Transient Combination Therapy Targeting the Immune Synapse Abrogates T Cell Responses and Prolongs Allograft Survival in Mice

Anti-TCRβ mAb Induces Long-Term Allograft Survival by Reducing Antigen-Reactive T Cells and Sparing Regulatory T Cells

(2012) Y. Miyahara et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Fatal PML associated with efalizumab therapy: Insights into integrin  L 2 in JC virus control

(2012) N. Schwab et al.   NEUROLOGY

LFA-1 Antagonism Inhibits Early Infiltration of Endogenous Memory CD8 T Cells into Cardiac Allografts and Donor-Reactive T Cell Priming

(2011) K. Setoguchi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Fates of CD4+ T Cells in a Tolerant Environment Depend on Timing and Place of Antigen Exposure

(2011) B. E. Burrell et al.   AMERICAN JOURNAL OF TRANSPLANTATION

LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function

(2011) N. M. Reisman et al.   BLOOD

T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis

(2011) Nuria Martínez-Martín et al.   IMMUNITY

Integrin antagonists for transplant immunosuppression: panacea or peril?

(2011) William H Kitchens et al.   Immunotherapy

Immunosuppression with Belatacept-Based, Corticosteroid-Avoiding Regimens in De Novo Kidney Transplant Recipients

(2010) R. Ferguson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Experience with a Novel Efalizumab-Based Immunosuppressive Regimen to Facilitate Single Donor Islet Cell Transplantation

(2010) N. A. Turgeon et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Islet Transplantation in Type 1 Diabetics Using an Immunosuppressive Protocol Based on the Anti-LFA-1 Antibody Efalizumab

(2010) A. M. Posselt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Advances in immunosuppression for renal transplantation

(2010) Antoine Durrbach et al.   Nature Reviews Nephrology

T10B9 monoclonal antibody: A short-acting nonstimulating monoclonal antibody that spares γδ T-cells and treats and prevents cellular rejection

(2010) Thomas Waid   Drug Design Development and Therapy

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

LFA-1 Affinity Regulation Is Necessary for the Activation and Proliferation of Naive T Cells

(2009) Yang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoclonal antibody-associated progressive multifocal leucoencephalopathy in patients treated with rituximab, natalizumab, and efalizumab: a Review from the Research on Adverse Drug Events and Reports (RADAR) Project

(2009) Kenneth R Carson et al.   LANCET ONCOLOGY

Complete but curtailed T-cell response to very low-affinity antigen

(2009) Dietmar Zehn et al.   NATURE

What's Next in the Pipeline

(2008) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY