Article
Dentistry, Oral Surgery & Medicine
Shuai Wang, Ke Li, Tong Zhao, Yawei Sun, Tao Zeng, Yan Wu, Liang Ding, Xiaofeng Huang, Antonio Celentano, Xihu Yang, Qingang Hu, Yanhong Ni
Summary: This study identified the metabolic characteristics of oral tongue squamous cell carcinoma (OTSCC) and established a diagnostic model with high accuracy. The research contributes to the investigation of the pathogenesis of OTSCC.
Article
Dentistry, Oral Surgery & Medicine
Oscar Rapado-Gonzalez, Nicolas Costa-Fraga, Aida Bao-Caamano, Jose Luis Lopez-Cedrun, Roberto Alvarez-Rodriguez, Ana Belen Crujeiras, Laura Muinelo-Romay, Rafael Lopez-Lopez, Angel Diaz-Lagares, Maria Mercedes Suarez-Cunqueiro
Summary: This is the first large-scale genome-wide DNA methylation study on OTSCC, identifying a group of novel tumor-specific DNA methylation markers with diagnostic potential in saliva.
Article
Veterinary Sciences
Alana R. Rodney, Zachary L. Skidmore, Jennifer K. Grenier, Obi L. Gri Th, Andrew D. Miller, Shirley Chu, Faraz Ahmed, Jeffrey N. Bryan, Santiago Peralta, Wesley C. Warren
Summary: By using whole exome sequencing and RNA sequencing, we have identified somatic mutations and gene expression changes associated with the occurrence of feline oral squamous cell carcinoma (FOSCC). FOSCC can serve as a comparative model for studying human head and neck squamous cell carcinoma (HNSCC) due to its similar formation and features. Our preliminary study reveals that FOSCC shows molecular similarities to human oral squamous cell carcinoma, including alterations in epithelial to mesenchymal transition and IL6/JAK/STAT pathways.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Wafaa Saleh, Seunghee Cha, Abdulaziz Banasser, Sarah G. Fitzpatrick, Indraneel Bhattacharyya, Jilan M. Youssef, Mohamed M. Anees, Islam A. Elzahaby, Joseph Katz
Summary: This study investigated the prevalence and localization of HPV-16 virus in oral squamous cell carcinoma (OSCC) and found a significant correlation between HPV-16 positivity and p16INK4A expression with the clinical and pathological features of OSCC. The highest positivity was observed in the hard palate. The use of p16INK4A as a surrogate marker for HPV detection in OSCC, complemented by RNA ISH for HPV subtyping, is recommended.
Article
Oncology
Andrea Necchi, Philippe E. Spiess, Marco Bandini, Giuseppe Basile, Petros Grivas, Gennady Bratslavsky, Joseph Jacob, Natalie Danziger, Douglas Lin, Brennan Decker, Ethan S. Sokol, Richard S. P. Huang, Sanjay B. Kulkarni, Jeffrey S. Ross
Summary: This study assesses genomic differences among a large series of pelvic squamous cell carcinoma (pSCC) cases to determine whether pSCC could potentially benefit from targeted therapies and/or immunotherapy.
Review
Biochemistry & Molecular Biology
Qin Niu, Qiannan Sun, Rushui Bai, Yunfan Zhang, Zimeng Zhuang, Xin Zhang, Tianyi Xin, Si Chen, Bing Han
Summary: Oral squamous cell carcinoma (OSCC) is a prevalent cancer worldwide with current treatment models presenting limitations. Nanomaterial-based photothermal therapy (PTT) has attracted research attention as a promising alternative. This paper reviews the latest progress in applying biological nanomaterials for PTT in OSCC and discusses different categories of photothermal nanomaterials and drug delivery systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Xu Zhang, Yuxiang Wang, Linghua Meng
Summary: Esophageal cancer is a highly lethal disease with rapid progression and poor prognosis. The two major subtypes, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), have distinct risk factors and molecular characteristics. Although surgical and chemoradiotherapy approaches have been applied, molecularly targeted therapy for esophageal cancer is still in its early stages. Advances in large-scale next-generation sequencing have revealed genomic alterations in ESCC and EAC, providing insights into their roles in the development and progression of esophageal cancer. Potential therapeutic targets have been identified, and novel strategies are under development to combat this disease.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Dentistry, Oral Surgery & Medicine
S. Y. Yang, S. H. Li, J. L. Liu, X. Q. Sun, Y. Y. Cen, R. Y. Ren, S. C. Ying, Y. Chen, Z. H. Zhao, W. Liao
Summary: This study developed a deep learning model to assist pathologists in diagnosing oral squamous cell carcinoma (OSCC), demonstrating improved diagnostic accuracy and speed in both junior and senior pathologists.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yin-Ling Wong, Anand Ramanathan, Kar Mun Yuen, Wan Mahadzir Wan Mustafa, Mannil Thomas Abraham, Keng Kiong Tay, Zainal Ariff Abdul Rahman, Yeng Chen
Summary: This study identified differentially expressed serum proteins as potential biomarkers for oral squamous cell carcinoma (OSCC) through comparative proteomics profiling. Decreased expression of CLU and HP could serve as complementary biomarkers of OSCC and assist in predicting patient outcomes. Further investigations with larger cohorts are needed for validation.
Article
Oncology
Wei-Chen Yen, Ian Yi-Feng Chang, Kai-Ping Chang, Chun-Nan Ouyang, Chiao-Rou Liu, Ting-Lin Tsai, Yi-Cheng Zhang, Chun- Wang, Ya-Hui Wang, Alice L. Yu, Hsuan Liu, Chih-Ching Wu, Yu-Sun Chang, Jau-Song Yu, Chia-Yu Yang
Summary: This study provides a comprehensive genomic analysis of OSCC PDXs and identifies high expression of matrix metalloproteinase-1 (MMP1) as a potential biomarker for predicting successful xenografts in OSCC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Krupal B. Patel, Tapan A. Padhya, Jinyong Huang, Juan C. Hernandez-Prera, Tingyi Li, Christine H. Chung, Liang Wang, Xuefeng Wang
Summary: This study found specific prognostic and diagnostic biomarkers for oral cavity squamous cell carcinoma (OCSCC) by comparing DNA methylation profiles in pre- and postsurgery plasma samples, supporting the utility of noninvasive biomarkers for OCSCC.
MOLECULAR CARCINOGENESIS
(2023)
Review
Medicine, General & Internal
Nai-Wen Su, Yu-Jen Chen
Summary: Metronomic therapy is a low-dose, repeated treatment approach for cancer that targets antiangiogenesis and immunomodulation mechanisms, showing comparative efficacy to traditional chemotherapy but with reduced side effects. In the treatment of oral cavity squamous cell carcinoma and other cancers, metronomic therapy has demonstrated promising results.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Leonardo de Oliveira da Rocha, Bruno Solano de Freitas Souza, Ricardo Della Coletta, Daniel W. Lambert, Clarissa A. Gurgel Rocha
Summary: Cell-in-cell (CIC) structures contribute to tumor aggressiveness and poor prognosis in oral squamous cell carcinoma (OSCC). In this study, spheroids obtained from OSCC and cancer-associated fibroblast (CAF) lines were used to investigate CIC structures. The spheroids showed the morphological aspects of the tumor microenvironment and CIC structures were found in both homotypic and heterotypic groups, predominantly in the proliferative zone of mixed spheroids. Complex cannibalism events were also observed. This model has the potential for further studies on CIC morphology, formation, and its relationship with tumor prognosis.
Article
Oncology
Hidenari Hirata, Atsushi Niida, Nobuyuki Kakiuchi, Ryutaro Uchi, Keishi Sugimachi, Takaaki Masuda, Tomoko Saito, Shun-Ichiro Kageyama, Yushi Motomura, Shuhei Ito, Tadamasa Yoshitake, Daisuke Tsurumaru, Yusuke Nishimuta, Akira Yokoyama, Takanori Hasegawa, Kenichi Chiba, Yuichi Shiraishi, Junyan Du, Fumihito Miura, Masaru Morita, Yasushi Toh, Masakazu Hirakawa, Yoshiyuki Shioyama, Takashi Ito, Tetsuo Akimoto, Satoru Miyano, Tatsuhiro Shibata, Masaki Mori, Yutaka Suzuki, Seishi Ogawa, Kousei Ishigami, Koshi Mimori
Summary: A study sequencing 52 tumor samples from 33 ESCC patients who received radiotherapy combined with 5-fluorouracil/platinum revealed the impact of chemoradiotherapy on clonal evolution, with MYC gain potentially serving as a marker for therapy resistance. The findings enhance understanding of therapeutic resistance and support the rationale for precision chemoradiotherapy.
Article
Oncology
Kai-Fang Hu, Chih-Wen Shu, Cheng-Hsin Lee, Ching-Jiunn Tseng, Yu-Hsiang Chou, Pei-Feng Liu
Summary: The roles of PFKFB3 and PFKFB4 in oral squamous cell carcinoma (OSCC) were investigated and it was found that they play different biological roles in OSCC cells. PFKFB3 is involved in cell viability, cell cycle progression, invasion, and migration, while PFKFB4 is involved in drug resistance and cancer stemness.
CANCER CELL INTERNATIONAL
(2023)