Article
Biology
Nil Vanli, Jinghao Sheng, Shuping Li, Zhengping Xu, Guo-Fu Hu
Summary: RNASE4 serves as a biomarker for prostate cancer and can predict aggressiveness of the disease and enhance diagnosis accuracy. It also promotes tumor cell proliferation and angiogenesis.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Julita Orzechowska, Dorota Anusewicz, Andrzej K. Bednarek
Summary: This study aimed to differentiate the Notch-driven course of prostate cancer based on patients' ages and disease stage. Specific combinations of Notch molecules were identified, which predicted unfavorable outcomes and could serve as a new prognostic and therapeutic approach for prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Min Yang, Jean Chong Li, Chang Tao, Sa Wu, Bin Liu, Qiang Shu, Benyi Li, Runzhi Zhu
Summary: The study analyzed the expression of membrane progesterone receptor genes in prostate cancer tissues, finding significant upregulation of PAQR6 and downregulation of other genes. PAQR6 upregulation was significantly correlated with disease progression and overall survival outcomes in these tissues.
Article
Endocrinology & Metabolism
Jaroslav Juracek, Marie Madrzyk, Michal Stanik, Michaela Ruckova, Karolina Trachtova, Hana Malcikova, Eva Lzicarova, Dominik A. Barth, Martin Pichler, Ondrej Slaby
Summary: This study identified a miRNA expression pattern associated with disease aggressiveness in prostate cancer patients and established a prognostic score combining miRNA levels and serum PSA level that can distinguish between benign and aggressive prostate cancer.
Article
Biochemistry & Molecular Biology
Xiaoyu Zhu, Ji Ren, Dianqin Xu, Di Cheng, Wei Wang, Jie Ren, Ziwen Xiao, Hongmei Jiang, Yan Ding, Yujie Tan
Summary: This study found a significant increase in TPT1 expression levels in cervical cancer tissue and serum, which were strongly correlated with lymph node metastasis and low differentiation of the cancer. The results suggest that TPT1 may serve as a potential biomarker for cervical cancer progression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Libin Zhang, Jun Liu, Han Wang, Zheyuan Xu, Yang Wang, Yun Chen, Hao Peng
Summary: This study investigated the clinical relevance of MYH16 upregulation in pan cancers, specifically lung adenocarcinoma (LUAD). The results demonstrated that MYH16 upregulation is associated with tumor aggressiveness, worse overall survival in women, increased immune infiltration, and altered gene expression pathways. This study provides valuable evidence of the importance of MYH16 in LUAD.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Medicine, General & Internal
Hui-Yi Lin, Xinnan Wang, Tung-Sung Tseng, Yu-Hsiang Kao, Zhide Fang, Patricia E. Molina, Chia-Ho Cheng, Anders E. Berglund, Rosalind A. Eeles, Kenneth R. Muir, Nora Pashayan, Christopher A. Haiman, Hermann Brenner, Jong Y. Park
Summary: Excessive alcohol intake alone was not significantly associated with PCa aggressiveness, but certain genetic variants interact with alcohol intake to significantly impact PCa aggressiveness. Patients with specific genotypes are more vulnerable to developing aggressive PCa due to excessive alcohol intake. Our findings suggest that the impact of excessive alcohol intake on PCa aggressiveness varies based on genetic profiles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sitong Wang, Linaer Gu, Lili Huang, Juemin Fang, Zhuqing Liu, Qing Xu
Summary: PYCR2 has been shown to be upregulated in various cancer types, correlating with poor patient prognosis and malignant clinicopathological characteristics. It is identified as an independent predictor of survival in colon cancer patients, and knocking down PYCR2 disrupts the activities of colon cancer cells. Gene set enrichment analysis suggests high PYCR2 expression correlates with the enrichment of specific signaling pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Yaser Gamallat, Muhammad Choudhry, Qiaowang Li, Jon George Rokne, Reda Alhajj, Ramy Abdelsalam, Sunita Ghosh, Jaron Arbet, Paul C. Boutros, Tarek A. Bismar
Summary: High expression of SRRT is associated with poor prognosis in prostate cancer and common genetic aberrations in lethal prostate cancer. Further research is needed to investigate its potential as a therapeutic target.
Article
Oncology
Vasiliki Lygirou, Konstantinos Fasoulakis, Rafael Stroggilos, Manousos Makridakis, Agnieszka Latosinska, Maria Frantzi, Ioannis Katafigiotis, Christos Alamanis, Konstantinos G. Stravodimos, Constantinos A. Constantinides, Antonia Vlahou, Jerome Zoidakis
Summary: Prostate cancer is the second most common cancer in men. This study aimed to identify proteins related to the progression and aggressiveness of prostate cancer, which could potentially serve as biomarkers for better risk stratification. Through proteomic analysis of prostate tissue specimens, seven proteins were identified that may play a critical role in prostate cancer aggressiveness. These findings provide valuable insights into the key regulators of prostate cancer progression and could be used for the development of risk assessment tools.
Article
Urology & Nephrology
C. G. H. Ronnau, S. Fussek, F. P. Smit, T. W. Aalders, O. van Hooij, P. M. C. Pinto, M. Burchardt, J. A. Schalken, G. W. Verhaegh
Summary: This study identified several novel deregulated miRNAs in CRPC tissue, including two microRNAs potentially involved in tumor invasion. The data support the hypothesized involvement of miRNAs in PCa tumorigenesis and progression to CRPC. The applicability of these miRNAs as novel biomarkers for CRPC needs further investigation.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Julio Bunay, Myriam Kossai, Christelle Damon-Soubeyrant, Angelique De Haze, Jean-Paul Saru, Amalia Trousson, Cyrille de Joussineau, Erwan Bouchareb, Ayhan Kocer, Marine Vialat, Sarah Dallel, Francoise Degoul, Frederic Bost, Stephan Clavel, Frederique Penault-Llorca, Marie-Pierre Valli, Laurent Guy, Jason Matthews, Yoan Renaud, Michael Ittmann, Jeffrey Jones, Laurent Morel, Jean-Marc Lobaccaro, Silvere Baron
Summary: Increasing evidence suggests a causal link between exposure to persistent organic pollutants (POPs) and increased incidence and aggressivity of various cancers. Dioxin and PCB-153, two widely found POPs, have been identified as significant sources of contamination. Experiments involving low doses of these POPs in ex vivo and in vivo models have shown that they increase growth and metastasis of prostate cancer cells. The up-regulation of Acetyl-CoA Acetyltransferase-1 (ACAT1) and ketone bodies pathway enzymes, identified as potential targets, has been confirmed in advanced prostate cancer. ACAT1 histoscore was also found to be significantly increased in patients exposed to the highly contaminated agent orange.
Article
Pathology
Hongxing Nan, Lisha Zhou, Weihua Liang, Jin Meng, Ke Lin, Man Li, Jun Hou, Lianghai Wang
Summary: Elevated expression of CCL20 in esophageal cancer is associated with poor prognosis and metastatic potential, as well as with promoter hypomethylation in tumor cells. Imbalance among CD4(+) T cell subtypes and abnormal CCL20 expression in the tumor microenvironment are observed during tumorigenesis. Targeting CCL20 may be a promising therapeutic approach for esophageal cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Hoiseon Jeong, Hwa Eun Oh, Hyesun Kim, Ju-Han Lee, Eung Seok Lee, Young-Sik Kim, Jung-Woo Choi
Summary: The study found that FATP4, CD36, and ACSL1 were overexpressed in NMIBC cases and associated with higher grade and stage, suggesting they may promote disease progression and be important for clinical risk stratification and targeted therapy.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Di Cui, Jianneng Li, Ziqi Zhu, Michael Berk, Aimalie Hardaway, Jeffrey McManus, Yoon-Mi Chung, Mohammad Alyamani, Shelley Valle, Ritika Tiwari, Bangmin Han, Maryam Goudarzi, Belinda Willard, Nima Sharifi
Summary: After androgen deprivation, prostate cancer frequently becomes castration resistant (CRPC), involving intratumoral androgen production. Cancer-associated fibroblasts (CAFs) increase 3 beta HSD1 expression and induce androgen synthesis, leading to CRPC.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Oncology
Faizan Haider Khan, Basharat Ahmad Bhat, Bashir Ahmad Sheikh, Lubna Tariq, Roshan Padmanabhan, Jay Prakash Verma, Amritesh Chandra Shukla, Afshin Dowlati, Ata Abbas
Summary: The lung microbiome has a crucial impact on maintaining healthy lung function and host immune homeostasis. Dysbiosis or disruption of the gut-lung axis can contribute to lung carcinogenesis by causing DNA damage, genomic instability, or altering the host's susceptibility to carcinogens. Most studies have focused on the association between microbial composition and lung cancer, while the mechanisms of host-microbe interactions and the epigenetic modifying potentials of microbial metabolites and toxins in lung tumorigenesis are not well understood.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
German Corredor, Paula Toro, Can Koyuncu, Cheng Lu, Christina Buzzy, Kaustav Bera, Pingfu Fu, Mitra Mehrad, Kim A. Ely, Mojgan Mokhtari, Kailin Yang, Deborah Chute, David J. Adelstein, Lester D. R. Thompson, Justin A. Bishop, Farhoud Faraji, Wade Thorstad, Patricia Castro, Vlad Sandulache, Shlomo A. Koyfman, James S. Lewis, Anant Madabhushi
Summary: This study investigates whether OP-TIL, a biomarker, can separate stage I HPV-associated OPSCC patients into low-risk and high-risk groups and aid in patient selection for de-escalation clinical trials.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Urology & Nephrology
Ilaha Isali, Ahmad Osama Khalifa, Subba Shankar, Stanley Dannemiller, Walter Horne, Michelle Evancho-Chapman, Phillip McClellan, Gregory T. MacLennan, Ozan Akkus, Adonis Hijaz
Summary: This study evaluates the use of sheep as a potential model for preclinical evaluation of urethral slings. The anatomical measurements and histological tissue integration in sheep show similar results to humans, suggesting the suitability of this model for biomaterial response assessment.
UROLOGIA INTERNATIONALIS
(2023)
Article
Multidisciplinary Sciences
Xiangxue Wang, Cristian Barrera, Kaustav Bera, Vidya Sankar Viswanathan, Sepideh Azarianpour-Esfahani, Can Koyuncu, Priya Velu, Michael D. Feldman, Michael Yang, Pingfu Fu, Kurt A. Schalper, Haider Mahdi, Cheng Lu, Vamsidhar Velcheti, Anant Madabhushi
Summary: This study utilizes image analysis to capture morphologic attributes and evaluates their association with survival in lung cancer and gynecological cancer patients treated with immune checkpoint inhibitors (ICIs).
Article
Oncology
Amr Mohamed, Namrata Vijayvergia, Matthew Kurian, Lisa Liu, Pingfu Fu, Satya Das
Summary: This study retrospectively analyzed the treatment outcomes of EP-NEC patients and found that dual ICPIs showed better progression-free survival and overall survival in patients with EP-NEC in the second-line setting, compared to single ICPIs or cytotoxic chemotherapy.
Article
Oncology
Sara Arabyarmohammadi, Patrick Leo, Vidya Sankar Viswanathan, Andrew Janowczyk, German Corredor, Pingfu Fu, Howard Meyerson, Leland Metheny, Anant Madabhushi
Summary: Computer-extracted morphology and texture features from chromatin patterns of myeloblasts can predict post-HCT relapse and prognosticate RFS in patients with AML/MDS.
JCO CLINICAL CANCER INFORMATICS
(2022)
Article
Oncology
Gary Wildey, Ashley M. Shay, Karen S. McColl, Suzy Yoon, Mohammad A. Shatat, Ahmad Perwez, Kyle B. Spainhower, Adam M. Kresak, MaryBeth Lipka, Michael Yang, Mohadese Behtaj, Pingfu Fu, Asrar Alahmadi, Wadad Mneimneh, Ata Abbas, Afshin Dowlati
Summary: Genomic studies have found that some small cell lung cancer (SCLC) tumors do not have RB1 mutations, contrary to the canonical model. This study examined RB1 protein expression and its function in SCLC and found that 14% of SCLC tumors expressed abundant RB1 protein, which was associated with neuroendocrine gene expression and enriched in YAP1 expression. SCLC cells with RB1 protein expression were sensitive to growth inhibition by the CDK4/6 inhibitor palbociclib, and a patient with wild-type RB1 SCLC showed a significant decrease in mutant TP53 ctDNA allelic fraction and tumor mass after treatment with the CDK4/6 inhibitor abemaciclib.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Mohd Shuaib, Kumari Sunita Prajapati, Sanjay Gupta, Shashank Kumar
Summary: In this study, it was found that Withaferin A (WA) can exert an anticancer effect on triple-negative breast cancer cells by modulating the expression of miRNA. The results showed that WA up-regulated the expression of miR-181c-5p and down-regulated the expression of miR-1275, among other miRNAs. These miRNAs were found to affect the expression of cancer-associated genes and signaling pathways. Additionally, co-treatment of WA and miR-181c-5p mimic inhibited cell growth, induced apoptosis, and regulated the expression of genes involved in cell cycle and apoptosis.
Editorial Material
Oncology
Smit Brahmbhatt, Herta H. H. Chao, Shiv Verma, Sanjay Gupta
Review
Oncology
Shashank Kumar, Mohd Shuaib, Abdullah F. AlAsmari, Faleh Alqahtani, Sanjay Gupta
Summary: Guanine nucleotide-binding protein-like 3 (GNL3) and proliferation-associated protein 2G4 (PA2G4) are overexpressed in several human cancers, including prostate cancer, and could serve as prognostic biomarkers of clinical significance in prostate cancer. Prostate cancer is a common disease in males and lacks reliable biomarkers for prognosis. In this review, the function of GNL3 and PA2G4 is highlighted, and their potential as prognostic biomarkers in prostate cancer is discussed.
Article
Oncology
Cristian Barrera, German Corredor, Vidya Sankar Viswanathan, Ruiwen Ding, Paula Toro, Pingfu Fu, Christina Buzzy, Cheng Lu, Priya Velu, Philipp Zens, Sabina Berezowska, Merzu Belete, David Balli, Han Chang, Vipul Baxi, Konstantinos Syrigos, David L. Rimm, Vamsidhar Velcheti, Kurt Schalper, Eduardo Romero, Anant Madabhushi
Summary: The tumor immune composition has an impact on prognosis and treatment sensitivity in lung cancer. Effective adaptive immune responses are associated with better clinical outcomes after immune checkpoint blockers, while immunotherapy resistance can occur due to T-cell exhaustion, immunosuppressive signals, and regulatory cells. This study investigates a new computational pathology approach called PhenoTIL, which uses machine learning to analyze the spatial interactions and functional features of immune cell niches associated with tumor rejection and patient outcomes in non-small cell lung cancer (NSCLC). The study demonstrates the potential of PhenoTIL as a valuable biomarker for treatment-specific outcomes in NSCLC.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Bolin Song, Kailin Yang, Vidya Sankar Viswanathan, Xiangxue Wang, Jonathan Lee, Sarah Stock, Pingfu Fu, Cheng Lu, Shlomo Koyfman, James S. Lewis, Anant Madabhushi
Summary: This study aimed to develop and validate a prognostic and predictive radiomic image signature (pRiS) using CT scans to inform survival and chemotherapy benefit in HPV-associated OPSCC. The results showed that pRiS was able to predict patient survival and determine whether chemotherapy provided additional benefit.
NPJ PRECISION ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Ali Vaziri-Gohar, Jonathan J. Hue, Ata Abbas, Hallie J. Graor, Omid Hajihassani, Mehrdad Zarei, George Titomihelakis, John Feczko, Moeez Rathore, Sylwia Chelstowska, Alexander W. Loftus, Rui Wang, Mahsa Zarei, Maryam Goudarzi, Renliang Zhang, Belinda Willard, Li Zhang, Adam Kresak, Joseph E. Willis, Gi-Ming Wang, Curtis Tatsuoka, Joseph M. Salvino, Ilya Bederman, Henri Brunengraber, Costas A. Lyssiotis, Jonathan R. Brody, Jordan M. Winter
Summary: The response to chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC) can be improved by hyperglycemia, which disrupts redox metabolism.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Afshin Dowlati, Ata Abbas, Timothy Chan, Brian Henick, Xuya Wang, Parul Doshi, Pingfu Fu, Jyoti Patel, Fengshen Kuo, Han Chang, David Balli
Summary: This study found that mutations in the RB1 gene are associated with survival outcomes in small-cell lung cancer (SCLC) patients treated with immune checkpoint blockade (ICB). RB1 mutant tumors showed downregulated expression of immune-related genes and an immune exclusion phenotype. SCLC patients with wild-type RB1 status or lower RB1 gene loss-of-function signature scores have better outcomes with ICB monotherapy.
JCO PRECISION ONCOLOGY
(2022)
Article
Oncology
Ali Vaziri-Gohar, Joel Cassel, Farheen S. Mohammed, Mehrdad Zarei, Jonathan J. Hue, Omid Hajihassani, Hallie J. Graor, Yellamelli V. V. Srikanth, Saadia A. Karim, Ata Abbas, Erin Prendergast, Vanessa Chen, Erryk S. Katayama, Katerina Dukleska, Imran Khokhar, Anthony Andren, Li Zhang, Chunying Wu, Bernadette Erokwu, Chris A. Flask, Mahsa Zarei, Rui Wang, Luke D. Rothermel, Andrea M. P. Romani, Jessica Bowers, Robert Getts, Curtis Tatsuoka, Jennifer P. Morton, Ilya Bederman, Henri Brunengraber, Costas A. Lyssiotis, Joseph M. Salvino, Jonathan R. Brody, Jordan M. Winter
Summary: This study reveals that nutrient-deprived conditions in the tumor microenvironment inhibit cancer cell viability, while wild-type isocitrate dehydrogenase 1 (wtIDH1) enables pancreatic cancer cells to adapt to these conditions. The study also shows the potent inhibitory effects of allosteric inhibitors of mutant IDH1 (mIDH1) on wtIDH1, and highlights the therapeutic potential of FDA-approved mIDH1 inhibitor ivosidenib (AG-120) in pancreatic cancer.
