Granulin Exacerbates Lupus Nephritis via Enhancing Macrophage M2b Polarization

Activated Renal Macrophages Are Markers of Disease Onset and Disease Remission in Lupus Nephritis

(2014) L. Schiffer et al.   JOURNAL OF IMMUNOLOGY

Lupus nephritis: A critical review

(2012) Andrea T. Borchers et al.   AUTOIMMUNITY REVIEWS

PGRN is a Key Adipokine Mediating High Fat Diet-Induced Insulin Resistance and Obesity through IL-6 in Adipose Tissue

(2012) Toshiya Matsubara et al.   Cell Metabolism

Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration

(2012) Basar Cenik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Production of anti-double-stranded DNA antibodies in activated lymphocyte derived DNA induced lupus model was dependent on CD4+ T cells

(2012) Z Wen et al.   LUPUS

A20 (TNFAIP3) Alleviates CVB3-Induced Myocarditis via Inhibiting NF-κB Signaling

(2012) Jun Gui et al.   PLoS One

Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity

(2012) Atsushi Tanaka et al.   ARTHRITIS RESEARCH & THERAPY

Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling

(2011) Boyoun Park et al.   IMMUNITY

Macrophage Differentiation and Polarization via Phosphatidylinositol 3-Kinase/Akt-ERK Signaling Pathway Conferred by Serum Amyloid P Component

(2011) W. Zhang et al.   JOURNAL OF IMMUNOLOGY

Structure, Function, and Mechanism of Progranulin; the Brain and Beyond

(2011) Huishi Toh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis

(2011) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Blockade of TLR9 signaling in B cells impaired anti-dsDNA antibody production in mice induced by activated syngenic lymphocyte-derived DNA immunization

(2011) Min Chen et al.   MOLECULAR IMMUNOLOGY

Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis

(2011) Marco Vercellino et al.   Multiple Sclerosis Journal

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

Amelioration of Lupus Nephritis by Serum Amyloid P Component Gene Therapy with Distinct Mechanisms Varied from Different Stage of the Disease

(2011) Weijuan Zhang et al.   PLoS One

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis

(2010) Jian Q. Feng et al.   FASEB JOURNAL

Blockade of Notch1 Signaling Alleviates Murine Lupus via Blunting Macrophage Activation and M2b Polarization

(2010) W. Zhang et al.   JOURNAL OF IMMUNOLOGY

Updates on the Treatment of Lupus Nephritis

(2010) A. S. Bomback et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages

(2010) A. Triantafyllopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The granulin gene family: from cancer to dementia

(2009) Andrew Bateman et al.   BIOESSAYS

Tripartite motif-containing 22 inhibits the activity of hepatitis B virus core promoter, which is dependent on nuclear-located RING domain

(2009) Bo Gao et al.   HEPATOLOGY

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serum Progranulin Concentrations May Be Associated With Macrophage Infiltration Into Omental Adipose Tissue

(2008) B.-S. Youn et al.   DIABETES

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark