Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation – Application on γ-Secretase

Identification of two novel synaptic γ-secretase associated proteins that affect amyloid β-peptide levels without altering Notch processing

(2012) Susanne Frykman et al.   NEUROCHEMISTRY INTERNATIONAL

Structure of γ-Secretase and Its Trimeric Pre-activation Intermediate by Single-particle Electron Microscopy

(2011) Fabiana Renzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in Nicastrin Protein Differentially Affect Amyloid β-Peptide Production and Notch Protein Processing

(2011) Annelie Pamrén et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating γ-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch Processing

(2010) Johanna Wanngren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic and Endosomal Localization of Active γ-Secretase in Rat Brain

(2010) Susanne Frykman et al.   PLoS One

Intramembrane Proteolysis by Signal Peptide Peptidases: A Comparative Discussion of GXGD-type Aspartyl Proteases

(2009) Regina Fluhrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Affinity pulldown of γ-secretase and associated proteins from human and rat brain

(2009) Yasuhiro Teranishi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Primary support cultures of hippocampal and substantia nigra neurons

(2009) Thomas Fath et al.   Nature Protocols

Active γ-secretase is localized to detergent-resistant membranes in human brain

(2008) Ji-Yeun Hur et al.   FEBS Journal

Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution

(2008) Pamela Osenkowski et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay

(2008) Ola Söderberg et al.   METHODS