Article
Cardiac & Cardiovascular Systems
Mikael Dellborg, Kok Wai Giang, Peter Eriksson, Hans Liden, Maria Fedchenko, Anders Ahnfelt, Annika Rosengren, Zacharias Mandalenakis
Summary: In recent decades, the survival rate of children with congenital heart disease (CHD) has greatly increased. However, this study found that adult survivors with CHD have a higher risk of mortality compared to the general population, although at least 75% of patients can live past middle age and become sexagenerians.
Article
Endocrinology & Metabolism
Weiwei Dong, Zhiyong Yang
Summary: An analysis of lipid profiles and lipid control among US adult survivors of stroke and/or myocardial infarction from 2001-2018 revealed a decrease in total cholesterol, LDL, and triglyceride concentrations, as well as an improvement in lipid control rates. However, variations were observed based on sex and race.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Marta Baviera, Giovanni Cioffi, Pierluca Colacioppo, Mauro Tettamanti, Ida Fortino, Maria Carla Roncaglioni
Summary: Despite the passage of time, individuals with rheumatoid arthritis continue to face higher risks of death and cardiovascular diseases compared to the general population, highlighting the persistent need for preventive interventions.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Chalotte W. Nicolajsen, Mette Sogaard, Nikolaj Eldrup, Martin Jensen, Torben B. Larsen, Samuel Z. Goldhaber, Peter B. Nielsen
Summary: This study observed a decrease in cardiovascular comorbidity at diagnosis, incidence of atherosclerotic cardiovascular disease, and all-cause mortality in patients diagnosed with abdominal aortic aneurysm. However, there is still a substantial cardiovascular burden and mortality rates, indicating the need for further improvement in medical cardioprotective therapy.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Murat Cimci, Fabienne Witassek, Dragana Radovanovic, Hans Rickli, Giovanni B. Pedrazzini, Paul Erne, Olivier Mueller, Franz R. Eberli, Marco Roffi
Summary: Among AMI patients in Switzerland over two decades, the age at presentation remained stable, while the mean number of CVRF increased in both men and women. The prevalence of smoking increased significantly in women, reducing the gender gap over time, while diabetes prevalence remained stable and obesity prevalence increased in men, with hypertension and dyslipidemia increasing in both genders.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Rheumatology
Tsai-Hung Yen, Yun-Wen Chen, Tsu-Yi Hsieh, Yi-Ming Chen, Wen-Nan Huang, Yi-Hsing Chen, Hsin-Hua Chen
Summary: This study aimed to assess the incidence and risk factors of major adverse cardiovascular events (MACEs) in patients with systemic sclerosis (SSc). A nationwide cohort study was conducted in Taiwan, including 1379 SSc patients and 2758 non-SSc individuals. The study found that SSc was associated with increased risk of myocardial infarction and peripheral arterial occlusion disease, but not of ischaemic stroke. Age, gender, residential area, valvular heart disease, rheumatoid arthritis, and the use of clopidogrel and aspirin were identified as independent risk factors for MACEs in SSc patients. The findings of this study are clinically significant in understanding the risk factors for MACEs in SSc patients.
Article
Cardiac & Cardiovascular Systems
Jessica Schubert, Bertil Lindahl, Hakan Melhus, Henrik Renlund, Margret Leosdottir, Ali Yari, Peter Ueda, Stefan James, Stephanie R. Reading, Paul J. Dluzniewski, Andrew W. Hamer, Tomas Jernberg, Emil Hagstrom
Summary: Clinical trials have shown that reducing LDL-C can decrease cardiovascular events, and a study found that larger reductions in LDL-C and more intensive statin therapy after myocardial infarction were associated with lower risks of cardiovascular outcomes and all-cause mortality.
EUROPEAN HEART JOURNAL
(2021)
Article
Environmental Sciences
Maud Miguet, Sotirios Venetis, Gull Rukh, Lars Lind, Helgi B. Schioth
Summary: This study suggests that spending more than 3.5 hours outdoors per day is a risk factor for myocardial infarction and stroke. Further research is needed to better understand the relationship between time spent outdoors and cardiovascular diseases.
ENVIRONMENTAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Madeleine Hummel, Essi Hantikainen, Hans-Olov Adami, Weimin Ye, Rino Bellocco, Stephanie Erika Bonn, Ylva Trolle Lagerros
Summary: This study found that total physical activity was inversely associated with the risk of myocardial infarction in women, while leisure time physical activity was inversely associated with the risk of myocardial infarction and stroke in men.
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Giuseppe Mancia, Roland E. Schmieder, Luis Ruilope, Krzysztof Narkiewicz, Markus Schlaich, Bryan Williams, Flavio Ribichini, Joachim Weil, Hsien-Li Kao, Oriol Rodriguez-Leor, Elias Noory, Tiong Kiam Ong, Thierry Unterseeh, Pedro de Araujo Goncalves, Andreas Zirlik, Khaled Almerri, Faisal Sharif, Lucas Lauder, Marianne Wanten, Martin Fahy, Michael Bohm
Summary: This study aimed to evaluate the impact of radiofrequency renal denervation (RDN) on time in therapeutic range (TTR) and its association with cardiovascular outcomes. The results showed sustained blood pressure reductions and higher TTR through 36 months after RDN. A 10% increase in TTR through 6 months was associated with significant risk reductions in major cardiovascular events from 6 to 36 months.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Nutrition & Dietetics
Jiaqi Yang, Yulin Zhang, Xiaona Na, Ai Zhao
Summary: This study conducted a systematic review and meta-analysis on the associations between beta-carotene supplementation and cardiovascular disease (CVD) risk. The results showed that beta-carotene supplementation had no beneficial effects on CVD incidence and could potentially increase cardiovascular mortality. Smoking behavior was also found to be associated with increased cardiovascular incidence and mortality in the beta-carotene intervention group.
Review
Biochemistry & Molecular Biology
Chinmay Sharma, Tejas P. Singh, Shivshankar Thanigaimani, Domenico Nastasi, Jonathan Golledge
Summary: This study assessed the incidence rate of major adverse cardiovascular events (MACE) in patients with unrepaired abdominal aortic aneurysm (AAA) and their association with modifiable risk factors (diabetes, hypertension) and medication use (aspirin, statins). The study found a high incidence of cardiovascular death, myocardial infarction (MI), and stroke in patients with unrepaired AAA, but the prescription rate of preventive medication was suboptimal. Therefore, greater emphasis should be placed on secondary prevention measures in this population.
Article
Public, Environmental & Occupational Health
Jiangbo Wang, Shiru Zhang, Yundi Jiao, Liqiang Zheng, Yingxian Sun, Zhaoqing Sun
Summary: In Chinese rural adults, cumulative blood pressure showed a stronger association with cardiovascular disease incidence compared to current blood pressure. Additionally, cumulative blood pressure slightly improved the predictive performance for cardiovascular disease. These findings highlight the incremental predictive value of cumulative blood pressure in cardiovascular disease risk assessment among Chinese rural adults.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Rock Bum Kim, Jin Yong Hwang, Hyun Woong Park, Ae-Young Her, Jang Hoon Lee, Moo Hyun Kim, Chang Hwan Yoon, Jae Young Cho, Sung-Il Woo, Yongcheol Kim, Jae-Young Han, Joon Hyouk Choi, Song Yi Kim, Si Wan Choi, Sung Ju Jee, Sang Yeub Lee, Ki-Bum Won, Kyeong-Soo Park, Dae Woo Hyun
Summary: The study introduced the development and characteristics of the Korean Registry of Acute Myocardial Infarction for Regional Cardiocerebrovascular Centers (KRAMI-RCC). With a focus on pre-hospital and post-hospital data, the registry aims to improve understanding of AMI disease management in Korea and aid in policy decisions to reduce case fatality rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Gad Abraham, Loes Rutten-Jacobs, Michael Inouye
Summary: Genetic factors play a significant role in the prediction of cardiovascular diseases, including stroke, and the development of polygenic risk scores has shown potential to improve risk prediction for stroke.
Article
Public, Environmental & Occupational Health
Terese Sara Hoj Jorgensen, Anna C. Meyer, Margareta Hedstrom, Stefan Fors, Karin Modig
Summary: The absence of close next of kin, especially a cohabiting partner, reduces the chance of older hip fracture patients returning to independent living and increases the use of home care.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2022)
Article
Public, Environmental & Occupational Health
Alexandra M. Wennberg, Weiyao Yin, Fang Fang, Nancy L. Pedersen, Sara Hagg, Juulia Jylhava, Karin Modig
Summary: This study evaluated the utility of a code-based frailty score in registry data and found that it may not capture the full spectrum of frailty among community-dwelling individuals, particularly at younger ages.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Marcus Ebeling, Anders Ahlbom, Per Gustavsson, Karin Modig
Summary: This study reveals significant differences in life expectancy at higher ages among occupational groups, suggesting that lifestyle factors may play a larger role than occupational factors for these differences.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Anna C. Meyer, Marcus Ebeling, Sven Drefahl, Margareta Hedstrom, Stina Ek, Glenn Sandstrom, Karin Modig
Summary: This study examined the impact of hip fractures on the trajectories of home care, nursing home residence, and mortality among individuals aged 65 years or more. The study also explored how living arrangements, cohabitation, frailty, and socioeconomic position influence these trajectories. The findings suggest that hip fractures have a significant impact on the use of elder-care services and mortality, and long-term care needs are largely related to poorer health profiles independent of the fracture itself.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Geriatrics & Gerontology
Alexandra M. Wennberg, Marcus Ebeling, Stina Ek, Anna Meyer, Mozhu Ding, Mats Talbaeck, Karin Modig
Summary: Frailty prevalence increases with age and has become more common in recent birth cohorts. The relationship between frailty and mortality has not changed over time, and there is no difference in this relationship based on gender.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Forestry
Anders Ahlbom, Marco Maschietti, Rudi Nielsen, Merima Hasani, Hans Theliander
Summary: Depolymerisation of kraft lignin under hydrothermal conditions was investigated at short residence times (1-12 min) with glycerol being used as a capping agent. The weight average molecular weight (M-w) of the products decreased within the first minute of residence time, with the inter-unit ether linkages breaking accordingly. Furthermore, the M-w of the product fractions decreased at increasing residence times, while the char yield increased. Short residence times thus appear to be beneficial for mitigating the formation of char. Also, addition of NaOH reduced the yield of char. Although the addition of glycerol caused a decrease in the M-w of the products, it seemed to increase the yield of char and therefore might not be a suitable capping agent for kraft lignin depolymerisation.
Article
Public, Environmental & Occupational Health
Terese S. H. Jorgensen, Merete Osler, Stefan Fors, Charlotte J. Nilsson, Anna Meyer, Karin Modig
Summary: This study examines the associations between adult offspring's socioeconomic resources and the risk of stroke development and survival among older adults in Denmark and Sweden. The findings suggest that lower levels of offspring's education, occupation, and income are associated with higher risk of stroke. The relationship between offspring's educational level and death after stroke is particularly pronounced after the acute phase.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Mozhu Ding, Ngoc Nguyen Viet, Bruna Gigante, Viktor Lind, Niklas Hammar, Karin Modig
Summary: The study explores the association between uric acid levels and the risk of new-onset atrial fibrillation (AF). The findings show that elevated uric acid levels are associated with an increased risk of AF in a dose-response manner. This association is observed not only in individuals with cardiovascular disease and risk factors, but also in those without.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Orthopedics
Katarina Greve, E. K. Stina, Erzsebet Bartha, Karin Modig, Margareta Hedstrom
Summary: The study explores the association between waiting time to surgery for hip fracture and adverse outcomes after discharge. Waiting more than 24 hours is associated with increased risk of atrial fibrillation/flutter, congestive heart failure, and acute ischemia.
Article
Public, Environmental & Occupational Health
Alexandra M. Wennberg, Anthony Matthews, Mats Talback, Marcus Ebeling, Stina Ek, Maria Feychting, Karin Modig
Summary: In this cohort study, researchers examined the frailty risk among breast cancer survivors compared to age-matched subjects. The study found a weak association between breast cancer survivorship and frailty, with higher risk observed in younger patients.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Alexandra Wennberg, Yining Tao, Stina Ek, Karin Modig
Summary: Frailty has been increasing over time regardless of education and income levels, but the association between frailty and 5-year mortality has remained stable. While the highest education and income levels had the highest mean HFRS scores, the lowest education and income levels accounted for greater proportions among the frail, particularly in earlier birth cohorts. Trends varied slightly by sex and age, with frailty being more strongly associated with mortality among men.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Oncology
Hanna Mogensen, Giorgio Tettamanti, Line Elmerdahl Frederiksen, Mats Talback, Juho Harkonen, Karin Modig, Camilla Pedersen, Anja Kroyer, Elli Hirvonen, Anniina Kyronlahti, Mats Heyman, Anna Sallfors Holmqvist, Henrik Hasle, Laura Madanat-Harjuoja, Nea Malila, Jeanette Falck Winther, Friederike Erdmann, Maria Feychting
Summary: This study investigates the impact of childhood cancer on the attainment of upper secondary education. The findings suggest that survivors of childhood cancer are at risk of facing difficulties in achieving this level of education, particularly those with central nervous system (CNS) tumors. However, most survivors, except for CNS tumor survivors, catch up with their peers and attain upper secondary education to a similar extent.
BRITISH JOURNAL OF CANCER
(2023)
Article
Geriatrics & Gerontology
Stina Ek, Anna C. Meyer, Alexandra Wennberg, Katarina Greve, Margareta Hedstrom, Karin Modig
Summary: This study investigated the association between length of hospital stay and risk of readmissions for hip fracture patients in Sweden. The results showed that shorter hospital stays did not increase the risk of readmission, while longer hospital stays were associated with a higher risk of readmission.
Article
Geriatrics & Gerontology
Shunsuke Murata, Anna C. Meyer, Marcus Ebeling, Karin Modig
Summary: Sweden's centenarian population is highly dependent on home care and care homes. Among the ones still living at home, the vast majority live alone and have low incomes. Strategies to manage the health and social care demands of this growing population group in the coming decade are important.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Forestry
Anders Ahlbom, Marco Maschietti, Rudi Nielsen, Merima Hasani, Hans Theliander
Summary: This study found that hydrothermal liquefaction can rapidly depolymerize kraft lignin in the initial stages, but as time progresses, there are less pronounced structural changes, indicating a recalcitrant carbon-carbon skeleton remains in the products. Additionally, the yields of char and monomers slowly increase with reaction time, necessitating careful tuning of the reaction time.