Journal
PLOS ONE
Volume 8, Issue 5, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0064439
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Funding
- MEXT/JSPS KAKENHI [23590549]
- Japan Science Society
- SRI (Shizuoka Research Institute)
- Japan Society for the Promotion of Science
- ERATO (Japan Science and Technology Agency)
- Ministries of Education, Culture, Sports, Science, and Technology
- Health, Labor, and Welfare of Japan
- Japan Initiative for Global Research Network on Infectious Diseases from the Ministries of Education, Culture, Sports, Science, and Technology
- National Institute of Allergy and Infectious Disease Public Health Service
- Grants-in-Aid for Scientific Research [23590549] Funding Source: KAKEN
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An influenza A virus that originated in pigs caused a pandemic in 2009. The sialidase activity of the neuraminidase (NA) of previous pandemic influenza A viruses are stable at low pH (<= 5). Here, we identified the amino acids responsible for this property. We found differences in low-pH stability at pH 5.0 among pandemic (H1N1) 2009 viruses, which enhanced the replication of these viruses. Low-pH-stable NA enhancement of virus replication may have contributed to the rapid worldwide spread and adaptation to humans of pandemic (H1N1) 2009 viruses during the early stages of the 2009 pandemic.
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