Article
Medicine, General & Internal
Qianwen Liu, Zhaozhong Zhu, Peter Kraft, Qiaolin Deng, Elisabet Stener-Victorin, Xia Jiang
Summary: This study found a genetic correlation between PCOS and obesity-related traits, including adult BMI, childhood BMI, and WHR. Cross-trait meta-analysis identified shared loci between PCOS and obesity-related traits. Mendelian randomization supported the causal role of adult BMI and childhood BMI in PCOS, but not WHR or WHRadjBMI. These findings provide insights into the shared genetic basis of obesity and PCOS and emphasize the role of weight management in PCOS prevention.
Article
Endocrinology & Metabolism
Qianwen Liu, Bowen Tang, Zhaozhong Zhu, Peter Kraft, Qiaolin Deng, Elisabet Stener-Victorin, Xia Jiang
Summary: The genetic link between type 2 diabetes, glycaemic traits and PCOS was found, influenced by both biological pleiotropy and causal mediation, some of which is independent of BMI. The study highlights the importance of controlling fasting insulin levels to mitigate the risk of PCOS, as well as screening for and monitoring type 2 diabetes in all women with PCOS, irrespective of BMI.
Review
Endocrinology & Metabolism
Yiming Gao, Caihong Xin, Huaying Fan, Xin Sun, Hongli Wang
Summary: In this meta-analysis, it was found that the levels of chemerin, a newly identified adipokine, were significantly higher in patients with PCOS compared to healthy controls. However, there was no significant difference in the levels of apelin, another adipokine, between the two groups.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Tiantian Zhu, Mark O. Goodarzi
Summary: PCOS is a common endocrine disorder affecting women, and its risk factors are not well understood. Mendelian randomization studies have found that obesity, testosterone levels, insulin levels, and other factors may have a causal role in PCOS. PCOS may increase the risk of breast cancer and decrease the risk of endometrioid ovarian cancer, but it has no direct causal effect on type 2 diabetes, coronary heart disease, or stroke.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Dan Shan, Jinbiao Han, Yitong Cai, Li Zou, Liangzhi Xu, Yongchun Shen
Summary: This study aimed to explore the reproductive health of first-degree relatives (FDRs) of patients with polycystic ovary syndrome (PCOS). The findings indicated that female PCOS FDRs have a higher prevalence of menstrual irregularities, ovarian morphological changes, and elevated levels of certain hormones. Additionally, fathers of PCOS patients exhibited a higher risk of premature baldness, and male FDRs had elevated levels of specific hormones. These results suggest that FDRs of PCOS patients experience reproductive endocrinological dysregulations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Pan Li, Ping Shuai, Sj Shen, Huimin Zheng, Ping Sun, Renfang Zhang, Shanwei Lan, Zixin Lan, Thisun Jayawardana, Yumei Yang, Jianhui Zhao, Yuping Liu, Xia Chen, Emad M. El-Omar, Zhengwei Wan
Summary: This study conducted a systematic review and meta-analysis, and found that gut dysbiosis in PCOS is characterized by decreased diversity and alterations in specific bacteria. The imbalance in gut microbiota may lead to a pro-inflammatory environment due to a reduction in short-chain fatty acid (SCFA)-producing and bile-acid-metabolizing bacteria. These findings provide important insights for further understanding the pathogenesis and treatment of PCOS.
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Review
Medicine, General & Internal
Pawel Dybciak, Dorota Raczkiewicz, Ewa Humeniuk, Tomasz Powrozek, Mariusz Gujski, Teresa Malecka-Massalska, Artur Wdowiak, Iwona Bojar
Summary: This meta-analysis utilized research utilizing the Hospital Anxiety and Depression Scale (HADS) to determine the prevalence, mean level, standardized mean difference, and probability of depression in patients with PCOS. The results indicate an increased risk of depressive symptoms in women with PCOS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Wenwen Yue, Xin Huang, Wenjing Zhang, Shumin Li, Xu Liu, Yian Zhao, Jiaxin Shu, Teng Liu, Weihua Li, Shaozhuang Liu
Summary: This study aimed to evaluate the therapeutic effects of metabolic surgery on obese patients with PCOS. The results showed that metabolic surgery significantly improved clinical symptoms and reproductive outcomes in patients with PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Yan Xu, Zhiqun Cao, Ting Chen, Jian Ren
Summary: PCOS is a common chronic disease that affects reproductive disorders in women of childbearing age worldwide. The cause of metabolic dysfunction in PCOS is still unknown, and there is a lack of systematic bibliometric analysis for this disease. This study analyzed 3,972 articles on metabolic dysfunction in PCOS published from 2012 to 2021 using scientometric analysis software, aiming to understand the research efforts, developing trends, and anticipate the progress in understanding PCOS-related metabolic dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Mujin Ye, Bin Hu, Weihui Shi, Fei Guo, Chenming Xu, Shuyuan Li
Summary: The study found a strong association between mtDNA(4977) DR and PCOS, suggesting that it may represent an independent risk factor for PCOS. Further research is needed to explore the potential value of mtDNA as a biomarker for PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Shu Zhou, Yiping Ji, Haimei Wang
Summary: The incidence of hypertensive disorders complicating pregnancy (HDCP) in patients with polycystic ovary syndrome (PCOS) is relatively high, with factors like age, BMI, family history of hypertension, history of adverse pregnancy, history of contraceptive pills use, and family history of HDCP being identified as independent risk factors. Early prevention and intervention measures targeting these risk factors can help reduce the occurrence of HDCP in PCOS patients.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Endocrinology & Metabolism
Noel Y. H. Ng, Hongjiang Wu, Eric S. H. Lau, Xinge Zhang, Aimin Yang, Atta Y. T. Tsang, Tiffany T. L. Yau, Alice P. S. Kong, Karen Ng, Jacqueline P. W. Chung, Elaine Y. K. Chow, Juliana C. N. Chan, Lai Ping Cheung, Andrea O. Y. Luk, Ronald C. W. Ma
Summary: This study aimed to determine the risk of progression to diabetes among Chinese women with PCOS. The findings showed that women with PCOS have a higher risk of developing diabetes, especially at a younger age. It is recommended to conduct frequent glycemic status screening and early diagnosis for young women with PCOS.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Medicine, General & Internal
Stefan Ghobrial, Johannes Ott, Johanna Steininger, Didier Dewailly, Gerhard Prager
Summary: Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is associated with obesity. The most effective method to achieve and maintain long-term weight loss is by the Roux-en-Y gastric bypass (RYGB). RYGB leads to adequate weight loss and reduction in BMI in obese PCOS patients, as well as improvements in testosterone levels, hirsutism, and cycle irregularities. However, more comprehensive studies are needed to evaluate fertility outcomes in this patient population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Yaokai Wen, Xiangrong Wu, Haoxin Peng, Caichen Li, Yu Jiang, Zixuan Su, Hengrui Liang, Jun Liu, Jianxing He, Wenhua Liang
Summary: Mendelian randomization analysis revealed a causal relationship between genetically predicted PCOS and increased risk of breast cancer, particularly for estrogen receptor-positive breast cancer. No causality was observed for estrogen receptor-negative breast cancer. The study did not find evidence of pleiotropy.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
