Article
Biochemistry & Molecular Biology
Junheng Zhao, Song Peng, Hongtu Cui, Panyu Li, Tianming Li, Luole Liu, Hanfeng Zhang, Zengyuan Tian, Haihong Shang, Ruqiang Xu
Summary: This study comprehensively identified and characterized CNGCs in cotton, revealing their expression patterns, regulatory mechanisms, and functional diversity. The findings lay the foundation for further research and utilization of CNGCs in cotton genetic improvement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Marine & Freshwater Biology
Jin-Jin Lv, Kuan-Kuan Yuan, Guan-Xiu Lu, Hong-Ye Li, Hang Fai Kwok, Wei-dong Yang
Summary: In this study, the distribution of ABC transporters in the mussel Perna viridis was analyzed comprehensively, and the responses of ABCB and ABCC transporters to DSP toxins-producing dinoflagellate Prorocentrum lima were observed. The study found that different types of PvABCBs and PvABCCs in P. viridis may contribute to the detoxification of DSP toxins in different tissues at different time after exposure. These findings provide new evidence for understanding the role of ABC transporters in the tolerance of mussels to DSP toxins.
AQUATIC TOXICOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Leonie Unterholzner
Summary: The DNA sensor cGAS and its adaptor STING form an ancient pathogen detection mechanism, but its conservation across the animal kingdom is uncertain. In this article in Cell, Kranzusch and colleagues identify numerous cGAS-like receptors and uncover networks of second messengers that activate innate immune responses in animals.
Article
Cell Biology
Zhijie Chen, Yingqian Zhong, Jiehong Chen, Shuxin Sun, Wenfeng Liu, Yu Han, Xincheng Liu, Cui Guo, Depei Li, Wanming Hu, Peiyu Zhang, Zhuopeng Chen, Zhongping Chen, Yonggao Mou, Guangmei Yan, Wenbo Zhu, Wei Yin, Ke Sai
Summary: This study demonstrated that cAMP triggered neuronal differentiation and compromised the self-renewal capacity in GSCs. In addition, cAMP induced negative feedback to antagonize the differentiation process by activating beta-catenin pathway.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Juliana C. Correa-Velloso, Paula J. Bartlett, Robert Brumer, Lawrence D. Gaspers, Henning Ulrich, Andrew P. Thomas
Summary: Rat hepatocytes express multiple purinergic P2Y and P2X receptors, leading to distinct Ca2+ oscillations. These oscillation patterns are shaped by protein kinase C, resulting in unique cellular responses to different agonists.
Article
Multidisciplinary Sciences
Georgia Katsioudi, Rene Dreos, Enes S. Arpa, Sevasti Gaspari, Angelica Liechti, Miho Sato, Christian H. Gabriel, Achim Kramer, Steven A. Brown, David Gatfield
Summary: The study demonstrates the importance of nonsense-mediated mRNA decay (NMD) in physiological control, particularly in regulating the circadian clock and gene expression.
Article
Cell Biology
Katherine Rothamel, Sarah Arcos, Byungil Kim, Clara Reasoner, Samantha Lisy, Neelanjan Mukherjee, Manuel Ascano
Summary: Research has shown that ELAVL1 transitions its binding sites upon cell immune stimulation and mediates RNA stability of genes regulating pathogen sensing and cytokine production pathways.
Article
Multidisciplinary Sciences
Kai P. Hoefig, Alexander Reim, Christian Gallus, Elaine H. Wong, Gesine Behrens, Christine Conrad, Meng Xu, Lisa Kifinger, Taku Ito-Kureha, Kyra A. Y. Defourny, Arie Geerlof, Josef Mautner, Stefanie M. Hauck, Dirk Baumjohann, Regina Feederle, Matthias Mann, Michael Wierer, Elke Glasmacher, Vigo Heissmeyer
Summary: Post-transcriptional gene regulation in T cells is a dynamic and complex process, involving multiple RNA-binding proteins and unexpected functions for certain transcription factors and signal transducers. By studying the regulation of Roquin-1 and Roquin-2, it was found that multiple RBPs contribute to the coregulation of mRNA targets by individual trans-acting factors.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Gillian Forbes, Zhi-Hui Chen, Koryu Kin, Pauline Schaap
Summary: Cell differentiation in Dictyostelia was studied using RNA-seq and lacZ expression validation to investigate the spatio-temporal expression pattern of cell-type specific genes. The study revealed common modes of regulation for spore and cup genes, and specific regulation for stalk-expressed genes. Additionally, the presence of a stem-cell like soma population in slugs was indicated.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haneui Bae, Jeff Coller
Summary: Translation by the ribosome is the final step in the process of producing proteins from DNA. Recent research has shown that the ribosome also plays a role in controlling mRNA stability and degradation. The rate at which the ribosome moves along the mRNA molecule affects the stability of the transcript. This process is influenced by the codon sequence, with some codons causing the ribosome to pause and adopt a specific conformation that triggers mRNA degradation. These findings suggest that the coding region of mRNA not only determines protein content, but also impacts protein levels by influencing the fate of the transcript.
Article
Cell Biology
Wing Yan So, Wai Nam Liu, Adrian Kee Keong Teo, Guy A. Rutter, Weiping Han
Summary: The transcription factor PAX6 plays a crucial role in regulating insulin secretion in beta cells through the CREB/Munc18-1/2 pathway, highlighting its potential therapeutic value in type 2 diabetes.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
M. Aguila Ruiz-Sola, Serena Flori, Yizhong Yuan, Gaelle Villain, Emanuel Sanz-Luque, Petra Redekop, Ryutaro Tokutsu, Anika Kuken, Angeliki Tsichla, Georgios Kepesidis, Guillaume Allorent, Marius Arend, Fabrizio Iacono, Giovanni Finazzi, Michael Hippler, Zoran Nikoloski, Jun Minagawa, Arthur R. Grossman, Dimitris Petroutsos
Summary: Photosynthetic algae have evolved mechanisms to cope with suboptimal light and CO2 conditions. Depletion of CO2 can drive photoprotection and carbon acquisition even in the absence of light, previously believed to be indispensable for these processes.
NATURE COMMUNICATIONS
(2023)
Review
Microbiology
Lorenzo Eugenio Leiva, Assaf Katz
Summary: In bacteria, the translation of genetic information can begin through at least three different mechanisms. One of these mechanisms is leaderless initiation, which relies on the ability of 70S ribosomal particles to bind to AUG located at or near the 5' end of mRNAs to initiate translation. Unlike canonical translation, leaderless mRNAs lack a 5' untranslated region and a Shine-Dalgarno sequence, so the regulation of translation initiation is different for these mRNAs.
Article
Developmental Biology
Chunfang Xu, Weijie Zhao, Xixi Huang, Zhuxuan Jiang, Lu Liu, Liyuan Cui, Xinyi Li, Dajin Li, Meirong Du
Summary: Decidualization is a process where the endometrium transforms to support embryo development, with defective decidualization being linked to pregnancy complications. The study highlights the role of DUSP1 in regulating MAPK signaling in endometrial cells, showing its importance in safeguarding IGFBP1 expression and suggesting its involvement in the pathogenesis of recurrent miscarriage.
Article
Biology
Yakun Wu, Kun Song, Wenzhuo Hao, Jack Li, Lingyan Wang, Shitao Li
Summary: This study demonstrates that HSV-1 infection causes the release of cGAS from the chromatin into the nuclear soluble fraction. The nuclear soluble cGAS acts as a nuclear DNA sensor and can detect nuclear-replicating DNA viruses, leading to an interferon response and limiting viral infection.
COMMUNICATIONS BIOLOGY
(2022)
Article
Engineering, Environmental
Marco Capolupo, Lisbet Sorensen, Kongalage Don Ranil Jayasena, Andy M. Booth, Elena Fabbri
Article
Environmental Sciences
Margherita Musella, Rasika Wathsala, Teresa Tavella, Simone Rampelli, Monica Barone, Giorgia Palladino, Elena Biagi, Patrizia Brigidi, Silvia Turroni, Silvia Franzellitti, Marco Candela
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Chemistry, Analytical
Daniele Fabbri, Alessandro G. Rombola, Ivano Vassura, Cristian Torri, Silvia Franzellitti, Marco Capolupo, Elena Fabbri
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
(2020)
Review
Engineering, Environmental
Kuddithamby Gunaalan, Elena Fabbri, Marco Capolupo
Article
Environmental Sciences
Paola Valbonesi, Marilin Profita, Ivo Vasumini, Elena Fabbri
Summary: Evaluating the occurrence of selected CECs in surface water at drinking water treatment plants, this study found that CFF, NP, PFOA, BPA, and CBZ were the most frequently detected contaminants in treated water. These contaminants showed a wide range of concentrations in the water samples.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Elena Biagi, Margherita Musella, Giorgia Palladino, Valeria Angelini, Sauro Pari, Chiara Roncari, Daniel Scicchitano, Simone Rampelli, Silvia Franzellitti, Marco Candela
Summary: The study found that almost all fecal samples from rescued sea turtles in the Northwestern Adriatic Sea between 2017 and 2019 contained plastic debris (PD), reflecting high levels of plastic pollution in the area. Higher plastic contamination was associated with putative marine pathogens, indicating that PD can transport environmental pathogenic bacteria into marine organisms. Sea turtles play a crucial role as flagship species for plastic pollution in the marine environment and the ingestion of PD may have potential impacts on the microbial community of large marine organisms, affecting animal and ecosystem health.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Biodiversity Conservation
Marta Meschini, Mariana Machado Toffolo, Erik Caroselli, Silvia Franzellitti, Chiara Marchini, Fiorella Prada, Alessio Boattini, Viviana Brambilla, Grit Martinez, Francesca Prati, Ginevra Simoncini, Marco Visentin, Valentina Airi, Simone Branchini, Stefano Goffredo
Summary: The study assessed the effectiveness of Glocal Education in improving tourist environmental interest, showing significantly positive impact on tourist knowledge, attitude, and awareness, while also increasing satisfaction and loyalty towards the tour operator hosting the project.
BIOLOGICAL CONSERVATION
(2021)
Article
Environmental Sciences
Marco Capolupo, Kuddithamby Gunaalan, Andy M. Booth, Lisbet Sorensen, Paola Valbonesi, Elena Fabbri
Summary: Ocean contamination by synthetic polymers can pose a risk to marine species due to leaching of chemical additives. This study evaluated the sub-lethal effects of plastic and rubber leachates on mussels, showing that different leachates can impact various biomarkers and enzyme activities. The mussel expert system (MES) categorized mussels' health status based on biomarker responses, indicating varying levels of stress from different leachates.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Rajapaksha Haddokara Gedara Rasika Wathsala, Margherita Musella, Paola Valbonesi, Marco Candela, Silvia Franzellitti
Summary: This study evaluated the transcriptional profiles of genes related to physiological responses in the digestive glands of Mytilus galloprovincialis under the influence of seasonal changes, gender bias, and gonadal development. The study also explored the composition of the DG microbiome. The results showed seasonal variations and gender-specific differences in the DG microbiome composition, with metabolic accommodations likely facing season progression and reproductive cycle.
MARINE POLLUTION BULLETIN
(2021)
Article
Multidisciplinary Sciences
Fiorella Prada, Leonardo Brizi, Silvia Franzellitti, Stefano Mengoli, Simona Fermani, Iryna Polishchuk, Nicola Baraldi, Francesco Ricci, Quinzia Palazzo, Erik Caroselli, Boaz Pokroy, Loris Giorgini, Zvy Dubinsky, Paola Fantazzini, Giuseppe Falini, Stefano Goffredo, Katharina E. Fabricius
Summary: This study found that four tropical zooxanthellate corals from Papua New Guinea underwater volcanic vent system exhibit increased skeletal porosity and changes in organic matrix and water content under long-term exposure to OA, suggesting a common phenotypic response to environmental pressures.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Marco Capolupo, Alessandro Girolamo Rombola, Sadia Sharmin, Paola Valbonesi, Daniele Fabbri, Elena Fabbri
Summary: The sorption of organic pollutants to marine plastic litter may pose risks to marine organisms, notably for what concerns their intake and transfer through microplastic (MP) ingestion. This study found that the sorption of chrysene (CHR) on polystyrene microplastics (MP) did not significantly alter the impact of virgin MP on mussels, and the effects of virgin MP and CHR-MP on mussels were similar.
APPLIED SCIENCES-BASEL
(2021)
Review
Endocrinology & Metabolism
Laura Canesi, Angelica Miglioli, Teresa Balbi, Elena Fabbri
Summary: Contaminants of Emerging Concerns (CECs) refer to chemicals that are not commonly monitored in aquatic ecosystems but have the potential to cause adverse effects on biota. This review focuses on the effects of CECs on the serotonergic system of bivalve molluscs, which is a sensitive target for neuroendocrine disruption in these animals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Rajapaksha Haddokara Gedara Rasika Wathsala, Elena Catasus Folgueras, Letizia Iuffrida, Marco Candela, Roberto Gotti, Jessica Fiori, Silvia Franzellitti
Summary: This study investigates the effects of glyphosate and its metabolite AMPA on cytoprotective and detoxification mechanisms in the haemocytes of Mytilus galloprovincialis. The results show that glyphosate and AMPA can increase MXR efflux activity and modulate the expression of P-glycoprotein. However, the mixtures of glyphosate and AMPA reduce MXR efflux activity and down-regulate ABCB. In addition, the modulation of lysosomal and immune functions by glyphosate and AMPA is consistent with their known effects, suggesting that they may pose a potential threat to the biological vulnerability of marine habitats.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Letter
Multidisciplinary Sciences
Changlei Xia, Su Shiung Lam, Huan Zhong, Elena Fabbri, Christian Sonne
Article
Biology
Fiorella Prada, Silvia Franzellitti, Erik Caroselli, Itay Cohen, Mauro Marini, Alessandra Campanelli, Lorenzo Sana, Arianna Mancuso, Chiara Marchini, Alessia Puglisi, Marco Candela, Tali Mass, Franco Tassi, Todd C. LaJeunesse, Zvy Dubinsky, Giuseppe Falini, Stefano Goffredo
Summary: Ocean acidification caused by increased atmospheric CO2 concentrations is threatening calcifying organisms such as corals. This study examined the adaptation of Mediterranean coral Balanophyllia europaea to low pH/high pCO(2) conditions. It found that the coral's dinoflagellate endosymbiont density increased at lower pH sites, along with changes in the distribution of symbiont haplotypes. The results also suggested an increase in autotrophy and diazotroph N-2 fixation in the coral tissue under ocean acidification. Overall, this study highlights the ability of some corals to adapt to predicted future ocean acidification scenarios.
COMMUNICATIONS BIOLOGY
(2023)
