Article
Physiology
Evgenia Dobrinskikh, Laura G. Sherlock, David J. Orlicky, Lijun Zheng, Robyn De Dios, Durga Balasubramaniyan, Thom Sizemore, Brittany Butler, Clyde J. Wright
Summary: Research has shown that toxic exposure to APAP can cause lung injury, changes in lung metabolism, and inflammation, indicating the need to examine both the acute and long-term pulmonary effects of APAP exposure during the perinatal period.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Thea N. Golden, Alessandro Venosa, Andrew J. Gow
Summary: In this study, macrophage origin was found to be a key determinant in the response to acute lung injury (ALI). By inhibiting iNOS, inflammation and recruitment in the lungs could be reduced.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Tianlong Li, Jiahao Zhang, Minghui Long, Xiaofang Jiang, Cheng Yang, Fengqin Wang, Lianjiu Su, Zhiyong Peng
Summary: This study found that serum MIF level might serve as a biomarker for predicting the occurrence, development, and outcomes of septic AKI.
Review
Clinical Neurology
Seyed Mohammad Piri, Zahra Ghodsi, Sina Shool, Ali Anjomshoa, Amir Azarhomayoun, Ehsan Jangholi, Hamid Reza Dehghan, Rasha Atlasi, Alexander R. Vaccaro, Vafa Rahimi-Movaghar
Summary: This study systematically reviewed the role of MMIF as a therapeutic target in SCI, showing that MMIF inhibition might be a potential therapeutic target through multiple different mechanisms. Most animal studies demonstrated significant neurologic improvement after administration of MMIF inhibitors, but these inhibitors have not been studied in humans yet.
EUROPEAN SPINE JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Mengmeng Ma, Tianping Bao, Jingyan Li, Linxia Cao, Bingrui Yu, Jingjing Hu, Huaiping Cheng, Zhaofang Tian
Summary: This study aimed to explore the role of the anti-inflammatory and anti-fibrotic drug Cryptotanshinone (CTS) in the treatment of inflammation and fibrosis in bronchopulmonary dysplasia (BPD). Results showed that CTS can attenuate the inflammatory response and level of fibrosis in BPD. The therapeutic potential of CTS in the treatment of BPD was highlighted.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Akos Tiboldi, Eva Hunyadi-Gulyas, Peter Wohlrab, Johannes A. Schmid, Klaus Markstaller, Klaus Ulrich Klein, Verena Tretter
Summary: Patients with ARDS often require mechanical ventilation and supplemental oxygen, but hyperoxia can cause lung injury. Hyperoxia-induced lung injury is a second hit to pre-existing lung injury, and ventilator-induced lung injury is attributed to oxidative stress. In our study, we investigated the effects of different oxygen conditions on the lung endothelium using a proteomic approach.
Review
Physiology
Yiwei Du, Hao Hao, Heng Ma, Hongbao Liu
Summary: Acute kidney injury (AKI) is a complex clinical syndrome with multiple etiologies and pathogenesis. Macrophage migration inhibitory factor (MIF) family proteins play a crucial role in AKI, but they can have both protective and detrimental effects on renal injury. Therefore, understanding the biological role and potential therapeutic targets of MIF family proteins in AKI is of great importance.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pediatrics
Xueyu Chen, Junyan Zhong, Dongshan Han, Fang Yao, Jie Zhao, Gerry. T. M. Wagenaar, Chuanzhong Yang, Frans J. Walther
Summary: Bronchopulmonary dysplasia (BPD) is a neonatal chronic lung disease with characteristics of arrested alveolar and vascular development, caused by lung immaturity, ventilator-induced lung injury, and hyperoxia exposure. Studies have shown a close association between platelet biogenesis and alveolarization in the developing lung. This association may explain the reduced platelet count in extremely premature infants with BPD.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pediatrics
Wenwen Chen, Ran Wang, Chao Chen
Summary: Neonatal hyperoxia exposure causes lung development arrest and impedes myelination in immature brain white matter, characterized by decreased myelin basic protein (MBP) and persistent astrogliosis.
Article
Medical Laboratory Technology
Jun-Xia Dai, Qun Lin, Hua-Jun Ba, Liang-Zhi Ye, Zhi-Wei Li, Jian-Yong Cai
Summary: This study found that serum MIF concentration was significantly higher in patients with severe traumatic brain injury compared to healthy controls, and was closely correlated with Glasgow coma scale scores and C-reactive protein concentration. Serum MIF concentration may be a useful biomarker for early detection of posttraumatic cerebrocardiac syndrome.
CLINICA CHIMICA ACTA
(2021)
Article
Cell Biology
Jung Yeon Hong, Mi Na Kim, Eun Gyul Kim, Jae Woo Lee, Hye Rin Kim, Soo Yeon Kim, Soon Min Lee, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn
Summary: Exposure to high oxygen concentrations leads to excessive generation of reactive oxygen species, causing cellular injury and multiple organ dysfunctions. Clusterin (CLU) expression is increased during prolonged hyperoxia-induced lung injury, and replenishment of CLU can alleviate hyperoxia-induced cell death.
Article
Virology
Alperen Aksakal, Bugra Kerget, Ferhan Kerget, Seda Askin
Summary: The study revealed the correlation between serum migration inhibitory factor (MIF) level and disease severity in COVID-19, with higher MIF levels potentially indicating a more severe condition. MIF levels can serve as an important predictive indicator for early disease prognosis in COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ziyu Chen, HaiQiang Lan, ZhaoHong Liao, JingWen Huang, XiaoTing Jian, Jijie Hu, Hua Liao
Summary: This review summarizes the role and functioning process of Treg cells in the treatment of skeletal muscle diseases, emphasizing their importance in skeletal muscle repair and providing new research perspectives.
CELL AND BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Juan Cai, Lin Huang, Hongri Tang, Hongling Xu, Lingjun Wang, Minghui Zheng, Hongsong Yu, Hui Liu
Summary: The MIF produced by Thelazia callipaeda can induce M2-like macrophage polarization through TLR4-mediated activation of the PI3K-Akt pathway, potentially aiding in disrupting the host immune system.
Article
Biochemistry & Molecular Biology
Mauro Vasella, Stefan Wolf, Eamon C. Francis, Gerrit Grieb, Pablo Pfister, Gregory Reid, Juergen Bernhagen, Nicole Lindenblatt, Epameinondas Gousopoulos, Bong-Sung Kim
Summary: Lipedema is a chronic disorder mainly affecting women, with an unknown etiology. Recent research suggests that the accumulation and polarization of macrophages may be involved in lipedema. This study provides evidence for the potential involvement of the MIF family, specifically the MIF-1-CD74 axis, in lipedema.
Article
Multidisciplinary Sciences
Shaojing Ye, Fei Ma, Dlovan F. D. Mahmood, Katherine L. Meyer-Siegler, Raymond E. Menard, David E. Hunt, Lin Leng, Richard Bucala, Pedro L. Vera
Summary: The study showed that urothelial MIF receptors CD74 and CXCR4 mediate bladder pain by releasing urothelial HMGB1. This mechanism may establish persistent pain loops in the bladder, indicating potential novel targets for interrupting bladder pain.
Review
Cell & Tissue Engineering
Ting Xie, Heather Lynn, William C. Parks, Barry Stripp, Peter Chen, Dianhua Jiang, Paul W. Noble
Summary: Recent advances in single-cell RNA sequencing and epithelium lineage labeling have identified multiple abnormal epithelial progenitor populations during lung regeneration after fibrotic injury. These abnormal cells, including basaloid/basal-like cells, ATII transition cells, and persistent epithelial progenitors (PEPs), accumulate in response to both chronic and acute pulmonary injury. Among these progenitors, PEPs express a distinct Krt8(+) phenotype rarely found in intact alveoli. Understanding the characteristics and functions of these abnormal epithelial progenitors and the signaling pathways regulating their phenotype could lead to new therapeutic targets for fibrosing lung diseases.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Neurosciences
Shaojing Ye, Fei Ma, Dlovan F. D. Mahmood, Katherine L. Meyer-Siegler, Lin Leng, Richard Bucala, Pedro L. Vera
Summary: Activation of intravesical PAR4 receptors leads to bladder hyperalgesia through release of urothelial MIF and HMGB1. NACA and EP partially block PAR4-induced hyperalgesia, while FR180204 has no effect. There is a significant correlation between intravesical HMGB1 levels and pain threshold.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
J. J. Shin, W. Fanr, J. Par-Youngs, M. Piecychna, L. Leng, K. Israni-Winger, H. Qing, J. Gu, H. Zhao, W. L. Schulz, S. Unlu, J. Kuster, G. Young, J. Liu, A. Ko, A. Baeza Garcia, M. Sauler, A. Wisnewski, L. Young, A. Orduna, A. Wang, K. Ocskay, A. Garcia-Blesa, P. Hegyi, M. E. Armstrong, P. D. Mitchell, D. Bernardo, A. Garami, I Kang, R. Bucala
Summary: This study found that the high-expression MIF CATT(7) allele was less frequent in COVID-19 patients compared to healthy controls, but more frequent in hospitalized patients compared to outpatients. In addition, hospitalized COVID-19 patients had higher serum MIF levels compared to outpatients and uninfected healthy controls. Experimental mice with a high-expression MIF allele showed more severe disease than those with a low-expression MIF allele. Therefore, the polymorphism of the MIF gene is associated with susceptibility to COVID-19 and disease severity.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Tianyang Mao, Benjamin Israelow, Mario A. Pena-Hernandez, Alexandra Suberi, Liqun Zhou, Sophia Luyten, Melanie Reschke, Huiping Dong, Robert J. Homer, W. Mark Saltzman, Akiko Iwasaki
Summary: This study developed a vaccine strategy called prime and spike, which activates mucosal immune memory within the respiratory tract and induces strong immune responses. It enhances both systemic and local immunity against SARS-CoV-2, and provides full protection against lethal infection in partially immune mice.
Article
Virology
Cesar Trifone, Lucia Baquero, Alejandro Czernikier, Paula Benencio, Lin Leng, Natalia Laufer, Maria Florencia Quiroga, Richard Bucala, Yanina Ghiglione, Gabriela Turk
Summary: In this study, the role of the MIF/CD74 axis in CD4(+) T lymphocytes during HIV infection was evaluated. The results suggest that MIF stimulation may contribute to viral pathogenesis by generating a microenvironment enriched in activating mediators and Th17-like CD4TLs. These findings establish a basis for considering MIF as a possible therapeutic target.
Article
Cell Biology
Keren David, Gilgi Friedlander, Bianca Pellegrino, Lihi Radomir, Hadas Lewinsky, Lin Leng, Richard Bucala, Idit Shachar, Shirly Becker Herman
Summary: This study investigated the transcriptional and regulatory function of CD74-ICD in normal B cells. It was found that CD74-ICD forms a complex with PAX5 and binds to chromatin at a higher number of sites compared to CLL cells. The CD74-ICD:PAX5 complex also downregulates the expression of the tumor-suppressor gene DMTF1 through transcriptional inhibition.
Article
Rheumatology
Wei Fan, Jennefer Par-Young, Kaiyan Li, Yi Zhang, Pingping Xiao, Li Hua, Lin Leng, Xuyan Chen, Richard Bucala
Summary: This retrospective study aimed to describe the clinical profiles and high-risk indicators of primary Sjogren's syndrome (pSS) patients with central nervous system (CNS) involvement (pSS-CNS). The study found that the prevalence of CNS involvement in pSS patients was 10.2%, with neurological manifestations as the initial symptom in 31.3% of the cases. Hemiparesis, paraparesis, dysphonia, blurred vision, and dysfunctional proprioception were common manifestations in pSS-CNS patients. Cerebral infarction, demyelination, myelitis, and angiostenosis were commonly found on imaging in these patients. Lung involvement, positive anti-SSA antibody test, and reduced C3 levels were identified as potential risk factors for CNS involvement in pSS. High-dose glucocorticoids and immunosuppressive therapy were effective in improving the condition in 60% of pSS-CNS patients.
CLINICAL RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xue Liu, Kristy Dai, Xuexi Zhang, Guanling Huang, Heather Lynn, Anas Rabata, Jiurong Liang, Paul W. Noble, Dianhua Jiang
Summary: This study identified and confirmed novel fibroblast subtypes in lung fibrosis through analyzing single-cell RNA sequencing data of mouse models and human lung fibrotic diseases. The researchers also identified specific cell surface proteins for each fibroblast subtype and found that lipofibroblasts and Ebf11 fibroblasts contribute to matrix deposition and possess enhanced invasive, proliferative, and contraction phenotypes. The study provides new insights for the development of therapeutics targeting lung fibroblast subtypes.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Cell Biology
Shaojing Ye, Dlovan F. D. Mahmood, Fei Ma, Lin Leng, Richard Bucala, Pedro L. Vera
Summary: Activation of intravesical protease activated receptors-4 (PAR4) leads to bladder pain through the release of urothelial macrophage migration inhibitory factor (MIF) and high mobility group box-1 (HMGB1). This study aimed to identify the downstream signaling events of HMGB1 at the bladder that cause HMGB1-induced bladder pain in MIF-deficient mice. The results showed that HMGB1 increased urothelial oxidative stress and ERK activation, which mediated bladder pain. Pre-treatment with N-acetylcysteine amide (NACA) or selective ERK1/2 inhibitor (FR) prevented HMGB1-induced bladder pain.
Article
Multidisciplinary Sciences
Yiheng Huang, Donghong Cui, Liujun Chen, Haibin Tong, Hong Wu, Grace K. Muller, Yadan Qi, Shuxia Wang, Jinjie Xu, Xiang Gao, Kathleen E. Fifield, Lingyan Wang, Zhengyuan Xia, Jacqueline L. Vanderluit, Suixin Liu, Lin Leng, Guang Sun, John McGuire, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: This study reports a non-inflammatory adipose mechanism of high fat-induced insulin resistance mediated by the loss of Pref-1. Pref-1, released from adipose Pref-1+ cells, inhibits MIF release from both Pref-1+ cells and adipocytes. High palmitic acid induces PAR2 expression in Pref-1+ cells, downregulating Pref-1 expression and release in an AMPK-dependent manner. The loss of Pref-1 increases adipose MIF secretion contributing to non-inflammatory insulin resistance in obesity.
Article
Multidisciplinary Sciences
Ilianna Barbayianni, Paraskevi Kanellopoulou, Dionysios Fanidis, Dimitris Nastos, Eleftheria-Dimitra Ntouskou, Apostolos Galaris, Vaggelis Harokopos, Pantelis Hatzis, Eliza Tsitoura, Robert Homer, Naftali Kaminski, Katerina M. Antoniou, Bruno Crestani, Argyrios Tzouvelekis, Vassilis Aidinis
Summary: This study found that the formation of podosomes in lung fibroblasts is closely associated with extracellular matrix invasion in patients with idiopathic pulmonary fibrosis and mouse models. Targeting podosome formation or organization may be a potential therapeutic option for pulmonary fibrosis.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Jiurong Liang, Guanling Huang, Xue Liu, Forough Taghavifar, Ningshan Liu, Yizhou Wang, Nan Deng, Changfu Yao, Ting Xie, Vrishika Kulur, Kristy Dai, Ankita Burman, Simon C. Rowan, S. Samuel Weigt, John Belperio, Barry Stripp, William C. Parks, Dianhua Jiang, Paul W. Noble
Summary: This study identified a deficiency of the zinc transporter SLC39A8 (ZIP8) in Type 2 alveolar epithelial cells (AEC2s) from both idiopathic pulmonary fibrosis (IPF) lungs and lungs of old mice, which is associated with impaired AEC2 renewal capacity and enhanced lung fibrosis. The regulation of AEC2 progenitor function by ZIP8 is dependent on SIRT1. Replenishment with exogenous zinc and activation of SIRT1 promote self-renewal and differentiation of AEC2s, and therapeutic strategies targeting zinc metabolism and SIRT1 signaling could potentially improve AEC2 progenitor function and mitigate fibrogenesis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Letter
Biochemistry & Molecular Biology
Xue Liu, Yinshan Fang, Paul W. W. Noble, Jianwen Que, Dianhua Jiang
MOLECULAR BIOMEDICINE
(2021)
Meeting Abstract
Medicine, General & Internal
Simon C. Rowan, Xue Liu, Jiurong Liang, Yizhou Wang, Paul W. Noble, Dianhua Jiang
IRISH JOURNAL OF MEDICAL SCIENCE
(2021)