Article
Biochemistry & Molecular Biology
Yumei Jia, Zhaoyuan Guo, Jiahao Zhu, Guanyu Qin, Wenwen Sun, Yu Yin, Haiying Wang, Renpeng Guo
Summary: The study shows that Snap29 plays a crucial role in the self-renewal and differentiation of mouse ESCs. Depletion of Snap29 does not affect the self-renewal and pluripotency-associated factor expression in ESCs, but enhances their differentiation into cardiomyocytes. Transcriptome analysis reveals that Snap29 deficiency significantly decreases the expression of genes required for germ layer differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Miaoling Tang, Meisongzhu Yang, Geyan Wu, Shuang Mo, Xingui Wu, Shuxia Zhang, Ruyuan Yu, Yameng Hu, Yingru Xu, Ziwen Li, Xinyi Liao, Jun Li, Libing Song
Summary: In liver cancer cells, the upregulation of MFF mediated by the TBX19/PRMT1 complex promotes mitochondrial fission and tumor-initiating capacity, indicating that PRMT1 may be a viable therapeutic target in liver cancer.
Article
Cell Biology
Warunya Chakritbudsabong, Somjit Chaiwattanarungruengpaisan, Ladawan Sariya, Sirikron Pamonsupornvichit, Joao N. Ferreira, Panithi Sukho, Dulyatad Gronsang, Theerawat Tharasanit, Andras Dinnyes, Sasitorn Rungarunlert
Summary: In addition to the four transcription factors, LIN28 is required for the effective induction of piPSCs and the maintenance of their long-term self-renewal and pluripotency towards the development of all germ layers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shinya Aramaki, Saya Kagiwada, Guangming Wu, David Obridge, Kenjiro Adachi, Eva Kutejova, Heiko Lickert, Karin Huebner, Hans R. Schoeler
Summary: The mesodermal transcription factor T has a global effect on pluripotency by binding to Oct4 and other pluripotency regulators, affecting cell differentiation pathways. Lower T levels promote germ cell differentiation, while higher levels enhance somatic differentiation and repress germ cell differentiation. In vivo, nascent germ cells are detected in areas with lower T levels, indicating a regulatory mechanism for germ cell segregation from somatic lineages.
Article
Multidisciplinary Sciences
Rita Silverio-Alves, Ilia Kurochkin, Anna Rydstrom, Camila Vazquez Echegaray, Jakob Haider, Matthew Nicholls, Christina Rode, Louise Thelaus, Aida Yifter Lindgren, Alexandra Gabriela Ferreira, Rafael Brandao, Jonas Larsson, Marella F. T. R. de Bruijn, Javier Martin-Gonzalez, Carlos-Filipe Pereira
Summary: The transcription factor GATA2 plays a critical role in definitive hematopoiesis by bookmarking genomic sites during mitosis. Its retention on chromatin during cell division is important for lineage commitment.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jiaxiong Lu, Kaitlyn Xiong, Xinye Qian, Jongsu Choi, Yoon-Kyung Shim, Jacob Burnett, Graeme Mardon, Rui Chen
Summary: SPATA7 is a gene that plays a crucial role in the function and maintenance of the retina. Its encoded protein is involved in maintaining the structure and function of the photoreceptor cells. Loss of SPATA7 in the adult retina leads to degeneration and dysfunction of the retina.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Lin Wang, Mande Xue, Huairen Zhang, Lijun Ma, Danhua Jiang
Summary: Plant TONSOKU (TSK) and its animal ortholog TON-SOKU-like (TONSL) play a crucial role in maintaining chromatin stability during DNA replication. TSK interacts with histone modifiers and Polycomb proteins to preserve repressive chromatin modifications. TSK is specifically involved in a critical period of time following DNA replication to ensure the preservation of chromatin states.
Article
Biochemistry & Molecular Biology
Naoki Ito, Yuko Miyagoe-Suzuki, Shin'ichi Takeda, Akira Kudo
Summary: In this study, the protective role of periostin, a matricellular protein, in skeletal muscle regeneration was identified. Periostin-null mice showed decreased muscle weight due to the loss of muscle fibers during repeated muscle regeneration. The decrease in CD31-positive blood vessels during muscle regeneration in periostin-null mice suggests that the decreased nutritional supply may be the cause of muscle fiber loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Rebecca A. Lea, Afshan McCarthy, Stefan Boeing, Todd Fallesen, Kay Elder, Phil Snell, Leila Christie, Sarah Adkins, Valerie Shaikly, Mohamed Taranissi, Kathy K. Niakan
Summary: KLF17 is expressed during human blastocyst development along with pluripotency-associated factors NANOG and SOX2. It can induce a naive-like transcriptome in hESCs, but is not essential for naive pluripotency acquisition in vitro. Loss of KLF17 function in naive hESCs leads to subtle effects on metabolism and signaling pathways, potentially indicating redundancy with other KLF paralogues.
Article
Multidisciplinary Sciences
Ines C. Osma-Garcia, Dunja Capitan-Sobrino, Mailys Mouysset, Sarah E. Bell, Manuel Lebeurrier, Martin Turner, Manuel D. Diaz-Munoz
Summary: The RNA binding protein HuR plays a crucial role in supporting germinal centre (GC) responses by promoting Myc-dependent transcription and influencing the expression and splicing patterns of genes involved in GC B cell proliferation and Ig somatic hypermutation. Additionally, HuR modulates mRNA splicing and abundance for cell cycle progression, and protects GC B cells from DNA damage and cell death.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Natalie R. Harris, Natalie R. Nielsen, John B. Pawlak, Amir Aghajanian, Krsna Rangarajan, D. Stephen Serafin, Gregory Farber, Danielle M. Dy, Nathan P. Nelson-Maney, Wenjing Xu, Disha Ratra, Sophia H. Hurr, Li Qian, Joshua P. Scallan, Kathleen M. Caron
Summary: This study reveals the essential role of VE-cadherin in the development and maintenance of cardiac lymphatics and its impact on lymphangiogenic signaling pathways. Surprisingly, despite the regression of cardiac lymphatics, Cdh5(flox/flox);Prox1CreER(T2) mice exhibited preserved cardiac function at baseline and after myocardial infarction compared with control mice. Mechanistically, loss of VE-cadherin leads to aberrant cellular internalization of VEGFR3, impairing downstream processes such as cellular proliferation.
CIRCULATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Liu Yang, Haiyan Yang, Yunxiang Chu, Yunhao Song, Lidan Ding, Bingtao Zhu, Wanli Zhai, Xuning Wang, Yanshen Kuang, Fangli Ren, Baoqing Jia, Wei Wu, Xiongjun Ye, Yinyin Wang, Zhijie Chang
Summary: This study reveals the essential role of CREPT in maintaining murine intestinal stem cells, with its deficiency impairing cell proliferation and regeneration. The downregulation of Wnt signaling due to CREPT deletion is identified as a key mechanism affecting ISC function.
NATURE COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Neha Goveas, Claudia Waskow, Kathrin Arndt, Julian A. Heuberger, Qinyu Zhang, Dimitra A. Alexopoulou, Andreas Dahl, Walter A. Birchmeier, Konstantinos Anastassiadis, A. Francis A. Stewart, Andrea Kranz
Summary: The research reveals the importance of MLL1 in maintaining intestinal stem cells, with loss of MLL1 leading to intestinal failure. Additionally, the location and expression of MLL1 in the intestine are closely related to its function in regulating intestinal stem cells.
Article
Immunology
Aiting Wang, Lei Ding, Zhongqiu Wu, Rui Ding, Xiao-Lu Teng, Feixiang Wang, Zhilin Hu, Lei Chen, Xiaoyan Yu, Qiang Zou
Summary: This study demonstrates that the E3 ubiquitin ligase ZFP91 promotes autophagy activation in regulatory T cells, maintaining their metabolic programming and functional integrity. Deletion of Zfp91 in T cells leads to dysfunction and exacerbates colonic inflammation and inflammation-driven colon cancer. TCR-triggered autophagy induction relies on T cell-derived ZFP91 to restrict hyperglycolysis for cell homeostasis maintenance.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Keji Yan, Wen Zong, Haibo Du, Xiaoyan Zhai, Rui Ren, Shuang Liu, Wei Xiong, Yanfei Wang, Zhigang Xu
Summary: In this study, it was found that BAIAP2L2 is localized at the tips of inner ear hair cells' stereocilia, and its inactivation leads to degeneration of mechanotransducing stereocilia, resulting in hearing loss. BAIAP2L2 binds to components of the row 2 complex and MET complex, indicating its crucial role in maintaining stereocilia.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)