Article
Medicine, General & Internal
Tomasz Pizon, Marek Rajzer, Wiktoria Wojciechowska, Tomasz Drozdz, Dorota Drozdz, Marta Rojek, Krystian Gruszka, Danuta Czarnecka
Summary: The study aimed to assess the relations between plasma renin activity (PRA), serum aldosterone concentration (ALDO), and selected asymptomatic organ damage (AOD) indices in mild primary arterial hypertension (AH). High PRA patients had higher ALDO levels, and those with simultaneously high PRA and ARR values showed more severe arterial stiffness and renal impairment. Assessment of the influence of the renin-angiotensin-aldosterone system on AOD should consider the relationship between renin and aldosterone.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Bao Zhong, Eun-Gyung Mun, Jin-Xi Wang, Youn-Soo Cha
Summary: The study found that Chinese traditional fermented soy sauce can prevent hypertension by reducing body weight, improving blood lipids, lowering blood pressure, and preventing hypertension-related kidney injury. Additionally, it showed beneficial effects on the renin-angiotensin-aldosterone system and adipogenesis, indicating its potential as a preventive measure for hypertension.
FERMENTATION-BASEL
(2021)
Article
Public, Environmental & Occupational Health
Yanli Ren, Enyu Tong, Chunhong Di, Yunheng Zhang, Liangwen Xu, Xiaohua Tan, Lei Yang
Summary: This study examined the association between single-nucleotide polymorphisms in the ABCA1 gene and hypertension in Chinese Han adults. The results showed significant associations between certain genotypes and hypertension, as well as specific haplotypes and blood pressure measures.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Endocrinology & Metabolism
Huai Heng Loh, Norlela Sukor
Summary: This review aims to collate and summarize current research on the association between primary aldosteronism and obstructive sleep apnea, including their relationship, clinical characteristics, implications, treatment outcomes, potential causal links, and mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
M. Ekholm, T. Kahan
Summary: Atherosclerosis is a disease caused by chronic inflammation and endothelial dysfunction, with up-regulated mediators of inflammation in affected individuals. Oxidative stress, imbalance between antioxidants and oxidants, leads to tissue damage. The renin-angiotensin-aldosterone system plays a vital role in vascular disease pathobiology, with angiotensin II causing hypertension and reactive oxygen species production. Blocking this system could potentially reduce inflammatory and thrombotic complications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Toxicology
Chenpeng Zhu, Weikuan Gu, Dianjun Sun, Wei Wei
Summary: The renin-angiotensin system (RAS) plays a crucial role in regulating blood pressure. Excess fluoride can increase blood pressure by dysregulating the RAS. The study found that fluoride reduces levels of renin, angiotensin II (Ang II), and angiotensin (1-7) [Ang (1-7)], and disrupts the balance of aldosterone and potassium levels. Excess fluoride also damages the kidneys, myocardium, and aorta, and affects the activation of different components of the RAS, leading to hypertension with low renin levels.
TOXICOLOGY LETTERS
(2023)
Article
Peripheral Vascular Disease
Barbara M. Alexander, Andrew South, Phyllis August, Mariane P. Bertagnolli, Erin L. Ferranti, Justin J. Grobe, Emily S. Jones, Analia Loria, Basmah Safdar, Maria Luisa Soledad Sequeira-Lopez
Summary: There is growing interest in the long-term cardiovascular health of women with complicated pregnancies and their affected offspring. Antenatal risk factors such as preeclampsia increase the risk of hypertension and cardiovascular disease in both the mother and the offspring, but the underlying mechanisms are complex and not fully understood. The renin-angiotensin-aldosterone system plays a critical role in maternal-fetal health and the development of pregnancy complications, and understanding its programming during pregnancy is crucial for identifying at-risk individuals and developing effective therapies. Preclinical and translational research should adhere to best practices in accurately measuring components of this system to ensure reliable results.
Article
Obstetrics & Gynecology
M. Aung, T. Konoshita, J. Moodley, T. Naicker, C. Connolly, O. P. Khaliq, P. Gathiram
Summary: This study aimed to investigate the role of ENPEP gene variants in the pathogenesis of preeclampsia, but found that in a homogeneous South African population of African ancestry, ENPEP gene variants do not play a role in the development of preeclampsia.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Maxime Berney, Nima Vakilzadeh, Marc Maillard, Mohamed Faouzi, Eric Grouzmann, Olivier Bonny, Lucie Favre, Gregoire Wuerzner
Summary: The study compared the effects of weight loss after RYGB surgery or dietary advice on blood pressure, RAAS, and urinary electrolyte excretion. The results showed that weight loss and plasma aldosterone concentration decrease were more pronounced in the RYGB group, with no significant difference in RAAS.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Behavioral Sciences
Angelina Gideon, Christine Sauter, Ulrike Ehlert, Roland von Kaenel, Petra H. Wirtz
Summary: The study found that hypertensive individuals exhibit increased sensitivity in aldosterone response to acute psychosocial stress.
HORMONES AND BEHAVIOR
(2021)
Article
Endocrinology & Metabolism
Fabio Bioletto, Chiara Lopez, Martina Bollati, Stefano Arata, Matteo Procopio, Federico Ponzetto, Guglielmo Beccuti, Giulio Mengozzi, Ezio Ghigo, Mauro Maccario, Mirko Parasiliti-Caprino
Summary: This study investigated the feasibility of using aldosterone-to-renin ratio (ARR) as a diagnostic criteria for primary aldosteronism (PA) in patients with resistant hypertension (RH). The results showed that in normokalemic patients, ARR had a lower diagnostic accuracy and may not accurately differentiate between PA and essential RH. However, in patients with hypokalemia, ARR had a higher diagnostic accuracy and may serve as a diagnostic criterion for PA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jun Yang, Stella May Gwini, Lawrence J. Beilin, Markus Schlaich, Michael Stowasser, Morag J. Young, Peter J. Fuller, Trevor A. Mori
Summary: Oral contraception can increase the aldosterone to renin ratio, leading to false positive results in the screening for primary aldosteronism. Until more reliable criteria for primary aldosteronism screening in oral contraception users are established, alternative contraception methods should be considered.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Paolo Mulatero, Chiara Bertello, Franco Veglio, Silvia Monticone
Summary: Primary aldosteronism is an overlooked condition with significant mortality and morbidity. The difficulty of screening patients on antihypertensive therapy has resulted in low testing rates. However, interference with medication may not always be necessary for accurate screening.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
M. Briere, M. Diedisheim, L. Dehghani, D. Dubois-Laforgue, E. Larger
Summary: This study found that anemia is common in diabetic patients and closely associated with renal failure. Female gender and longer duration of diabetes are risk factors for anemia. The use of antiplatelet agents and renin-angiotensin system blockers (RASBs) is associated with an increased risk of anemia in diabetic patients.
DIABETES & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Natalie Arnold, Iris M. Hermanns, Andreas Schulz, Omar Hahad, Volker H. Schmitt, Marina Panova-Noeva, Juergen H. Prochaska, Harald Binder, Norbert Pfeiffer, Manfred Beutel, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild
Summary: This study investigates the predictive ability of direct plasma renin and aldosterone concentrations as well as their ratio (aldosterone-to-renin, ARR) for incident hypertension in the general population. The study finds that ARR has a stronger predictive value for incident hypertension than renin or aldosterone alone, especially in obese subjects.
CARDIOVASCULAR RESEARCH
(2023)
Letter
Cardiac & Cardiovascular Systems
Lin-dan Ji, Nelson L. S. Tang, Jin Xu
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2016)
Review
Peripheral Vascular Disease
L-D Ji, J-Y Li, B-B Yao, X-B Cai, Q-J Shen, J. Xu
JOURNAL OF HUMAN HYPERTENSION
(2017)
Article
Peripheral Vascular Disease
L. D. Ji, S. P. Hu, J. Y. Li, B. B. Yao, Q. J. Shen, J. Xu
JOURNAL OF HUMAN HYPERTENSION
(2017)
Article
Infectious Diseases
Lin-dan Ji, Wei-nan Xu, Peng-fei Chai, Wei Zheng, Hai-xia Qian, Jin Xu
INFECTION GENETICS AND EVOLUTION
(2014)
Article
Endocrinology & Metabolism
Lin-dan Ji, Jin Xu, Dong-dong Wu, Si-da Xie, Nelson L. S. Tang, Ya-ping Zhang
JOURNAL OF PINEAL RESEARCH
(2010)
Article
Biochemistry & Molecular Biology
Lin-dan Ji, Yu-qing Qiu, Jin Xu, David M. Irwin, Siu-Cheung Tam, Nelson L. S. Tang, Ya-ping Zhang
MOLECULAR BIOLOGY AND EVOLUTION
(2012)
Editorial Material
Infectious Diseases
Lin-Dan Ji, Peng-Fei Chai, Bi-Bo Zhou, Nelson L. S. Tang, Wen-Hua Xing, Fang Yuan, Li-Juan Fei, Li-Na Zhang, Jin Xu
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
(2013)
Article
Multidisciplinary Sciences
Holly Y. Chen, Suk Ling Ma, Wei Huang, Lindan Ji, Vincent H. K. Leung, Honglin Jiang, Xiaoqiang Yao, Nelson L. S. Tang
SCIENTIFIC REPORTS
(2016)
Article
Endocrinology & Metabolism
Yan-ming Chen, Qiong Zhu, Jie Cai, Zhi-jia Zhao, Bin-bin Yao, Li-ming Zhou, Lin-dan Ji, Jin Xu
Summary: This study investigated the role of circRNAs in gestational diabetes mellitus (GDM) by analyzing the differentially expressed circRNAs and their target mRNAs in GDM patients and healthy pregnant women. The findings suggest that upregulation of the T cell receptor signaling pathway may play a major role in the pathogenesis of GDM.
FRONTIERS IN ENDOCRINOLOGY
(2022)