Article
Clinical Neurology
Xi Chen, Xiaoli Zhang, Wenhua Li, Wendong Li, Yong Wang, Shan Zhang, Changlian Zhu
Summary: Preterm births with different etiologies are associated with varying neonatal complications, but no differences in neurodevelopmental outcomes were observed at 12 months of corrected age.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Avinash S. Patil, Chad A. Grotegut, Nilesh W. Gaikwad, Shelley D. Dowden, David M. Haas
Summary: Plasma levels of DOC and 16 alpha-OHP in early gestation, combined with patient demographic and clinical data, can predict significant neonatal morbidity, neonatal length of stay, and the risk for very preterm delivery. Validation studies are needed to confirm these findings. Early identification of pregnancies at risk for preterm delivery and neonatal morbidity can lead to timely multidisciplinary care and improved perinatal outcomes.
Article
Pediatrics
Henni Hiltunen, Maria Carmen Collado, Helena Ollila, Terhi Kolari, Satu Tolkko, Erika Isolauri, Seppo Salminen, Samuli Rautava
Summary: The gut microbiota in preterm neonates differs from those born full term. Spontaneous preterm birth is reflected in changes in the gut microbiota composition of both preterm neonates and their mothers. The maternal gut microbiota plays a more significant role in determining the initial neonatal gut colonization after spontaneous preterm delivery than iatrogenic preterm delivery.
PEDIATRIC RESEARCH
(2022)
Article
Obstetrics & Gynecology
Diane Korb, Francois Goffinet, Loic Sentilhes, Gilles Kayem, Marie Victoire Senat, Elie Azria, Thomas Schmitz
Summary: This study assessed the survival of very preterm twins to discharge without severe neonatal morbidity based on the planned mode of delivery. The results showed that planned cesarean delivery was not associated with higher survival rates compared to planned vaginal delivery. This suggests that very preterm delivery should not automatically be an indication for planned cesarean in twin pregnancies.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Oncology
Laura K. Seppala, Kim Vettenranta, Maarit K. Leinonen, Viena Tommiska, Laura-Maria Madanat-Harjuoja
Summary: A nationwide study in Finland found that preterm birth, especially early preterm birth, is associated with an increased risk of childhood cancer, including germ cell tumors and acute myeloid leukemia. Neonatal therapies, such as mechanical ventilation, are also linked to an increased risk of childhood cancer independent of gestational age.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Pediatrics
Praveen Chandrasekharan, Sylvia Gugino, Carmon Koenigsknecht, Justin Helman, Lori Nielsen, Nicole Bradley, Jayasree Nair, Deepika Sankaran, Mausma Bawa, Munmun Rawat, Satyan Lakshminrusimha
Summary: This study investigated the effects of different interventions (delayed cord clamping with ventilation, umbilical cord milking without ventilation, umbilical cord milking with ventilation, early cord clamping followed by ventilation) on red cell volume and hemodynamics in asphyxiated preterm lambs. The results showed that umbilical cord milking with ventilation led to higher red cell volume, while umbilical cord milking without ventilation resulted in greater fluctuations in carotid blood flow.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Juan D. Rios, Prakesh S. Shah, Marc Beltempo, Deepak Louis, Amit Mukerji, Shahirose Premji, Vibhuti Shah, Shoo K. Lee, Petros Pechlivanoglou
Summary: The study developed and validated an itemized costing algorithm for in-patient neonatal intensive care unit (NICU) costs for prematurely born infants. Results showed that NICU costs for preterm infants increase as gestational age decreases and length of stay increases. The cost estimates provided are easily accessible, transparent, and consistent with previous estimates.
JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Xue Yu, Chunhua He, Yanping Wang, Leni Kang, Lei Miao, Jian Chen, Qihui Zhao, Xiaona Huang, Jun Zhu, Juan Liang, Qi Li, Meixian Wang, Hanmin Liu
Summary: This study analyzed the epidemic characteristics of neonatal mortality due to preterm birth at 28-36 weeks gestation in different regions of China from 2009 to 2018. The study found that preterm birth was the main cause of neonatal deaths, with a significant downward trend in preterm neonatal mortality rates, and there were regional differences in the proportion of preterm neonatal deaths, as well as in the delivery patterns of preterm neonates among different regions.
Article
Neuroimaging
Peppar E. P. Cyr, Rachel E. Lean, Jeanette K. Kenley, Sydney Kaplan, Dominique E. Meyer, Jeffery J. Neil, Dimitrios Alexopoulos, Rebecca G. Brady, Joshua S. Shimony, Thomas L. Rodebaugh, Cynthia E. Rogers, Christopher D. Smyser
Summary: Preterm-born children have high rates of motor impairments, but mechanisms for early identification remain limited. This study investigated the relationship between neonatal motor system functional connectivity (FC) and motor outcomes in very preterm (VPT) infants with and without brain injury. The results showed that interhemispheric motor cortex FC was positively related to gross motor outcomes in the brain-injured group. This suggests that changes in motor system FC in newborns may provide prognostic information about impairments in children with brain injury.
NEUROIMAGE-CLINICAL
(2022)
Article
Medicine, General & Internal
Elisabeth C. McGowan, Julie A. Hofheimer, T. Michael O'Shea, Howard Kilbride, Brian S. Carter, Jennifer Check, Jennifer Helderman, Charles R. Neal, Steve Pastyrnak, Lynne M. Smith, Marie Camerota, Lynne M. Dansereau, Sheri A. Della Grotta, Barry M. Lester
Summary: This study found that high-risk neonatal neurobehavioral patterns at NICU discharge were associated with adverse cognitive, motor, and behavioral outcomes at 2 years.
Article
Urology & Nephrology
Chih-Chia Chen, Chi-Hsiang Chu, Yung-Chieh Lin, Chao-Ching Huang
Summary: This study found that neonatal oliguric acute kidney injury (AKI) is associated with neurodevelopmental impairment in very preterm-birth children. The study also suggests that long-term follow-up of head size and neurodevelopment after neonatal AKI is necessary.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Obstetrics & Gynecology
Sarah Saleem, Shiyam Sunder S. Tikmani, Shivaprasad Goudar, Kay Hwang, Sangappa Dhaded, Gowder G. Guruprasad, Naveen B. Nadig, Varun Kusagur, Lingaraja Gowda C. Patil, E. S. Siddartha, S. S. Yogeshkumar, Manjunath Somannavar, Sana Roujani, Mashal Khan, Mehmood Shaikh, Muhammad M. Hanif, Carla M. Bann, Elizabeth L. McClure, Robert Goldenberg, PURPOSE Study Group
Summary: This study investigated the potential reasons for the differences in preterm neonatal mortality between neonatal intensive care units (NICUs) in India and Pakistan. Despite equivalent weights and gestational ages, the neonatal mortality in the Pakistani NICU was twice that of the Indian NICU. Shorter length of stay and fewer diagnostic tests in the Pakistani NICU may explain the higher mortality.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Multidisciplinary Sciences
Byoung Kook Lee, Jun Hyeok Lee, Jeongmin Shin, Young Hwa Jung, Chang Won Choi
Summary: The study found that low BMI at birth was associated with an increased risk of bronchopulmonary dysplasia and necrotizing enterocolitis in preterm infants, while high BMI was not associated with adverse neonatal outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Jinjun Zhou, Shuangshuang Li, Li Gu, Xiaohua Zhang, Zhen Tang
Summary: The study found a correlation between poor GM scores in preterm infants and low NBNA scores, as well as between abnormal cerebral MRI results and low NBNA scores. Additionally, preterm infants with poor GM scores were more likely to have abnormal results in cerebral MRI assessments.
Article
Peripheral Vascular Disease
Daniela Ravizzoni Dartora, Adrien Flahault, Carolina N. R. Pontes, Ying He, Alyson Deprez, Anik Cloutier, Gael Cagnone, Perrine Gaub, Gabriel Altit, Jean-Luc Bigras, Jean-Sebastien Joyal, Thuy Mai Luu, Yan Burelle, Anne Monique Nuyt
Summary: This study found that neonatal hyperoxia in rats resulted in impaired left ventricle mitochondrial structure and function, and lower levels of humanin in preterm adults. These findings suggest that preterm birth-related conditions may lead to cardiac changes and increased risk for heart health.
Article
Obstetrics & Gynecology
S. Nagai, M. Kawai, M. Myowa-Yamakoshi, T. Morimoto, T. Matsukura, T. Heike
JOURNAL OF PERINATOLOGY
(2017)
Review
Pediatrics
Masahiko Kawai
PEDIATRICS INTERNATIONAL
(2017)
Review
Obstetrics & Gynecology
Masahiko Kawai
AMERICAN JOURNAL OF PERINATOLOGY
(2018)
Article
Obstetrics & Gynecology
Masahiro Imafuku, Masahiko Kawai, Fusako Niwa, Yuta Shinya, Masako Myowa
EARLY HUMAN DEVELOPMENT
(2019)
Article
Pediatrics
Seiichi Tomotaki, Katsuaki Toyoshima, Tomoyuki Shimokaze, Masahiko Kawai
PEDIATRICS INTERNATIONAL
(2019)
Article
Obstetrics & Gynecology
Seiichi Tomotaki, Kougoro Iwanaga, Shintaro Hanaoka, Hiroko Tomotaki, Takashi Matsukura, Fusako Niwa, Masahiko Kawai
Summary: The study found that infants who received a complete course of AGs had a significantly lower incidence of RH in the first week of life compared to other groups. However, there was no significant difference in the incidence of RH after the first week of life among the groups.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Pathology
Akiko Kitano, Masato Nakaguro, Seiichi Tomotaki, Shintaro Hanaoka, Masahiko Kawai, Akiko Saito, Masahiro Hayakawa, Yoshiyuki Takahashi, Hidenori Kawasaki, Takahiro Yamada, Masahiko Ikeda, Tetsuo Onda, Kazutoshi Cho, Hironori Haga, Atsuko Nakazawa, Sachiko Minamiguchi
DIAGNOSTIC PATHOLOGY
(2020)
Article
Endocrinology & Metabolism
Akane Yamamoto, Kogoro Iwanaga, Takashi Matsukura, Fusako Niwa, Takeshi Morimoto, Junko Takita, Masahiko Kawai
CLINICAL ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Shintaro Hanaoka, Kogoro Iwanaga, Seiichi Tomotaki, Fusako Niwa, Junko Takita, Masahiko Kawai
CLINICAL ENDOCRINOLOGY
(2020)
Article
Nutrition & Dietetics
Kouji Motokura, Seiichi Tomotaki, Shintaro Hanaoka, Takeru Yamauchi, Hiroko Tomotaki, Kougoro Iwanaga, Fusako Niwa, Junko Takita, Masahiko Kawai
Summary: High-dose phosphorus supplementation through parenteral nutrition can prevent metabolic bone disease in extremely low-birth-weight infants by maintaining high calcium intake, reducing ALP levels, and decreasing the risk of bone disease.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Seiichi Tomotaki, Ryosuke Araki, Kouji Motokura, Yutaro Tomobe, Takeru Yamauchi, Shintaro Hanaoka, Hiroko Tomotaki, Kougoro Iwanaga, Fusako Niwa, Junko Takita, Masahiko Kawai
Summary: This study found that the passage of ingested material through the digestive tract is not important for fetal secretion of GLP-1 and GIP, but enteral feeding plays a crucial role in the postnatal secretion of these incretins. Preprandial serum concentrations of GLP-1 and GIP in infants were positively correlated with the amount of enteral feeding, indicating the importance of nutrition in incretin secretion after birth.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Pediatrics
Ryosuke Araki, Seiichi Tomotaki, Mitsuyo Akita, Kouji Motokura, Yutaro Tomobe, Takeru Yamauchi, Shintaro Hanaoka, Hiroko Tomotaki, Kogoro Iwanaga, Fusako Niwa, Junko Takita, Masahiko Kawai
Summary: This study aimed to evaluate the association between electrical activity of the diaphragm (Edi) waveform patterns and peripheral oxygen saturation (SpO(2)) in extremely preterm infants ventilated with neurally adjusted ventilatory assist (NAVA). The study found that different Edi waveform patterns were associated with desaturation of SpO(2) in extremely preterm infants. The phasic pattern had a significantly lower proportion in the desaturation group, while the central apnea, irregular low-voltage, and tonic burst patterns had significantly higher proportions in the desaturation group.
PEDIATRIC PULMONOLOGY
(2021)
Article
Multidisciplinary Sciences
Hoshinori Kanazawa, Yasunori Yamada, Kazutoshi Tanaka, Masahiko Kawai, Fusako Niwa, Kougoro Iwanaga, Yasuo Kuniyoshi
Summary: Spontaneous movements in the early developmental stage play a crucial role in structuring and organizing sensorimotor interactions in the entire body, leading to subsequent coordinated behaviors. These movements exhibit specific regularities and temporal characteristics that contribute to the development of sensorimotor modules.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Takeru Yamauchi, Masatoshi Imamura, Kei Takasawa, Keisuke Nakajima, Ryuichi Nakagawa, Maki Gau, Manabu Sugie, Atsuko Taki, Masahiko Kawai, Kenichi Kashimada, Tomohiro Morio
Article
Endocrinology & Metabolism
Kougoro Iwanaga, Akane Yamamoto, Takashi Matsukura, Fusako Niwa, Masahiko Kawai
CLINICAL ENDOCRINOLOGY
(2017)