Review
Dermatology
Leonie Huitema, Taylor Phillips, Vitali Alexeev, Olga Igoucheva
Summary: Hereditary epidermolysis bullosa is a mechanobullous skin fragility disorder characterized by skin blistering under mechanical stress, with no cure currently available. Recent data suggest systemic immunological defects in patients, particularly affecting antibacterial immunity.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Ignacia Fuentes, Maria Joao Yubero, Pilar Morande, Carmen Varela, Karen Orostica, Francisco Acevedo, Boris Rebolledo-Jaramillo, Esteban Arancibia, Lorena Porte, Francis Palisson
Summary: Epidermolysis bullosa (EB) is a genetic disorder characterized by fragile skin and the formation of blisters and wounds. This study investigated the bacterial composition and susceptibility in wound resolution of severe EB patients in Chile. The findings showed that bacterial colonization, including the presence of Staphylococcus aureus, had a significant impact on wound healing. Notably, ciprofloxacin-resistant SA was more common in chronic wounds, and atoxigenic Corynebacterium diphtheriae was the second most abundant bacteria found. Infection was found to be negatively associated with wound healing status.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Vitali Alexeev, Leonie Huitema, Taylor Phillips, Rodrigo Cepeda, Diego de los Cobos, Regina Isabella Matus Perez, Mauricio Salas-Garza, Oscar R. Fajardo-Ramirez, Franziska Ringpfeil, Jouni Uitto, Julio Cesar Salas-Alanis, Olga Igoucheva
Summary: This study found that RDEB wounds and epithelial cells are frequently infected with Staphylococcus sp. and Pseudomonas sp. RDEB wound-associated T cells contain CD4(+) and CD8(+) peripheral memory T cells that respond to microbial antigens, and CD8(+) cytotoxic T lymphocytes can recognize and kill infected cells. However, in RDEB, immune suppression mediated by PD-1/Treg may inhibit adaptive T cell-mediated immunity.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Immunology
Laura Garcia-Espinosa, Teresa del Rosal, Lucia Quintana, Rocio Maseda, Carlos Grasa, Iker Falces-Romero, Juan Jose Menendez-Suso, Isabel Perez-Conde, Ana Mendez-Echevarria, Francisco Javier Aracil Santos, Luis Alfonso Alonso, Raul de Lucas, Cristina Calvo, Fernando Baquero-Artigao
Summary: This retrospective study examined 37 episodes of bloodstream infections (BSI) in 126 children with epidermolysis bullosa (EB) in Spain from 2015 to 2020. The most common pathogens were Pseudomonas aeruginosa and Staphylococcus aureus. Skin cultures performed in the previous 2 months were helpful in guiding treatment decisions for EB patients with sepsis.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Dermatology
C. L. Ebens, J. A. McGrath, J. A. Riedl, A. R. Keith, G. Lilja, S. Rusch, D. R. Keene, S. F. Tufa, M. J. Riddle, R. Shanley, A. E. Van Heest, J. Tolar
Summary: This study evaluated the effects of allogeneic epidermal skin grafts on wound healing and durability in patients with RDEB. The results showed significant reductions in wound area, successful fusion of epidermal grafts, and improvement in RDEB pseudosyndactyly.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Karen Snelson, Annette Downe
Summary: In recent years, the use of topical morphine gel has increased in palliative care to reduce pain in chronic wounds and fungating tumours, but there is limited evidence supporting its effectiveness. This study aims to demonstrate the efficacy of topical morphine gel in various types of EB wounds and the reported reduction in pain by patients through case studies.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Food Science & Technology
Anna Budzynska, Krzysztof Skowron, Agnieszka Kaczmarek, Magdalena Wietlicka-Piszcz, Eugenia Gospodarek-Komkowska
Summary: Staphylococcus aureus strains isolated from chronic wounds show higher resistance to antibiotics and harbor more virulence genes compared to strains isolated from blood, indicating a greater threat in wound infections.
Review
Dermatology
Magdalena Nita, Jacek Pliszczynski, Maciej Kosieradzki, Piotr Fiedor
Summary: Epidermolysis bullosa (EB) is a hereditary genetic skin disorder without effective therapy or cure at present. However, advances in treatment methods such as gene therapy and protein replacement therapy have raised hopes for modifying the disease and improving patients' quality of life. Tissue engineering scientists are developing materials to mimic the structure and natural healing process for promoting skin reconstruction.
DERMATOLOGY AND THERAPY
(2021)
Article
Cell Biology
Elham Torkamaniha, Mohammad Amir Amirkhani, Mostafa Dahmardehei, Paolo Rebulla, Andrea Piccin, Shamim Hortamani, Maryam Heidari-Kharaji, Parvin Mansouri, Amir Ali Hamidieh, Mohammad Ali Nilforoushzadeh
Summary: Epidermolysis bullosa (EB) is a rare genetic disorder characterized by blisters and wounds in skin and mucous membranes, which can be managed through proper wound care and prevention techniques to improve patient's quality of life. In this study, the therapeutic effects of allogeneic platelet gel from umbilical cord blood were investigated in DEB patients, showing promising results in promoting wound healing and reducing pain levels post-surgery.
WOUND REPAIR AND REGENERATION
(2021)
Article
Public, Environmental & Occupational Health
Ambrina Khatoon, Syed F. Hussain, Syed M. Shahid, Santosh Kumar Sidhwani, Salman Ahmed Khan, Omer Ahmed Shaikh, Abdulqadir J. Nashwan
Summary: Despite the increasing incidence of Staphylococcus aureus infection and dissemination in Pakistan, research on the epidemiology of different Staphylococcus aureus clones has been limited. This study used multilocus sequence typing (MLST) to analyze the epidemiology of Staphylococcus aureus in the area, finding high diversity of locally circulating clones defined by their geographic epidemiology.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2024)
Letter
Dermatology
Manrup K. Hunjan, Ajoy Bardhan, Louise Zuzarte, Dario Leonardo Balacco, Natasha Harper, Adrian Heagerty
Summary: Our study shows that severity scores do not correlate well with the impact of localized EBS on quality of life. There is a lack of research examining the relationship between disease severity and patient-reported outcome measures in EB. Current scoring systems fail to account for the palmoplantar blistering and keratoderma which significantly affect the morbidity in EBS patients.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Engineering, Biomedical
Mahdi Zafari, Mahsa Adibi, Mohsen Chiani, Negin Bolourchi, Seyed Mahmoud Barzi, Mohammad Sadegh Shams Nosrati, Zeinab Bahari, Parisa Shirvani, Kambiz Akbari Noghabi, Mojgan Ebadi, Nazanin Rahimirad, Morvarid Shafiei
Summary: The study aimed to evaluate the anti-biofilm activity of cefazolin-loaded nanoparticles against MRSA isolates, showing promising results in effectively treating biofilm-mediated infections.
BIOMEDICAL MATERIALS
(2021)
Article
Materials Science, Textiles
Ngan Yi Kitty Lam, Xue Luo, Li Li
Summary: By interviewing EB patients, children with EB, and their parents, this study systematically investigated the needs for functional apparel that alleviates the symptoms of EB, and found that the proposed apparel system not only meets the needs of EB patients, but also other patients with skin diseases.
JOURNAL OF THE TEXTILE INSTITUTE
(2022)
Article
Dermatology
Fuying Chen, Ruoqu Wei, Dan Deng, Xue Zhang, Yu Cao, Chaolan Pan, Yumeng Wang, Qiaoyu Cao, Jianbo Wang, Ming Zeng, Linting Huang, Yan Gu, Zhirong Yao, Ming Li
Summary: This study analyzed the genotype-phenotype correlation in Chinese individuals with EB and identified rare phenotypes and complex genotypes.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Genetics & Heredity
Alex du Rand, John M. T. Hunt, Vaughan Feisst, Hilary M. Sheppard
Summary: Skin wound healing is a crucial process, especially for individuals with epidermolysis bullosa (EB) who suffer from severe blistering and poor healing. Investigational therapies using tissue-engineered skin substitutes have shown promising results in promoting long-term wound closure. Different types of substitutes have been developed and tested, with epidermal substitutes demonstrating encouraging efficacy. However, the molecular heterogeneity between EB subtypes poses challenges, and autologous composite substitutes are being investigated as a potential solution. Future research is also focused on using gene-corrected patient skin cells for improved long-term wound healing.
MOLECULAR DIAGNOSIS & THERAPY
(2022)
Article
Multidisciplinary Sciences
Corinna Glasner, Mirjan M. van Timmeren, Tim Stobernack, Till F. Omansen, Erwin C. Raangs, John W. Rossen, Marcus C. de Goffau, Jan P. Arends, Greetje A. Kampinga, Denny G. A. M. Koedijk, Jolanda Neef, Girbe Buist, Mehri Tavakol, Willem J. B. van Wamel, Abraham Rutgers, Coen A. Stegeman, Cees G. M. Kallenberg, Peter Heeringa, Jan Maarten van Dijl
SCIENTIFIC REPORTS
(2015)
Article
Infectious Diseases
Till F. Omansen, Jessica L. Porter, Paul D. R. Johnson, Tjip S. van der Werf, Ymkje Stienstra, Timothy P. Stinear
PLOS NEGLECTED TROPICAL DISEASES
(2015)
Article
Public, Environmental & Occupational Health
Matthias I. Groschel, Till F. Omansen, Wiel de Lange, Tjip S. van der Werf, Mariette Lokate, Erik Bathoorn, Onno W. Akkerman, Ymkje Stienstra
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2016)
Article
Infectious Diseases
John R. Wallace, Kirstie M. Mangas, Jessica L. Porter, Renee Marcsisin, Sacha J. Pidot, Brian Howden, Till F. Omansen, Weiguang Zeng, Jason K. Axford, Paul D. R. Johnson, Timothy P. Stinear
PLOS NEGLECTED TROPICAL DISEASES
(2017)
Article
Microbiology
Nicole C. Ammerman, Rosemary Swanson, Elaine M. Bautista, Deepak Almeida, Vikram Saini, Till F. Omansen, Haidan Guo, Yong Seok Chang, Si-Yang Li, Asa Tapley, Rokeya Tasneen, Sandeep Tyagi, Fabrice Betoudji, Chivonne Moodley, Bongani Ngcobo, Logan Pillay, Linda A. Bester, Sanil D. Singh, Richard E. Chaisson, Eric Nuermberger, Jacques H. Grosset
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Infectious Diseases
Dorien T. Beeres, Sofanne J. Ravensbergen, Annelies Heidema, Darren Cornish, Machiel Vonk, Leonie D. Wijnholds, Jessica J. H. Hendriks, Johanneke Kleinnijenhuis, Till F. Omansen, Ymkje Stienstra
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Public, Environmental & Occupational Health
Janine de Zeeuw, Sridevi Duggirala, Willemien A. Nienhuis, K. Mohammed Abass, Wilson Tuah, Till F. Omansen, Tjip S. van der Werf, Ymkje Stienstra
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2013)
Article
Infectious Diseases
Janine de Zeeuw, Till F. Omansen, Marlies Douwstra, Yves T. Barogui, Chantal Agossadou, Ghislain E. Sopoh, Richard O. Phillips, Christian Johnson, K. Mohammed Abass, Paul Saunderson, Pieter U. Dijkstra, Tjip S. van der Werf, Ymkje Stientstra
PLOS NEGLECTED TROPICAL DISEASES
(2014)
Article
Infectious Diseases
Janine de Zeeuw, Marlies Douwstra, Till F. Omansen, Ghislain E. Sopoh, Christian Johnson, Richard O. Phillips, Marike Alferink, Paul Saunderson, Tjip S. Van der Werf, Pieter U. Dijkstra, Ymkje Stienstra
PLOS NEGLECTED TROPICAL DISEASES
(2014)
Article
Microbiology
Till F. Omansen, Deepak Almeida, Paul J. Converse, Si-Yang Li, Jin Lee, Ymkje Stienstra, Tjip van der Werf, Jacques H. Grosset, Eric L. Nuermberger
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Article
Immunology
Hendrik Karsten, Leon Cords, Tim Westphal, Maximilian Knapp, Thomas Theo Brehm, Lennart Hermanussen, Till Frederik Omansen, Stefan Schmiedel, Robin Woost, Vanessa Ditt, Sven Peine, Marc Luetgehetmann, Samuel Huber, Christin Ackermann, Melanie Wittner, Marylyn Martina Addo, Alessandro Sette, John Sidney, Julian Schulze zur Wiesch
Summary: This study comprehensively compared the CD4(+) T-cell responses directed against the SARS-CoV-2 spike glycoprotein between vaccinees, COVID-19 patients, and individuals who experienced both infection and vaccination. The results showed that both SARS-CoV-2 infection and vaccination prime broadly directed T-cell responses against the spike glycoprotein.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)