Article
Clinical Neurology
Tehila Eilam-Stock, Pamela Best, Kathleen Sherman, Michael T. Shaw, Joseph Ventura, Lauren B. Krupp, Leigh E. Charvet
Summary: The study utilized the Cognitive Assessment Interview (CAI) to assess individuals with MS, finding that processing speed, working memory, and learning and memory problems were most commonly reported. CAI ratings showed moderate correlation with self-report measures, but only mild correlation with objective neuropsychological measures specific to executive functions.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Monica N. Toba, Chiara Pagliari, Marco Rabuffetti, Norbert Nighoghossian, Gilles Rode, Francois Cotton, Lucia Spinazzola, Francesca Baglio, Raffaella Migliaccio, Paolo Bartolomeo
Summary: Differential actigraphy is a novel and objective method for quantifying motor neglect. The study found that some patients with unilateral stroke exhibit contralesional motor neglect, while the variability in lesion location suggests that motor neglect is a heterogeneous condition.
Article
Medicine, Research & Experimental
Hanadi Matar Alharthi, Muneera Mohammed Almurdi
Summary: This study investigated the association between cognitive impairment (CI) and motor dysfunction (MD) in patients with multiple sclerosis (MS). The results showed that CI was significantly associated with motor coordination, balance impairment, gait abnormalities, and increased fall risk, but not muscle strength. Therefore, fall risk and upper extremity incoordination appeared to be the best indicators of CI in patients with MS.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Rehabilitation
Lewis A. Ingram, Annie A. Butler, Matthew A. Brodie, Phu Hoang, Simon C. Gandevia, Stephen R. Lord
Summary: The upper-limb Physiological Profile Assessment (PPA) is a valid and clinically suitable assessment for evaluating upper-limb function in people with multiple sclerosis (MS). Motor speed, fine motor control, and functional tasks are the most commonly and significantly impaired domains in upper-limb function among MS patients.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Review
Chemistry, Analytical
Josko Soda, Sanda Pavelin, Igor Vujovic, Maja Rogic Vidakovic
Summary: Transcranial magnetic stimulation (TMS) is a noninvasive technique used for evaluating the corticospinal tract and primary motor cortices. Motor evoked potentials (MEPs) are important in TMS studies. This review focuses on the assessment and outcome measures of MEPs using different TMS system implementations (TMS without navigation, line-navigated TMS, and e-field-navigated TMS) to map corticospinal tract integrity in multiple sclerosis (MS) patients. The use of e-field TMS assessment is suggested to improve the accuracy of corticospinal tract integrity testing by providing a more objective correspondence with clinical classifications.
Review
Clinical Neurology
Cristina Granziera, Jens Wuerfel, Frederik Barkhof, Massimiliano Calabrese, Nicola De Stefano, Christian Enzinger, Nikos Evangelou, Massimo Filippi, Jeroen J. G. Geurts, Daniel S. Reich, Maria A. Rocca, Stefan Ropele, Alex Rovira, Pascal Sati, Ahmed T. Toosy, Hugo Vrenken, Claudia A. M. Gandini Wheeler-Kingshott, Ludwig Kappos
Summary: Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS, allowing comparisons across different regions, patients, and centres. In patients with multiple sclerosis, quantitative MRI techniques offer insight into disease mechanisms beyond what traditional MRI can provide, including assessment of diffuse damage, heterogeneity of lesions, and specific damage to CNS tissues. Emerging applications of quantitative MRI in both research and clinical settings aim to improve patient stratification, assess disease progression, and evaluate treatment response.
Article
Endocrinology & Metabolism
Kathryn L. West, Dinesh K. Sivakolundu, Mark D. Zuppichini, Monroe P. Turner, Jeffrey S. Spence, Hanzhang Lu, Darin T. Okuda, Bart Rypma
Summary: In multiple sclerosis patients, increased cerebral blood flow and oxygen metabolic rate were observed in the central motor regions, while decreased responses were found in the surrounding areas. Additionally, the physiological responses in the central and surrounding areas were correlated with motor function and white matter damage.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Cell Biology
Gianmaria Mancioppi, Laura Fiorini, Erika Rovini, Filippo Cavallo
Summary: This review highlights the importance of identifying valid and noninvasive markers for Mild Cognitive Impairment (MCI) using quantitative Motor and Cognitive Dual-Task (MCDT) with the aid of various technologies. The study emphasizes the potential clinical landmarks, risk prediction, and intervention optimization that MCDT can provide for MCI patients. However, there is still a need for standardization and harmonization of protocols in this area.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Clinical Neurology
Alessio Maranzano, Barbara Poletti, Federica Solca, Silvia Torre, Eleonora Colombo, Matteo Fare, Roberta Ferrucci, Laura Carelli, Federico Verde, Claudia Morelli, Vincenzo Silani, Nicola Ticozzi
Summary: This study found that the burden of upper motor neuron involvement is associated with the presence of behavioral impairment in ALS patients, suggesting a preferential spreading of pathology from the motor cortex to the ventromedial prefrontal and orbitofrontal cortex.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Damiano Mistri, Nicolo Tedone, Diana Biondi, Carmen Vizzino, Elisabetta Pagani, Maria A. Rocca, Massimo Filippi
Summary: This study identified five cognitive phenotypes with varying degrees of impairment in multiple sclerosis (MS) patients and described their characteristics. The findings suggest potential variations in the neural substrates of dysfunction throughout disease stages in MS.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Michelle H. Chen, Nancy D. Chiaravalloti, John DeLuca
Summary: Cognitive impairment is a common and disabling symptom in multiple sclerosis, with limited evidence supporting the efficacy of disease-modifying therapies in treating cognitive dysfunction. Cognitive rehabilitation in MS has shown promise in the past decade, with both restorative and compensatory programs proving efficacious. Clinicians should consider this low-cost, low-risk, yet effective treatment approach for their patients.
JOURNAL OF NEUROLOGY
(2021)
Article
Psychology, Multidisciplinary
Sabrina Maffezzini, Veronica Pucci, Alice Riccardi, Sonia Montemurro, Marco Puthenparampil, Paola Perini, Francesca Rinaldi, Paolo Gallo, Giorgio Arcara, Sara Mondini
Summary: This study highlights the crucial role of cognitive reserve (CR) in modulating cognitive efficiency in people with multiple sclerosis (MS). Higher levels of CR predict better cognitive performance, unless severe motor disability is present.
BEHAVIORAL SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chris W. J. van der Weijden, Jan F. Meilof, Anouk van der Hoorn, Junqing Zhu, Chunying Wu, Yanming Wang, Antoon T. M. Willemsen, Rudi A. J. O. Dierckx, Adriaan A. Lammertsma, Erik F. J. de Vries
Summary: This study aimed to evaluate [C-11]MeDAS as a PET tracer for myelin imaging in humans. The 2T3k model was found to be the optimal compartment model, and MLAIR2 was the best simplified method for quantification. [C-11]MeDAS PET can be used for quantification of myelin density in MS patients and is able to distinguish differences in myelin density within MS lesions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Environmental Sciences
Maria Cuerda-Ballester, David Martinez-Rubio, Maria Pilar Garcia-Pardo, Belen Proano, Laura Cubero, Antonio Calvo-Capilla, David Sancho-Cantus, Jose Enrique de la Rubia Orti
Summary: The objective of this study was to determine the possible relationship between motor, cognitive and emotional alterations in patients with multiple sclerosis (MS). The results showed a relationship between motor and emotional variables, specifically state anxiety was related to walking resistance. However, no relationship was found between depression and cognitive alteration and balance or walking ability, only age had an effect in these relationships.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Psychology, Multidisciplinary
Sara Lago, Francesca Bevilacqua, Maria Rosaria Stabile, Cristina Scarpazza, Valentina Bambini, Giorgio Arcara
Summary: Pragmatics, the ability to integrate language and context for effective communication, may be impaired in Multiple Sclerosis (MS). This article presents the case of an active secondary progressive MS patient whose pragmatic abilities declined markedly after receiving corticosteroid treatment.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Claudio Solaro, Rachele Di Giovanni, Erica Grange, Giampaolo Brichetto, Margit Mueller, Andrea Tacchino, Rita Bertoni, Francesco Patti, Angelo Pappalardo, Luca Prosperini, Letizia Castelli, Rosalba Rosato, Davide Cattaneo, Davide Marengo
Summary: The study aims to evaluate the associations between Manual Ability Measure-36 (MAM-36) and objective measures, including the Nine Hole Peg Test (9-HPT), Box and Block Test (BBT), and Hand Grip Strength (HGS) in people with multiple sclerosis (PwMS). The study found small correlations between MAM-36 and these objective measures, with different correlations seen in different subgroups. Combining 9-HPT and HGS can enhance the assessment of upper limb function in daily activities.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Darin T. Okuda, Orhun Kantarci, Christine Lebrun-Frenay, Maria Pia Sormani, Christina J. Azevedo, Francesca Bovis, Le H. Hua, Lilyana Amezcua, Ellen M. Mowry, Christophe Hotermans, Jason Mendoza, John S. Walsh, Christian von Hehn, Wendy S. Vargas, Stacy Donlon, Robert T. Naismith, Annette Okai, Gabriel Pardo, Pavle Repovic, Olaf Stuve, Aksel Siva, Daniel Pelletier
Summary: This study evaluated the impact of therapeutic intervention in preventing the first symptom manifestation in individuals with radiologically isolated syndrome (RIS), the pre-clinical phase of multiple sclerosis (MS). The results showed that drug treatment significantly reduced the risk of clinical symptoms.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Vincenzo Daniele Boccia, Caterina Lapucci, Maria Cellerino, Francesco Tazza, Andrea Rossi, Simona Schiavi, Maria Margherita Mancardi, Matilde Inglese
Summary: The contribution of the central vein sign (CVS) to the diagnosis of multiple sclerosis (MS) was compared between pediatric-onset (POMS) and adult-onset (AOMS) patients. The study found that CVS had lower sensitivity in POMS patients, possibly due to the exclusion of a high proportion of periventricular confluent lesions from CVS assessment.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Irene Schiavetti, Lucrezia Barcellini, Caterina Lapucci, Francesco Tazza, Maria Cellerino, Elisabetta Capello, Diego Franciotta, Matilde Inglese, Maria Pia Sormani, Antonio Uccelli, Alice Laroni
Summary: This exploratory study found that the increase in anti-SARS-CoV2 antibodies following the third dose of COVID-19 vaccination in fingolimod-treated MS patients may be correlated to lymphocyte subsets and demographic features. Specifically, the percentage of CD19+ B lymphocytes was found to be associated with the increase in antibody levels. Therefore, evaluating the percentage of CD19+ B cells may be important in identifying patients at risk of reduced protection from COVID-19.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Silvia Morbelli, Massimiliano Gambella, Anna Maria Raiola, Chiara Ghiggi, Matteo Bauckneht, Tania Di Raimondo, Caterina Lapucci, Gianmario Sambuceti, Matilde Inglese, Emanuele Angelucci
Summary: This study evaluated the brain metabolic effects of CAR-T cell therapy in diffuse large B-cell lymphoma patients, finding that CRS and ICANS lead to different patterns of brain metabolism, with ICANS patients showing more extensive metabolic abnormalities in the frontal and temporal lobes.
JOURNAL OF NEUROIMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Piet M. Bouman, Samantha Noteboom, Fernando A. Nobrega Santos, Erin S. Beck, Gregory Bliault, Marco Castellaro, Massimiliano Calabrese, Declan T. Chard, Paul Eichinger, Massimo Filippi, Matilde Inglese, Caterina Lapucci, Andrzej Marciniak, Bastiaan Moraal, Alfredo Morales Pinzon, Mark Muehlau, Paolo Preziosa, Daniel S. Reich, Maria A. Rocca, MennoM. Schoonheim, Jos W. R. Twisk, Benedict Wiestler, Laura E. Jonkman, Charles R. G. Guttmann, Jeroen J. G. Geurts, Martijn D. Steenwijk
Summary: This study evaluated the detection ability of artificial intelligence-generated double inversion recovery (DIR) and phase-sensitive inversion recovery (PSIR) images for cortical and juxtacortical multiple sclerosis lesions in a multicenter setting, compared with MRI-acquired images. The results showed that the AI-generated images performed well compared to the MRI-acquired images and demonstrated good reliability in a multicenter setting, with good interpretative agreement between readers and centers.
Article
Clinical Neurology
Maria Pia Sormani, Irene Schiavetti, Marta Ponzano, Elisa Colato, Nicola De Stefano
Summary: The objective of this study was to assess the mediating effect of treatment on MRI-derived measures of brain atrophy and focal lesions on cognitive outcomes in MS clinical trials. The study analyzed published randomized trials in MS lasting at least 2 years and found that treatment effect on cognitive performance was strongly associated with the treatment effect on brain atrophy, but not with active MRI lesions. These results suggest that brain atrophy can be a main outcome measure for clinical trials targeting cognitive impairment and neurodegeneration in MS.
ANNALS OF NEUROLOGY
(2023)
Review
Clinical Neurology
Ruth Ann Marrie, Jeremy Chataway, Barbara E. Bierer, Marcia Finlayson, Elena H. Martinez-Lapiscina, Jennifer Panagoulias, Maria Pia Sormani, Mitzi Joi Williams, Lilyana Amezcua
Summary: This article summarizes recommendations for enhancing diversity and inclusion in clinical trials for multiple sclerosis (MS), including the use of diversity plans, community engagement and education, cultural competency training, adaptive designs, and reducing participant burden.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Review
Clinical Neurology
Maria Pia Sormani, Jeremy Chataway, David M. Kent, Ruth Ann Marrie
Summary: Multiple sclerosis (MS) has varied outcomes, and evaluating heterogeneity of treatment effect (HTE) is important. Various statistical techniques can assess HTE, with multivariable predictive approaches offering more patient-centered results. This review examines methods used to estimate HTE in MS clinical trials.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Review
Clinical Neurology
Ruth Ann Marrie, Maria Pia Sormani, Sean Apap Mangion, Francesca Bovis, Winson Y. Cheung, Gary R. Cutter, Peter Feys, Michael D. Hill, Marcus Werner Koch, Morgan McCreary, Ellen M. Mowry, Jay J. H. Park, Fredrik Piehl, Amber Salter, Jeremy Chataway
Summary: The current designs for clinical trials treating progressive multiple sclerosis (MS) have limitations and have not been successful. This paper discusses complex innovative trial designs and intermediate and composite outcomes to improve trial design efficiency in MS. Recommendations include increasing the use of complex innovative designs, developing biomarkers to enrich trial populations, prioritizing intermediate outcomes targeting therapeutic mechanisms, and investigating data linkage for long-term outcomes. Novel trial designs and further development of intermediate outcomes may improve clinical trial efficiency and address novel therapeutic questions in MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Neurosciences
Laura Bonzano, Monica Biggio, Sabrina Brigadoi, Ludovico Pedulla, Monica Pagliai, Costanza Iester, Giampaolo Brichetto, Simone Cutini, Marco Bove
Summary: This study used fNIRS to investigate cortical activations during the execution of a manual dexterity test. The results showed that participants with a larger execution time difference had higher activation in prefrontal cortical areas, and there was a significant linear relationship between Delta HPT and right BA10 activity.
Article
Clinical Neurology
Andrea Tacchino, Rachele Di Giovanni, Erica Grange, Maria Marcella Spirito, Michela Ponzio, Mario Alberto Battaglia, Giampaolo Brichetto, Claudio Marcello Solaro
Summary: This study evaluates the equivalence between paper-and-pencil and electronic versions of patient-reported outcome (PRO) measures in people with multiple sclerosis (PwMS). The results suggest a high level of equivalence between the two versions, and show that PwMS prefer the electronic method.
NEUROLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Jessica Podda, Andrea Tacchino, Anna Verri, Mario Alberto Battaglia, Giampaolo Brichetto, Michela Ponzio
Summary: The aim of this study was to develop and validate the Caregivers' Knowledge of Multiple Sclerosis (CareKoMS), a self-assessed questionnaire, to test MS knowledge in caregivers of people with MS. The results indicate that CareKoMS is a reliable self-assessed questionnaire that can be used in clinical practice and research.
Article
Health Care Sciences & Services
Marissa Betts, Kyle Fahrbach, Binod Neupane, Mahmoud Slim, Maria Pia Sormani, Gary Cutter, Thomas P. A. Debray, Marvin Rock
Summary: This study evaluates eight approaches for handling overlapping publications in network meta-analyses of real-world evidence (RWE) studies and recommends establishing an a priori hierarchy for selection.
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2023)
Article
Health Care Sciences & Services
Andrea Tacchino, Michela Ponzio, Paolo Confalonieri, Letizia Leocani, Matilde Inglese, Diego Centonze, Eleonora Cocco, Paolo Gallo, Damiano Paolicelli, Marco Rovaris, Loredana Sabattini, Gioacchino Tedeschi, Luca Prosperini, Francesco Patti, Placido Bramanti, Elisabetta Pedrazzoli, Mario Alberto Battaglia, Giampaolo Brichetto
Summary: This paper describes the design, development, and usability testing of MS Fitness Intervention Training (MS-FIT), a Kinect-based tool implementing customized Pilates exercises for people with MS. The user-centered design approach was used to create an accessible and challenging tool for balance training. The usability testing showed that MS-FIT is a promising system for enhancing the motivation and engagement of people with MS in performing exercises.
JMIR SERIOUS GAMES
(2023)