Article
Cell Biology
Michal Pac, Natalia Krata, Barbara Moszczuk, Aleksandra Wyczalkowska-Tomasik, Beata Kaleta, Bartosz Foroncewicz, Witold Rudnicki, Leszek Paczek, Krzysztof Mucha
Summary: Glomerular diseases such as IgA nephropathy and membranous nephropathy are influenced by NR3C1 gene polymorphisms, which can affect treatment susceptibility and clinical outcomes. Specific associations were found between certain SNPs and these diseases, as well as response to steroid therapy.
Article
Medicine, General & Internal
Camille Cohen, Severine Coulon, Kanit Bhukhai, Antoine Neuraz, Michael Dussiot, Guillemette Fouquet, Marie-Benedicte Le Stang, Martin Flamant, Francois Vrtovsnik, Aurelie Hummel, Bertrand Knebelmann, Laurent Mesnard, Eric Rondeau, Thiago T. Maciel, Fabrizia Favale, Nicole Casadevall, Thao Nguyen-Khoa, Stephane Moutereau, Christophe Legendre, Marc Benhamou, Renato C. Monteiro, Olivier Hermine, Khalil El Karoui, Ivan C. Moura
Summary: The involvement of IgA1 in unexplained polycythemia/erythrocytosis (PE) of IgA nephropathy (IgAN) patients was evaluated in this study. It was found that IgA1 plays a role in regulating erythropoiesis and elevated IgA1 levels increase the sensitivity of erythroid progenitors to Epo.
Article
Microbiology
Fengtao Cai, Chenfen Zhou, Na Jiao, Xinling Liang, Zhiming Ye, Wei Chen, Qiongqiong Yang, Hui Peng, Ying Tang, Chaoqun Niu, Guoping Zhao, Zefeng Wang, Guoqing Zhang, Xueqing Yu
Summary: By conducting large-scale 16S rRNA gene sequencing, this study found microbial dysbiosis in IgAN patients across multiple niches. Opportunistic pathogens increased in the oral and pharynx, while beneficial commensals decreased. These alterations were also observed in different stages of CKD progression.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Zi Wang, Xinfang Xie, Jingyi Li, Xue Zhang, Jiawei He, Manliu Wang, Jicheng Lv, Hong Zhang
Summary: Excessive complement activation is implicated in the formation of crescents, especially diffuse crescent formation, in IgA nephropathy patients. Urinary C4d is correlated with the proportion of crescents and may serve as a potential biomarker for monitoring disease progression in crescentic IgA nephropathy. Combining urine complement products improves predictive ability for renal survival compared to crescents alone.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
J. Yuan, Z. Wang, Y. -P. Wang
Summary: This study identified 47 common differentially expressed genes (DEGs) between CD and IgAN, with CXCL2 being highlighted as a potential therapeutic target due to its correlation with immune infiltration. The diagnostic value of these genes was evaluated and further experimental and clinical research is needed to confirm the results and explore potential therapeutic avenues.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Xuanli Tang, Yuan Yuan, Xiaoli Liang, Xue Jiang
Summary: This study aimed to investigate the potential of Mfn2 as a biomarker to evaluate the degree of podocyte injury in IgA nephropathy. The findings suggest that the absence of Mfn2 indicates severe podocyte injury and a high degree of podocyte effacement in IgA nephropathy.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Immunology
Jie Hou, Li Zhang, Hao Wu, Pujun Gao, Zhonggao Xu
Summary: The study revealed that in patients with IgA nephropathy, levels of circulating CD14+Tim-3+ cells were elevated and correlated with pathological features, indicating a potential involvement of Tim-3+ monocytes/macrophages in the pathogenesis of the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Taro Misaki, Shuhei Naka, Hitoshi Suzuki, Mingfeng Lee, Ryosuke Aoki, Yasuyuki Nagasawa, Daiki Matsuoka, Seigo Ito, Ryota Nomura, Michiyo Matsumoto-Nakano, Yusuke Suzuki, Kazuhiko Nakano
Summary: The presence of cnm-positive S. mutans is associated with IgAN, but the exact mechanism is unclear. This study found a significant association between the glomerular staining intensity of IgA and the positive rate of cnm-positive S. mutans. There was also a significant association between the glomerular staining intensity of Gd-IgA1 and the positive rate of cnm-positive S. mutans.
Article
Immunology
Wanyin Hou, Sufang Shi, Xujie Zhou, Suxia Wang, Qingqing Cai, Pei Chen, Lijun Liu, Li Zhu, Jicheng Lv, Hong Zhang
Summary: This study investigates the role of CFH/CFHRs gene variants in IgAN with microangiopathy. The results show that CFH variants are associated with the development and progression of IgAN with microangiopathy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Urology & Nephrology
Yan-na Wang, Ting Gan, Shu Qu, Lin-lin Xu, Yong Hu, Li-jun Liu, Su-fang Shi, Ji-cheng Lv, Lam C. Tsoi, Matthew T. Patrick, Kevin He, Celine C. Berthier, Hu-ji Xu, Xu-jie Zhou, Hong Zhang
Summary: Multiple genome-wide association studies have identified the MTMR3 gene locus as being associated with IgA nephropathy. This study further investigated the causal variant, implicated gene, and altered mechanisms, and found that the risk allele of rs4823074 may modulate disease susceptibility by affecting serum IgA levels through increased MTMR3 expression. In vitro and in vivo studies demonstrated that MTMR3 is involved in IgA production and immune response, and its deficiency can lead to defective IgA production and kidney damage in mice.
KIDNEY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Alejandra Orozco Guillen, Virgilia Soto Abraham, Bernardo Moguel Gonzalez, Giorgina Barbara Piccoli, Magdalena Madero
Summary: IgA nephropathy is rarely associated with primary podocytopathy and has not been reported in pregnancy, mainly due to the infrequent use of kidney biopsy during pregnancy. We report a case of IgA nephropathy in a pregnant woman, which was timely diagnosed and successfully treated, resulting in a healthy baby and good maternal outcome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Qianqian Li, Li Zhu, Sufang Shi, Damin Xu, Jicheng Lv, Hong Zhang
Summary: In this study, a large IgAN-associated pedigree was investigated, revealing a likely pathogenic variant in the WT1 gene that may contribute to the proteinuria phenotype and progression of IgAN.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Yen-Ling Chiu, Wei-Chou Lin, Kai-Hsiang Shu, Yi-Wen Fang, Fan-Chi Chang, Yu-Hsiang Chou, Ching-Fang Wu, Wen-Chih Chiang, Shuei-Liong Lin, Yung-Ming Chen, Ming-Shiou Wu
Summary: The study found that IgAN patients had higher levels of C5a, factor Ba, and Gd-IgA(1) in plasma compared to healthy controls, with Gd-IgA(1) positively correlated with C5a and factor Ba. Factor Ba and Gd-IgA(1) levels were positively associated with proteinuria, and negatively associated with renal function. Immunosuppressive therapy significantly reduced plasma levels of C5a, factor Ba, and Gd-IgA(1) in patients, leading to decreased proteinuria and stable renal function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pediatrics
Nan Zhou, Hui Wang, Xin-yu Wang, Ye-ping Jiang, Qian Fu, Ying Liang, Guo-shuang Feng
Summary: We analyzed the demographic and clinical characteristics of children with immunoglobulin A (IgA) nephropathy using data in the first pages of electronic health records. This is a large sample, multi-center study. The incidence of IgA nephropathy in males increased gradually with age. Age was an important factor affecting CKD. The disease was related to environment and economic status.
PEDIATRIC RESEARCH
(2023)
Article
Urology & Nephrology
Samar M. Said, Alejandro Best Rocha, Anthony M. Valeri, Mohamad Sandid, Anhisekh Sinha Ray, Mary E. Fidler, Mariam Priya Alexander, Christopher P. Larsen, Samih H. Nasr
Summary: FGN-IgAN is a rare dual glomerulopathy, with clinical presentation and demographics closer to FGN than IgAN. Prognosis is guarded, with a median renal survival of 3.6 years.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Otorhinolaryngology
Dan Bao, Yanfeng Zhao, Zhou Liu, Haijun Xu, Ya Zhang, Meng Yuan, Lin Li, Meng Lin, Xinming Zhao, Dehong Luo
Summary: This study developed a model based on MRI radiomics and clinical features to predict radiation-induced temporal lobe injury (RTLI) in patients with nasopharyngeal carcinoma (NPC). The clinical-radiomics model and radiomics signature both showed excellent performance in predicting RTLI in patients with NPC.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Yanfeng Zhao, Dan Bao, Xiaoyi Wang, Meng Lin, Lin Li, Zheng Zhu, Xinming Zhao, Dehong Luo
Summary: This study investigates the performance of a predictive model for carotid artery invasion in patients with head and neck masses using computed tomography (CT). The results show that a predictive model based on patient characteristics and CT data can be established to aid in surgical planning and invasion evaluation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fan Yang, Yujie Li, Huizi Lei, Haoran Wei, Qiang Du, Xiaoduo Yu, Xiaolu Li, Yanfeng Zhao, Lin Li, Lizhi Xie, Meng Lin
Summary: This study analyzed the association between histogram parameters derived from synthetic MRI (SyMRI) and different histopathological factors in head and neck squamous cell carcinoma (HNSCC). The results showed that histogram parameters of SyMRI were associated with histological grade, HPV infection, Ki-67, EGFR, and p53 statuses. These findings suggest that histogram parameters derived from SyMRI may serve as a potential biomarker for discriminating relevant histopathological features.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Urology & Nephrology
Zihan Ma, Chenfeng Mao, Yiting Jia, Fang Yu, Ping Xu, Ying Tan, Qing-Hua Zou, Xu-Jie Zhou, Wei Kong, Yi Fu
Summary: In this study, it was found that ADAMTS7-mediated degradation of CFH contributes to complement activation and renal injuries. ADAMTS7 may be a promising therapeutic target for anticomplement treatments without increasing the risk of bacterial infection.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fan Yang, Yujie Li, Xiaolu Li, Xiaoduo Yu, Yanfeng Zhao, Lin Li, Lizhi Xie, Meng Lin
Summary: The study aims to investigate the diagnostic performance of synthetic magnetic resonance imaging (SyMRI) in differentiating nasopharyngeal carcinoma (NPC) from nasopharyngeal hyperplasia (NPH) and evaluating occipital clivus (OC) invasion. The results showed that the T1, T2, and PD map-derived models had excellent diagnostic performance in discriminating NPC from NPH. In addition, the SyMRI models also showed excellent performance in distinguishing OC invasion from non-invasion.
BMC MEDICAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yanfeng Zhao, Dan Bao, Wenli Wu, Wei Tang, Gusheng Xing, Xinming Zhao
Summary: A predictive model for pneumothorax after computed tomography-guided coaxial core needle biopsy (CCNB) was developed and validated. The model showed good predictive performance and may help improve individualized preoperative prediction.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dan Bao, Yanfeng Zhao, Wenli Wu, Hongxia Zhong, Meng Yuan, Lin Li, Meng Lin, Xinming Zhao, Dehong Luo
Summary: This study evaluated the predictive potential of histogram analysis derived from ADC maps in radiation-induced temporal lobe injury (RTLI) in nasopharyngeal carcinoma (NPC) patients after intensity-modulated radiotherapy (IMRT). The results showed that the combination of ADC histogram parameters and T stage had a satisfactory ability to predict RTLI in NPC after IMRT.
INSIGHTS INTO IMAGING
(2022)
Article
Urology & Nephrology
Xu-Jie Zhou, Tao Su, Jingyuan Xie, Qiong-Hong Xie, Li-Zhong Wang, Yong Hu, Gang Chen, Yan Jia, Jun-Wen Huang, Gui Li, Yang Liu, Xiao-Juan Yu, Swapan K. Nath, Lam C. Tsoi, Matthew T. Patrick, Celine C. Berthier, Gang Liu, Su-Xia Wang, Huji Xu, Nan Chen, Chuan-Ming Hao, Hong Zhang, Li Yang
Summary: This study identified two candidate genome regions associated with susceptibility to acute tubulointerstitial nephritis (ATIN), suggesting a genetically conferred risk of immune dysregulation is involved in the pathogenesis of ATIN.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Ya-Li Ren, Yang Li, Jie Gao, Xu-Jie Zhou, Li Yang, Su-Xia Wang
Summary: This study aimed to explore the clinicopathological features of late-onset oligomeganephronia (OMN) using histomorphometric analysis. The results showed that late-onset OMN is a relatively slow progressing disease characterized by hypertrophy of the sparsely distributed nephron. Patients with late-onset OMN exhibited mild to moderate proteinuria and/or renal dysfunction, along with renal tubular injury.
Article
Radiology, Nuclear Medicine & Medical Imaging
Fan Yang, Haoran Wei, Xiaolu Li, Xiaoduo Yu, Yanfeng Zhao, Lin Li, Yujie Li, Lizhi Xie, Sicong Wang, Meng Lin
Summary: This study aimed to investigate the potential of synthetic MRI (SyMRI) in prognostic assessment of patients with nonmetastatic nasopharyngeal carcinoma (NPC), and its predictive value when combined with diffusion-weighted imaging (DWI) and clinical factors. Results showed that SyMRI combined with histogram analysis could predict disease progression in NPC patients, and the SyMRI + DWI + Clinic model further improved the predictive performance.
INSIGHTS INTO IMAGING
(2023)
Article
Rheumatology
Yaoyang Liu, Zhiguo Zhang, Zijian Kang, Xu-jie Zhou, Shujun Liu, Shicheng Guo, Qianmei Jin, Ting Li, Ling Zhou, Xin Wu, Yan-na Wang, Liangjing Lu, Yanran He, Fubin Li, Hong Zhang, Yuncai Liu, Huji Xu
Summary: In this study, the decrease and disruption of B-ND cells in SLE patients were characterized, and IL-4 was identified as an important cytokine driving these pathological changes. Furthermore, it was demonstrated that IL-4 reverses B cell anergy by promoting BCR recycling via STAT6 signaling.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Urology & Nephrology
Yuqi Kang, Boyang Xu, Sufang Shi, Xujie Zhou, Pei Chen, Lijun Liu, Yebei Li, Yueqi Leng, Jicheng Lv, Li Zhu, Hong Zhang
Summary: In Chinese patients with IgA nephropathy, variant rs6677604 is associated with mesangial C3 deposition, and mesangial C3 deposition, but not rs6677604, is associated with IgA nephropathy severity and progression.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fan Yang, Xiaolu Li, Yujie Li, Huizi Lei, Qiang Du, Xiaoduo Yu, Lin Li, Yanfeng Zhao, Lizhi Xie, Meng Lin
Summary: Our study found that histogram parameters derived from synthetic magnetic resonance imaging (SyMRI) were positively correlated with prognostically relevant factors in nasopharyngeal carcinoma (NPC). These results suggest that these histogram parameters have potential value in assessing the expression levels of Ki-67 and EGFR, histological type, EBV DNA level, EA-IgA, and tumor stage in NPC.
EUROPEAN RADIOLOGY
(2023)
Review
Multidisciplinary Sciences
Xu-Jie Zhou, Xu-Hui Zhong, Li-Xin Duan
Summary: Kidney disease is a leading cause of death worldwide. The current diagnosis and severity grading of kidney diseases are mainly based on clinical features, which do not reveal the underlying molecular pathways. The application and integration of artificial intelligence (AI) and multi-omics offer opportunities to develop novel diagnostic and therapeutic means in kidney diseases.
FUNDAMENTAL RESEARCH
(2023)
Article
Urology & Nephrology
Zhuo-ran Song, Yang Li, Yanqin Zhang, Xu-jie Zhou, Hong Zhang
JOURNAL OF NEPHROLOGY
(2022)
