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Pharmacology & Pharmacy
Lipeng Tang, Tong Li, Bowen Zhang, Zihao Zhang, Xiaoyi Sun, Ying Zhu, Bing Feng, Zuqing Su, Laijun Yang, Hongxia Li, Huazhen Liu, Yuchao Chen, Zhenhua Dai, Xirun Zheng, Mingxian Li, Chutian Li, Jie Zhao, Xinmin Qiu, Shuyan Ye, Han Liu, Guangjuan Zheng, Ben Li, Chuanjian Lu
Summary: Punicalagin (PUN) shows therapeutic potential for psoriasis by inhibiting inflammatory response and cell signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Masashi Mizuno, Rei Nakano, Saki Nose, Moeka Matsumura, Yasuyuki Nii, Kentaro Kurogochi, Hiroshi Sugiya, Masami Uechi
Summary: In this study, it was found that interleukin 1 beta (IL-1 beta) induces the expression of interleukin 8 (IL-8) in canine cardiac fibroblasts through the activation of nuclear factor (NF)-kappa B p65.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Hui Zhao, Peng Yan
Summary: The study showed that LINC00265 is significantly up-regulated in cartilage tissues of OA patients. Stimulation of IL-1 beta in chondrocytes promotes the expression of LINC00265, inflammatory factors, ROS production, and ECM degradation. Knockdown of LINC00265 reduces inflammation, cell proliferation, oxidative stress, and slows down ECM degradation progression stimulated by IL-1 beta. Additionally, knockdown of LINC00265 inhibits IL-1 beta-induced activation of the MAPK/NF-Kappa B pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Immunology
D. Alejandro Canaria, Maia G. Clare, Bingyu Yan, Charlotte B. Campbell, Zachariah A. Ismaio, Nicole L. Anderson, Sungtae Park, Alexander L. Dent, Majid Kazemian, Matthew R. Olson
Summary: This study reveals the importance of IL-2 in the differentiation of Th9 cells, as IL-2 signaling is required for optimal NF-kB activation and IL-9 production. The addition of the NF-kB-activating cytokine IL-1 beta can rescue Th9 differentiation under IL-2 limiting conditions by enhancing the sensitivity of Th9 cells to limited IL-2 resources.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yue Xia, Minghuan Ge, Ling Xia, Guang Shan, Huijun Qian
Summary: This study reveals that the aberrant expression of cathepsin V (CTSV) is associated with a poor outcome in bladder cancer patients. CTSV enhances the inflammatory reaction, thereby promoting the development of bladder cancer. Overexpression of CTSV increases the proliferation and viability of bladder cancer cells, while deletion of CTSV significantly inhibits their proliferation and viability. Furthermore, overexpression of CTSV activates the inflammatory signaling pathway, which can be restored by introducing an NF-kappa B inhibitor.
Article
Cell Biology
Yan-Lin Chen, De-Yi Yan, Chen-Yu Wu, Jiang-Wei Xuan, Chen-Qiang Jin, Xin-Li Hu, Guo-Dong Bao, Yu-Jie Bian, Zhi-Chao Hu, Zhong-Hai Shen, Wen-Fei Ni
Summary: OA is characterized by destruction of articular cartilage and inflammation plays a key role in its progression. Maslinic acid (MA) from olive fruit has been shown to have anti-inflammatory effects. In in vitro and in vivo experiments, MA was found to attenuate inflammatory mediators and inhibit the progression of OA disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Environmental Sciences
Chiung-Ju Chen, Hung-Sheng Shang, Yuan-Li Huang, Ni Tien, Yung-Liang Chen, Sheng-Yao Hsu, Rick Sai-Chuen Wu, Chien-Lun Tang, Jin-Cherng Lien, Mei-Hui Lee, Hsu-Feng Lu, Te-Chun Hsia
Summary: We evaluated the antimetastasis activity of Bisdemethoxycurcumin (BDMC) in human glioblastoma (GBM) cells and found that BDMC may have the potential to inhibit cell migration and invasion in GBM by suppressing key signaling pathways involved in cell proliferation, uptake, and motility.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wan Li, Hongqing Cai, Liwen Ren, Yihui Yang, Hong Yang, Jinyi Liu, Sha Li, Yizhi Zhang, Xiangjin Zheng, Wei Tan, Guanhua Du, Jinhua Wang
Summary: This study identified sphingosine kinase 1 (SPHK1) as an up-regulated gene in glioblastoma (GBM) patients, and demonstrated its association with poor prognosis and reduced overall survival. Overexpression of SPHK1 promoted the proliferation, invasion, metastasis, and clonogenicity of GBM cells, while silencing SPHK1 had the opposite effect. SPHK1 promoted inflammation and proliferation of GBM cells through the NF-KB/IL-6/STAT3 and JNK signaling pathways, and formed a positive feedback loop with PTX3 to enhance GBM growth. Inhibition of SPHK1 by the inhibitor PF543 decreased tumorigenesis in GBM mouse models.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Integrative & Complementary Medicine
Fang Xu, Liang-Jun Zhao, Ting Liao, Zhao-Cong Li, Lei-Lei Wang, Pan-Yu Lin, Rui Jiang, Qing-Jun Wei
Summary: The study suggests that Ononin has potential therapeutic effects on osteoarthritis. It can alleviate inflammation and prevent cartilage degeneration by interfering with the abnormal activation of the MAPK and NF-κB signaling pathways.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Oncology
Limin Tao, Sisun Liu, Juying Xiong, Huimin Yang, Yanfang Wu, Anli Xu, Yanfeng Gong
Summary: IL-1 beta promotes the release of CCL-2 and activates NF-kappa B signaling pathway, enhancing the migration and invasion ability of cervical cancer cells. Targeting the IL-1 beta/NF-kappa B/CCL-2 pathway may hold promise for cervical cancer treatment and prevention.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2021)
Article
Immunology
Shouye Hu, Yanqi Li, Bo Wang, Kan Peng
Summary: The study showed that TRIM38 can alleviate IL-1 beta-induced apoptosis and degeneration of chondrocytes by suppressing the NF-kappa B signaling pathway. This work suggests a potential role of TRIM38 in osteoarthritis and proposes it as a new therapeutic target for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhendong Liu, Ruizhou Liu, Rui Wang, Jihang Dai, Hui Chen, Jingcheng Wang, Xiaolei Li
Summary: Sinensetin (SIN), a natural flavonoid, has anti-inflammatory and antioxidant properties, which can reduce the production of inflammatory mediators in human osteoarthritis chondrocytes and protect the degradation of extracellular matrix. It also inhibits the activation of NF-κB and delays the progression of osteoarthritis in rats, protecting cartilage.
Article
Pharmacology & Pharmacy
Yufei Luo, Bojun Xiong, Haiping Liu, Zehong Chen, Huihui Huang, Changxi Yu, Jian Yang
Summary: Koumine inhibits NLRP3 inflammasome activation and reduces neutrophil infiltration and IL-1β production, both in vitro and in vivo. The inhibitory effect involves blocking the ROS/NF-kappa B/NLRP3 signal axis, suggesting potential clinical applications for NLRP3 inflammasome-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Jing Zhang, Xiaojing Yang, Yushan Yang, Min Xiong, Ning Li, Lan Ma, Jiaqi Tian, Haoyu Yin, Lin Zhang, Yulan Jin
Summary: Long-term exposure to respirable silica particles can cause pulmonary inflammation and fibrosis, primarily promoted by cytokines released from alveolar macrophages. This study explored the mechanism of IL-1 beta biosynthesis and release from the perspective of nuclear factor kappa B (NE-kappa B). The results showed that silica nanoparticles (SiNPs) were internalized by macrophages, leading to cell damage. SiNPs exposure enhanced the expression of IL-1 beta and NE-kappa B, but this effect could be suppressed by BAY 11-7082, an NF-kappa B specific inhibitor. Animal experiments confirmed that silica exposure caused pulmonary inflammation and fibrosis, along with pathological changes in lung tissue.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Hongyan Yu, Mingxu Xie, Zhaoyue Meng, Chun-Yin Lo, Franky Leung Chan, Liwen Jiang, Xiangqi Meng, Xiaoqiang Yao
Summary: Prostate cancer (Pca) is the most common cancer type among males worldwide, with dysregulation of Ca2+ signaling playing important roles during Pca progression. In this study, it was found that MCOLN2 expression is significantly elevated in Pca tissues, promoting Pca development through the IL-1 beta/NF-kappa B pathway. Targeting MCOLN2 could be a potential therapeutic strategy in Pca treatment.
BRITISH JOURNAL OF CANCER
(2021)
Review
Immunology
Chien-Chung Yang, Chuen-Mao Yang
Summary: The pathogenesis of inflammatory diseases is associated with pro-inflammatory factors, ROS, bacterial toxins, and viruses. Oxidative stress plays a role in maintaining cellular redox balance, but excessive ROS production is often induced by excessive stimulation of the mitochondrial electron transport chain and xanthine oxidase, leading to inflammation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ming-Hui Yang, Yi-Ming Arthur Chen, Shan-Chen Tu, Pei-Ling Chi, Kuo-Pin Chuang, Chin-Chuan Chang, Chiang-Hsuan Lee, Yi-Ling Chen, Che-Hsin Lee, Cheng-Hui Yuan, Yu-Chang Tyan
Summary: The study on GNMT knockout mice revealed the impact on the expression levels of specific proteins related to neuronal function and neurodegenerative diseases in brain tissues. Proteomic analysis indicated that the GnRH signaling pathway is associated with aging, potentially offering new insights into the mechanisms of aging and neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pei-Ling Chi, Chin-Chang Cheng, Cheng-Chung Hung, Mei-Tzu Wang, Hsien-Yueh Liu, Meng-Wei Ke, Min-Ci Shen, Kun-Chang Lin, Shu-Hung Kuo, Pin-Pen Hsieh, Shue-Ren Wann, Wei-Chun Huang
Summary: This study found that levels of MMP-1 and MMP-10 were increased in the vessel wall, serum, and M1-polarized macrophages of PAH patients and PAH rodent models. MMP-10 promotes the malignant phenotype of PASMCs by promoting their proliferation and migration. Inhibition of STAT1 can suppress hypoxia-induced MMP-10 expression in M1-polarized macrophages.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Zih-Yao Yu, Chuen-Mao Yang
Summary: This study demonstrates that rhamnetin attenuates the enhanced expression of MMP-9 induced by BK through inhibiting PKC delta/NOX/ROS/ERK1/2-dependent NF-kappa B activity in RBA-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Chen-Yu Wang, Chien-Chung Yang, Li-Der Hsiao, Chuen-Mao Yang
Summary: This study investigated the expression and regulatory mechanisms of NRROS in astrocytes under the influence of 15d-PGJ(2). The results demonstrated that 15d-PGJ(2) induced NRROS expression through the PI3K/Akt-dependent phosphorylation of FoxO1 and Sp1, as well as the Nrf2 cascade, which effectively suppressed ROS generation and IL-6 expression.
NEUROTOXICITY RESEARCH
(2022)
Article
Anatomy & Morphology
Chih-Yang Hsu, Pei-Ling Chi, Hsin-Yu Chen, Shih-Hsiang Ou, Kang-Ju Chou, Hua-Chang Fang, Chien-Liang Chen, Chien-Wei Huang, Tzung-Yo Ho, Po-Tsang Lee
Summary: The study demonstrates successful regeneration of kidneys through seeding cells on acellular scaffolds, showing functional abilities to produce urine and reabsorb substances. This research holds promise in addressing organ shortage issues and providing therapeutic solutions for patients.
Article
Cell Biology
Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Chih-Kai Hsu, Chia-Yu Hu, Chuen-Mao Yang
Summary: Thrombin triggers the upregulation of COX-2 to promote the secretion of PGE(2), which involves the PAR1/G(q) or G(i/o)/PKCα/MAPK-dependent activation of NF-κB in HTSMCs.
MEDIATORS OF INFLAMMATION
(2022)
Article
Cell Biology
Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Hsin-Hui Lin, Chuen-Mao Yang
Summary: This study demonstrated that DDF induced upregulation of HO-1 expression via the EGFR/PKCα/PI3K/Akt-dependent Sp1 pathway in HCFs, leading to attenuation of inflammation responses.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Mei-Hsiu Su, Chuen-Mao Yang
Summary: This study explores the comprehensive mechanisms of how S1P promotes the expression of COX-2 and PGE(2) and induces apoptosis in human cardiac fibroblasts (HCFs) through the activation of MMP9/EGFR-mediated PI3K/Akt/MAPKs-dependent AP-1 activity.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, Li-Der Hsiao, Ya-Fang Shih, Ching- Chang, Chuen-Mao Yang
Summary: 15d-PGJ(2) induces the expression of HO-1 in bEnd.3 cells through the activation of NOX- and mitochondria-derived ROS-dependent PKC delta/JNK1/2/Sp1/AP-1 signaling pathway, thus protecting against inflammatory responses.
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, Li-Der Hsiao, Chen-Yu Wang, Wei-Ning Lin, Ya-Fang Shih, Yi-Wen Chen, Rou-Ling Cho, Hui-Ching Tseng, Chuen-Mao Yang
Summary: This study demonstrates that kaempferol (KPR) can induce HO-1 expression and attenuate inflammation in pulmonary alveolar epithelial cells (HPAEpiCs) through the activation of NOX/ROS/c-Src/Pyk2/PKCα/p38α MAPK and JNK1/2 pathways. The findings suggest that KPR could be a potential strategy for protecting against pulmonary inflammation.
Article
Biochemistry & Molecular Biology
Chuen-Mao Yang, Chien-Chung Yang, Wun-Hsin Hsu, Li-Der Hsiao, Hui-Ching Tseng, Ya-Fang Shih
Summary: Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of cardiac injury, inflammation, and apoptosis. TNF-alpha-induced CCL20 secretion in human cardiac fibroblasts is mediated through a TNFR1-dependent EGFR/p38 MAPK and JNK1/2/FoxO1 or NF-kappa B cascade.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, I-Ta Lee, Yan-Jyun Lin, Wen-Bin Wu, Li-Der Hsiao, Chuen-Mao Yang
Summary: This study confirmed that thrombin induces the production of COX-2 and PGE(2) in human tracheal smooth muscle cells, leading to inflammation in the airways and lungs. The study identified specific signaling pathways involved, including the PKC delta/Pyk2/c-Src/EGFR/PI3K/Akt/AP-1 pathway. Resveratrol was also found to inhibit COX-2 and PGE(2) production by blocking the activation of these signaling molecules, suggesting its potential use in managing airway inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Shue-Ren Wann, Horng-Ren Lo, Yun-Te Chang, Jia-Bin Liao, Zhi-Hong Wen, Pei-Ling Chi
Summary: Vibrio vulnificus infection induces hyperinflammatory and cytotoxic inflammation, with P2X7R playing a crucial role in macrophages and providing new therapeutic opportunities in bacterial infections.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mei-Tzu Wang, Ming-Ji Charng, Pei-Ling Chi, Chin-Chang Cheng, Cheng Chung Hung, Wei-Chun Huang
Summary: This multi-center study identified gene mutations in BMPR2, ALK1, CAV1, and ENG in Han Chinese patients with PAH. Females were more susceptible to PAH, and patients with BMPR2 mutations tended to be relatively young.