Editorial Material
Cardiac & Cardiovascular Systems
Christoph Binder, Giuseppe Danilo Norata
CARDIOVASCULAR RESEARCH
(2021)
Article
Endocrinology & Metabolism
Michela Palmieri, Ha-Neui Kim, Horacio Gomez-Acevedo, Xuchu Que, Sotirios Tsimikas, Robert L. Jilka, Stavros C. Manolagas, Joseph L. Witztum, Elena Ambrogini
Summary: E06 can potentially promote trabecular and cortical bone growth in female and male mice by neutralizing OxPL, leading to reduced osteoblast apoptosis. Homozygous E06-scFv mice have higher bone mass than hemizygous, indicating a dose effect of the transgene.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Tian X. Zhao, Muhammad Aetesam-Ur-Rahman, Andrew P. Sage, Saji Victor, Rincy Kurian, Sarah Fielding, Hafid Ait-Oufella, Yi-Da Chiu, Christoph J. Binder, Mikel Mckie, Stephen P. Hoole, Ziad Mallat
Summary: The use of Rituximab in patients with acute ST-elevation myocardial infarction (STEMI) appears to be safe and has a substantial impact on circulating B-cell subsets. These findings provide important new insights on the feasibility and pharmacodynamics of Rituximab in acute STEMI, which will inform further clinical translation of this potential therapy.
CARDIOVASCULAR RESEARCH
(2022)
Article
Medicine, General & Internal
Miriam Klausberger, Mark Duerkop, Helmuth Haslacher, Gordana Wozniak-Knopp, Monika Cserjan-Puschmann, Thomas Perkmann, Nico Lingg, Patricia Pereira Aguilar, Elisabeth Laurent, Jelle De Vos, Manuela Hofner, Barbara Holzer, Maria Stadler, Gabriele Manhart, Klemens Vierlinger, Margot Egger, Lisa Milchram, Elisabeth Gludovacz, Nicolas Marx, Christoph Koeppl, Christopher Tauer, Juergen Beck, Daniel Maresch, Clemens Gruenwald-Gruber, Florian Strobl, Peter Satzer, Gerhard Stadlmayr, Ulrike Vavra, Jasmin Huber, Markus Wahrmann, Farsad Eskandary, Marie-Kathrin Breyer, Daniela Sieghart, Peter Quehenberger, Gerda Leitner, Robert Strassl, Alexander E. Egger, Christian Irsara, Andrea Griesmacher, Gregor Hoermann, Guenter Weiss, Rosa Bellmann-Weiler, Judith Loeffler-Ragg, Nicole Borth, Richard Strasser, Alois Jungbauer, Rainer Hahn, Juergen Mairhofer, Boris Hartmann, Nikolaus B. Binder, Gerald Striedner, Lukas Mach, Andreas Weinhaeusel, Benjamin Dieplinger, Florian Grebien, Wilhelm Gerner, Christoph J. Binder, Reingard Grabherr
Summary: In this study, two quantitative SARS-CoV-2 antibody tests were developed, showing high specificity and sensitivity. These tests, based on spike receptor binding domain and nucleocapsid protein antigens, demonstrated comparable performance to fully-automated CE-marked test systems. Comprehensive evaluation of antigens and optimal cut-off modeling allowed for reliable serodiagnosis in various clinical settings.
Article
Pharmacology & Pharmacy
Philipp J. Hohensinner, Max Lenz, Patrick Haider, Julia Mayer, Manuela Richter, Christoph Kaun, Laura Goederle, Mira Brekalo, Manuel Salzmann, Smriti Sharma, Michael B. Fischer, Stefan Stojkovic, Daniel Ramsmayer, Christian Hengstenberg, Bruno K. Podesser, Kurt Huber, Christoph J. Binder, Johann Wojta, Walter S. Speidl
Summary: The inhibition of fatty acid oxidation has been shown to reduce atherosclerotic plaque growth by decreasing the activation of the NLRP-3 system and subsequently lowering the levels of the proinflammatory cytokine IL-1 beta.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Florentina Porsch, Ziad Mallat, Christoph J. Binder
Summary: Research indicates that B cells and humoral immunity play a crucial role in atherosclerotic cardiovascular disease, involving antibody levels, B-cell subsets, and antigen-specific antibody generation. B cells mediate both protective and detrimental effects in cardiovascular disease by regulating adaptive and innate immune responses and other immune cells.
CARDIOVASCULAR RESEARCH
(2021)
Article
Medicine, General & Internal
Thomas Perkmann, Nicole Perkmann-Nagele, Thomas Koller, Patrick Mucher, Astrid Radakovics, Michael Wolzt, Oswald F. Wagner, Christoph J. Binder, Helmuth Haslacher
Summary: Individuals with previous SARS-CoV-2 infection showed significantly higher antibody response after receiving the first dose of the Pfizer vaccine compared to those who were naive to the virus. This suggests the need for further research on whether individuals with prior infection would benefit from a two-dose vaccination schedule or if the second doses could be saved for others in need.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Infectious Diseases
Thomas Perkmann, Nicole Perkmann-Nagele, Patrick Mucher, Astrid Radakovics, Manuela Repl, Thomas Koller, Galateja Jordakieva, Oswald F. Wagner, Christoph J. Binder, Helmuth Haslacher
Summary: The study suggests that antibody levels quantified before the booster shot with the Roche Elecsys SARS-CoV-2 S assay may predict post-booster responses to BNT162b2, but not to AZD1222. There is a vaccine-dependent effect on antibody responses, with age playing an ambivalent role in the immune response.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Dimitrios Tsiantoulas, Mahya Eslami, Georg Obermayer, Marc Clement, Diede Smeets, Florian J. Mayer, Mate G. Kiss, Lennart Enders, Juliane Weisser, Laura Goderle, Jordi Lambert, Florian Frommlet, Andre Mueller, Tim Hendrikx, Maria Ozsvar-Kozma, Florentina Porsch, Laure Willen, Taras Afonyushkin, Jane E. Murphy, Per Fogelstrand, Olivier Donze, Gerard Pasterkamp, Matthias Hoke, Stefan Kubicek, Helle F. Jorgensen, Nicolas Danchin, Tabassome Simon, Hubert Scharnagl, Winfried Marz, Jan Boren, Henry Hess, Ziad Mallat, Pascal Schneider, Christoph J. Binder
Summary: This study reveals that genetic ablation or antibody-mediated depletion of APRIL exacerbates atherosclerosis in mice. Mechanistically, APRIL confers atheroprotection by binding to heparan sulfate chains of HSPG2, limiting the retention of low-density lipoproteins. Treatment with a specific anti-APRIL antibody reduces experimental atherosclerosis, indicating the physiological significance of APRIL in vascular homeostasis.
Article
Cardiac & Cardiovascular Systems
Huijuan Dou, Andriana Kotini, Wenli Liu, Trevor Fidler, Kaori Endo-Umeda, Xiaoli Sun, Malgorzata Olszewska, Tong Xiao, Sandra Abramowicz, Mustafa Yalcinkaya, Brian Hardaway, Sotirios Tsimikas, Xuchu Que, Alexander Bick, Conor Emdin, Pradeep Natarajan, Eirini P. Papapetrou, Joseph L. Witztum, Nan Wang, Alan R. Tall
Summary: Hematopoietic Lnk deficiency promotes NETosis and arterial thrombosis. Individuals carrying the JAK2(VF) mutation along with the LNK R262W allele are at increased risk of coronary artery disease.
Review
Cardiac & Cardiovascular Systems
Mate G. Kiss, Christoph J. Binder
Summary: The complement system plays an important role in the pathogenesis of atherosclerosis, with both protective and proatherogenic properties. The role of local complement activation in lesion formation remains unclear.
Review
Cardiac & Cardiovascular Systems
Sean M. Davidson, Chantal M. Boulanger, Elena Aikawa, Lina Badimon, Lucio Barile, Christoph J. Binder, Alain Brisson, Edit Buzas, Costanza Emanueli, Felix Jansen, Miroslava Katsur, Romaric Lacroix, Sai Kiang Lim, Nigel Mackman, Manuel Mayr, Philippe Menasche, Rienk Nieuwland, Susmita Sahoo, Kaloyan Takov, Thomas Thum, Pieter Vader, Marca H. M. Wauben, Kenneth Witwer, Joost P. G. Sluijter
Summary: This article provides an overview of the techniques and technologies available for the separation and characterization of EVs from different sources. It discusses methods for determining the protein, RNA, and lipid content of EVs. The guidance provided in this document is important for investigating the role of EVs in cardiovascular diseases and highlights key methodological issues to consider.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Hidde Douna, Virginia Smit, Gijs H. M. van Puijvelde, Mate G. Kiss, Christoph J. Binder, Llze Bot, Vijay K. Kuchroo, Andrew H. Lichtman, Johan Kuiper, Amanda C. Foks
Summary: This study found that Tim-1(delta mucin) mice played an important role in the development of atherosclerosis, showing significant impairment of IL-10+ B cells and an imbalance in the Th1/Th2 ratio.
Article
Biochemistry & Molecular Biology
Adam Taleb, Peter Willeit, Shahzada Amir, Thomas Perkmann, Maria Ozsvar Kozma, Martin L. Watzenboeck, Christoph J. Binder, Joseph L. Witztum, Sotirios Tsimikas
Summary: This study shows that high levels of IgM antibodies to oxidation-specific epitopes (OSEs) may be protective against acute myocardial infarction (AMI) in humans. The levels of IgM OSEs were significantly lower in AMI patients compared to controls. These findings provide important clinical information and support the hypothesis that IgM OSEs have a protective effect against AMI.
JOURNAL OF LIPID RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Justine Deroissart, Christoph J. Binder
Summary: IgM antibodies are considered as risk markers of atherosclerotic cardiovascular disease, but the specific antigens and their full range of functions are still unclear. A better understanding of the potential diversity of antigens recognized by IgM will help in unraveling the role of IgM in atherosclerosis.
NATURE REVIEWS CARDIOLOGY
(2023)