Article
Fisheries
Almendra Benavides, Daniela Gutierrez, Nadia Epuyao, Brenda Modak, Monica Imarai, Beatriz Valenzuela
Summary: Alpinone, a flavonoid derived from the resinous exudate of Heliotropium huascoense, exhibits antiviral activity against ISAV in farmed Atlantic salmon. The study reveals that Alpinone can induce the expression of specific genes and signaling pathways to exert its antiviral effects.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Immunology
Byron Morales-Lange, Felipe Ramirez-Cepeda, Paulina Schmitt, Fanny Guzman, Leidy Lagos, Margareth Overland, Valentina Wong-Benito, Monica Imarai, Derie Fuentes, Sebastian Boltana, Javier Alcaino, Carlos Soto, Luis Mercado
Summary: This study investigated the effect of IFN gamma on the expression of cell-surface markers on splenocytes of Atlantic salmon. The results showed that IFN gamma could stimulate the gene expression and protein availability of cell-surface markers, enhancing the function of immune cells. In vivo experiments demonstrated that during a natural outbreak of Piscirickettsia salmonis, the expression of IFN gamma in Atlantic salmon increased simultaneously with the up-regulation of cell-surface markers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Dilsad Herkiloglu, Sefik Gokce, Ozge Cevik
Summary: The present study reveals the association between IFN-gamma and IRF5 with missed abortion, showing that their protein levels and gene expression levels are significantly increased in cases of missed abortion. These findings suggest that IFN-gamma and IRF5 play an important role in placental invasion and pregnancy, and can be used as markers for endometrial implantation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Immunology
Carlos Munoz, Josue Gonzalez-Lorca, Mick Parra, Sarita Soto, Natalia Valdes, Ana Maria Sandino, Rodrigo Vargas, Alex Gonzalez, Mario Tello
Summary: The study explored the use of Lactococcus lactis as a type I interferon expression system in Atlantic salmon to stimulate the antiviral immune response, showing that oral administration of L. lactis producing interferon I induces systemic effects, reduces IPNV viral load, and increases Mx and PKR expression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Federico Marziali, Yuxin Song, Xuan-Nhi Nguyen, Lucid Belmudes, Julien Burlaud-Gaillard, Philippe Roingeard, Yohann Coute, Andrea Cimarelli
Summary: This study identified NDFIP2 protein adaptor as an important regulator of IFITM3 levels and showed that NDFIP2 recruits IFITM3 and NEDD4 and mediates their distribution in lysosomal vesicles, thereby regulating the accumulation of IFITM3. The study reveals a novel and potentially dynamic layer of regulation of IFITM3.
Article
Oncology
Lata Singh, Mithalesh Kumar Singh, Maria Cristina Kenney, Martine J. Jager, Moshahid Alam Rizvi, Rachna Meel, Neiwete Lomi, Sameer Bakhshi, Seema Sen, Seema Kashyap
Summary: The study showed that the expression of PD-1 and PD-L1 in UM is related to TILs presence and patient prognosis. TILs promote the expression of PD-1 and PD-L1, impacting the DFS rate. Treatment of UM cells with IFN-gamma induced PD-1 expression, while also leading to increased PD-L1 expression.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Maaike E. Straat, Borja Martinez-Tellez, Huub J. van Eyk, Maurice B. Bizino, Suzanne van Veen, Eleonora Vianello, Rinke Stienstra, Tom H. M. Ottenhoff, Hildo J. Lamb, Johannes W. A. Smit, Ingrid M. Jazet, Patrick C. N. Rensen, Mariette R. Boon
Summary: There are differences in immune gene expression between South Asian and Europid individuals with T2D, with a more activated IFN-signaling pathway in South Asians, particularly in women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biology
Lucie Gerber, Kathy A. Clow, Anthony K. Gamperl
Summary: Acclimation to 20 degrees Celsius can protect the cardiac mitochondrial function of Atlantic salmon, decrease ROS production, and improve membrane integrity, but the plasticity may be limited when combined with other stressors.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jeleel O. Agboola, Dominic D. Mensah, Jon O. Hansen, David Lapena, Liv T. Mydland, Magnus O. Arntzen, Svein J. Horn, Ove Oyas, Charles McL. Press, Margareth Overland
Summary: This study investigated the effects of yeasts on intestinal health and transcriptomic profiles of Atlantic salmon fed SBM-based diets. The results showed that Cyberlindnera jadinii and Wickerhamomyces anomalus yeasts improved intestinal health and reduced inflammation in fish fed plant-based diets. CJ yeast controlled inflammation by promoting wound healing and taurine metabolism, while WA yeast dampened inflammation by down-regulating pathways associated with inflammatory signaling. These findings suggest that these yeasts can serve as novel high-quality protein sources for Atlantic salmon.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Qiang Fu, Yuqing Li, Hao Zhang, Min Cao, Lu Zhang, Chengbin Gao, Xin Cai, Defeng Chen, Ziying Yang, Jie Li, Ning Yang, Chao Li
Summary: This study conducted RNA-seq analysis on spleen tissue of Atlantic salmon after Aeromonas salmonicida subsp. masoucida (ASM) vaccination to reveal genes, their expression patterns, and pathways involved in immune protections. The results showed that differentially expressed genes were involved in cytokine-cytokine receptor interaction, HTLV-I infection, MAPK signaling pathway, PI3K-Akt signaling pathway, and TNF signaling pathway. The study provided insights into gene regulation and pathways involved in immune response to the vaccine.
MARINE BIOTECHNOLOGY
(2022)
Article
Immunology
Yi Cai, Yejun Wang, Chenyan Shi, Youchao Dai, Fuxiang Li, Yuzhong Xu, Peize Zhang, Fanhui Kong, Guofang Deng, Zhihua Wen, Qi Zhou, Boxi Chris Kang, Amit Singhal, Qianting Yang, Carl G. Feng, Xinchun Chen
Summary: The study reveals the landscape of local T cell immunity in tuberculosis and provides insights into the involvement of specific T cell populations in the pathogenesis of tuberculous pleural effusion (TPE). The findings suggest a link between clonal expansion of Granzyme K-expressing CD8 T cells and TPE.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Fisheries
Aleksandra H. Crossman, Eric. H. Ignatz, Jennifer. R. Hall, Surendra Kumar, Mark. D. Fast, Khalil Eslamloo, Matthew. L. Rise
Summary: Atlantic salmon is an economically important aquaculture species, but disease poses a significant threat to the industry. The study focuses on understanding the genes and molecular pathways involved in the immune responses of Atlantic salmon, which is crucial for breeding disease-resistant broodstock and developing effective mitigation strategies.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Fisheries
Giovanni M. Turchini, Jessica A. Conlan, James A. Emery, Fernando Norambuena, Taiwo O. Akanbi, David S. Francis
Summary: Previous research on lipid nutrition in farmed fish has focused mainly on n-3 LC-PUFA, with limited understanding of the relationship between different dietary fatty acids. This study found a direct link between the physical properties of dietary fatty acids and omega-3 fatty acid metabolism in Atlantic salmon, suggesting new possibilities for lipid nutrition in aquaculture species.
Article
Immunology
Byron Morales-Lange, Jeleel Opeyemi Agboola, Jon Ovrum Hansen, Leidy Lagos, Ove Oyas, Luis Mercado, Liv Torunn Mydland, Margareth Overland
Summary: The study showed that soybean meal (SBM) compared to fishmeal induces down-regulation of ion binding and transport pathways, and increases levels of pro-inflammatory cytokines like tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ) at the protein level. Additionally, the inclusion of ACJ in the diets can control the pro-inflammatory profile of SBM, increasing Interleukin 10 (IL-10) levels and decreasing TNFα production, triggering an immune response similar to that of fish fed a fishmeal-based diet.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Arianna De Matteis, Manuela Colucci, Marianna N. Rossi, Ivan Caiello, Pietro Merli, Nicola Tumino, Valentina Bertaina, Manuela Pardeo, Claudia Bracaglia, Franco Locatelli, Fabrizio De Benedetti, Giusi Prencipe
Summary: The activation profile of CD8(+) T cells can distinguish different types of HLH patients and those with early sepsis. The frequency of CD4(dim)CD8(+) T cells is correlated with the severity of MAS.
Review
Fisheries
Toni Erkinharju, Roy A. Dalmo, Miroslava Hansen, Tore Seternes
Summary: Controlling sea lice infestations is costly for farmers, with limited options available such as traditional chemotherapeutants and cleaner fish as the most effective method. The use of wild-caught mature fish as brood stock for farmed production poses biosecurity risks. Vaccine development for sea lice in fish is lagging behind the widespread use of aquaculture species.
REVIEWS IN AQUACULTURE
(2021)
Article
Biology
Tiril H. Slettjord, Hege J. Sekkenes, Heng Chi, Jarl Bogwald, Trilochan Swain, Roy A. Dalmo, Jaya Kumari Swain
Article
Biology
Zuobing Zhang, Miao Tian, Ruxin Song, Xiao Xing, Yong Fan, Lan Wang, Cuijuan Niu, Roy A. Dalmo
Article
Multidisciplinary Sciences
Jaya Kumari Swain, Yamila Carpio, Lill-Heidi Johansen, Janet Velazquez, Liz Hernandez, Yeny Leal, Ajey Kumar, Mario Pablo Estrada
Editorial Material
Immunology
Hetron M. Munang'andu, Irene Salinas, Carolina Tafalla, Roy Ambli Dalmo
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Fisheries
Tore Seternes, Jarl Bogwald, Roy A. Dalmo
Summary: Scavenger endothelial cells (SEC) are defined based on their functional and structural characteristics, playing a role in the catabolism of waste macromolecules in vertebrates. SEC in different vertebrate classes share common features such as unique receptors, endocytosis mechanisms, and specific tissue locations.
JOURNAL OF FISH DISEASES
(2021)
Article
Multidisciplinary Sciences
Liliana Barbieri, Huw Colin-York, Kseniya Korobchevskaya, Di Li, Deanna L. Wolfson, Narain Karedla, Falk Schneider, Balpreet S. Ahluwalia, Tore Seternes, Roy A. Dalmo, Michael L. Dustin, Dong Li, Marco Fritzsche
Summary: Quantifying rapid and small cellular forces is a major challenge in mechanobiology. Here, the authors show a >2-fold spatially and >10-fold temporally force sampling improvement combining traction force microscopy with total internal reflection fluorescence super-resolution structured illumination microscopy.
NATURE COMMUNICATIONS
(2021)
Article
Optics
Ida S. Opstad, Daniel H. Hansen, Sebastian Acuna, Florian Strohl, Anish Priyadarshi, Jean-Claude Tinguely, Firehun T. Dullo, Roy A. Dalmo, Tore Seternes, Balpreet S. Ahluwalia, Krishna Agarwal
Summary: Photon chip-based total internal reflection fluorescence microscopy (c-TIRFM) is a new technology that allows for the introduction of temporal fluctuations in the illumination pattern in wide waveguides, exploiting the multimodal nature for super-resolution imaging using the multiple signal classification algorithm. The resolution improvement compared to conventional images was measured to be 2.2-3.6-fold.
Review
Fisheries
Torill Bakkelund Blix, Roy Ambli Dalmo, Anna Wargelius, Anne Ingeborg Myhr
Summary: Novel genome editing techniques have been utilized in aquaculture for targeted improvement, focusing on traits like reproduction, growth, and disease resistance in species such as Nile tilapia and Atlantic salmon. The top three countries with research on this topic are China, the United States, and Norway, showcasing global interest in utilizing genome editing for sustainable aquaculture solutions.
REVIEWS IN AQUACULTURE
(2021)
Review
Biochemistry & Molecular Biology
Jarl Bogwald, Roy A. Dalmo
Summary: Oral vaccination is considered a suitable method for mass immunization of large and stress-sensitive fish populations, as it can induce mucosal immunity. By encapsulating antigens and viruses in alginate microspheres and other carriers, oral vaccines can effectively deliver to the intestine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Filipe Figueiredo, Harald Kristoffersen, Shripathi Bhat, Zuobing Zhang, Jacques Godfroid, Stefano Peruzzi, Kim Praebel, Roy Ambli Dalmo, Xiaoli Xu
Summary: Activation of immune cells is energetically costly and requires tight control of cellular metabolism, including in innate immune cells. Immunostimulants such as Astragalus, Hyaluronic acid, Imiquimod, and Poly I:C can modulate antiviral and metabolic gene expression in early life stages of Atlantic salmon, potentially improving disease resistance. Pattern recognition receptors like TLR3, TLR7, and MDA5 serve as early warning signals for antiviral response. Treatment with these immunostimulants induced robust antiviral defense and perturbed cell metabolism in fish larvae.
Article
Chemistry, Multidisciplinary
Stefano Buccelli, Federico Tessari, Fausto Fanin, Luca De Guglielmo, Gianluca Capitta, Chiara Piezzo, Agnese Bruschi, Frank Van Son, Silvia Scarpetta, Antonio Succi, Paolo Rossi, Stefano Maludrottu, Giacinto Barresi, Ilaria Creatini, Elisa Taglione, Matteo Laffranchi, Lorenzo De Michieli
Summary: Float is an upper-limb exoskeleton designed to promote and accelerate the motor and functional recovery of the shoulder joint complex. It enables patients to move freely in a large workspace by using a passive polyarticulated arm to support the weight, facilitating a deeper interaction with the surrounding environment for enhanced rehabilitation.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Trygve A. H. Stromsnes, Sebastian E. E. Schmidke, Mitra Azad, Oyvind Singstad, Idun M. M. Gronsberg, Roy A. A. Dalmo, Arinze S. S. Okoli
Summary: Atlantic salmon is one of the most profitable farmed fish species globally. However, its production growth is threatened by various problems. In this study, gene loci of A. salmon were efficiently edited using CRISPR/Cas technology, and edited cells were enriched and expanded through flow cytometer-activated cell sorting and clonal isolation. This research provides new insights for gene editing of salmonid cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Proceedings Paper
Automation & Control Systems
Federico Tessari, Renato Galluzzi, Andrea Tonoli, Nicola Amati, Matteo Laffranchi, Lorenzo De Michieli
2020 IEEE/RSJ INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS (IROS)
(2020)