greis, Karsten Heubach, Maik Hoberg, Ulrich Irlenbusch
Summary: This study uses a new bone loss grading system to evaluate factors that could influence bone loss at the proximal humerus. Results show that gender has the greatest influence on bone loss after stemless shoulder arthroplasty.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Chemistry, Physical
Noppakorn Thanamoon, Narong Chanlek, Pornjuk Srepusharawoot, Pairot Moontragoon, Prasit Thongbai
Summary: This study investigates the improvement of giant dielectric properties (GDPs) of TiO2 by co-doping it with Tb and Nb ions. The TNTO ceramics exhibit a compact microstructure and microwave dielectric phases, with low temperature dependence of dielectric permittivity and low tan delta values.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Medicine, Research & Experimental
Tianyu Xie, Wenyu Feng, Mingwei He, Xinli Zhan, Shijie Liao, Juliang He, Zhaojie Qin, Feicui Li, Jiake Xu, Yun Liu, Qingjun Wei
Summary: Osteosarcoma is a common malignant bone tumor in children and adolescents, and the five-year survival rate is estimated to be around 70%. This study found that high expression of EVI2B gene is associated with good prognosis in osteosarcoma patients.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zheng Wang, Chi Ma, Diane Chen, Caitlin Haslett, Chunmei Xu, Changchun Dong, Xiaofang Wang, Minghao Zheng, Yan Jing, Jian Q. Feng
Summary: This study reveals that tendon cells directly form fibrocartilage through cell transdifferentiation, shedding light on the mechanisms underlying enthesopathy and sporting injuries.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Reona Wada, Shun Fujinuma, Hirokazu Nakatsumi, Masaki Matsumoto, Keiichi Nakayama
Summary: Mechanistic target of rapamycin complex 1 (mTORC1) is a serine-threonine kinase activated by extracellular signals, regulating various biological processes. PBX2 was identified as a novel target dephosphorylated downstream of mTORC1. The phosphorylation of PBX2 is regulated by the antagonistic actions of glycogen synthase kinase 3 (GSK3) and protein phosphatase 1 (PP1).
JOURNAL OF BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Minhao Gao, Bin Zhu, Jing Fan, Youshui Gao, Feng Xue, Guangyi Li, Alysia Hubbard, Xiangrong Gao, Jing Sun, Jing Ling, Longxiang Cao, Delin Liu, Jun Yuan, Qing Jiang, John Papadimitriou, Weiguo Zou, Jian Q. Feng, Liu Yang, Changqing Zhang, Junjie Gao, Minghao Zheng
Summary: In this study, the morphological and transcriptomic expression of osteocytes from murine calvaria and mid-shaft femoral cortical bone were characterized using confocal structured illumination microscopy and mRNA-sequencing analysis. The results showed that calvarial and cortical osteocytes exhibited differences in morphology and gene expression, potentially due to their distinct pathways of ossification.
Article
Medicine, Research & Experimental
Fan Yang, Yuangang Su, Jiamin Liang, Keyi Wang, Haoyu Lian, Junchun Chen, Jiake Xu, Jinmin Zhao, Qian Liu
Summary: Postmenopausal osteoporosis is a chronic metabolic disease characterized by low bone mineral density and bone fragility. In this study, it was found that Casticin inhibits osteoclast activation and differentiation induced by the receptor activator of nuclear factor-κB ligand. Casticin also prevents bone loss and reduces osteoclast activity in vivo, suggesting its potential as a preventive treatment for osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Shangfu Li, Dian Teguh, Depeng Wu, Lesong Liu, Chaofeng Hu, Jinbo Yuan, Charles A. Inderjeeth, Jiake Xu
Summary: This study investigated the effects of acetylcholinesterase inhibitors (AChEIs) on osteoclast differentiation and function. The findings showed that AChEIs, particularly Donepezil and Rivastigmine, can inhibit osteoclastogenesis and bone resorption by regulating MAPK and NFATc1 signaling pathways through downregulating AChE. These results have important clinical implications for elderly patients with dementia and osteoporosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Cell Biology
Emel Rothzerg, Wendy N. Erber, Christopher L. M. H. Gibbons, David Wood, Jiake Xu
Summary: Osteohematology is an emerging field studying the interaction between hematopoietic and bone stromal cells to understand hematological and skeletal malignancies and diseases. The Notch signaling pathway plays critical roles in embryonic development and cancer progression, including osteosarcoma, leukemia, and multiple myeloma. Dysregulation of Notch-mediated malignant cells disrupts normal bone and bone marrow function, leading to disorders such as osteoporosis and bone marrow dysfunction. This mini-review summarizes the interplay between cells in bone and bone marrow under the Notch signaling pathway in both physiological and tumor microenvironments.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Materials Science, Biomaterials
M. Natividad Gomez-Cerezo, Nataliya Perevoshchikova, Rui Ruan, Kevin M. Moerman, Randy Bindra, David G. Lloyd, Ming Hao Zheng, David J. Saxby, Cedryck Vaquette
Summary: This study proposes the use of a Bone-Ligament-Bone (BLB) 3D-printed polyethylene terephthalate (PET) scaffold for the treatment of ruptured scapholunate interosseous ligament (SLIL). The scaffold mimics the native tissue architecture and exhibits adequate mechanical properties to support physiological loading. Biofunctionalization of the scaffold enhances cell viability and protein secretion, promoting SLIL regeneration.
BIOMATERIALS ADVANCES
(2023)
Article
Multidisciplinary Sciences
Katsuhiko Takahashi, Hitoshi Amano, Tomohiko Urano, Minqi Li, Meiko Oki, Kazuhiro Aoki, Norio Amizuka, Keiichi I. Nakayama, Keiko Nakayama, Nobuyuki Udagawa, Nobuaki Higashi
Summary: The study found that p57(Kip2) plays an important role in bone development and is associated with the vitamin D receptor (VDR). 1,25-(OH)(2)VD3 can promote the differentiation of osteoblasts by regulating p57(Kip2), and simultaneously reduce the generation of osteoclasts.
Article
Multidisciplinary Sciences
Chisa Shiraishi, Akinobu Matsumoto, Kazuya Ichihara, Taishi Yamamoto, Takeshi Yokoyama, Taisuke Mizoo, Atsushi Hatano, Masaki Matsumoto, Yoshikazu Tanaka, Eriko Matsuura-Suzuki, Shintaro Iwasaki, Shouji Matsushima, Hiroyuki Tsutsui, Keiichi I. Nakayama
Summary: This study reveals that the RPL3L-encoded ribosomal protein specifically expressed in heart and skeletal muscle affects translation elongation dynamics, and its deficiency impairs cardiac contractility in mice. The results provide insights into the mechanisms and physiological relevance of tissue-specific translational regulation.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Pei Ying Ng, Amy B. P. Ribet, Qiang Guo, Benjamin H. Mullin, Jamie W. Y. Tan, Euphemie Landao-Bassonga, Sebastien Stephens, Kai Chen, Jinbo Yuan, Laila Abudulai, Maike Bollen, Edward T. T. T. Nguyen, Jasreen Kular, John M. Papadimitriou, Kent Soe, Rohan D. Teasdale, Jiake Xu, Robert G. Parton, Hiroshi Takayanagi, Nathan J. Pavlos
Summary: Using organelle-resolution proteomics, the authors identified Slc37a2 as a sugar transporter in osteoclast secretory lysosomes. They found that Slc37a2 is required for the maintenance of skeletal bone mass and that its deficiency leads to high bone mass in mice. This study provides new insights into the molecular composition and spatiotemporal organization of secretory lysosomes in osteoclasts.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Shun Fujinuma, Hirokazu Nakatsumi, Hideyuki Shimizu, Shigeaki Sugiyama, Akihito Harada, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, Masatomo Takahashi, Yoshihiro Izumi, Mikako Yagi, Dongchon Kang, Mari Kaneko, Mayo Shigeta, Takeshi Bamba, Yasuyuki Ohkawa, Keiichi I. Nakayama
Summary: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder that can lead to nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). The transcription factor FOXK1 plays a key role in hepatic lipid metabolism by suppressing lipid catabolism. Inhibition of FOXK1 has shown promising results in improving hepatic steatosis, inflammation, fibrosis, and tumorigenesis, making it a potential therapeutic strategy for NAFLD-NASH and HCC.
Article
Multidisciplinary Sciences
Kanae Yumimoto, Shigeaki Sugiyama, Saori Motomura, Daisuke Takahashi, Keiichi I. Nakayama
Summary: ROS poses a risk for the transition of vertebrates from aquatic to terrestrial life, and how ancestral organisms adapted to such ROS exposure has remained a mystery. By studying the evolution of Keap1 gene, researchers found that the duplication of Keap1 gene in fish and the lower affinity of Keap1B for Cul3 contributed to robust Nrf2 induction in response to ROS exposure. Mutation of mammalian Keap1 to resemble zebrafish Keap1A resulted in an attenuated Nrf2 response and increased sensitivity to ultraviolet radiation. These findings suggest that the molecular evolution of Keap1 was essential for adaptation to terrestrial life.
Review
Orthopedics
Mengyuan Li, Duanyong Chen, Yuanchen Ma, Minghao Zheng, Qiujian Zheng
Summary: In this study, a systematic review and meta-analysis were conducted to evaluate the effectiveness of stem cell therapy combined with core decompression for avascular necrosis of the femoral head. The results showed that adding stem cell therapy to core decompression improved clinical outcomes.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Geriatrics & Gerontology
Jun Yuan, Steve Pedrini, Rohith Thota, James Doecke, Pratishtha Chatterjee, Hamid R. Sohrabi, Charlotte E. Teunissen, Inge M. W. Verberk, Erik Stoops, Hugo Vanderstichele, Bruno P. Meloni, Christopher Mitchell, Stephanie Rainey-Smith, Kathryn Goozee, Andrew Chi Pang Tai, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Junjie Gao, Delin Liu, Frank Mastaglia, Charles Inderjeeth, Minghao Zheng, Ralph N. Martins
Summary: This study investigated the association between plasma SOST levels and brain amyloid-beta load in older individuals. The results showed that plasma SOST levels were higher in individuals with brain amyloid-beta load, and the combination of plasma SOST and Aβ 42/Aβ40 ratio improved the predictive accuracy for preclinical Alzheimer's disease.