The C-Terminal Region Mesd Peptide Mimics Full-Length Mesd and Acts as an Inhibitor of Wnt/β-Catenin Signaling in Cancer Cells

N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis

(2012) Wen Liu et al.   EMBO Molecular Medicine

Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6

(2011) Victoria E. Ahn et al.   DEVELOPMENTAL CELL

Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

(2011) Shuo Chen et al.   DEVELOPMENTAL CELL

Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo

(2011) Cuihong Lin et al.   FEBS LETTERS

The wnt/β-catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer

(2011) Taj D. King et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

(2011) Zhihong Cheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FZD7 has a critical role in cell proliferation in triple negative breast cancer

(2011) L Yang et al.   ONCOGENE

Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway

(2011) Wenyan Lu et al.   PLoS One

Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells

(2011) Desheng Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Structural and Functional Domains of MESD Required for Proper Folding and Trafficking of LRP5/6

(2011) Jianglei Chen et al.   STRUCTURE

Mesd Is a Universal Inhibitor of Wnt Coreceptors LRP5 and LRP6 and Blocks Wnt/β-Catenin Signaling in Cancer Cells

(2010) Wenyan Lu et al.   BIOCHEMISTRY

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

(2010) Eric Bourhis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt Isoform-Specific Interactions with Coreceptor Specify Inhibition or Potentiation of Signaling by LRP6 Antibodies

(2010) Yan Gong et al.   PLoS One

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

(2010) S. A. Ettenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

(2010) C.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

The Wnt Co-Receptor Lrp6 Is Required for Normal Mouse Mammary Gland Development

(2009) Charlotta Lindvall et al.   PLoS One

R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression

(2008) Wenyan Lu et al.   FEBS LETTERS

Regulation of Epithelial Branching Morphogenesis and Cancer Cell Growth of the Prostate by Wnt Signaling

(2008) Bu-Er Wang et al.   PLoS One