Osteoprotegerin Inhibits Calcification of Vascular Smooth Muscle Cell via Down Regulation of the Notch1-RBP-Jκ/Msx2 Signaling Pathway
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Title
Osteoprotegerin Inhibits Calcification of Vascular Smooth Muscle Cell via Down Regulation of the Notch1-RBP-Jκ/Msx2 Signaling Pathway
Authors
Keywords
Notch signaling, Calcification, Signal inhibition, Osteoblast differentiation, Gene expression, Calcium signaling, Chronic kidney disease, Muscle differentiation
Journal
PLoS One
Volume 8, Issue 7, Pages e68987
Publisher
Public Library of Science (PLoS)
Online
2013-07-10
DOI
10.1371/journal.pone.0068987
References
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- Inhibitory Role of Notch1 in Calcific Aortic Valve Disease
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- Notch Signaling Induces Osteogenic Differentiation and Mineralization of Vascular Smooth Muscle Cells
- (2009) Takehisa Shimizu et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Tumor necrosis factor-α increases alkaline phosphatase expression in vascular smooth muscle cells via MSX2 induction
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- Notch1 represses osteogenic pathways in aortic valve cells
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- Elevated osteoprotegerin is associated with all-cause mortality in CKD stage 4 and 5 patients in addition to vascular calcification
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- Notch and Vascular Smooth Muscle Cell Phenotype
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- Notch Signaling in Cardiac Development
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- The capability of plasma osteoprotegerin as a predictor of cardiovascular disease: a systematic literature review
- (2008) Mads Nybo et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Circulating Osteoprotegerin Levels and Long-Term Prognosis in Patients With Acute Coronary Syndromes
- (2008) Torbjørn Omland et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Non-traditional risk factors predict coronary calcification in chronic kidney disease in a population-based cohort
- (2007) U. Baber et al. KIDNEY INTERNATIONAL
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