Article
Physiology
Penghui Yuan, Taotao Sun, Zhengyang Han, Yinwei Chen, Qingjun Meng
Summary: Through multi-omics analysis, we identified the genetic alterations and corresponding regulatory network underlying the interaction between erectile dysfunction and chronic prostatitis/chronic pelvic pain syndrome. These findings expanded our understanding of the molecular mechanism of erectile dysfunction with chronic prostatitis/chronic pelvic pain syndrome.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Nasrin Aktar, Ahmed Moudud, Tingting Chen, Xiaoqing Gao, Hanhui Min, Meng Tang, Xiaohui Zhou
Summary: Chronic prostatitis/chronic pelvic pain syndrome type III is associated with irritative voiding, sexual dysfunction, and pelvic pain. Various pharmacological treatments are used clinically, but they mainly focus on symptom relief without addressing the root cause of the condition.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Cell & Tissue Engineering
Xufeng Peng, Hailin Guo, Ji Yuan, Yu Chen, Yuguo Xia, Lin Wang, Ying Wang, Yichen Huang, Hua Xie, Yang Wang, Fang Chen
Summary: The study found that administration of iMSCs-EVs significantly alleviated pain, improved voiding dysfunction, suppressed inflammatory reactions, and facilitated prostatic tissue repair. These functions are mediated by downregulating the overexpression of COX-2 and restoring the imbalance of Th1/Th2 and Treg/Th17 cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pharmacology & Pharmacy
Hanchao Liu, Zhenqing Wang, Qigen Xie, Ani Chi, Yanqing Li, Jian Dai, Min Zhang, Chunhua Deng, Guihua Liu
Summary: This study demonstrated that Ningmitai capsules can alleviate inflammation and pain in mouse prostates by affecting the CCL2-MAPK pathway, and can regulate systemic and local immunity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Andrology
Xufeng Peng, Hui Gao, Jihong Wang
Summary: Cryotherapy showed significant efficacy in treating CP/CPPS by alleviating voiding symptoms, ameliorating pain, and improving quality of life. The most noticeable improvement was in VAS after 4 weeks, while the improvement in IPSS remained stable after 4 weeks.
Article
Geriatrics & Gerontology
Yu-Chang Liu, Chung-Han Ho, Yi-Chen Chen, Chien-Chin Hsu, Hung-Jung Lin, Chia-Ti Wang, Chien-Cheng Huang
Summary: This study found that older patients with CP had a higher risk of ACS compared to those without CP in the older population. The risk of ACS increased with longer follow-up periods.
Review
Medicine, General & Internal
Hao Wang, Jiwei Zhang, Dongyue Ma, Ziwei Zhao
Summary: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common disease in urology and its treatment can be challenging. Acupuncture, as a traditional Chinese medicine therapy, has been found to improve CP/CPPS symptoms and reduce pain. This study aims to summarize the characteristics and benefits of acupuncture therapy for CP/CPPS and analyze its related mechanisms.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Orthopedics
Moheb S. Yani, Sandrah P. Eckel, Daniel J. Kirages, Larissa Rodriguez, Daniel M. Corcos, Jason J. Kutch
Summary: This study found that men with CP/CPPS have changes in neural drive that impair their ability to relax pelvic floor muscles. The impaired ability to relax was strongest in men who reported ejaculation-related pain.
Review
Urology & Nephrology
Brian A. Parsons, Sanchia Goonewardene, Saeed Dabestani, Luis Pacheco-Figueiredo, Yuhong Yuan, Valentin Zumstein, Angela M. Cottrell, Jan Borovicka, Paulo Dinis-Oliveira, Bary Berghmans, Sohier Elneil, John Hughes, Bert E. J. Messelink, Amanda C. de C. Williams, Andrew P. Baranowski, Daniel S. Engeler
Summary: Botulinum toxin A (BTX-A) may have beneficial effects on certain subtypes of chronic pelvic pain syndrome (CPPS), but the current level of clinical evidence is insufficient to recommend its use for treating CPPS.
EUROPEAN UROLOGY FOCUS
(2022)
Review
Urology & Nephrology
Brian A. Parsons, Andrew P. Baranowski, Bary Berghmans, Jan Borovicka, Angela M. Cottrell, Paulo Dinis-Oliveira, Sohier Elneil, John Hughes, Bert E. J. Messelink, Amanda C. de C. Williams, Pedro Abreu-Mendes, Valentin Zumstein, Daniel S. Engeler
Summary: Management of chronic pelvic pain remains a huge challenge, with unimodal therapeutic options often unsuccessful. Individualised multimodal management appears to be the most promising approach, leading to improvement for a large proportion of patients. The European Association of Urology Chronic Pelvic Pain Guideline Group provides an overview of important concepts for successfully diagnosing and treating this challenging disease.
Review
Urology & Nephrology
Ioannis Mykoniatis, Nikolaos Pyrgidis, Ioannis Sokolakis, Petros Sountoulides, Georgios Hatzichristodoulou, Apostolos Apostolidis, Dimitrios Hatzichristou
Summary: This study confirmed the efficacy and safety of low-intensity shockwave therapy for patients with chronic prostatitis/chronic pelvic pain syndrome through a systematic review and meta-analysis, showing significant improvements in pain and quality of life for patients.
Article
Medicine, General & Internal
Monica Magarinos Lopez, Maria Jose Lobato Rodriguez, Angela Menendez Garcia, Sophie Garcia-Cid, Ana Royuela, Augusto Pereira
Summary: The study found that women with CPP have high levels of neuroticism, low extraversion, and low conscientiousness, along with moderate to severe levels of depression, high levels of trait and state anxiety, catastrophizing, and low pain acceptance. These psychological factors are important to consider in developing interventions to improve the clinical course of CPP.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Andrology
Hailan He, Hui Luo, Biao Qian, Hui Xu, Guoxi Zhang, Xiaofeng Zou, Junrong Zou
Summary: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common and non-lethal urological condition with painful symptoms. Recent findings indicate that the autonomic nervous system plays a critical role in the pathogenesis of CP/CPPS. This review summarizes the detailed processes and mechanisms of the involvement of the autonomic nervous system in developing CP/CPPS and provides new perspectives for new therapeutic approaches.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Andrology
Nai-Wen Chen, Jing Jin, Hong Xu, Xue-Cheng Wei, Ling-Feng Wu, Wen-Hua Xie, Yu-Xiang Cheng, Yi He, Jin-Lai Gao
Summary: The study showed that the superoxide dismutase (SOD) from thermophilic bacterium HB27 has potential therapeutic effects on chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), reducing inflammation and oxidative stress.
ASIAN JOURNAL OF ANDROLOGY
(2022)
Article
Neurosciences
Shengyang Ge, Qingfeng Hu, Guowei Xia, Yifan Tan, Yijun Guo, Chuanyu Sun
Summary: This study used fMRI to analyze the spontaneous abnormal activated regions in the brains of CP/CPPS patients and found that the dysfunction in the thalamus, inferior parietal lobule, and cingulate gyrus may be implicated in the pathogenesis of CP/CPPS.