Editorial Material
Endocrinology & Metabolism
Zhongjie Fu, Lois E. H. Smith
Summary: Pathologic angiogenesis in eye diseases leading to blindness can be attributed to cell senescence, as demonstrated by the bioinformatics study conducted by Crespo-Garcia, Tsuruda, and Dejda. Their findings were validated in human and mouse retina models, where clearance of senescent cells effectively suppressed neovessel growth.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Cell Biology
Yingyu Mao, Silvia C. Finnemann
Summary: The diurnal phagocytosis of spent photoreceptor outer segment fragments by retinal pigment epithelial cells is essential for visual function. Formation of phagocytic cups beneath surface-tethered POS requires the signaling of MerTK and activation of Rac1, with RhoA pathway inactivation playing a crucial role in the phagocytic process. Ultimately, manipulating RhoA pathway can restore phagocytic capacity to MerTK-deficient RPE.
Article
Ophthalmology
Romain Touze, Marc M. Abitbol, Dominique Bremond-Gignac, Matthieu P. Robert
Summary: This study confirms the dysfunction of the retinal pigment epithelium (RPE) in patients with neurofibromatosis type 1 (NF1), characterized by a lower dark trough (DT) and a corresponding higher light peak (LP)/DT ratio. This pattern may be due to a dysregulation of melanocytogenesis, leading to disrupted calcium ion flux and abnormal polarization of the RPE.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Lyndsay L. Leach, Nicholas J. Hanovice, Stephanie M. George, Ana E. Gabriel, Jeffrey M. Gross
Summary: Research has revealed that zebrafish RPE has strong intrinsic regenerative potential, with elements of immune response identified as critical mediators in the regeneration process. Macrophage/microglia cells are responsive to RPE damage and essential for the timely progression of regenerative response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Ophthalmology
M. Helena Cardoso, Michael J. Hall, Thomas Burgoyne, Pedro Fale, Tina Storm, Cristina Escrevente, Pedro Antas, Miguel C. Seabra, Clare E. Futter
Summary: This study aimed to model the effects of chloroquine on the retinal pigment epithelium in vivo and investigate the impact of mild chloroquine treatment on lysosome function and turnover. The research found that low-dose chloroquine treatment inhibits lysosome reformation, leading to a gradual depletion of lysosomes' ability to interact with cargo-carrying vacuoles and degrade their content. The accumulation of pro-cathepsin D and LAMP1 reflects the inhibition of normal turnover of lysosomal constituents and possibly lysosomes themselves. Understanding the mechanisms underlying lysosome reformation may contribute to the development of new treatments for chloroquine-induced retinopathy.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Song Yang, Jun Zhou, Dengwen Li
Summary: The retinal pigment epithelium is crucial for visual functions, but damage to its structure and function can lead to various retinopathies with no cure currently available. Understanding the development, function, and pathobiology of the retinal pigment epithelium is essential for preventing and treating retinopathies. This review discusses potential strategies for treatment and provides new perspectives for future research in this field.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Ophthalmology
Rodrigo Vilares-Morgado, Carolina Madeira, Manuel Falcao, Goncalo Godinho, Margarida Ribeiro, Joao Beato, Ana Catarina Pedrosa, Elisete Brandao, Fernando Falcao-Reis, Angela Carneiro
Summary: The study found that RPE remodelling was evident in half of the sample, and was associated with a younger age, smaller and narrower PED at RPE tear diagnosis, and the presence of SRF at tear diagnosis. However, this structural recovery did not result in a better functional outcome.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Janet R. Sparrow, Rait Parmann, Stephen H. Tsang, Rando Allikmets, Stanley Chang, Ruben Jauregui
Summary: When using SD-OCT to assess the outer retina, different retinal diseases may present similar hyperreflective lesions. These lesions, associated with mutations in proteins expressed in photoreceptor cells, indicate degenerative processes in the photoreceptor cells.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yuqin Liang, Feng Tan, Xihao Sun, Zekai Cui, Jianing Gu, Shengru Mao, Hon Fai Chan, Shibo Tang, Jiansu Chen
Summary: This study established an iPSCs model of a PRPF6-related adRP patient and generated a disease model of RPE cells, revealing the effects of PRPF6 mutation on the morphology, gene expression, and function of RPE cells. This research is of great significance for understanding PRPF6-related RPE cells and future cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jongmin Kim, Yeo Jin Lee, Jae Yon Won
Summary: This review highlights the roles and pathogenesis of retinal pigment epithelium (RPE) in AMD, emphasizing the importance of understanding the etiology of AMD and discussing potential treatment strategies targeting RPE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Kristine A. Tsantilas, Whitney M. Cleghorn, Celia M. Bisbach, Jeremy A. Whitson, Daniel T. Hass, Brian M. Robbings, Martin Sadilek, Jonathan D. Linton, Austin M. Rountree, Ana P. Valencia, Mariya T. Sweetwyne, Matthew D. Campbell, Huiliang Zhang, Connor S. R. Jankowski, Ian R. Sweet, David J. Marcinek, Peter S. Rabinovitch, James B. Hurley
Summary: The study revealed that aged mice had reduced retinal responses to light stimuli, with relatively stable metabolic flux and ATP levels in retinal tissues. However, there was a decrease in glutamine utilization in the Krebs Cycle in eyecups while other metabolic parameters remained constant. This suggests that external factors may play a role in influencing ocular metabolism in vivo.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Neurosciences
Erwin Vera, Isabel Cornejo, Maria Isabel Niemeyer, Francisco Sepulveda, L. Pablo Cid
Summary: Kir7.1 K+ channel expressed in retinal pigment epithelium is mutated in inherited retinal degeneration diseases. Mutations changing Arg 162 to Trp or Gln interfere with channel function, while smaller volume amino acids are tolerated or even enhance function. R162, K164, and possibly K159 form crucial binding sites for phosphoinositide, essential for channel activity.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Ophthalmology
Yusong Wang, Jieqiong Chen, Junran Sun, Tong Li, Suqin Yu, Yuanyuan Gong, Yang Yu, Xiaoling Wan, Huixun Jia, Jihong Wu, Fei Yuan, Xi Shen, Zhiliang Wang, Tong Qiao, Qiang Wu, Yu Xu, Zhaoyang Wang, Chenhao Yang, Jifang Qu, Jianjun Chen, Xiaodong Sun
Summary: By studying the outer retinal tubulation (ORT) in the eyes of Chinese patients with Bietti crystalline dystrophy (BCD), it was found that ORT may be a precursor of retinal pigment epithelium (RPE) atrophy in early-stage BCD, and it may suggest slower progression in late-stage BCD.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Materials Science, Multidisciplinary
Biola F. Egbowon, Enzo Fornari, Joseph M. Pally, Alan J. Hargreaves, Bob Stevens, T. Martin Mcginnity, Barbara K. Pierscionek
Summary: This study demonstrates that human RPE cell lines (ARPE-19) can be cultured on ultrathin suspended electrospun nanofibre scaffolds (ENS) composed of hydrophobic polymer polyacrylonitrile (PAN) and a water-soluble aliphatic diamine, without or with fluocinolone acetonide (FA) treatment. The cells survived and maintained their morphology for up to 150 days with FA-treated ENS, showing an epithelial phenotype with biomarkers critical for retinal characteristics. This technique has potential for subretinal transplantation.
MATERIALS & DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Elliot H. Choi, Anahita Daruwalla, Susie Suh, Henri Leinonen, Krzysztof Palczewski
Summary: The text explains the isomerization process of visual pigments in rod and cone photoreceptor cells driven by photons, and the mechanism of visual signal transmission. It discusses the regeneration of retinoids achieved through a series of reactions, as well as the importance of RGR as an adjunct pathway.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Cell Biology
Jingyu Yao, Lin Jia, Naheed Khan, Chengmao Lin, Sayak K. Mitter, Michael E. Boulton, Joshua L. Dunaief, Daniel J. Klionsky, Jun-Lin Guan, Debra A. Thompson, David N. Zacks
Article
Ophthalmology
Shameka J. Shelby, Kecia L. Feathers, Anna M. Ganios, Lin Jia, Jason M. Miller, Debra A. Thompson
EXPERIMENTAL EYE RESEARCH
(2015)
Review
Ophthalmology
Debra A. Thompson, Robin R. Ali, Eyal Banin, Kari E. Branham, John G. Flannery, David M. Gamm, William W. Hauswirth, John R. Heckenlively, Alessandro Iannaccone, K. Thiran Jayasundera, Naheed W. Khan, Robert S. Molday, Mark E. Pennesi, Thomas A. Reh, Richard G. Weleber, David N. Zacks
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2015)
Article
Medicine, General & Internal
J. W. B. Bainbridge, M. S. Mehat, V. Sundaram, S. J. Robbie, S. E. Barker, C. Ripamonti, A. Georgiadis, F. M. Mowat, S. G. Beattie, P. J. Gardner, K. L. Feathers, V. A. Luong, S. Yzer, K. Balaggan, A. Viswanathan, T. J. L. de Ravel, I. Casteels, G. E. Holder, N. Tyler, F. W. Fitzke, R. G. Weleber, M. Nardini, A. T. Moore, D. A. Thompson, S. M. Petersen-Jones, M. Michaelides, L. I. van den Born, A. Stockman, A. J. Smith, G. Rubin, R. R. Ali
NEW ENGLAND JOURNAL OF MEDICINE
(2015)
Article
Ophthalmology
Hsien-Chang Lin, Joshua D. Stein, Bin Nan, David Childers, Paula Anne Newman-Casey, Debra A. Thompson, Julia E. Richards
JAMA OPHTHALMOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Chunhe Chen, Leopold Adler, Patrice Goletz, Federico Gonzalez-Fernandez, Debra A. Thompson, Yiannis Koutalos
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Cell Biology
Jingyu Yao, Yaoyan Qiu, Eric Frontera, Lin Jia, Naheed W. Khan, Daniel J. Klionsky, Thomas A. Ferguson, Debra A. Thompson, David N. Zacks
Editorial Material
Cell Biology
Debra A. Thompson, Daniel J. Klionsky
Article
Ophthalmology
Qitao Zhang, Feriel Presswalla, Kecia Feathers, Xu Cao, Bret A. Hughes, David N. Zacks, Debra A. Thompson, Jason M. L. Miller
EXPERIMENTAL EYE RESEARCH
(2019)
Article
Ophthalmology
Abigail T. Fahim, Zaina Bouzia, Kari H. Branham, Neruban Kumaran, Mauricio E. Vargas, Kecia L. Feathers, N. Dayanthi Perera, Kelly Young, Naheed W. Khan, John R. Heckenlively, Andrew R. Webster, Mark E. Pennesi, Robin R. Ali, Debra A. Thompson, Michel Michaelides
BRITISH JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Cell Biology
Yaoyan Qiu, Jingyu Yao, Lin Jia, Debra A. Thompson, David N. Zacks
CELL DEATH & DISEASE
(2019)
Article
Biotechnology & Applied Microbiology
Kecia L. Feathers, Lin Jia, Nirosha Dayanthi Perera, Adrienne Chen, Feriel K. Presswalla, Naheed W. Khan, Abigail T. Fahim, Alexander J. Smith, Robin R. Ali, Debra A. Thompson
HUMAN GENE THERAPY
(2019)
Article
Medicine, Research & Experimental
Abigail T. Fahim, Debra A. Thompson
RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY
(2019)
Article
Ophthalmology
Qitao Zhang, Feriel Presswalla, Melissa Calton, Carol Charniga, Jeffrey Stern, Sally Temple, Douglas Vollrath, David N. Zacks, Robin R. Ali, Debra A. Thompson, Jason M. L. Miller
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Ophthalmology
Jingyu Yao, Lin Jia, Shameka J. Shelby, Anna M. Ganios, Kecia Feathers, Debra A. Thompson, David N. Zacks
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2014)