Article
Biochemistry & Molecular Biology
Ye Wang, Amy K. Y. Fu, Nancy Y. Ip
Summary: The interaction between neurons and glia in the adult hippocampus is region-specific and regulated by secreted factors; IL-33 plays a key role in modulating glia-driven neuromodulations through activity-dependent astrocyte-synapse and microglia-synapse interactions in hippocampal circuits.
DNA AND CELL BIOLOGY
(2021)
Review
Neurosciences
Tian-Chi Gao, Cheng-Hao Wang, Yan-Qing Wang, Wen-Li Mi
Summary: IL-33 plays a pivotal role in chronic pain and itch, affecting primary sensory neurons, the spinal cord, and the brain. Understanding the mechanisms and functions of IL-33 may provide new insights into the treatment of chronic pain and itch.
Review
Biochemistry & Molecular Biology
Punniyakoti Veeraveedu Thanikachalam, Srinivasan Ramamurthy, Poojitha Mallapu, Sudhir Rama Varma, Jayaraj Narayanan, Mohammed A. S. Abourehab, Prashant Kesharwani
Summary: IL-33 is a cytokine that belongs to the IL-1 family and promotes the production of Th2 cytokines by binding with ST2L and IL-1RAcP. It has demonstrated protective effects against cardiovascular diseases by inducing Th2 cytokines and promoting alternative activating M2 polarization. However, the soluble decoy form of ST2 mitigates its effects, exacerbating cardiovascular diseases. IL-33 also plays a significant role in the development of asthma, arthritis, atopic dermatitis, and anaphylaxis. This review aims to explore the protective role of IL-33 against cardiovascular diseases and the potential of serum soluble ST2 as a diagnostic biomarker for these diseases. Therefore, IL-33 holds promise as a potential therapeutic target for cardiovascular diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Allergy
Alexandra Schroeder, Lars P. Lunding, Ulrich M. Zissler, Christina Vock, Sina Webering, Johanna C. Ehlers, Zane Orinska, Adam Chaker, Carsten B. Schmidt-Weber, Niklas J. Lang, Herbert B. Schiller, Marcus A. Mall, Heinz Fehrenbach, Charles A. Dinarello, Michael Wegmann
Summary: The study found that IL-37 downregulates allergic airway inflammation by counterbalancing the disease-amplifying effects of IL-1 beta and IL-33.
Article
Immunology
Minghang Pei, Xinshu Liu, Peizeng Yang, Chan Zhao, Fei Gao, Yi Qu, Anyi Liang, Junyan Xiao, Meifen Zhang
Summary: IL33/ST2 gene polymorphisms are associated with the development of BDU, with specific alleles showing significant differences in BD patients with different clinical features, indicating the important role of IL33/ST2 in the pathogenesis of BDU.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Qiong Wu, Zongwen Liang, Jing Jiang, Xiaoming Feng, Jinming Liu, Zongfeng Zhang, Honglin Wang, Ning Wang, Yanling Gou, Zhi Li, Yingying Cao
Summary: IL-33 secreted from macrophages regulates ferroptosis in eESCs through the P38/JNK/ATF3 pathway, ultimately protecting eESCs from iron-induced cell death.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Qiyun Ma, Yan Qian, Jingxian Jiang, Jingjing Wu, Meijuan Song, Xinyu Li, Zhongqi Chen, Zhengxia Wang, Ranran Zhu, Zhixiao Sun, Mao Huang, Ningfei Ji, Mingshun Zhang
Summary: The IL-33/ST2 axis may play a protective role in neutrophil-dominant allergic airway inflammation, and deficiencies in IL-33 and ST2 can lead to excessive production of neutrophilic chemokines, exacerbating the severity of allergic inflammation in the lungs.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Shangbo Lei, Jiamin Jin, Xiangfeng Zhao, Lihua Zhou, Guangying Qi, Jinfeng Yang
Summary: The IL-33/ST2 signaling pathway plays a crucial role in the immune system and regulates the tumor microenvironment and Treg immunotherapy by activating various intracellular kinases and factors.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Ning Xiang, Haijun Liao, Zichen Zhai, Jingwen Gong
Summary: The levels of IL-33 and ST2 in the peripheral serum of heart failure patients are correlated with TNF-α and BNP, and these levels increase with the rise of cardiac function grade.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Immunology
Yuanji Dong, Bingxia Ming, Rongfen Gao, Qian Mo, Xuefen Wu, Fang Zheng, Jixin Zhong, Lingli Dong
Summary: The IL-33/ST2 axis may play a role in the development of primary Sjogren's syndrome (pSS) by enhancing salivary epithelial cell activation and the type 1 immune response. This study provides insights into the molecular mechanisms of pSS and suggests potential therapeutic targets.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Oncology
Mi-Yeon Yu, Soie Kwon, Jong Joo Moon, Yong-Chul Kim, Eun Young Song, Hajeong Lee, Kyung Chul Moon, Jongwon Ha, Dong Ki Kim, Sang-Woong Han, Gheun-Ho Kim, Yon Su Kim, Seung Hee Yang
Summary: The IL-33/ST2 pathway is involved in modulating immune response and inflammation, particularly in the context of allograft dysfunction and rejection. Higher levels of IL-33 and ST2 were found in recipients with acute antibody-mediated rejection and acute cell-mediated rejection compared to chronic antibody-mediated rejection, indicating their potential role in renal allograft rejection. Treatment with an anti-ST2 antibody showed promise in ameliorating rejection outcomes, suggesting it could be a viable therapeutic strategy for managing renal allograft rejection.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Bojan Stojanovic, Nevena Gajovic, Milena Jurisevic, Milica Dimitrijevic Stojanovic, Marina Jovanovic, Ivan Jovanovic, Bojana S. Stojanovic, Bojan Milosevic
Summary: IL-33 plays a critical role in breast cancer biology, influencing cancer progression and immune response, and may serve as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Shixin Duan, Jun Wang, Xinyi Lou, Dongxin Chen, Peiyunfeng Shi, Hongchao Jiang, Zhiming Wang, Wen Li, Feng Qian
Summary: IL-33 is an important member of the IL-1 family and plays a crucial role in modulating inflammatory responses. The researchers developed an effective anti-human IL-33 monoclonal antibody named 5H8, which binds to the FVLHN epitope of IL-33 and inhibits its biological activity. In vitro and in vivo experiments showed that 5H8 suppressed IL-33-induced IL-6 expression and relieved HDM-induced asthma and PR8-induced acute lung injury. The study also demonstrated that 5H8 has good thermal stability and high affinity. These findings suggest that 5H8 has potential as a therapeutic antibody for inflammatory diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xuena Yang, Beiting Su, Jing Liu, Li Zheng, Peizhi Tao, Yusen Lin, Xiaoling Zou, Hailing Yang, Wenbin Wu, Ping Meng, Tiantuo Zhang, Hongtao Li
Summary: Tobacco smoke exposure is a significant risk factor for the development and progression of asthma. CpG oligodeoxynucleotide (CpG-ODN) has been shown to inhibit TSLP-dendritic cells and reduce Th2/Th17-related inflammatory response in smoke-related asthma, but the mechanism is unclear. In this study, a combined house dust mite (HDM)/cigarette smoke extract (CSE) model was used to investigate the effects of CpG-ODN on airway inflammation and immune response. The results demonstrated that CpG-ODN attenuated airway inflammation, collagen deposition, and goblet cell hyperplasia in the combined model. In vitro experiments also showed that CpG-ODN inhibited TSLP production in bronchial epithelial cells. The underlying mechanism may involve the downregulation of the IL-33/ST2 axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xue-Ming Hu, Wei Yang, Meng-Ting Zhang, Li-Xia Du, Jia-He Tian, Jian-Yu Zhu, Yu Chen, Feng Hai, Shen-Bin Liu, Qi-Liang Mao-Ying, Yu-Xia Chu, Hong Zhou, Yan-Qing Wang, Wen-Li Mi
Summary: The study identified that repeated morphine injections increased IL-33 and ST2 expression, leading to hyperalgesia and analgesic tolerance. Inhibiting IL-33 or ST2 could alleviate these effects, suggesting that targeting the IL-33-ST2 signaling pathway may enable sustained analgesic effects in chronic pain management.