Article
Virology
Nastaran Rafiee, Mehrdad Ravanshad, Bahador Asadi, Roya Kianfar, Ali Maleki
Summary: The study found that MS patients had a stronger response to EBV peptides compared to healthy subjects, reflected in increased levels of IL-2 and IFN-gamma. The results suggest that EBV peptides may reactivate T lymphocytes, indirectly inducing inflammation and promoting the development of MS.
Article
Medicine, General & Internal
Qingguo Ren, Yanli Feng
Summary: Ganciclovir combined with interferon atomization inhalation can regulate the changes of T lymphocyte subsets in patients with EBV infection, improve the patient's condition, and has no obvious adverse reactions.
Article
Pharmacology & Pharmacy
Hao Ji, Taihua Yang, Chunlai Li, Youwei Zhu, Zhigang Zheng, Jiaxu Zhang, Yuan Liu, Yijin Gao, Huimin Wu, Jinxing Jiang, Junekong Yong, Mengke Chen, Yuanjia Tang, Qiang Xia, Feng Xue
Summary: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after transplantation, with 80% of patients being positive for Epstein-Barr virus (EBV). However, monitoring EBV DNA load for preventing and diagnosing EBV-PTLD has limited accuracy. Therefore, there is an urgent need for new diagnostic molecular markers. This study discovered that BHRF1-1 and BART2-5p, elevated in EBV-PTLD patients, promote proliferation and suppress apoptosis. Mechanistically, they inhibit the tumor suppressor gene LZTS2 and activate the PI3K-AKT pathway. These findings suggest that BHRF1-1 and BART2-5p could serve as potential diagnostic markers and therapeutic targets for EBV-PTLD.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Virology
A. Moyano, N. M. Ferressini Gerpe, E. De Matteo, M. Preciado, P. Chabay
Summary: In pediatric Epstein Barr virus (EBV) infection, macrophages primarily polarize towards M1 phenotype, even in the presence of immunomodulatory cytokines IL10 and TGF-β. This finding suggests a significant plasticity of macrophages in response to different extrinsic stimuli.
JOURNAL OF VIROLOGY
(2022)
Article
Microbiology
Rachel Hood Edwards, Nancy Raab-Traub
Summary: This study evaluated the impact of EBV and BART lncRNAs on cellular expression, showing that they induce changes in cellular miRs and lncRNAs. In vivo expression changes reflect increased cellular miRs in all tumors, while the BART lncRNA may inhibit the function of induced cellular miRs. The study provides insights into the total effects of EBV and BART lncRNA on cellular RNA expression.
Article
Virology
Diana A. Dominguez-Martinez, Jose I. Fontes-Lemus, Alejandro Garcia-Regalado, Angel Juarez-Flores, Ezequiel M. Fuentes-Panana
Summary: Helicobacter pylori and EBV are major risk factors for gastric cancer, and both can establish persistent infections and are considered carcinogenic. The study suggests that Helicobacter pylori infection facilitates the chemoattraction of EBV-infected B lymphocytes to the gastric mucosa, with IL-8 being identified as a powerful chemoattractant and CXCR2 as the main IL-8 receptor induced by EBV. Inhibition of IL-8 and CXCR2 reduces the chemoattraction of EBV-infected B lymphocytes, indicating an interaction mechanism between Helicobacter pylori and EBV.
Article
Microbiology
Quincy Rosemarie, Elijah Kirschstein, Bill Sugden
Summary: We have discovered how Epstein-Barr virus (EBV) induces the reorganization of cellular chromatin, with viral DNA replication occurring in the chromatin-free regions. Five families of DNA viruses induce similar reorganization, and they infect a variety of hosts. The viral genes and processes required for EBV's chromatin reorganization have been identified, and a two-step model for the process has been proposed. The importance of chromatin reorganization in viral life cycles is emphasized. Overall, a 9 out of 10 score is given for the importance of this research.
Article
Immunology
Tingting Cui, Jingshi Wang, Zhao Wang
Summary: This study aimed to build a model for predicting the risk of death during induction therapy in patients with Epstein-Barr virus (EBV)-related hemophagocytic lymphohistiocytosis (HLH). The study included 234 patients with EBV-HLH, of whom 65 (27.4%) died during induction therapy. A nomogram was developed to stratify patients into high-risk and low-risk groups with a high predictive accuracy. The high-risk patients had a significantly higher risk of death compared to the low-risk patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Hiroki Hosoi, Akiko Niibori-Nambu, Giselle Sek Suan Nah, Avinash Govind Bahirvani, Michelle Meng Huang Mok, Takaomi Sanda, Alan Prem Kumar, Daniel G. Tenen, Yoshiaki Ito, Takashi Sonoki, Motomi Osato
Summary: The study demonstrates the crucial role of super-enhancers for the expression of RUNX3 and MYC in EBV-positive malignant B cells. The deletion of super-enhancers resulted in the downregulation of both genes, leading to suppressed cell proliferation and colony formation. These findings suggest that seR3s could be a potential therapeutic target for EBV-related tumors.
Article
Multidisciplinary Sciences
Yosuke Nagasawa, Masami Takei, Mitsuhiro Iwata, Yasuko Nagatsuka, Hiroshi Tsuzuki, Kenichi Imai, Ken-Ichi Imadome, Shigeyoshi Fujiwara, Noboru Kitamura
Summary: EBV infection in hu-NOG mice may induce erosive arthritis through human osteoclast activation, demonstrating the potential for studying the association of EBV infections with rheumatoid arthritis and human bone metabolism in this mouse model.
Article
Virology
Mingqian Xu, Liang Zhang, Jinfu Feng, Shuaibing Yang, Yixuan Wang, Yuyi Wang, Meiyang Chen, Li Zhou, Junjie Zhang, Qingsong Qin
Summary: EBV-associated gastric cancer is a subtype of gastric cancer characterized by the presence of EBV genome and limited viral gene expression in malignant epithelial cells. Two EBV-positive gastric cancer cell lines have been established to study the role of EBV in different contexts of gastric carcinogenesis. These cell lines can serve as models to investigate the role of EBV in gastric cancer and identify new therapeutics against EBVaGC.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Jeremy T. Keane, Ali Afrasiabi, Stephen D. Schibeci, Nicole Fewings, Grant P. Parnell, Sanjay Swaminathan, David R. Booth
Summary: The study found gender-specific associations with EBV traits and MS risk SNP/gene pairs, with some genes showing gender differences in correlation of gene expression level with Estrogen Receptor 2. Estradiol treatment altered MS risk gene expression, LCL proliferation rate, EBV DNA copy number, and EBNA2 expression in a sex-dependent manner, indicating estrogen-mediated gender-specific differences in MS risk gene expression and EBV functions. This may contribute to gender differences in host response to EBV and MS susceptibility.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xubing Long, Ziwei Yang, Yang Li, Qinqin Sun, Xiaojuan Li, Ersheng Kuang
Summary: The study reveals that BRLF1 regulates cellular and viral gene expression and transcription during EBV primary infection, impacting pathways such as DNA replication and metabolism. BRLF1 binds to transcription factors and spliceosome components, influencing RNA polymerase II-dependent transcription and pre-mRNA splicing.
Article
Chemistry, Multidisciplinary
Fang Zhang, Baokai Zhang, Huihua Ding, Xiangyue Li, Xilin Wang, Xiaomin Zhang, Qiaojie Liu, Qiuyun Feng, Mingshun Han, Longlong Chen, Linlin Qi, Dan Yang, Xiaojing Li, Xingguo Zhu, Qi Zhao, Jiaqian Qiu, Zhengjiang Zhu, Huiru Tang, Nan Shen, Hongyan Wang, Bin Wei
Summary: Systemic lupus erythematosus (SLE) is associated with abnormal lipid and cholesterol metabolism, as well as type I interferon (IFN-I) signaling. An analysis reveals increased levels of 7α,25-dihydroxycholesterol (7α,25-OHC) in SLE patients, which binds to its receptor EBI2 in macrophages and suppresses immune activation. EBI2-deficient macrophages produce higher levels of chemokines and cytokines, exacerbating SLE. This study highlights the potential of targeting the EBI2 pathway for diagnostic and therapeutic purposes in SLE.
Review
Immunology
Gianmarco Bellucci, Angela Albanese, Caterina Rizzi, Virginia Rinaldi, Marco Salvetti, Giovanni Ristori
Summary: Interferon-beta (IFN-beta) for Multiple Sclerosis (MS) is celebrating its 30th anniversary. The COVID-19 pandemic has reignited interest in the biology of interferon in health and disease, expanding its potential applications beyond neuroinflammation. The antiviral properties of IFN-beta align with the viral etiology hypothesis of MS, particularly in relation to the Epstein-Barr Virus. Furthermore, IFNs play a crucial role in the acute phase of SARS-CoV-2 infection, and IFN-beta has shown protective effects against SARS-CoV-2 in individuals with MS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Neurosciences
Phillippa J. Carling, Heather Mortiboys, Claire Green, Simeon Mihaylov, Cynthia Sandor, Aurelie Schwartzentruber, Rosie Taylor, Wenbin Wei, Chris Hastings, Siew Wong, Christine Lo, Samuel Evetts, Hannah Clemmens, Matthew Wyles, Sam Willcox, Thomas Payne, Rachel Hughes, Laura Ferraiuolo, Caleb Webber, Winston Hide, Richard Wade-Martins, Kevin Talbot, Michele T. Hu, Oliver Bandmann
PROGRESS IN NEUROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Taha Elmetwali, Asmaa Salman, Wenbin Wei, Syed A. Hussain, Lawrence S. Young, Daniel H. Palmer
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Massimo Granai, Lucia Mundo, Ayse U. Akarca, Maria Chiara Siciliano, Hasan Rizvi, Virginia Mancini, Noel Onyango, Joshua Nyagol, Nicholas Othieno Abinya, Ibrahim Maha, Sandra Margielewska, Wenbin Wi, Michele Bibas, Pier Paolo Piccaluga, Leticia Quintanilla-Martinez, Falko Fend, Stefano Lazzi, Lorenzo Leoncini, Teresa Marafioti
INFECTIOUS AGENTS AND CANCER
(2020)
Article
Psychiatry
Michail S. Kukharsky, Natalia N. Ninkina, Haiyan An, Vsevolod Telezhkin, Wenbin Wei, Camille Rabesahala de Meritens, Johnathan Cooper-Knock, Shinichi Nakagawa, Tetsuro Hirose, Vladimir L. Buchman, Tatyana A. Shelkovnikova
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Cell Biology
Ying-Wooi Wan, Rami Al-Ouran, Carl G. Mangleburg, Thanneer M. Perumal, Tom Lee, Katherine Allison, Vivek Swarup, Cory C. Funk, Chris Gaiteri, Mariet Allen, Minghui Wang, Sarah M. Neuner, Catherine C. Kaczorowski, Vivek M. Philip, Gareth R. Howell, Heidi Martini-Stoica, Hui Zheng, Hongkang Mei, Xiaoyan Zhong, Jungwoo Wren Kim, Valina L. Dawson, Ted M. Dawson, Ping-Chieh Pao, Li-Huei Tsai, Jean-Vianney Haure-Mirande, Michelle E. Ehrlich, Paramita Chakrabarty, Yona Levites, Xue Wang, Eric B. Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K. Sieberts, Larsson Omberg, Kristen D. Dang, James A. Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J. Ebert, David C. Airey, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, Gregory W. Carter, David A. Collier, Todd E. Golde, Allan Levey, David A. Bennett, Karol Estrada, T. Matthew Townsend, Bin Zhang, Eric Schadt, Philip L. De Jager, Nathan D. Price, Nilufer Ertekin-Taner, Zhandong Liu, Joshua M. Shulman, Lara M. Mangravite, Benjamin A. Logsdon
Article
Chemistry, Medicinal
John G. M. Mina, Rebecca L. Charlton, Edubiel Alpizar-Sosa, Douglas O. Escrivani, Christopher Brown, Amjed Alqaisi, Maria Paula G. Borsodi, Claudia P. Figueiredo, Emanuelle de Lima, Emily A. Dickie, Wenbin Wei, Robson Coutinho-Silva, Andy Merritt, Terry K. Smith, Michael P. Barrett, Bartira Rossi-Bergmann, Paul W. Denny, Patrick G. Steel
Summary: This study successfully identified an over-the-counter antihistamine, clemastine fumarate, as a potential candidate for the treatment of leishmaniasis. Through multiple screenings and experiments, the drug showed promising activity and effectiveness, suggesting it could be repurposed for the treatment of this disease.
ACS INFECTIOUS DISEASES
(2021)
Article
Neurosciences
Hannah Larbalestier, Marcus Keatinge, Lisa Watson, Emma White, Siri Gowda, Wenbin Wei, Katjusa Koler, Svetlana A. Semenova, Adam M. Elkin, Neal Rimmer, Sean T. Sweeney, Julie Mazzolini, Dirk Sieger, Winston Hide, Jonathan McDearmid, Pertti Panula, Ryan B. MacDonald, Oliver Bandmann
Summary: In this study, a loss of function zebrafish gch1(-/-) mutant was generated using CRISPR/Cas technology to investigate the mechanisms by which GCH1 deficiency may contribute to PD. The results suggest that GCH1 deficiency may indirectly contribute to neuronal cell death via immune-mediated mechanisms. The study highlights the importance of functional validation for GWAS risk factors and emphasizes the role of inflammation in the pathogenesis of PD.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Haiyan An, Gioana Litscher, Naruaki Watanabe, Wenbin Wei, Tadafumi Hashimoto, Takeshi Iwatsubo, Vladimir L. Buchman, Tatyana A. Shelkovnikova
Summary: This study reveals that SG-like structures formed by mutant FUS are structurally distinct from SGs, unlikely to functionally replace SGs, and affect a spectrum of cellular pathways.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Agronomy
Abdulkarim Lakmes, Abdullah Jhar, R. Varma Penmetsa, Wenbin Wei, Adrian C. Brennan, Abdullah Kahriman
Summary: This study used genetic mapping to identify quantitative trait loci (QTLs) for days to first flowering and flower color in chickpea, demonstrating the quantitative inheritance and potential of wild relatives as a source of novel alleles for chickpea breeding.
Article
Infectious Diseases
Edubiel A. Alpizar-Sosa, Nur Raihana Binti Ithnin, Wenbin Wei, Andrew W. Pountain, Stefan K. Weidt, Anne M. Donachie, Ryan Ritchie, Emily A. Dickie, Richard J. S. Burchmore, Paul W. Denny, Michael P. Barrett
Summary: Amphotericin B resistance in Leishmania is associated with changes in sterol composition, which are caused by gene mutations. The sensitivity of the cells to the drug also varies depending on the growth medium. Some resistant lines show reduced virulence, but still retain their resistance phenotype.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Edubiel A. Alpizar-Sosa, Yasmine Kumordzi, Wenbin Wei, Phillip D. Whitfield, Michael P. Barrett, Paul W. Denny
Summary: With the global spread of the neglected tropical disease leishmaniasis, the validation of new drug targets in the causative insect vector is crucial. Using CRISPR Cas9 technology, a study reveals the essentiality of a gene and the possibility of simultaneous deletion of two genes, providing insights into the physiological process of the parasite.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Agronomy
Abdulkarim Lakmes, Abdullah Jhar, R. Varma Penmetsa, Wenbin Wei, Adrian C. Brennan, Abdullah Kahriman
Summary: This study aims to investigate the inheritance of seed weight and plant growth habit in chickpea and identifies the associated quantitative trait loci (QTL). The findings provide important insights for chickpea breeding.
Article
Cell Biology
Benjamin Allcock, Wenbin Wei, Kirsty Goncalves, Henry Hoyle, Alisha Robert, Rebecca Quelch-Cliffe, Adam Hayward, Jim Cooper, Stefan Przyborski
Summary: Cells respond to their microenvironment, and this has implications for cell culture practices. In this study, the cellular processes that occur when a cell is cultured on 2D or 3D surfaces for a short period of time were examined. The study found that this priming process improved the cell's functionality and drug toxicity profiles. The findings have broad significance in the field of cell biology, demonstrating the fundamental impact of mechanotransduction in bioengineering and cell biology.
Article
Microbiology
Karunakaran Kalesh, Wenbin Wei, Brian S. Mantilla, Theodoros Roumeliotis, Jyoti Choudhary, Paul W. Denny
Summary: This study identified RNA-binding proteins in Leishmania, including proteins that interact with non-adenylated RNAs. The study also revealed the involvement of RNA-protein interactions in various biological processes in Leishmania, such as gene regulation and protein synthesis. Additionally, the study showed the impact of heat shock protein 90 inhibition on RNA-protein interactions in Leishmania.
MICROBIOLOGY SPECTRUM
(2022)
Article
Evolutionary Biology
Xiaoyan Gu, Adrian Brennan, Wenbin Wei, Guangqin Guo, Keith Lindsey
EVOLUTIONARY BIOINFORMATICS
(2020)