Article
Geriatrics & Gerontology
Yiying Zhou, Ke Zhang, Fangmin Wang, Jiali Chen, Shanshan Chen, Manqing Wu, Miaojun Lai, Yisheng Zhang, Wenhua Zhou
Summary: This study investigates the regenerative mechanisms of knockdown the RNA-binding protein polypyrimidine tract binding protein (PTB) in reversing depression-like behaviors and cognition impairment in mice with lesioned cholinergic neurons. The findings suggest that supplementing cholinergic neurons after PTB knockdown may be a promising therapeutic strategy to revert depression-like behaviors and cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Zhen Li, Zekang Ye, Jiazheng Ma, Qian Gu, Jianzhen Teng, Xiaoxuan Gong
Summary: The study revealed that miR-133b alleviated doxorubicin-induced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2, suggesting that miR-133b may be a potential biomarker for doxorubicin-induced cardiac injury.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Eliezra Glasser, Debanjana Maji, Giulia Biancon, Anees Mohammed Keedakkatt Puthenpeedikakkal, Chapin E. Cavender, Toma Tebaldi, Jermaine L. Jenkins, David H. Mathews, Stephanie Halene, Clara L. Kielkopf
Summary: This study reveals the flexibility of U2AF2 in recognizing polypyrimidine tracts of nascent transcripts and the tolerance of nucleotide substitutions at the central position of the Py tract. The results highlight the importance of RNA flexibility for protein recognition and provide insights into the relationship between splice site motifs and pre-mRNA splicing efficiencies.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jianong Zhang, Liang Zhang, Ji Nie, Yan Lin, Yao Li, Wei Xu, Jian-Yuan Zhao, Shi-Min Zhao, Chenji Wang
Summary: Calcineurin interacts with the mitochondrial gatekeeper enzyme PDC to enhance cellular metabolism and suppress cancer cell proliferation. Inhibition of the calcineurin-PDC pathway by CNIs may promote tumorigenesis, suggesting a potential mechanism for the increased cancer incidence in transplant recipients.
Article
Oncology
Qiao-Xia Zhang, Yu-Ming Pan, Hong-Li Xiao, Na An, Si -Si Deng, Xin DU
Summary: Alternative splicing is a crucial post-transcriptional regulation process in tumors, and PTBP1 might be a potential target for AML therapy.
Article
Geriatrics & Gerontology
Zhepei Wang, Shengjun Zhou, Jikuang Zhao, Sheng Nie, Jie Sun, Xiang Gao, Cameron Lenahan, Zhiqin Lin, Yi Huang, Gao Chen
Summary: This study found that DNA methylation levels in the promoter region of the PTBP1 gene are significantly associated with the development of IA. The methylation of PTBP1 may serve as a potential predictive marker for the occurrence of IA.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jimin Wang, Aristidis Sachpatzidis, Thomas D. Christian, Ivan B. Lomakin, Alan Garen, William H. Konigsberg
Summary: The human polypyrimidine-binding splicing factor (PSF/SFPQ) is a tumor suppressor protein that regulates gene expression and binds to specific RNA sequences. The crystal structures of a truncated form of PSF alone and in complex with RNA revealed how PSF recognizes RNA and undergoes conformational changes. These findings provide insights into a new regulatory mechanism involved in promoting malignancies and other human diseases.
Article
Gastroenterology & Hepatology
Jihua Xue, Jun Cheng, Xuejiao Ma, Yixian Shi, Huafa Yin, Yufeng Gao, Jiabin Li
Summary: RAN is found to be significantly induced in HCV infection, leading to the cytoplasmic redistribution of PTB. The interaction between RAN and PTB plays a crucial role in influencing HCV infection by mediating the cytoplasmic translocation of PTB.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Masakatsu Fukuda, Yudai Ogasawara, Hiroyasu Hayashi, Katsuyuki Inoue, Hideaki Sakashita
Summary: Resveratrol exhibits selective anti-cancer effects on oral cancer cells by inducing autophagy through the regulation of SREBP1 expression in lipid metabolism.
Article
Oncology
Mengnan Liu, Chunyu Lin, Fang Liu, Qinghua Cao
Summary: This study found that high expression of PTBP1 is closely related to multiple clinicopathological features in gastric cancer, indicating poor prognosis. Experimental results showed that silencing PTBP1 in gastric cancer cells significantly suppressed cell proliferation, migration, and invasion. Therefore, PTBP1 may serve as a biomarker of poor prognosis and a novel target in treating gastric cancer.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Zhe Yang, Zhi Liu, Yanping Yang, Yanping Dai, Xiaoqin Gao
Summary: Sertoli cells (SCs) are crucial for spermatogenesis, and the blood-testis barrier (BTB) composed of SCs plays a vital role in the development and maturity of spermatogenic cells. The downregulation of PTBP1 in SCs may disrupt the tight junctions between cells, leading to impaired spermatogenesis, suggesting PTBP1's role in maintaining BTB integrity and regulating spermatogenesis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Haini Wang, Junli Zuo
Summary: Overexpressed survivin is associated with worse survival of several types of human tumors. In this study, the antitumor activity of shikonin in non-small-cell lung cancer (NSCLC) by regulating survivin pathway was investigated. Result showed that shikonin inhibited the NSCLC H1299 cell proliferation in a dose-dependent manner. Moreover, shikonin fits well with survivin by molecular docking. Shikonin also inhibited the mRNA expression and protein level of survivin in H1299 cells. Shikonin arrested H1299 cell cycle at the G0/G1 phase by regulating CDK/cyclin family members. In addition, shikonin regulated the expression of X-linked inhibitor of apoptosis- (XIAP-) mediated caspases 3 and 9, thus leading to the damage of mitochondrial membrane potential and induction of H1299 cell apoptosis. Overall, shikonin inhibited H1299 cell growth by inducing apoptosis and blocking the cell cycle. The underlying mechanism involves targeting survivin, which subsequently regulates the protein expression of XIAP/caspase 3/9, CDK2/4, and cyclin E/D1. Thus, shikonin, a survivin inhibitor, is a promising therapeutic strategy in NSCLC treatment.
ANALYTICAL CELLULAR PATHOLOGY
(2021)
Article
Cell Biology
Tao Guo, Ke You, Xi Chen, Yuqi Sun, Ying Wu, Ping Wu, Yingying Jiang
Summary: The protein RBM47 has been found to inhibit tumor behaviors in hepatocellular carcinoma (HCC) by suppressed growth and metastasis of xenograft tumors. It was also found to positively regulate UPF1 in HCC by enhancing its stability and promoting its transcription.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Marika Rossini, Fernanda Martini, Elena Torreggiani, Francesca Fortini, Giorgio Aquila, Francesco Vieceli Dalla Sega, Simone Patergnani, Paolo Pinton, Pio Maniscalco, Giorgio Cavallesco, Paola Rizzo, Mauro Tognon
Summary: Malignant pleural mesothelioma is an aggressive cancer linked to asbestos exposure with poor prognosis. Dysregulation of Notch signaling may contribute to cancer progression. Metformin is an effective anti-tumor drug, showing inhibitory effects on MPM cell proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tian Hua, Rui-Min Wang, Xiao-Chong Zhang, Bei-Bei Zhao, Shao-Bei Fan, Deng-Xiang Liu, Wei Wang
Summary: ZNF76 shows decreased expression in ovarian cancer, correlated with platinum resistance and poor prognosis, serving as a promising biomarker for predicting outcomes in ovarian cancer patients.
BIOSCIENCE REPORTS
(2021)