Diacylglycerol Acyltransferase-1 (DGAT1) Inhibition Perturbs Postprandial Gut Hormone Release

Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release-Potential insight into mechanism of action

(2013) Jinqi Liu et al.   Obesity

Meal pattern analysis in neural-specific proopiomelanocortin-deficient mice

(2011) Christian D. Richard et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Modeling the Mechanism of Action of a DGAT1 Inhibitor Using a Causal Reasoning Platform

(2011) Ahmed E. Enayetallah et al.   PLoS One

Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

(2011) Robert L. Dow et al.   ACS Medicinal Chemistry Letters

Dipeptidyl Peptidase-4 Inhibitors Administered in Combination With Metformin Result in an Additive Increase in the Plasma Concentration of Active GLP-1

(2010) E M Migoya et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Coenzyme A: Diacylglycerol acyltransferase 1 inhibitor ameliorates obesity, liver steatosis, and lipid metabolism abnormality in KKAy mice fed high-fat or high-carbohydrate diets

(2010) Toshihiro Yamamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation

(2010) Suneil K. Koliwad et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestine-specific expression of acyl CoA:diacylglycerol acyltransferase 1 reverses resistance to diet-induced hepatic steatosis and obesity inDgat1−/−mice

(2010) Bonggi Lee et al.   JOURNAL OF LIPID RESEARCH

Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4)

(2009) Nancy A. Thornberry et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Role of MGAT2 and DGAT1 in the release of gut peptides after triglyceride ingestion

(2009) Mayumi Okawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery of a Potent, Selective, and Orally Efficacious Pyrimidinooxazinyl Bicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 Inhibitor

(2009) Alan M. Birch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intestinal Vitamin D Receptor Is Required for Normal Calcium and Bone Metabolism in Mice

(2008) Yingben Xue et al.   GASTROENTEROLOGY

Lifestyle and Pharmacological Approaches to Weight Loss: Efficacy and Safety

(2008) George A. Bray   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor

(2008) Gang Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY