Article
Medicine, Research & Experimental
Seongho Ma, Jiah Yeom, Young-Hee Lim
Summary: This study investigates the mechanism of MUC2 expression in intestinal goblet cells stimulated by the short-chain fatty acid propionate. The study finds that propionate metabolism via a beta-oxidation-like pathway leads to hypoxia, which activates HIF-2 alpha and stimulates MUC2 production. These findings suggest that propionate-induced selective HIF-2 alpha stimulation plays a role in intestinal mucosal defense.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Amna Parveen, Seungho Choi, Ju-Hee Kang, Seung Hyun Oh, Sun Yeou Kim
Summary: Sweet potato is considered a superfood with protective effects on intestinal barrier function. The study identified trifostigmanoside I (TS I) as an active compound in sweet potato, which induced mucin production, promoted PKC alpha/beta phosphorylation, and protected tight junction function to maintain intestinal barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Beatriz Lopez-Cauce, Andres Urquia, Luis Menchen, Kohei Homma, Francisco Bolas-Fernandez, Juan J. Garcia-Rodriguez, Marta Puerto
Summary: This study evaluated the immunomodulatory effect of AHCC(R) in a murine model of Trichinella spiralis infection. The results showed that AHCC(R) could modulate the expression levels of Th1 and Th2 cytokines, reduce tissue damage, decrease the number of adult Trichinella spiralis, and promote parasite expulsion.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Natasha Haskey, Jiayu Ye, Mehrbod Estaki, Andrea A. Verdugo Meza, Jacqueline A. Barnett, Mitra Yousefi, Blake W. Birnie, Samantha Gruenheid, Sanjoy Ghosh, Deanna L. Gibson
Summary: There is a growing awareness of the interaction between diet, gut microbiota, and the immune system in the development of inflammatory bowel disease (IBD). High-fat diets have been shown to exacerbate IBD, while the fat blend found in the Mediterranean diet (MD) may have protective effects. A study in mice found that a diet mimicking the MD fat blend reduced disease activity and inflammation, and improved metabolic parameters in a mouse model of IBD.
Article
Multidisciplinary Sciences
Fatema Al-Rashed, Dania Haddad, Ashraf Al Madhoun, Sardar Sindhu, Texy Jacob, Shihab Kochumon, Lina M. Obeid, Fahd Al-Mulla, Yusuf A. Hannun, Rasheed Ahmad
Summary: This study investigated the role of acyl-CoA synthetase-1 (ACSL1) in promoting the foamy/inflammatory phenotype of monocytes/macrophages under acute-high-fat feeding (AHFF) conditions. ACSL1 inhibition/knockdown suppressed the foamy/inflammatory phenotype by inhibiting the CD36-FABP4-p38-PPAR delta signaling axis. Oral administration of ACSL1 inhibitor triacsin-C in mice normalized the inflammatory/foamy phenotype of circulatory monocytes by suppressing FABP4 expression. Targeting ACSL1 can provide a therapeutic strategy to prevent AHFF-induced macrophage foaming and inflammation.
Article
Immunology
Siyue He, Jing Xia, Huijie Jia, Qianlong Dai, Cui Chen, Yue Zhou, Xiao Bo Wang
Summary: 5-Fluorouracil (5-FU) is an important drug for colorectal cancer patients, but it causes severe side effects like chemotherapy intestinal mucositis (CIM). The therapeutic role of peficitinib, a Janus Kinase (JAK) inhibitor, in CIM is still unclear. This study found that peficitinib alleviates mucositis by reducing aging, inflammation, and oxidative stress, and enhances the anticancer activity of 5-FU. Rating: 8 points.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Microbiology
Beatriz Lopez-Cauce, Marta Puerto, Juan Jose Garcia, Manuel Ponce-Alonso, Federico Becerra-Aparicio, Rosa del Campo, Isabel Peligros, Maria J. Fernandez-Acenero, Yesica Gomez-Navarro, Jose M. Lara, Jose Miranda-Bautista, Ignacio Marin-Jimenez, Rafael Banares, Luis Menchen
Summary: Inflammatory bowel disease (IBD) is associated with dysbiosis and mucin depletion, which lead to intestinal barrier dysfunction. This study examines these parameters in IL-10 deficient mice and finds that gut microbiota alterations and mucin depletion precede overt gut inflammation in this animal model of IBD.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medical Laboratory Technology
Emmanuel Somm, Sophie A. Montandon, Ursula Loizides-Mangold, Nadia Gaia, Vladimir Lazarevic, Claudio De Vito, Elodie Perroud, Marie-Luce Bochaton-Piallat, Charna Dibner, Jacques Schrenzel, Francois R. Jornayvaz
Summary: The study shows that the GLP-1 receptor agonist liraglutide can prevent the accumulation of C16 and C24 ceramides/sphingomyelins species, alleviate inflammation, and inhibit the initiation of fibrosis in the liver of MCD-diet-fed mice. Additionally, liraglutide influences the composition of gut microbiota induced by the MCD-diet.
TRANSLATIONAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Minlan Yuan, Xiao Chen, Tianxia Su, Yan Zhou, Xiaohong Sun
Summary: The study showed that kiwifruit polyphenol extracts (KPE) could inhibit the increase of intestinal permeability caused by high fat diet and promote the expression of tight junction protein. KPE reshaped the gut microbiome, reducing inflammation and protecting the intestines.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Dong Liu, Yanglin Ji, Qian Cheng, Yamin Zhu, Haibo Zhang, Yatu Guo, Xiupeng Cao, Hao Wang
Summary: The study found that astaxanthin-rich extract (ASTE) can inhibit body weight increase, lipid accumulation, and atherosclerotic lesions. It also showed potential benefits in preventing AS-retinopathy and protecting the colon's mucosal epithelium. Furthermore, ASTE was found to promote bile acid excretion and the growth of Akkermansia by altering gene expression and reshaping gut microbiota.
Article
Food Science & Technology
Xiaotian Xu, Ailin Luo, Xi Lu, Meng Liu, Huideng Wang, Hengzhi Song, Chengqiong Wei, Yuhui Wang, Xiaoqun Duan
Summary: The study demonstrates that HA, an active metabolite of HD, can alleviate colitis and promote intestinal mucosal repair by activating the ERB signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Agnes Draxler, Amelie Blaschke, Jessica Binar, Maria Weber, Michael Haslacher, Viktoria Bartak, Laura Bragagna, George Mare, Lina Maqboul, Rebecca Klapp, Theresa Herzog, Marton Sz, Agnese Petrera, Brenda Laky, Karl-Heinz Wagner, Rainer Thell
Summary: COVID-19 infections are associated with changes in inflammatory pathways and oxidative stress, leading to DNA damage. This study found elevated levels of inflammatory proteins in the serum of COVID-19 patients, as well as increased DNA damage in younger patients. Although oxidative stress markers were not altered, there was an increase in the ratio of oxidized to reduced glutathione and a decrease in unconjugated bilirubin levels in COVID-19 patients.
Article
Pharmacology & Pharmacy
Vanessa D'Antongiovanni, Luca Antonioli, Laura Benvenuti, Carolina Pellegrini, Clelia Di Salvo, Marco Calvigioni, Adelaide Panattoni, Larisa Ryskalin, Gianfranco Natale, Sebastiano Banni, Gianfranca Carta, Emilia Ghelardi, Matteo Fornai
Summary: Treatment with Saccharomyces boulardii CNCM I-745 prevents diclofenac-induced enteropathy through anti-inflammatory and antioxidant activities, likely by improving butyrate uptake by the enteric mucosa.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nannan Zhao, Yuhang Yang, Chen Chen, Tengfang Jing, Yun Hu, Haixu Xu, Shuai Wang, Yu He, Enqi Liu, Jue Cui
Summary: Betaine attenuates colitis by regulating the inflammatory response, enhancing the intestinal barrier, and altering gut microbiota, making it a potential treatment for human diseases.
Article
Medicine, General & Internal
Hong-Xia Pan, Chang-Song Zhang, Chia-Hui Lin, Min-Min Chen, Xiao-Zhong Zhang, Nong Yu
Summary: The protein expression of MUC1 and IL-11 in the intestinal mucosa of children with NEC is significantly downregulated after surgery, while the serum levels of TNF-alpha and IL-1 beta are significantly elevated. The protein expression of MUC-1 and IL-11 negatively correlates with serum inflammatory response factors in children with NEC.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Nursing
Hannah G. Juncker, Michelle Romijn, Veerle N. Loth, Eliza J. M. Ruhe, Sjors Bakker, Saskia Kleinendorst, Christianne J. M. de Groot, Dasja Pajkrt, Aniko Korosi, Johannes B. van Goudoever, Marit J. van Gils, Britt J. van Keulen
Summary: In lactating mothers in the Netherlands, 23.1% of human milk contains IgA antibodies against SARS-CoV-2. This suggests that many breastfed infants may receive passive immunity and protection against COVID-19.
JOURNAL OF HUMAN LACTATION
(2021)
Article
Nutrition & Dietetics
Britt J. van Keulen, Michelle Romijn, Albert Bondt, Kelly A. Dingess, Eva Kontopodi, Karlijn van der Straten, Maurits A. den Boer, Judith A. Burger, Meliawati Poniman, Berend J. Bosch, Philip J. M. Brouwer, Christianne J. M. de Groot, Max Hoek, Wentao Li, Dasja Pajkrt, Rogier W. Sanders, Anne Schoonderwoerd, Sem Tamara, Rian A. H. Timmermans, Gestur Vidarsson, Koert J. Stittelaar, Theo T. Rispens, Kasper A. Hettinga, Marit J. van Gils, Albert J. R. Heck, Johannes B. van Goudoever
Summary: The study found that human milk from mothers who recovered from COVID-19 contains SARS-CoV-2 specific antibodies, which retained neutralization capacity after pasteurization using High Pressure Pasteurization (HPP). This suggests a safe and effective immunization strategy post-HPP.
Article
Nutrition & Dietetics
Stefanie M. P. Kouwenhoven, Manja Fleddermann, Martijn J. J. Finken, Jos W. R. Twisk, Eline M. van der Beek, Marieke Abrahamse-Berkeveld, Bert J. M. van de Heijning, Dewi van Harskamp, Johannes B. van Goudoever, Berthold Koletzko
Summary: The study found that reducing protein intake by 20% did not result in a different metabolic profile in formula-fed infants at 4 months of age. Formula-fed infants had lower insulin sensitivity compared to breast-fed infants. There were associations between all metabolic and hormonal markers (except for IGF-1) determined at age 4 months and growth and body composition up to two years of age.
Article
Nutrition & Dietetics
Elise Mank, Eva Kontopodi, Annemieke C. Heijboer, Ruurd M. van Elburg, Kasper Hettinga, Johannes B. van Goudoever, Letty van Toledo
Summary: This study compared the effect of different techniques on the insulin concentration in donor human milk (DHM) and found that thermoultrasonication (TUS), ultraviolet-C irradiation (UV-C), and high-pressure processing (HPP) can preserve insulin in DHM. These new techniques may serve as alternatives to holder pasteurization (HoP).
CLINICAL NUTRITION
(2021)
Article
Nursing
Hannah G. Juncker, Sien J. Mulleners, Marit J. van Gils, Christianne J. M. de Groot, Dasja Pajkrt, Aniko Korosi, Johannes B. van Goudoever, Britt J. van Keulen
Summary: The study aimed to determine the effect of vaccination with BNT162b2 on the levels of SARS-CoV-2 specific IgA in human milk. A biphasic response was observed, with SARS-CoV-2 specific IgA levels starting to increase between day 5 and 7 after the first dose of the vaccine, and an accelerated response after the second dose. This suggests that vaccination can lead to the presence of SARS-CoV-2 specific antibodies in human milk, potentially providing protection to infants against COVID-19.
JOURNAL OF HUMAN LACTATION
(2021)
Article
Virology
Joanna Kaczorowska, Aurelija Cicilionyte, Anne L. Timmerman, Martin Deijs, Maarten F. Jebbink, Johannes B. van Goudoever, Britt J. van Keulen, Margreet Bakker, Lia van der Hoek
Summary: Research has shown that beta- and gammatorqueviruses colonize humans in the first few months of life, and breastfeeding may play a role in their transmission.
Article
Nursing
Sien J. Mulleners, Hannah G. Juncker, Marit J. van Gils, Johannes B. van Goudoever, Britt J. van Keulen
Summary: Heterologous vaccination with AZD1222 and an mRNA-based vaccine can elicit a significant SARS-CoV-2 specific IgA response in human milk.
JOURNAL OF HUMAN LACTATION
(2022)
Review
Nutrition & Dietetics
Stefanie M. P. Kouwenhoven, Jacqueline Muts, Martijn J. J. Finken, Johannes B. van Goudoever
Summary: This article discusses the relationship between low-protein infant formula and the risk of obesity, analyzing and summarizing trials with different protein intake levels in formula-fed infants.
Article
Biology
Sien J. J. Mulleners, Hannah G. G. Juncker, Eliza J. M. Ruhe, Aniko Korosi, Johannes B. B. van Goudoever, Marit J. J. van Gils, Britt J. J. van Keulen
Summary: The longitudinal study investigated the antibody response in human milk of lactating women who received an mRNA-based booster vaccine for SARS-CoV-2. The results showed that both homologous and heterologous boosters enhanced SARS-CoV-2-specific antibodies in human milk. This study suggests that booster immunization may restore and prolong passive immunity for infants through human milk.
COMMUNICATIONS BIOLOGY
(2023)
Article
Infectious Diseases
Sanne J. M. Zilver, Christianne J. M. de Groot, Marloes Grobben, Sharon Remmelzwaal, Esmee Burgers, Daniela Nunez Velasco, Hannah G. Juncker, Britt J. van Keulen, Johannes B. van Goudoever, Robert A. de Leeuw, Marit J. van Gils, Carrie Ris-Stalpers, Elisabeth van Leeuwen
Summary: This study aimed to determine the optimal timing of COVID-19 vaccination to protect pregnant women and neonates. The results suggest that vaccination in early second trimester is advised for the optimum balance between maternal and placental antibody transfer to the neonate.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Microbiology
Nina M. Frerichs, Sofia el Manouni el Hassani, Nancy Deianova, Mirjam M. van Weissenbruch, Anton H. van Kaam, Daniel C. Vijlbrief, Johannes B. van Goudoever, Christian V. Hulzebos, Boris. W. Kramer, Esther J. d'Haens, Veerle Cossey, Willem P. de Boode, Wouter J. de Jonge, Alfian N. Wicaksono, James A. Covington, Marc A. Benninga, Nanne K. H. de Boer, Hendrik J. Niemarkt, Tim G. J. de Meij
Summary: Early detection of late-onset sepsis (LOS) in preterm infants is essential. Fecal volatile organic compounds (VOCs) can serve as a non-invasive biomarker for detecting LOS. The study analyzed fecal samples of LOS infants and matched controls using gas chromatography-ion mobility spectrometry and gas chromatography-time of flight-mass spectrometry. Differences in VOCs were found before the onset of Escherichia coli LOS and gram-negative LOS. This study highlights the potential of VOCs as a non-invasive preclinical diagnostic biomarker for LOS.
Article
Pediatrics
Hannah Hoeben, Milene T. Alferink, Anne A. M. W. van Kempen, Johannes B. van Goudoever, Nicole R. van Veenendaal, Sophie R. D. van der Schoor
Summary: This study aims to evaluate the effectiveness of family-centered rounds (FCR) in family-integrated care and explore their impact on parents, infants, healthcare professionals, and organizations. By conducting a randomized trial and analyzing biomarkers, this study hopes to provide evidence on FCR and offer practical materials for other hospitals.
Article
Multidisciplinary Sciences
Hannah G. Juncker, Maritt van Doesburg, Christianne J. M. de Groot, Dasja Pajkrt, Aniko Korosi, Marit J. van Gils, Johannes B. van Goudoever, Britt J. van Keulen
Summary: This study examines the impact of physical activity on SARS-CoV-2-specific antibodies in human milk and serum. Through questionnaire surveys and experimental analysis, it was found that the intensity of physical activity is associated with antibody levels in human milk and serum, while the duration of exercise is not. These findings suggest that physical activity contributes to enhanced immune protection against COVID-19 for infants.
Article
Pediatrics
Nicole R. van Veenendaal, Nanon H. M. Labrie, Silke Mader, Anne A. M. W. van Kempen, Sophie R. D. van der Schoor, Johannes B. van Goudoever
Summary: This study aims to understand the facilitators and barriers to parent-infant closeness in neonatal care in 19 countries. The study found that despite the implementation of family integrated care practices, parent-infant separation is still common in neonatal and/or maternity care. The study also identified culture, collaboration, capacities, and coaching as key factors affecting parent-infant closeness.
PEDIATRIC INVESTIGATION
(2022)
Article
Education, Special
A. M. Nieuwenhuijse, D. L. Willems, J. B. van Goudoever, E. Olsman
Summary: This article explores the perspectives of professional caregivers on the Quality of Life (QoL) of persons with Profound Intellectual and Multiple Disabilities (PIMD). Professional caregivers mostly describe good QoL in emotional terms such as happiness and pleasure, while poor QoL is described in physical terms such as pain and sickness. They assess QoL through sensing, testing, and discussing with colleagues, emphasizing the dependency of PIMD individuals on caregivers. The relationship between QoL of PIMD individuals and professional caregivers requires further investigation.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL DISABILITIES
(2022)