Article
Toxicology
Ebru Gueclue, Ilknur Cinar Ayan, Hatice Guel Dursun, Hasibe Vural
Summary: The aim of this study was to investigate the anticancer effects of tomentosin on pancreatic cancer cells. The results showed that tomentosin suppressed colony formation, increased apoptosis rate and ROS production, and affected the expression levels of apoptosis-related genes. Additionally, tomentosin inhibited cell migration and invasion.
TOXICOLOGY IN VITRO
(2022)
Article
Oncology
Lun Liu, Ruijing Wang, Zian Zhang, Xiangda Wang
Summary: NGX6 is downregulated in osteosarcoma, and its overexpression inhibits cell viability, migration, invasion, and promotes apoptosis in OS cells. Additionally, NGX6 inhibits xenograft tumor growth by blocking the Wnt/beta-catenin signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Food Science & Technology
Yu Kang, Xiao Wang, Xingchuan Wei, Dongli Li, Lishe Gan, Jingwei Jin, Rihui Wu, Panpan Wu, Zhaojun Sheng, Kun Zhang, Susan Goodin, Xuetao Xu, Xi Zheng
Summary: Both a-Humulene and sclareol in combination synergistically inhibit the growth of pancreatic cancer cells by inducing apoptosis, suppressing migration, invasion, and sphere formation. Mechanistically, the combination decreases the levels of NF-kappa B, pAkt, and Bcl-2 and increases the level of Bax. In addition, the combination also suppresses tumor growth in an in vivo xenograft model.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biotechnology & Applied Microbiology
Xuelian Gong, Ling Jiang, Wei Li, Qingbin Liang, Zhen Li
Summary: The study showed that curcumin effectively inhibited cell viability of renal cell carcinoma, induced apoptosis and autophagy by suppressing the AKT/mTOR pathway. Using curcumin to target the AKT/mTOR pathway could be a promising alternative treatment for RCC.
Article
Biochemistry & Molecular Biology
Woonghee Lee, Gwonhwa Song, Hyocheol Bae
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with high resistance to conventional treatment. In this study, Glucotropaeolin (GT), a compound from Brassicaceae family, showed potential as a therapeutic drug against PDAC by inhibiting cell proliferation and inducing apoptosis through multiple pathways.
Article
Biochemistry & Molecular Biology
Xing Jiang, Haihui Yin, Wenqing Su, Haiyan Quan, Xinye Yuan, Xu Feng, Pei Li, Yan He, Junhui Xiao, Rong Li
Summary: Nasopharyngeal carcinoma (NPC) is a recurrent and metastatic tumor in southern China, and traditional Chinese herbal medicine, with its mild therapeutic effects and minimal side effects, has gained popularity in treating various diseases. Trifolirhizin, a natural flavonoid derived from leguminous plants, has been found to effectively inhibit the proliferation, migration, and invasion of NPC cells by suppressing the PI3K/Akt signaling pathway. This study provides valuable insights into the potential therapeutic applications of trifolirhizin for NPC treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Food Science & Technology
Ting Gu, Wei Yuan, Chen Li, Zhilong Chen, Yuting Wen, Qiyi Zheng, Qing Yang, Xingyao Xiong, Anwen Yuan
Summary: alpha-Solanine exhibits inhibitory effects on human choriocarcinoma cells, reducing colony formation, increasing cell apoptosis, and decreasing migration and invasion abilities. The mechanism may involve the downregulation of matrix metalloproteinases. Its suppressive effects were further confirmed in vivo, with smaller tumor volumes and promoted apoptosis in xenograft tumors.
Article
Biochemistry & Molecular Biology
Xiaohu Li, Xin Zhang, Inam Ullah Khan, Nina N. Guo, Bing Wang, Yifeng Guo, Bufan Xiao, Yueshan Zhang, Yimin Chu, Junsong Chen, Fang Guo
Summary: This study found that the combination of lobaplatin and microwave hyperthermia effectively reduced viability, invasion, and metastasis of breast cancer cells while inducing apoptosis and autophagy. The mechanism for this effect may involve the activation of the JNK signaling pathway, inactivation of the AKT/mTOR signaling pathway, and down-regulation of Bcl-2 and IAP proteins.
BIOSCIENCE REPORTS
(2022)
Article
Plant Sciences
Junyi Shen, Xinrui Zhu, Zhenru Wu, Yujun Shi, Tianfu Wen
Summary: Uvangoletin can induce apoptotic and autophagic cell death, inhibit cell proliferation and metastasis on HepG2 cells through Akt/mTOR, MAPK, and TGF beta/Smad2 signal pathways.
Article
Biochemistry & Molecular Biology
Hong-Mei Li, Hui Ma, Xiaolong Sun, Bohan Li, Chengjiang Cao, Yiqun Dai, Meilin Zhu, Cheng-Zhu Wu
Summary: Ginkgolic acids (GAS) isolated from Ginkgo biloba exhibit anti-cancer properties by inhibiting the growth and metastasis of human cancer cells, with low toxicity in animal experiments. The study suggests that GAS may serve as promising Hsp90 inhibitors for the development of anti-nasopharyngeal carcinoma agents.
Article
Oncology
Raphaela Schwappacher, Walburga Dieterich, Dejan Reljic, Christian Pilarsky, Debabrata Mukhopadhyay, David K. Chang, Andrew Biankin, Juergen Siebler, Hans J. Herrmann, Markus F. Neurath, Yurdagul Zopf
Summary: Exercise-induced cytokines in serum from advanced-stage pancreatic cancer patients inhibit cancer cell growth and migration, and induce cancer cell death. This study provides new insights into the cancer-protective function of exercise in pancreatic cancer and supports the use of sport therapies for cancer patients.
Article
Biochemistry & Molecular Biology
Yiqun Dai, Xiaolong Sun, Bohan Li, Hui Ma, Pingping Wu, Yingping Zhang, Meilin Zhu, Hong-Mei Li, Minjian Qin, Cheng-Zhu Wu
Summary: Hispidulin, a flavonoid extracted from Salvia plebeia, has shown anti-proliferative, apoptosis-inducing, migration and invasion inhibiting effects in nasopharyngeal carcinoma cells. Experimental results suggest that hispidulin may be a potentially effective agent for NPC treatment.
Article
Endocrinology & Metabolism
Lichao Zhang, Shaoxia Zi
Summary: This study demonstrates that parthenolide inhibits cell viability and induces apoptosis in melanoma cells through the inhibition of the PI3K/AKT signaling pathway. It may serve as an adjuvant therapy.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Medicine, Research & Experimental
Xun Wang, Shuang Zou, Tong Ren, Li-Jun Zhao, Li-Fei Yu, Xiang-Yu Li, Xin Yan, Li-Jun Zhang
Summary: This study demonstrated that ATL activates cofilin by targeted inhibition of LIMK enzyme activity, leading to an increase in the G/F actin ratio and inhibition of GBM cell migration and invasion. Conversely, the activation of cofilin and G-actin can be co-transferred to the mitochondria to initiate the mitochondrial-cytochrome c pathway to induce apoptosis. These findings highlight the potential of ATL in inhibiting the metastatic phenotype of GBM cells and inducing apoptosis through multiple pathways and targets in GBM models.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Chantana Boonyarat, Kanlaya Sangchavee, Kusawadee Plekratoke, Chavi Yenjai, Prasert Reubroycharoen, Rawiwun Kaewamatawong, Pornthip Waiwut
Summary: The study aimed to investigate the inhibitory activity of candidone on human hepatoblastoma cells. Candidone was found to induce apoptosis and inhibit migration and invasion of HepG2 cells by regulating protein expression levels.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Genetics & Heredity
Weitie Wang, Yong Wang, Hulin Piao, Bo Li, Zhicheng Zhu, Dan Li, Tiance Wang, Kexiang Liu
Summary: This study integrated miRNA and mRNA profiling analyses to demonstrate the critical roles of miR-193a-3p and ACTG2 in the pathogenesis of aortic dissection. miR-193a-3p may serve as a novel regulator of phenotypic switching in VSMCs, and the miR-193a-3p/ACTG2 axis could be a promising diagnostic biomarker and therapeutic candidate for aortic dissection.
FRONTIERS IN GENETICS
(2021)
Article
Cardiac & Cardiovascular Systems
Weitie Wang, Qing Liu, Yong Wang, Hulin Piao, Zhicheng Zhu, Dan Li, Tiance Wang, Kexiang Liu
Summary: The study reveals that linc01278 regulates VSMC phenotypic switching by controlling miR-500b-5p and ACTG2, playing a significant role in the pathogenesis of AD. This axis may have potential implications in developing diagnostic markers and therapeutic targets for AD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cell Biology
Yichen Wang, Lin Jia, Cong Wang, Zhonghua Du, Shilin Zhang, Lei Zhou, Xue Wen, Hui Li, Huiling Chen, Yuanyuan Nie, Dan Li, Shanshan Liu, Daniela Salgado Figueroa, Ferhat Ay, Wei Xu, Songling Zhang, Wei Li, Jiuwei Cui, Andrew R. Hoffman, Hui Guo, Ji-Fan Hu
Summary: Wang et al. identify Peln1 as a key chromatin long non-coding RNA that controls pluripotency exit and intrachromosomal looping in stem cells. Peln1 interacts with the Oct4 promoter, recruits DNMT3A, and alters the epigenotype to disrupt the intrachromosomal loop, leading to pluripotency exit. Peln1 also targets multiple pathway genes associated with stem cell self-renewal.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qing Dong, Xiuna Jia, Yuling Wang, Hao Wang, Qiong Liu, Dan Li, Jin Wang, Erkang Wang
Summary: Pancreatic cancer is difficult to diagnose in the early stage due to the lack of symptoms. Current diagnosis techniques have limitations in terms of personnel expertise and cost. Therefore, alternative detection methods are highly demanded. In this study, a new strategy combining nanoparticles and amplification reaction was proposed to improve the sensitivity of pancreatic cancer cell detection. The strategy showed good specificity and potential for clinical diagnosis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Xiuna Jia, Mengmeng Lv, Yunwei Fei, Qing Dong, Hao Wang, Qiong Liu, Dan Li, Jin Wang, Erkang Wang
Summary: Diagnosis-guided synergistic treatment based on innovative nanomaterials is important for the development of anti-cancer therapies. This study developed a smart carrier named LPAR, which can selectively deliver and release genes using near-infrared light and convert the light into heat for photothermal synergistic therapy. LPAR also possesses the capability of triple-modal imaging.
Article
Chemistry, Physical
Hao Wang, Jinxing Chen, Qing Dong, Xiuna Jia, Dan Li, Jin Wang, Erkang Wang
Summary: Recently, there has been increased attention on the study of mimic enzymes. However, research on the oxidoreductase activity of electron mediators in the biological respiratory chain is still limited. In this study, we found that cadmium sulfide (CdS) nanorods can catalyze the formation of superoxide anions and exhibit NADH oxidase-like activity and Cyt c reductase-like activity. This provides a new perspective for the in-depth study of new nanozymes.
Article
Chemistry, Multidisciplinary
Xiuna Jia, Deming Liu, Cong Yu, Niu Niu, Dan Li, Jin Wang, Erkang Wang
Summary: This study presents a new strategy for the rational design and development of a safe and efficient single near-infrared laser-triggered synergistic treatment platform for hypoxic cancer, based on the characteristics of the tumor microenvironment.
Article
Chemistry, Physical
Hao Wang, Jinxing Chen, Qing Dong, Xu Sun, Qiong Liu, Dan Li, Erkang Wang, Jin Wang
Summary: In this study, N, P, or S doped carbon nanotubes (CNTs) were used as enzyme mimics of nicotinamide adenine dinucleotide (NADH) oxidase and cytochrome c (Cyt c) reductase. Through N doping, the NADH oxidase-like activity of CNTs was significantly enhanced, with a 4.28-fold increase in the maximum initial velocity for N-doped CNTs (N-CNTs) compared to the unmodified ones. Biologically active NAD* was produced during NADH oxidation, and oxygen was selectively reduced to water or hydrogen peroxide, consistent with natural NADH oxidase. Additionally, it was discovered for the first time that carbon nanotubes can facilitate the electron transfer from NADH to Cyt c, mimicking the properties of Cyt c reductase.
Article
Oncology
Huikun Niu, Dexiang Wang, Tingting Wen, Han Liu, Jing Jie, Lei Song, Dan Li
Summary: Background: Anwuligan (ANW), isolated from nutmeg, has been found to have potential therapeutic effects in diseases. However, its effect on lung cancer is still unclear. Methods: In this study, the cytotoxicity of ANW on non-small cell lung cancer (NSCLC) cells was investigated using various assays. Results: ANW treatment showed clear cytotoxicity against NSCLC cells, inhibiting cell proliferation and migration both in vitro and in vivo. The overexpression of let-7c-3p also inhibited the growth of NSCLC cells. Conclusions: ANW inhibits the growth and metastasis of NSCLC cells by upregulating the expression of let-7c-3p and targeting PIK3CA.
Article
Engineering, Biomedical
Shuaining Ma, Weiguo Xu, Yunwei Fei, Dan Li, Xiuna Jia, Jin Wang, Erkang Wang
Summary: A TME-responsive nanoplatform is designed for synergistic photothermal therapy and photodynamic therapy against cancer. The nanoplatform allows for effective tumor accumulation and payload release through aptamer modification and acid degradable shell. It also exhibits excellent photodynamic therapy properties and achieves synergistic therapy through a single wavelength of near-infrared laser.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Hao Wang, Jinxing Chen, Qing Dong, Xu Sun, Qiong Liu, Dan Li, Erkang Wang, Jin Wang
Summary: Most nanozyme research focuses on oxidase and peroxidase capabilities, but this study explores N, P, or S doped carbon nanotubes (CNTs) as enzyme mimics of NADH oxidase and Cyt c reductase. Doping N significantly enhances the NADH oxidase-like activity of CNTs, increasing the maximum initial velocity by 4.28 times. NAD(+) is produced as a biologically active product during NADH oxidation, while oxygen is selectively reduced to water or hydrogen peroxide, similar to natural NADH oxidase. Additionally, carbon nanotubes can promote electron transfer from NADH to Cyt c, mimicking the properties of Cyt c reductase.
Article
Chemistry, Analytical
Wei Zhang, Ling Wang, Dan Li, Douglas H. Campbell, Bradley J. Walsh, Nicolle H. Packer, Qing Dong, Erkang Wang, Yuling Wang
Summary: Circulating sEVs derived from PDAC cells have potential applications in cancer diagnosis. The phenotype of sEVs is closely associated with the presence and progression of PDAC, and can be validated through various imaging techniques. The proposed SERS assay enables simultaneous detection of multiple surface membrane proteins on sEVs, providing a potential method for PDAC diagnosis and early cancer stage prediction.
ANALYTICAL METHODS
(2022)
Article
Biotechnology & Applied Microbiology
Zhonghua Du, Xue Wen, Yichen Wang, Lin Jia, Shilin Zhang, Yudi Liu, Lei Zhou, Hui Li, Wang Yang, Cong Wang, Jingcheng Chen, Yajing Hao, Huiling Chen, Dan Li, Naifei Chen, Ilkay Celik, Yanbo Zhu, Zi Yan, Changhao Fu, Shanshan Liu, Benzheng Jiao, Zhuo Wang, Hui Zhang, Gunhan Gulsoy, Jianjun Luo, Baoming Qin, Sujun Gao, Philipp Kapranov, Miguel A. Esteban, Songling Zhang, Wei Li, Ferhat Ay, Runsheng Chen, Andrew R. Hoffman, Jiuwei Cui, Ji-Fan Hu
Summary: Platr10 is a novel chromatin RNA molecule activated during somatic cell reprogramming, essential for maintaining pluripotency by modulating chromatin architecture and regulating DNA methylation.
Article
Ophthalmology
Shujia Xu, Qian Li, Bingyang Bian, Hongli Zhou, Dan Li
Article
Thermodynamics
Dan Li, Dehui Xiao, Xiaoman Liu, Juan Zhao, Xinlu Xu, Cheng Wang, Wugang Wang
JOURNAL OF CHEMICAL THERMODYNAMICS
(2020)
